Abstract: This invention relates to a process of preparing phthalein indicator dyes including phthalides and naphthalides derived from certain hydroxy-substituted carbocyclic aryl compounds, such as phenols, and from certain N-heterocyclic aryl compounds, such as indoles, and to a process of preparing novel intermediates useful therein. According to the present invention, the selected carbocyclic compound or the selected N-heterocyclic compound is reacted with phthalaldehydic or naphthalaldehydic acid to form the corresponding (na)phthalidyl adduct which is treated with an oxidizing agent to yield the subject intermediates. To prepare the indicator dye, the intermediate, i.e., the oxidation product thus obtained is then reacted with a carbocyclic or heterocyclic aryl compound to yield the corresponding indicator dye. The oxidation products comprising the novel intermediates of the present invention may be dehydro or hydrated (na)phthalidyl adducts.
Abstract: Perfluoroalkylthio glycols and esters thereof can be prepared by the free-radical catalyzed addition of a perfluoroalkylthiol to an acetylenic alcohol or ester thereof. The compounds obtained are useful intermediates for the synthesis of fluorochemicals with low free surface energies having oil and water repellent properties. In one embodiment, a perfluoroalkylthio glycol can be reacted with a diisocyanate to obtain a polyurethane containing perfluoroalkylthio groups, which polyurethanes are useful as coatings to provide oil and water repellence to textiles and as additives to plastics to provide mold-release and other desirable properties.
Type:
Grant
Filed:
November 12, 1975
Date of Patent:
January 4, 1977
Assignee:
Ciba-Geigy Corporation
Inventors:
Robert Ernest Arthur Dear, Robert Allan Falk
Abstract: N-chloroformyl carbamic acid amides and esters having the functional group ##EQU1## are prepared by reacting phosgene with an imino compound having the functional group ##EQU2## and free of interfering radicals. Preferably the starting material has the formula ##EQU3## in which R.sup.1 is a monovalent or divalent optionally substituted aliphatic, cycloaliphatic, araliphatic or aromatic radical,R.sup.2 is an optionally substituted alkyl or aralkyl radical,R.sup.3 is a monovalent optionally substituted aliphatic, cycloaliphatic, araliphatic or aromatic radical, and any two of the radicals R.sup.1, R.sup.2 and R.sup.3 can conjointly be a constituent of a 4-membered to 7-membered heterocyclic ring,X is oxygen, sulfur or an N--R.sup.4 radical, in whichR.sup.4 is an optionally substituted C.sub.1 -C.sub.6 alkyl, cycloalkyl, aralkyl or aromatic radical, orR.sup.3 and R.sup.4 together optionally form a constituent of a 4-membered to 7-membered ring, andn is 1 when R.sup.1 is monovalent and 2 when R.sup.1 is divalent.
Abstract: Polyethers having utility as adhesion promoters for various polymers to metals and other substrates comprise repeating monomer units represented by the general formula: ##STR1## wherein Z is --CH=CR.sub.1 R.sub.2, or ##STR2## wherein G is hydroxyl, halogen or amine, R.sub.1 and R.sub.2 are individually hydrogen or a monovalent organic radical and e is 1 or 2. Exemplary of Z are --C=CH.sub.
Abstract: A new and useful 1-N-[(S)-.alpha.-hydroxy-.omega.-aminoacyl]derivative of an aminoglycosidic antiobiotic, including its deoxy derivative, such as kanamycin B, 3'-deoxyneamine, 3',4'-dideoxyneamine, 3',4'-dideoxyribostamycin or 3', 4'-dideoxykanamycin B is now synthetized from the parent substance, aminoglycosidic antibiotic. The new 1-N-[(S)-.alpha.-hydroxy-.omega.-aminoacyl] derivative shows a wider and/or higher antibacterial activity than the parent substance and is useful in the treatment of infections by gram-negative and gram-positive bacteria, including drug-resistant strains thereof. The preparation of this new derivative may be made by 1-N-acylating the parent aminoglycosidic antibiotic with (S)-.alpha.-hydroxy-.omega.-aminocarboxylic acid with the amino group being protected, and chromatographically separating the acylated products to isolate the desired 1-N-acyl derivative, followed by the removal of the amino-protecting group.
Type:
Grant
Filed:
October 1, 1973
Date of Patent:
January 4, 1977
Assignee:
Zaidan Hojin Biseibutsu Kagaku Kenkyo Kai
Abstract: Isoindolin-1-one derivatives carrying on the nitrogen atom in the 2-position a phenyl or pyridyl radical, optionally carrying one or two substituents selected from halogen, alkyl (C.sub.1 -C.sub.4), alkoxy (C.sub.1 -C.sub.4), cyano and trifluoromethyl, and in the 3-position a grouping --O--T--NR.sub.1 R.sub.2 wherein T is alkylene (C.sub.2 -C.sub.6), and R.sub.1 and R.sub.2 represent hydrogen or alkyl (C.sub.1 -C.sub.4), are new compounds possessing pharmacodynamic properties and are useful as anti-arrhythmic agents.
Type:
Grant
Filed:
February 7, 1974
Date of Patent:
January 4, 1977
Assignee:
Rhone-Poulenc S.A.
Inventors:
Claude Cotrel, Claude Jeanmart, Mayer Naoum Messer
Abstract: Organic isocyanate compositions are prepared by reacting organic polyisocyanates alone or in the presence of other organic compounds which contain reducible functional groups with catalytically activated hydrogen. New N-formyl-N,N'-disubstituted diisocyanato ureas may be prepared by this method. The products of this invention are particularly useful for producing light fast lacquers, coatings, adhesives, telomers and foam plastics.
Abstract: Alkyl (C.sub.4 -C.sub.12), cycloalkyl (C.sub.3 -C.sub.8), and unsaturated hydrocarbyl (C.sub.3 -C.sub.10) esters of 2-nitro-5-(halophenoxy)benzic acids comprise a class of compounds that are highly effective pre- and post-emergence herbicides.
Abstract: A method of slowing sublimation of sublimable material comprises mixing the sublimable material with beta-1, 4-glucan and then pulverizing the mixture.
Abstract: Cardioactive glycosides of the formula ##STR1## are disclosed, wherein R.sub.1 is saturated aliphatic hydrocarbon having 1 - 4 carbon atoms or unsaturated aliphatic hydrocarbon having 2 - 4 carbon atoms or phenyl and R.sub.2 is hydrogen or hydroxyl, as are methods for making the same by reacting the corresponding aglycone with an acylated 1-halo-hexopyranose of the formula ##STR2## wherein Hal is halogen, R.sub.3 is hydrogen or alkanoyloxy having 1 - 4 carbon atoms, and R.sub.4 is alkanoyl having 1 - 4 carbon atoms or benzoyl, and subsequently cleaving the acyl groups.
Type:
Grant
Filed:
April 5, 1976
Date of Patent:
January 4, 1977
Assignee:
Knoll A.G. Chemische Fabriken
Inventors:
Hans Peter Albrecht, Guenter Neugebauer
Abstract: This invention discloses chemical compounds of the formula ##STR1## wherein X is chlorine or bromine and each of Y.sup.1, Y.sup.2, Y.sup.3 and Y.sup.4 are hydrogen, chlorine or bromine. Further disclosed are combustible polymers which have incorporated therein a fire retardant amount of a compound of the foregoing description.
Abstract: Disclosed herein is an improved process for producing sulfonated lignin surfactants for use as dispersants for disperse dyes and vat dyes. The improved process is to react a sulfonated lignin and epihalohydrin under certain conditions to block a portion of the free-phenolic hydroxyl group and at the same time cross-link the lignin molecules to increase the molecular weight. Another aspect of the process of this invention is to oxidize the thus treated lignin to stabilize its properties. Dispersants made according to this process have improved fiber staining and heat stability properties over other lignin-based dispersants.
Abstract: The invention relates to derivatives of 1,2-diarylethylene and to a process for their preparation. The compounds have valuable pharmaceutical properties and may be used as medicaments.
Type:
Grant
Filed:
March 7, 1975
Date of Patent:
January 4, 1977
Assignee:
Hoechst Aktiengesellschaft
Inventors:
Hermann Teufel, Wilhelm Bartmann, Ernold Granzer, Josef Musil
Abstract: This invention relates to herbicidal 2-fluoro-4-halo-phenyl-4,5,6,7-tetrahydro-2H-isoindole-1,3-diones. These compounds may be used for selective weed control in certain crops or for total vegetation control.
Abstract: This invention relates to a process of preparing phthalein indicator dyes including phthalides and naphthalides derived from certain hydroxy-substituted carbocyclic aryl compounds, such as phenols, and from certain N-heterocyclic aryl compounds, such as indoles, and to a process of preparing novel intermediates useful therein. According to the present invention, the selected carbocyclic compound or the selected N-heterocyclic compound is reacted with phthalaldehydic or naphthalaldehydic acid to form the corresponding (na)phthalidyl adduct which is treated with an oxidizing agent to yield the subject intermediates. To prepare the indicator dye, the intermediate, i.e., the oxidation product thus obtained is then reacted with a carbocyclic or heterocyclic aryl compound to yield the corresponding indicator dye. The oxidation products comprising the novel intermediates of the present invention may be dehydro or hydrated (na)phthalidyl adducts.
Abstract: This invention relates to a class of indicator dyes useful as optical filter agents in photographic processes to protect a selectively exposed photosensitive material from further exposure during processing in the presence of incident light. Such dyes comprise 3,3-disubstituted phthalides and 3,3-disubstituted naphthalides wherein one of the 3,3-substituents is an indol-3-yl radical substituted with hydrogen on the heterocyclic N atom and the other of said 3,3 substituents is a p-hydroxycarbocyclic aryl radical selected from a 4'-hydroxy-1'-phenyl radical and a 4'-hydroxy-1'-naphthyl radical.
Abstract: Cyclic dodecapeptide analogs of somatostatin without cysteine amino acid residues and intermediates obtained in the synthesis of such compounds are described. These cyclic dodecapeptides inhibit the secretion of glucagon and hence have application in the treatment of diabetes mellitus.
Abstract: New insecticides are compounds of the formula ##STR1## WHEREIN TWO OF R.sup.1, R.sup.2 and R.sup.3 each represent methyl and the third represents hydrogen, Z represents H, CH.sub.3 --, --CN or --C.tbd.CH, Y represents O or S, Z.sup.1 and Z.sup.2, which may be the same or different, each represent halogen or methyl, and n is 0, 1 or 2.
Type:
Grant
Filed:
July 29, 1975
Date of Patent:
December 28, 1976
Assignee:
National Research Development Corporation
Inventors:
Michael Elliott, Norman Frank Janes, David Allen Pulman
Abstract: Novel 3-aryl-2-halothiopropionic acid compounds of the formula ##STR1## wherein X is chlorine or bromine,R.sup.1 is hydrogen, a salt-forming cation, an aliphatic radical or a substituted aliphatic radical wherein the substituent is halogen, haloalkyl, hydroxy, alkoxy, alkoxy-carbonyl or aryl,R.sup.2 is hydrogen, halogen or alkylR.sup.3 is hydrogen or alkyln is an integer from 0 to 3; andR.sup.4 is halogen, alkyl, haloalkyl or nitro and wherein the radical R.sup.4, when n is 2 or 3, may be the same or different,Are outstandingly effective herbicides, exhibiting particularly selective action.