Patents Examined by Lyle A. Alexander
  • Patent number: 12025554
    Abstract: A method for quantitative analysis of hydrogen gas generated due to the decomposition of Si—OH (silanol) in porous silica, which is a support of a metallocene catalyst is provided. The analysis enables the measurement of the content of hydrogen present in trace amounts in silica by employing an inert gas fusion-infrared absorption (IGFIA) method under specific pressure and temperature conditions.
    Type: Grant
    Filed: January 16, 2019
    Date of Patent: July 2, 2024
    Assignee: LG Chem, Ltd.
    Inventors: Sumin Na, Jieun Kim, Sunah Shin, Min Hwan Jung
  • Patent number: 12017220
    Abstract: The present invention relates to a microfluidic chip and valve, production process and uses thereof according to the independent claims.
    Type: Grant
    Filed: July 13, 2020
    Date of Patent: June 25, 2024
    Inventors: Pawel Solczynski, Piotr Garstecki
  • Patent number: 12005439
    Abstract: A microfluidic device for thermocycling of a reaction mixture is provided. The device comprises an inlet opening, an outlet opening, a flow channel connecting the inlet opening and the outlet opening and defining a flow direction from the inlet opening through the flow channel to the outlet opening, wherein the flow channel comprises a first flow channel surface and a second flow channel surface opposite to the first flow channel surface, and an array of wells provided in the first flow channel surface for fluidic communication with the inlet opening and the outlet opening. Further, the first flow channel surface provides a first hydrophilicity and at least a part of the second flow channel surface provides a second hydrophilicity, wherein the first hydrophilicity is greater than the second hydrophilicity.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: June 11, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Alexander Meier, Chris Steinert, Michael Zeder
  • Patent number: 11986818
    Abstract: This disclosure provides systems and methods for the production of formulations of active pharmaceutical ingredients (APIs). In some embodiments, the disclosure provides an automated medicine formulation system comprising a portable and self-contained API formulating apparatus where the API and excipients are formulated to make a drug product meeting drug quality and safety specifications. The automated formulation system produces liquid formulations including, for example, injectable and intravenous medicines. The systems are capable of producing a plurality of individual sterile injectable doses of drug comprising a specific API and excipient(s), which can be formulated on demand in a GMP and FDA acceptable manner.
    Type: Grant
    Filed: March 24, 2023
    Date of Patent: May 21, 2024
    Assignee: ODH IP CORP.
    Inventors: Mahdi Ramezani, Akshaya Nair, Gordon Brezicki, Jonathan Samuel, Alec Nicewick, Griffin Whittredge
  • Patent number: 11946926
    Abstract: A method of testing a biological sample, the method comprising: providing a centrifuge sample holder having a camera; arranging a transparent container comprising a fluid test medium in a recess of said centrifuge sample holder, wherein the camera is arranged to image a portion of the container comprising said fluid test medium; arranging said biological sample above and not in contact with said fluid test medium in said container; and with the camera, imaging a mixing of said biological sample with said fluid test medium while centrifuging the sample holder.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: April 2, 2024
    Assignee: Bio-Rad Europe GmbH
    Inventors: Emmanuel Guignet, Stephane Bombard
  • Patent number: 11925455
    Abstract: Various methods of diagnosing and monitoring a subject infected with a Plasmodium parasite are described. Also, compositions and methods for attracting mosquitos are also described.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: March 12, 2024
    Assignee: Washington University
    Inventors: Audrey Odom John, Chad Schaber, Indi Trehan, Baranidharan Raman, Nalin Katta
  • Patent number: 11898960
    Abstract: A method for rapid detection of actinides including the steps of having a support including a colorimetric complexation, placing the support in communication with a sample through urinalysis, and receiving a visual indicator from the colorimetric complexation. The sample having an unknown concentration of at least one actinide within it. The colorimetric complexation is configured to activate when contacted by a threshold concentration of an actinide.
    Type: Grant
    Filed: September 2, 2021
    Date of Patent: February 13, 2024
    Assignee: U.S. Department of Energy
    Inventors: Catherine Riddle, Rick L. Demmer
  • Patent number: 11879862
    Abstract: A sensor and a method of using the sensor are disclosed. The sensor includes a conductive region in electrical communication with two electrodes, the conductive region including a MXene material combined with a mercaptoimidazolyl metal-ligand complex, wherein the MXene has the formula Mn+1Xn and M is at least one of a Group 3 transition metal, Group 4 transition metal, Group 5 transition metal, and Group 6 transition metal, X is carbon, nitrogen or a combination thereof, and n has a value of 1 to 3. The sensor can be used to detect volatile compounds that have a double or triple bond.
    Type: Grant
    Filed: December 10, 2020
    Date of Patent: January 23, 2024
    Assignee: Carrier Corporation
    Inventors: Winston Yen-Yu Chen, Lia Antoaneta Stanciu, Alexander Wei, Aiganym Yermembetova
  • Patent number: 11866311
    Abstract: A cap removal device and a thrombelastography device having same are disclosed. The cap removal device comprises a drive part (1), a connection shaft (2), and a cap removal member (3). The connection shaft (2) can move upward when driven by the drive part (1). The cap removal member (3) has an end (31) and the other end (32); the end (31) is pivotally connected to the connection shaft (2), so that when the connection shaft (2) moves upward when driven by the drive part (1), the cap removal member (3) rotates, due to the upward movement, around a pivot point (4) located between the end (31) and the other end (32) of the cap removal member (3), so that the other end (32) of the cap removal member (3) moves downward to contact a cap (5) to be removed, thereby removing the cap (5).
    Type: Grant
    Filed: August 28, 2020
    Date of Patent: January 9, 2024
    Assignee: Haemonetics Corporation
    Inventors: Feng Jiang, Jian Xiao, Gong Liu, Aiqin Chen, Bangzhong Yu
  • Patent number: 11850593
    Abstract: Methods and devices for concentrating target cells using dielectrophoresis (DEP) are disclosed. The method allows relatively high throughput of sample through a microfluidic device in order to allow rapid capture of target cells even when they are present in low concentrations within the sample. The method utilizes multiple chambers through which samples will flow, the chambers arranged such that the first capture area has a larger area and faster flow rate than a second chamber, the second chamber being positioned downstream of the first capture area and being smaller with a slower flow rate to further concentrate the material captured in the first capture area.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: December 26, 2023
    Inventors: Jonathan O'Halloran, Heather Murton, Stephen Osborne, Eduardo Boada, Jonathan Salmon
  • Patent number: 11850588
    Abstract: A microfluidic device for detection of an analyte in a fluid is described. The microfluidic device comprises a substrate having a first surface defining entrances to one or more chambers defined in the substrate, surfaces of the chambers defining a second surface of the substrate, the first surface being modified for selective targeting and capture of at least one analyte to operably effect a blocking of the entrance to at least one of the chambers, and wherein a response characteristic of the microfluidic device is operably varied by the blocking of the entrance to the at least one of the chambers, thereby providing an indication of the presence of the analyte within the fluid.
    Type: Grant
    Filed: July 5, 2022
    Date of Patent: December 26, 2023
    Inventors: Robert Forster, Elaine Spain, Kellie Adamson, Eadaoin Carthy, David Boyle
  • Patent number: 11828689
    Abstract: Methods, apparatuses, and systems associated with aerosol collection devices (such as, but not limited to, breath-aerosol collector devices, breathalyzers) are provided. An example aerosol collection device includes a sample transfer adapter configured to receive a sample and a device body connected to the sample transfer adapter. In some examples, the device body defines a flow channel that guides the sample to a filter component, and the filter component contains a buffer solution.
    Type: Grant
    Filed: September 1, 2021
    Date of Patent: November 28, 2023
    Assignee: Hand Held Products, Inc.
    Inventors: Adam Dewey McBrady, Moin Shafai, Oscar Ponte Rivas, Aoife Celoria, Philip C. Foster, Dustin Michael Brandt, Giorgio Carlo Isella, Jose Guadalupe Sanchez De La Rosa, Emir Rahislic, Amanda Esther Sall Childers, Gennady Germaine, Thomas Merritt Haggerty
  • Patent number: 11786914
    Abstract: A magnetic separation filter has an unsupported magnetically soft material layer having a plurality of pores, and, optionally, a passivation layer disposed on the magnetically soft material layer. The magnetic separation filter may be part of a microfluidic device having a lateral flow channel and a vertical flow magnetic separation filter. The magnetic separation device may be used to separate magnetically tagged particles, such as cells.
    Type: Grant
    Filed: October 4, 2016
    Date of Patent: October 17, 2023
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David Issadore, Venkata Yelleswarapu, Jina Ko
  • Patent number: 11779918
    Abstract: 3D nanochannel interleaved devices for molecular manipulation are provided. In one aspect, a method of forming a device includes: forming a pattern on a substrate of alternating mandrels and spacers alongside the mandrels; selectively removing the mandrels from a front portion of the pattern forming gaps between the spacers; selectively removing the spacers from a back portion of the pattern forming gaps between the mandrels; filling i) the gaps between the spacers with a conductor to form first electrodes and ii) the gaps between the mandrels with the conductor to form second electrodes; and etching the mandrels and the spacers in a central portion of the pattern to form a channel (e.g., a nanochannel) between the first electrodes and the second electrodes, wherein the first electrodes and the second electrodes are offset from one another across the channel, i.e., interleaved. A device formed by the method is also provided.
    Type: Grant
    Filed: December 5, 2019
    Date of Patent: October 10, 2023
    Assignee: International Business Machines Corporation
    Inventors: Lawrence A. Clevenger, Kangguo Cheng, Donald Canaperi, Shawn Peter Fetterolf
  • Patent number: 11772969
    Abstract: The solar-powered oxygen production system for hospitals is useful for producing oxygen in hospital settings without the need for an external power source. The system includes one or more photovoltaic (PV) solar panels mounted on the roof of a hospital and an oxygen production system housed within the equipment room of the hospital. The solar panels provide the electrical power needed for the oxygen production system. The solar panels are mounted on the roof using solar panel supports. The number of panels and the power output of each panel can be selected depending on the electrical power requirements of the oxygen production system. The oxygen production system includes an LED for activating a black phosphorous catalyst in the atmospheric air to convert water vapor in the air into hydrogen and oxygen.
    Type: Grant
    Filed: April 28, 2022
    Date of Patent: October 3, 2023
    Inventors: Aisha Al-Olayan, Hessa Al-Mousa, Marwah Al-Mutayib
  • Patent number: 11747356
    Abstract: A support element for a modular transport plane with a plurality of transport module units each comprising a driving surface assembly is presented. The support element has an upper support surface supporting the driving surface assemblies of at least two neighboring transport module units. The upper support surface has driving surface assembly interfaces engaged with complementary interfaces of the supported driving surface assemblies. The support element comprises a lower part having a mounting structure and an upper part having the upper support surface. The upper part connects lengthwise to the lower part via a connection structure. The connection structure restrains a relative movement between the lower part and the upper part in the longitudinal direction of the support element and allows a limited relative movement between the lower part and the upper part in a plane perpendicular to the longitudinal direction of the support element.
    Type: Grant
    Filed: December 21, 2020
    Date of Patent: September 5, 2023
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Christopher Bates, Julian Pfaff, Noelia Gonzalez Vila, Adrian Fernandez Vazquez, Kyle Benton, Attila Sapi
  • Patent number: 11745181
    Abstract: This disclosure provides fluidic devices and methods for performing a bioassay, for example bioassays performed on zebrafish. The disclosure provides various fluidic devices for performing a bioassay that include a sample chamber in fluid communication with an air valve; and a bioassay channel that can include a first bioassay region, for example for studying zebrafish in early stages of development and a second bioassay region, for studying zebrafish in later stages of development. The first bioassay region and second bioassay region can be defined using pillars, such as a first and second array of pillars. The fluidic device can have additional structures that are provided herein. Also provided herein are sample loading manifold devices for loading zebrafish embryos into fluidic devices and reagent delivery manifold devices for delivering reagents to fluidic devices. Furthermore, methods using any or all of the devices are provided.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: September 5, 2023
    Assignee: UNCHAINED LABS
    Inventor: Deepak Solomon
  • Patent number: 11703475
    Abstract: A method includes mounting an integrated electro-microfluidic probe card to a device area on a bio-sensor device wafer, wherein the electro-microfluidic probe card has a first major surface and a second major surface opposite the first major surface. The method further includes electrically connecting at least one electronic probe tip extending from the first major surface to a corresponding conductive area of the device area. The method further includes stamping a test fluid onto the device area. The method further includes measuring via the at least one electronic probe tip a first electrical property of one or more bio-FETs of the device area based on the test fluid.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: July 18, 2023
    Inventors: Yi-Shao Liu, Fei-Lung Lai, Chun-Ren Cheng, Chun-Wen Cheng
  • Patent number: 11630101
    Abstract: The present invention relates to a method for diagnosing anomalies in the coagulation of blood, comprising the following successive steps: a) placing a sample of total blood in a holder containing two pairs of electrodes connected to an apparatus generating an electrical current; b) incubating this sample for 60 to 180 seconds in the presence of calcium; c) adding to this sample tissue factor in a concentration high enough to trigger the coagulation of the blood; d) measuring the impedance variation between the electrodes as a function of time, for a period comprised between 10 and 30 minutes from step (c), and generating a curve of the impedance values as a function of time; e) comparing the value of the area under the curve generated in step (d) with the value of an area under a reference curve.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: April 18, 2023
    Inventor: Christophe Nougier
  • Patent number: 11567049
    Abstract: Systems and methods for the detection of one or more target molecules, such as benzene, are described. The systems and methods may include a molecularly imprinted polymer film; a sensing material, wherein the molecularly imprinted polymer film comprises a polymer host with one or more binding sites for one or more target molecules. The molecularly imprinted polymer film may be coated upon the sensing material.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: January 31, 2023
    Inventor: Joseph J. BelBruno