Abstract: A treatment system including one or more of a wound dressing having one or more of a substrate element, a dressing member disposed on the substrate element, an adhesive element disposed on the substrate element, and a tether connecting the wound dressing to a treatment device.

Abstract: An energy harvester converts into electrical energy the external stresses applied to the implant at the rhythm of the heartbeats. This harvester comprises an inertial unit. A transducer provides an oscillating electrical signal that is rectified and regulated, for powering the implant and/or charging a battery. The instantaneous variations of this electrical signal between two heartbeats are analyzed inside successive time windows, to derive therefrom a physiological parameter and/or a physical activity parameter of the patient with the implant, in particular as a function of a peak of amplitude of the first oscillation of the electrical signal, and of the level of this signal after the bounce phase of the signal oscillation.

Abstract: System for electrically ablating tissue of a patient through a plurality of electrodes includes a memory, a processor and a treatment control module stored in the memory and executable by the processor. The treatment control module generates an estimated treatment region based on the number of electrical pulses to be applied.

Abstract: A system including a sensor interface coupled to a processor. The sensor interface is configured to receive and process an analog electrocardiogram signal of a subject and provide a digitized electrocardiogram signal sampled over a first time period and a second time period that is subsequent to the first time period. The processor is configured to receive the digitized electrocardiogram signal, to analyze a frequency domain transform of the digitized electrocardiogram signal sampled over the first and second time periods and determine first and second metrics indicative of metabolic state of a myocardium of the subject during the first and second time periods, respectively, to compare the first and second metrics to determine whether the metabolic state of the myocardium of the subject is improving, and to indicate administration of an intervention to the subject in response to a determination that the metabolic state is not improving.

Abstract: An object of the present invention is to provide an electrocardiogram measurement apparatus capable of significantly reducing the number of electrodes and measuring even a faint signal. The present invention provides an electrocardiogram measurement apparatus including a first electrode and a second electrode to be brought into contact with a body surface near an artery, an electrocardiogram measurement means for measuring a signal obtained from the first electrode and the second electrode, an artery position measurement means for identifying a position at which a measured value of a measured signal is largest as a position of an artery; and a notification means for notifying a user of information indicating the position of an artery.

Abstract: Various embodiments of the present technology generally relate to a single monolithic IC to perform simultaneous optogenetic neural inhibition and extracellular electrophysiological recording in-vivo. Some embodiments include a low input capacitance (e.g., 9.7 pF) amplifier particularly tailored for the use of high-impedance electrodes to conduct single neuron extracellular recording integrated with programmable high current drivers for optogenetic stimulation or inhibition on the same IC chip. Some embodiments use a noise model to guide the IC design process to obtain parameters for optimal signal-to-noise ratio. The performance of the IC chip was demonstrated on an anesthetized gerbil expressed with inhibitory optogenetic protein (Halorhodopsin). Spontaneous action potentials from the fifth nerve of the brainstem were recorded by the amplifier and were subsequently inhibited by laser illumination.

Abstract: Presented are concepts for monitoring a physical or mental capability of a person. One such concept employs the step of detecting a value of a property of the person or an object manipulated by the person. A trend in a physical or mental capability of the person may then be determined based on the detected value and historical data relating to one or more previously detected values of the property.

Abstract: The present disclosure provides systems and methods for classifying signals of interest in a cardiac rhythm management (CRM) device. A CRM device includes an intrinsic activation sensing circuit configured to pass signals falling within a first passband, a crosstalk sensing circuit configured to pass signals falling within a second passband, wherein the second passband contains higher frequencies than the first passband, and a computing device communicatively coupled to the intrinsic activation sensing circuit and the crosstalk sensing circuit, the computing device configured to classify a signal of interest as one of an intrinsic activation signal and a crosstalk signal based on whether the signal of interest is passed by the intrinsic activation sensing circuit and the crosstalk sensing circuit.

Abstract: Systems and methods are provided for optimizing hemodynamics within a patient. Specifically, the system incorporates invasive sensor data (e.g., pressure measurements) combined with mechanisms to dynamically change the loading conditions of the heart and/or heart rate, in order to understand hemodynamic parameters. Computational analyses on dynamic sensor data are used to understand and guide heart rate, filling pressures, and/or volume resuscitation in critically ill patients. By pacing the heart or inducing tricuspid regurgitation, the system may cause dynamic changes in sensor data to understand optimal loading conditions and heart rates. While determining optimal hemodynamic parameters, the system may then automatically optimize the heart rate and/or filling pressures in critically ill patients.

Abstract: The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject and operate signal-processing algorithms to elaborate stimulation parameter settings; one or more multi-electrode arrays suitable to cover a portion of the spinal cord of the subject; and an Implantable Pulse Generator (IPG) configured to receive the stimulation parameter settings from the signal processing device and simultaneously deliver independent current or voltage pulses to the one or more multiple electrode arrays, wherein the independent current or voltage pulses provide multipolar spatiotemporal stimulation of spinal circuits and/or dorsal roots. Such system advantageously enables effective control of nervous system functions in the subject by stimulating the spinal cord, such as the dorsal roots of the spinal cord, with spatiotemporal selectivity.

Abstract: A medical device comprises therapy delivery circuitry and processing circuitry. The therapy delivery circuitry is configured to deliver anti-tachycardia pacing (ATP) therapy to a heart of a patient. The ATP therapy includes one or more pulse trains and each of the one or more pulse trains includes a plurality of pacing pulses. The processing circuitry is configured to, for at least one of the plurality of pacing pulses of at least one of the one or more pulse trains, determine at least one latency metric of an evoked response of the heart to the pacing pulse. The processing circuitry is further configured to modify the ATP therapy based on the at least one latency metric.

Abstract: An apparatus configured to control transmission of wireless energy supplied to an electrically operable medical device adapted to be implanted in a mammal patient, is disclosed. The apparatus comprises an external energy source, an internal energy receiver located inside the patient and being adapted to receive the wireless energy, a stabilizing unit adapted to stabilize the wirelessly received energy in the electrically operable medical device, and a control unit comprising at least one of an internal control unit and an external control unit.

Abstract: Circuitry useable to protect and reliably charge a rechargeable battery, even from a zero-volt state, is disclosed, and is particularly useful when employed in an implantable medical device. The circuit includes two charging paths, a first path for trickle charging the battery, and a second path for charging the battery at relatively higher currents. A passive diode is used in the first trickle-charging path which allows trickle charging even when the battery voltage is too low for reliable gating, while a gateable switch (preferably a PMOS transistor) is used in the second higher-current charging path when the voltage is higher and the switch can therefore be gated more reliably. A second diode between the two paths ensures no leakage to the substrate through the gateable switch during trickle charging. The load couples to the battery through the switch, and preferably through a second switch specifically used for decoupling the load.

Abstract: A portable biological signal measurement/transmission system includes: a body unit; and at least one biological signal processing unit detachably connected to the body unit, and including a signal processor which processes a biological signal, the biological signal processing unit including a first transmitter which transmits the biological signal to the body unit when the biological signal processing unit is connected to the body unit.

Abstract: Provided is a physiological information detection sensor capable of implementing miniaturization by substantially securing a creepage distance and an air distance (e.g., implementing defibrillation protection). The physiological information detection sensor includes: a plurality of first substrates arranged in multiple tiers; a second substrate; a first connecting portion that electrically connects adjacent first substrates to each other among the plurality of first substrates; and an insulating member. Each of the plurality of first substrates has a defibrillation protection resistor mounted thereon and electrically connected to a physiological information detection unit. The second substrate has a circuit mounted thereon to process physiological information input from the physiological information detection unit via the defibrillation protection resistor. The insulating member is disposed between adjacent first substrates among the plurality of first substrates.

Abstract: A medical device capacitor assembly can include a capacitor including a plurality of anodes and cathodes, wherein the capacitor has a first major face, a second major face opposite the first major face, and a third face extending between the first major face and the second major face. A first insulating film can be sized and shaped to assemble against the first major face, and can include a first set of flaps sized and shaped to cover at least a portion of the third face. A second insulating film sized and shaped to assemble against the second major face, and can include a second set of flaps sized and shaped to cover at least a portion of the third face.

Abstract: A system and method of positioning an atrial pacing lead for delivery of a cardiac pacing therapy that includes sensing electrical activity of tissue of a patient from a plurality of external electrodes and determining a distribution of bi-atrial activation in response to the sensed electrical activity. A target site for delivering the atrial pacing therapy is adjusted based on a change in bi-atrial dyssynchrony that is determined in response to the determined distribution of bi-atrial activation, and placement of the atrial pacing lead for delivery of the atrial pacing therapy is determined in response to the adjusting.

Abstract: An apparatus includes analog-to-digital conversion (ADC) circuitry, digital processing logic, and digital-to-analog conversion (DAC) circuitry. The ADC circuitry is coupled to digitize multiple analog input signals so as to generate digital samples. The digital processing logic is configured to extract, from the digital samples, one or more first digital signals corresponding to a first selected subset of the analog input signals, and one or more second digital signals corresponding to a second selected subset of the analog input signals. The digital processing logic is further configured to output the one or more first digital signals to a digital medical instrument. The DAC circuitry is coupled to convert the one or more second digital signal into one or more analog output signals, and to output the one or more analog output signals to an analog medical instrument.

Abstract: A filter feedthrough for an AIMD includes an electrically conductive ferrule. An insulator hermetically seals a ferrule opening with either a first gold braze, a ceramic seal, a glass seal or a glass-ceramic seal. At least one conductive pathway is hermetically sealed to and disposed through the insulator body in non-conductive relationship with the ferrule. A feedthrough capacitor includes at least one active and ground electrode plate disposed within a capacitor dielectric and electrically connected to a capacitor active metallization and a capacitor ground metallization, respectively. At least a first edge of the feedthrough capacitor extends beyond a first outermost edge of the ferrule. At least a second edge of the feedthrough capacitor does not extend beyond a second outermost edge of the ferrule, or said differently, the second edge is either aligned with or setback from the second outermost edge of the ferrule.

Abstract: A filter feedthrough for an AIMD includes ferrule with an insulator hermetically sealing a ferrule opening, both cooperatively separating a body fluid side from a device side. A first conductive pathway is hermetically sealed to and disposed through the insulator. A feedthrough capacitor is disposed on the device side and includes at least one active electrode plate disposed parallel and spaced from at least one ground electrode plate within a capacitor dielectric. A capacitor active metallization is electrically connected to the active electrode plate and is in non-electrically conductive relation with the ground electrode plate. A capacitor ground metallization is electrically connected to the ground electrode plate and is in non-electrically conductive relation with the active electrode plate. An anisotropic conductive layer is disposed on the device side. The anisotropic conductive layer electrically connects the capacitor active metallization to the first conductive pathway.