Patents Examined by Melanie J. Yu
  • Patent number: 8404495
    Abstract: In one aspect, the present invention is a system, a device and a method for sensing the concentration of an analyte in a fluid or matrix. The analyte may be glucose or any other chemical of interest. The fluid or matrix may be, for example, the fluid in a bioreactor, a food or agricultural product, any fluid or matrix in the body of an animal, or any other fluid or matrix whose concentration of an analyte is under investigation. In one embodiment, the analyte sensing device includes a housing having an interior space. Contained within the housing and in the interior space is one or more analyte sensing component(s). The analyte sensing component, in one embodiment, includes one or more radiation converting element(s), for example, converting chromophores. The radiation converting element(s) are capable of converting or modifying radiation of one or more wavelengths into radiation of one or more different wavelengths.
    Type: Grant
    Filed: January 22, 2007
    Date of Patent: March 26, 2013
    Assignee: BioTex, Inc.
    Inventors: Ralph Ballerstadt, Roger McNichols, Ashok Gowda
  • Patent number: 8383421
    Abstract: An object of the present invention is to provide a cartridge for automatic measurement used in an automatic measuring device, capable of automatically performing measurement including heat treatment of a sample, and a measuring device using the cartridge. The present invention relates to a cartridge for use in measuring a component to be measured contained in a sample, comprising: at least a heat-treatment well for performing heat treatment of the sample; and a reaction well for reacting the component to be measured in the sample with a material specifically reacting therewith.
    Type: Grant
    Filed: January 17, 2006
    Date of Patent: February 26, 2013
    Assignee: Mitsubishi Chemical Medience Corporation
    Inventors: Atsushi Yanagida, Takashi Kurihara, Hiroyuki Yokoi, Atsushi Koyata, Yoshikazu Okamura, Daishi Miyamoto
  • Patent number: 8367399
    Abstract: A procedure for the quantitative determination of interactions of ligands with receptors adsorbed or immobilized on the surface of a solid material which can be functionalized, transparent and with low refractive index, by direct measure of the reflection of light. The procedure includes utilizing a planar surface, flat or rough, of a transparent solid material formed from a hydrophobic amorphous polymer, having a refractive index between 1.3200 and 1.3500, which is brought into a solution of a mixture containing from 1 nanogram/ml to 10 milligrams/ml in concentration of molecules with a function of receptor or reagent.
    Type: Grant
    Filed: March 14, 2007
    Date of Patent: February 5, 2013
    Assignee: Universita' degli Studi di Milano
    Inventors: Tommaso Bellini, Marco Buscaglia, Stefano Pezzati
  • Patent number: 8361808
    Abstract: Methods, materials, apparatus and systems are described for performing capillary flow assay. In one aspect, a system includes a sample collection unit to collect a sample liquid and a sample testing and storing unit to interface with the sample collection unit to test and store the collected sample liquid. The sample testing and storing unit includes a sample inlet shaped to receive the collected sample from the sample collection unit, and a sample well positioned below the sample inlet to retain at least a portion of the sample liquid. The sample testing and storing unit includes a sample housing unit to store a remainder of the sample liquid not retained in the sample well, and an analyte testing unit housing shaped to receive an analyte detecting unit to test a presence of a target analyte in the sample liquid.
    Type: Grant
    Filed: December 30, 2009
    Date of Patent: January 29, 2013
    Assignee: Oranoxis, Inc.
    Inventor: Dequn Wang
  • Patent number: 8361810
    Abstract: Methods are disclosed for producing a bioweapon-sensitive fibrous-network product, wherein the subject products exhibit a color change in response to exposure to a biological agent (or portion thereof) as used in a biological weapon. Also disclosed are fibrous-network products that contain units of biopolymeric material that impart a color change to the products in response to exposure to a biological agent (or portion thereof) as used in a biological weapon.
    Type: Grant
    Filed: April 2, 2009
    Date of Patent: January 29, 2013
    Inventors: Dennis Farwell, Keith Baumann
  • Patent number: 8354280
    Abstract: The technology provided herein generally relates to reusable detection surfaces and methods for reusing a detection surface after using the detection surface in an assay for an analyte.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: January 15, 2013
    Assignee: BioScale, Inc.
    Inventors: Jaime E. Arenas, Hyun-Goo Choi, William Matthew Dickerson, Sarah Beth Hembree, Lara Louise Madison, Brett P. Masters, Michael F. Miller, Wayne U. Wang
  • Patent number: 8349618
    Abstract: The present invention relates to analytical methods, platforms, and devices for the rapid and efficient immunochromatic determination of one or more components in fluid samples.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: January 8, 2013
    Assignee: ZBX Corporation
    Inventor: Qinwei Shi
  • Patent number: 8343440
    Abstract: A cancer cell separating apparatus includes: a flow channel including an antibody fixation area having antibodies which bind specifically to cancer cells fixed thereon, wherein the cancer cells and non-cancer cells are separated using a difference in velocity of movement between the cancer cells and the non-cancer cells in cell slurry introduced into the flow channel.
    Type: Grant
    Filed: March 23, 2010
    Date of Patent: January 1, 2013
    Assignee: Seiko Epson Corporation
    Inventor: Satomi Yoshioka
  • Patent number: 8338189
    Abstract: The invention features methods and devices for the detection of biomarker complexes and their components and for the sequential detection of multiple epitopes of a biomarker. The invention also features methods for diagnosing disease and evaluating the efficacy of treatment of a subject with a disease.
    Type: Grant
    Filed: March 4, 2009
    Date of Patent: December 25, 2012
    Assignee: Axela Inc.
    Inventors: Yixin Lin, Jean-Francois Houle
  • Patent number: 8338188
    Abstract: The present invention relates to the identification and use of proteins with clinical relevance to rheumatoid arthritis (RA). In particular, the invention provides the identity of marker proteins that specifically react with RA-associated autoantibodies. Also provided are methods, arrays and kits for using these proteins in the diagnosis of RA, and in the selection and/or monitoring of treatment regimens.
    Type: Grant
    Filed: May 12, 2009
    Date of Patent: December 25, 2012
    Assignee: Inserm (Institut National de la Sante et de la Recherche Medicale)
    Inventors: Jean Roudier, Isabelle Auger
  • Patent number: 8338191
    Abstract: The invention relates to a device for performing binding assays. In particular, the invention relates to a centrifugal device for performing such assays. The invention also relates to a method of performing binding assays involving antigen-antibody binding, nucleic acid hybridization, or receptor-ligand interaction.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: December 25, 2012
    Assignee: Corbett Life Science Pty Ltd
    Inventors: John Michael Corbett, John Michael Corbett, Jr.
  • Patent number: 8334107
    Abstract: The invention relates to lipid bilayer coated beads and methods of using those beads in immunoassays, in analytical assay and the like.
    Type: Grant
    Filed: April 7, 2009
    Date of Patent: December 18, 2012
    Assignee: STC.UNM
    Inventors: Gabriel Lopez, Reema Zeineldin, Menake Piyasena
  • Patent number: 8323986
    Abstract: The present invention relates to a molecular assembly on a substrate usable for studying and/or performing biological interactions and/or reactions The invention further relates to an in vitro method to provide a substrate with a heparin coating presenting biotinylated biomolecules comprising linking avidin to a surface capable of binding avidin. A heparin conjugate is then linked to the avidin treated surface to form a layer of heparin thereon. Finally, a biotinylated biological probe or biomolecule is linked to the avidin through the layer of heparin thereby forming an essentially biologically inert surface with biotinylated probes extending out from the surface.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: December 4, 2012
    Assignee: Corline Systems AB
    Inventors: Javier Sanchez, Rolf Larsson
  • Patent number: 8318098
    Abstract: Embodiments of the present technique facilitate the detection of analytes. Detection is generally achieved by binding agents labeled with non-radiative energy transfer acceptors. The binding agents, when bound to a specific analyte, change conformation such that the distance between the respective non-radiative energy transfer acceptors and a respective quantum dot or quantum well changes. Certain embodiments of the present technique also comprise readout circuitry configured to determine rates of non-radiative energy transfer electrically and not optically.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: November 27, 2012
    Assignee: General Electric Company
    Inventor: Rogerio Geraldes Rodrigues
  • Patent number: 8313917
    Abstract: Disclosed are procedures and methods for diagnosing latent and active cancers in a subject. The described methods include the use of sandwich ELISA assays containing antibodies specific for certain epitopes on the A-protein. This enables the assay to discriminate between the monomelic and homopolymeric forms of A-protein.
    Type: Grant
    Filed: December 29, 2008
    Date of Patent: November 20, 2012
    Assignee: Ask Diagnostics, Inc.
    Inventor: Geoffrey Schmidt
  • Patent number: 8313956
    Abstract: An apparatus for the selective release of a bound species based on the presence of an analyte, the apparatus comprising: a first and second receptor species, the first receptor species linked with a bound species and configured to interact with an analyte to form a first intermediate complex, the bound species for causing increased porosity of a membrane of an in-contact analyte sensor apparatus to correspondingly increase exposure of a sensing element of the analyte sensor apparatus to allow for production of a detectable electrical signal which can be used to sense the presence of the analyte, the second receptor species for interacting with the first intermediate complex to form a second intermediate complex; and a cleaving species, the cleaving species configured to interact with the second intermediate complex to release the bound species for use in sensing the presence of the analyte.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: November 20, 2012
    Assignee: Nokia Corporation
    Inventor: Marc James Ashton Bailey
  • Patent number: 8309345
    Abstract: Provided is a method for detecting an antigen without use of a labeled-antibody. A support having an antibody and a multi-copper oxidase CueO immobilized thereon is brought into contact with a first buffer solution containing the antigen, a current is measured by a potentiostat method using the support and a second buffer solution, and when the measured current is greater than or equal to 1.5×(blank value), it is determined that the antigen exists. The second buffer solution contains a substrate of the CueO and has an ionic strength falling within a range of not less than 0.3 mM and not more than 1.0 mM.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: November 13, 2012
    Assignee: Panasonic Corporation
    Inventors: Kazuaki Nishio, Nozomu Matsukawa, Shigeo Yoshii
  • Patent number: 8309364
    Abstract: An electrochemical immunosensor system with reduced interference, comprising: a first immunosensor that generates an electrochemical signal based on the formation of a sandwich between an immobilized antibody, a target analyte and a labeled antibody, wherein a portion of the signal arises from non-specific binding of the labeled antibody in the region of the first immunosensor, and a second immunosensor that acts as an immuno-reference sensor and generates a signal that is the same as or predictably related to the degree of non-specific binding which occurs in the region of the first immunosensor, and has an immunocomplex between an immobilized antibody and an endogenous or exogenous protein that is in the sample and that is not the target analyte.
    Type: Grant
    Filed: February 18, 2010
    Date of Patent: November 13, 2012
    Assignee: Abbott Point of Care Inc.
    Inventors: Cary James Miller, John Lewis Emerson Campbell
  • Patent number: 8304197
    Abstract: The present invention concerns methods for detecting a hepcidin precursor in a sample from a patient and involves contacting the sample with an antibody or fragment thereof that specifically binds to one or more epitopes of a hepcidin precursor amino acid sequence located within amino acids 20-50 of SEQ ID NO: 2.
    Type: Grant
    Filed: July 18, 2011
    Date of Patent: November 6, 2012
    Assignee: DRG International, Inc.
    Inventors: Hasan Kulaksiz, Cyril E. Geacintov, Alfred Janetzko, Wolfgang Stremmel
  • Patent number: 8304230
    Abstract: The invention features methods for separating cells from a sample (e.g., separating fetal red blood cells from maternal blood). The method begins with the introduction of a sample including cells into one or more microfluidic channels. In one embodiment, the device includes at least two processing steps. For example, a mixture of cells is introduced into a microfluidic channel that selectively allows the passage of a desired type of cell, and the population of cells enriched in the desired type is then introduced into a second microfluidic channel that allows the passage of the desired cell to produce a population of cells further enriched in the desired type. The selection of cells is based on a property of the cells in the mixture, for example, size, shape, deformability, surface characteristics (e.g., cell surface receptors or antigens and membrane permeability), or intracellular properties (e.g., expression of a particular enzyme).
    Type: Grant
    Filed: March 21, 2007
    Date of Patent: November 6, 2012
    Assignee: The General Hospital Corporation
    Inventors: Mehmet Toner, George Truskey, Ravi Kapur