Patents Examined by Lyle A. Alexander
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Patent number: 11630101Abstract: The present invention relates to a method for diagnosing anomalies in the coagulation of blood, comprising the following successive steps: a) placing a sample of total blood in a holder containing two pairs of electrodes connected to an apparatus generating an electrical current; b) incubating this sample for 60 to 180 seconds in the presence of calcium; c) adding to this sample tissue factor in a concentration high enough to trigger the coagulation of the blood; d) measuring the impedance variation between the electrodes as a function of time, for a period comprised between 10 and 30 minutes from step (c), and generating a curve of the impedance values as a function of time; e) comparing the value of the area under the curve generated in step (d) with the value of an area under a reference curve.Type: GrantFiled: November 15, 2016Date of Patent: April 18, 2023Assignee: HOSPICES CIVILS DE LYONInventor: Christophe Nougier
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Patent number: 11567049Abstract: Systems and methods for the detection of one or more target molecules, such as benzene, are described. The systems and methods may include a molecularly imprinted polymer film; a sensing material, wherein the molecularly imprinted polymer film comprises a polymer host with one or more binding sites for one or more target molecules. The molecularly imprinted polymer film may be coated upon the sensing material.Type: GrantFiled: March 30, 2020Date of Patent: January 31, 2023Assignee: FRESHAIR SENSOR, LLCInventor: Joseph J. BelBruno
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Patent number: 11525813Abstract: A container assembly for use with a high-pressure liquid chromatography (HPLC) instrument is disclosed, in which the container assembly, when coupled to a source of pressurized gas, provides fluid medium to the HPLC instrument at positive pressure. The container assembly has an external exterior container shell, an internal fluid container for holding fluid medium, an interstitial volume between the external exterior container shell and the internal fluid container, a port for fluidly connecting the volume to a pressurized gas source, and a port for fluidly connecting the internal fluid container to the HPLC instrument. As a pressurized gas in the interstitial volume increases, fluid medium flows out of the port connected to the internal fluid bag and container assembly at a positive pressure. A system incorporating the container assembly, and method of use of the same, are also disclosed.Type: GrantFiled: January 31, 2018Date of Patent: December 13, 2022Assignee: Bio-Rad Laboratories, Inc.Inventors: Nathan Wrench, William Mainwaring-Burton, Chris Butcher, Nick Harrison
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Patent number: 11513038Abstract: The application relates to a sample holder (110) and a system (100). The application also relates to a method for processing a biological sample (S) and use of the sample holder or of the system in an analytical method or a diagnostic method. The sample holder (110) comprises a tubular member (111) with a wall that is at least locally transparent and at least locally permeable for reagents, wherein the tubular member consists at least partially of a transparent material.Type: GrantFiled: June 29, 2015Date of Patent: November 29, 2022Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Reinhold Wimberger-Friedl, Jacobus Hermanus Maria Neijzen, Anja Van De Stolpe
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Patent number: 11493501Abstract: Disclosed are methods, materials and devices for approximation of blood volume in a fluid, such as in a biological fluid collected during a surgical procedure. The method and devices include the use of a RBC flocculant, such as polyDADMAC, and an approximate blood hematocrit for the type of animal, as well as a calculated RBC packing ratio corresponding to the collection device being used. Also provided is a Blood Indicator Panel (BIP), comprising a series of markings calculated from an observed red blood settlement volume, the average animal type hematocrit, and a calculated RBC packing ratio “?” value for the collection device. Pediatric (about 200 ml or 250 ml size container), adult human (about 1,000 ml-1,500 ml) and veterinary (about 500 ml-2,500 ml) collection containers are also disclosed, that include a RBC flocculant, for use in approximating blood volume in a fluid.Type: GrantFiled: January 25, 2019Date of Patent: November 8, 2022Assignee: CYPHER MEDICAL, LLCInventors: Christopher A. Carew, Jian Ling
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Patent number: 11493502Abstract: Disclosed are methods, materials and devices for approximation of blood volume in a fluid, such as in a biological fluid collected during a surgical procedure. The method and devices include the use of a RBC flocculant, such as polyDADMAC, and an approximate blood hematocrit for the type of animal, as well as a calculated RBC packing ratio corresponding to the collection device being used. Also provided is a Blood Indicator Panel (BIP), comprising a series of markings calculated from an observed red blood settlement volume, the average animal type hematocrit, and a calculated RBC packing ratio “?” value for the collection device. Pediatric (about 200 ml or 250 ml size container), adult human (about 1,000 ml-1,500 ml) and veterinary (about 500 ml-2,500 ml) collection containers are also disclosed, that include a RBC flocculant, for use in approximating blood volume in a fluid.Type: GrantFiled: March 25, 2019Date of Patent: November 8, 2022Assignee: CYPHER MEDICAL, LLCInventors: Christopher A. Carew, Jian Ling, Harold T. Duperier, III
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Patent number: 11485965Abstract: A data storage medium is disclosed comprising a two-dimensional (2D) support structure onto which artificially synthesized DNA molecules encoding digital information are placed and then covered with a protective layer. The 2D support structure is formed from a material such as metal foil, glass, or plastic. The 2D support structure may be functionalized with positively charged molecules to improve DNA adhesion. The DNA is protected from degradation by encapsulation in a protective layer of a non-reactive material such as silica or a thin layer of metal. A process for storing DNA on 2D support structures is also disclosed. Correlation of specific DNA molecules with a physical storage location on a 2D support structure provides geometric addressability for selective access to specific digital information.Type: GrantFiled: November 2, 2018Date of Patent: November 1, 2022Assignee: MICROSOFT TECHNOLOGY LICENSING, LLCInventors: Karin Strauss, Bichlien Hoang Nguyen, Robert N. Grass, Alexander Xavier Christof Kohll, Weida Chen
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Patent number: 11478799Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.Type: GrantFiled: March 20, 2018Date of Patent: October 25, 2022Assignee: The University of ChicagoInventors: Rustem F. Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
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Patent number: 11440004Abstract: A microparticle sorting microchip for a flow cytometer is provided to enable sorting of microparticles at higher speed, higher purity, and higher acquisition rate. The microparticle sorting microchip includes a main channel through which a microparticle-containing fluid flows, a trap channel coaxially communicating with the main channel, a trap chamber communicating with the trap channel, and a gate channel intersecting the trap channel. The trap channel has an opening intersecting the gate channel. The trap channel has a smaller cross-sectional area upstream of the opening than downstream of the opening along a direction in which the microparticle-containing fluid flows.Type: GrantFiled: November 9, 2018Date of Patent: September 13, 2022Assignee: Sony CorporationInventors: Tatsumi Ito, Kazuya Takahashi, Masahiro Matsumoto
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Patent number: 11413615Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.Type: GrantFiled: March 20, 2018Date of Patent: August 16, 2022Assignee: The University of ChicagoInventors: Rustem F. Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
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Patent number: 11413614Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.Type: GrantFiled: March 31, 2016Date of Patent: August 16, 2022Assignee: The University of ChicagoInventors: Rustem F. Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
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Patent number: 11413595Abstract: Provided is a fluid flow device having high freedom of choosing means for detecting flow errors. The fluid flow device includes a channel forming body. The channel forming body forms a plurality of fluid channels, a plurality of detection spaces corresponding to the fluid channels, respectively, and a plurality of communication channels providing respective communications between the fluid channels and the detection spaces corresponding thereto, respectively. Each of the detection spaces contains a detection fluid and a detection gas aligned in a longitudinal direction thereof, and an interface is formed therebetween. The detection gas is contained in the detection space so as to allow the position of the interface to be changed with the pressure change of a processing object fluid that flows through the fluid channels.Type: GrantFiled: June 26, 2018Date of Patent: August 16, 2022Assignee: Kobe Steel, Ltd.Inventors: Akira Matsuoka, Koji Noishiki, Tomohiro Ozono
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Patent number: 11376592Abstract: A single junction sorter for a microfluidic particle sorter, the single-junction sorter comprising: an input channel, configured to receive a fluid containing particles; an output sort channel and an output waste channel, each connected to the input channel for receiving the fluid therefrom; a bubble generator, operable to selectively displace the fluid around a particle to be sorted and thereby to create a transient flow of the fluid in the input channel; and a vortex element, configured to cause a vortex in the transient flow in order to direct the particle to be sorted into the output sort channel.Type: GrantFiled: April 19, 2018Date of Patent: July 5, 2022Assignee: Cellular Highways Ltd.Inventors: Mikhail Bashtanov, Richard Gold, Calum Hayes, Fred Hussain, Robyn Pritchard, Salman Samson Rogers, Nuno Varelas, Alexander Zhukov
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Patent number: 11366051Abstract: A device including a microfluidic channel structure formed on a substrate and including a first channel and a fluid actuator within the microfluidic channel structure. A sense region within the first channel is to receive a fluid flow of target biologic particles for counting in a single file pattern, with the sense region having a volume on a same order of magnitude as a volume of a single one of the target biologic particles.Type: GrantFiled: January 30, 2015Date of Patent: June 21, 2022Assignee: Hewlett-Packard Development Company, L.P.Inventors: Jeremy Sells, Nick McGuinness, Chantelle Domingue, Manish Giri
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Patent number: 11353379Abstract: A sampling apparatus (100) employs a cell-positioning system to move a sample capture cell (138) relative to a specimen positioning system (124). The cell-positioning system may be controlled to move sample capture cell (138) opposite to movement of the specimen positioning system (124) to maintain alignment of the sample capture cell (138) with an optical path of a laser beam of a sample generator (108). Alternatively or additionally, the cell-positioning system may be controlled to move sample capture cell (138) in response to alignment deviation of a reference beam on a quadrant detector (404).Type: GrantFiled: October 1, 2019Date of Patent: June 7, 2022Assignee: Elemental Scientific Lasers, Inc.Inventors: Shane Robert Hilliard, Leif Christian Summerfield, Erik Barnholt Larsen
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Patent number: 11291999Abstract: A method and system for improving throughput of a fluidic system such as a biopolymer analysis system by cleaning accumulated or clogging biopolymer from the fluidic system is disclosed. The method and system utilize a light energy source to photocleave the biopolymer molecules that may accumulate or aggregate in the fluidic system or clog a passageway. The accumulated biopolymer may be exposed to a light energy source for a sufficient period of time such that the biopolymer molecule is dosed with sufficient energy to photocleave the biopolymer molecules, thereby restoring the efficiency of and flow through the system.Type: GrantFiled: August 31, 2015Date of Patent: April 5, 2022Assignee: Bionano Genomics, Inc.Inventors: David Xian Wei Yao, William K. Ridgeway
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Patent number: 11278898Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.Type: GrantFiled: March 20, 2018Date of Patent: March 22, 2022Assignee: The University of ChicagoInventors: Rustem F. Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
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Patent number: 11275071Abstract: Sensors for detecting and distinguishing metals in a sample comprise phenol group-containing azo dyes, the phenol group having one hydroxy involved in reversible metal ion binding and a second hydroxy alkylated to an optically transparent substrate. The sensors have utility for detecting chromium, calcium, magnesium, copper, mercury, nickel, zinc, cobalt, manganese, cadmium, lead, tin, aluminum, potassium, sodium, or arsenic ions in a sample.Type: GrantFiled: October 14, 2016Date of Patent: March 15, 2022Assignee: UWM Research Foundation, Inc.Inventors: Alan Schwabacher, Peter Geissinger, Trevor Hagemann, Sarah Oehm, Tyler G. Fenske
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Patent number: 11268962Abstract: A sample is dissolved in a reagent 4 containing an organic solvent in a conversion vessel 11. A gas is supplied from a first gas supply part into the conversion vessel 11 via a reagent introduction tube 17, and thus the interior of the conversion vessel 11 is pressurized. A gas is supplied from a second gas supply part into the reagent 4 in the conversion vessel 11 via a reagent discharge tube 18, and thus gas bubbles 41 are formed in the reagent 4.Type: GrantFiled: February 20, 2015Date of Patent: March 8, 2022Assignee: SHIMADZU CORPORATIONInventors: Tomoko Yamaguchi, Natsuki Iwata
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Patent number: 11266383Abstract: Various embodiments are described herein for a system and a method for obtaining samples of tissue for analysis by mass spectrometry. A region of interest can be identified in tissue using image data from a first imaging modality that is other than mass spectrometry. At least one tissue sample can be acquired using a tissue sampler from a sampling location related to the region of interest. Mass spectrum data can be generated for the acquired tissue samples using a mass spectrometer. In some embodiments, polarimetry may be used on a tissue slice, mass spectrometry may be performed on the same tissue slice and then H&E imaging may be performed on the same tissue slice.Type: GrantFiled: September 22, 2016Date of Patent: March 8, 2022Assignee: University Health NetworkInventors: Arash Zarrine-Afsar, David A. Jaffray, Alessandra Tata, Michael Woolman, Alexander Vitkin