Patents Examined by Michelle Adams
  • Patent number: 10352946
    Abstract: An improved qualitative or semi-quantitative diagnostic test for low levels of any analyte, such as hCG, in a biological sample, such as urine. The test comprises of a test device containing reagents for the detection of the monitored analyte and an electronic reader that measures color development at a detection area of the device. The color development is converted to an electronic or digital signal. Improvements were made to the detection process to optimize the detection of a valid fluid front, increase the detection limit without compromising the reliability and accuracy of the test system, and improve the determination of test result validity.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: July 16, 2019
    Assignee: Church & Dwight Co., Inc.
    Inventors: Albert R. Nazareth, Andy Sturman, Benedict Zin
  • Patent number: 10352864
    Abstract: An automatic analyzer includes sample vessels containing samples to be measured and; reaction vessels in which to mix a sample and a reagent. A sample dispenser 5 dispenses a sample from any of the sample vessels to any of the reaction vessels. A reagent dispenser dispenses a reagent from a reagent vessel to a reaction vessel, and a stirrer stirs the sample-reagent mix contained in the reaction vessel. A photometric measurement unit is provided for obtaining multiple measurement data points during the progress of reaction of a mixed solution. At least one approximation formula is performed and an approximation curve from the measurement data points is generated. A shape descriptor is calculated from the approximation curve and abnormalities based on the shape descriptor are determined. This not only allows abnormalities to be detected accurately from each measurement result, but also allows the causes of the abnormalities to be identified.
    Type: Grant
    Filed: July 4, 2011
    Date of Patent: July 16, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Kumiko Kamihara, Satoshi Mitsuyama, Tomonori Mimura, Chihiro Manri
  • Patent number: 10338044
    Abstract: A gas transport system includes at least one chemical reactor having at least one inlet and at least one gas outlet and at least one sample introduction unit for delivering the sample into the chemical reactor. The gas transport system at least one carrier gas line fluidly coupled to the chemical reactor inlet for introducing into the chemical reactor carrier gas from a carrier gas source, at least one gas outlet line from the chemical reactor gas outlet, and at least one gas recycling line connected to the gas outlet and/or the gas outlet line by a first gas line junction that is arranged between the chemical reactor and a downstream detection unit on the gas outlet line. The gas transport system is adapted to allow recycling of at least a portion of gas emerging from the chemical reactor outlet back to the chemical reactor via the gas recycling line.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: July 2, 2019
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Johannes Schwieters, Michael Krummen, Hans-Juergen Schlueter, Oliver Kracht
  • Patent number: 10324012
    Abstract: A method for detecting and quantifying haloether contamination in aqueous samples. A flow state is artificially induced upon an aqueous sample and a solid phase microextraction (SPME) fiber, upon which an electric potential is applied, is exposed to the flowing aqueous sample in direct immersion mode. Halide ions liberated from electrophoretically dehalogenated haloether compounds contained in the aqueous sample are absorbed upon the SPME fiber, then later desorbed at a gas chromatograph, separated into individual halide ions and analyzed by mass spectrometry. Effects of various parameters such as absorption time, sample pH, salt content, applied voltage, SPME fiber type, flow rate and background matrix are also described.
    Type: Grant
    Filed: January 6, 2016
    Date of Patent: June 18, 2019
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Chanbasha Basheer, Abdulnaser Khaled Alsharaa
  • Patent number: 10317414
    Abstract: Methods of assessing the risk of cardiovascular disease in a subject by detecting the level of at least one metabolite in a sample from the subject are disclosed herein. The level of the metabolite is indicative of the risk of cardiovascular disease in the subject. The metabolites may be acylcarnitines, amino acids, ketones, free fatty acids or hydroxybutyrate. The cardiovascular disease may be risk of a cardiovascular event, presence of coronary artery disease or risk of development of coronary artery disease.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: June 11, 2019
    Assignee: Duke University
    Inventors: Svati H. Shah, Christopher B. Newgard, William E. Kraus, Elizabeth R. Hauser, Geoffrey S. Ginsburg, L. Kristin Newby
  • Patent number: 10315134
    Abstract: The invention relates to a chromatography column assembly that offers an affordable self-packed column for performing chromatographic separation. The chromatography column assembly comprises a column tube having a first and a second opening at substantially opposite ends, and an end cap of either a snap fit design or a bolted design. The column assembly may further include an adaptor shaft inserted into the column through the end cap for achieving a desired bed volume. The column assembly may also include a second end cap enclosing the second opening, and an optional adaptor shaft may be inserted into the column through the second end cap, enabling further adjustment of the bed volume.
    Type: Grant
    Filed: August 15, 2014
    Date of Patent: June 11, 2019
    Assignee: GE Healthcare Bio-Science AB
    Inventors: Veena Rao, Manoj Ramakrishna, Nikhil Kamble
  • Patent number: 10302572
    Abstract: A reagent card analyzer comprises an optical signal source configured to transmit an optical signal and an optical signal detector spaced a distance from the optical signal source to define an optical signal path into which the optical signal is transmitted, the optical signal detector configured to detect the optical signal and to output an electrical signal indicative of the optical signal. A reader is configured to read a reagent pad of a reagent card. A reagent card moving mechanism is configured to move the reagent card having the reagent pad including a leading and trailing end through the optical signal path. An optical detector interface is electrically coupled with the optical signal detector and configured to receive electrical signals and to output a pad detect signal indicative of at least one of the leading and the trailing end as the reagent card is moved through the optical signal path.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: May 28, 2019
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Lawrence Milesky, George N. Zantos
  • Patent number: 10302624
    Abstract: The present invention relates to methods for the diagnosis and risk assessment of plasmalogen deficiency mediated diseases of aging. The present invention describes the relationship between plasmalogen biosynthesis dysfunction and the biochemical and clinical manifestations of age related disorders. Specifically the present invention describes an increased prevalence of colon cancer, prostate cancer, lung cancer, breast cancer, ovary cancer, kidney cancer, cognitive impairment and dementia in subjects suffering from adult onset plasmalogen biosynthesis disorder (AO-PBD).
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: May 28, 2019
    Assignee: Med-Life Discoveries LP
    Inventor: Dayan Goodenowe
  • Patent number: 10295546
    Abstract: A Method for the detection of the conformational state of a protein contained in a complex mixture of further proteins and/or other biomolecules, is proposed as well as assays for such a method. The method comprises the following steps: (1) Limited proteolysis of the complex mixture under a condition where the protein is in the conformational state to be detected leading to a first fragment sample; (2) Denaturation of the first fragment sample to a denaturated first fragment sample; (3) Complete fragmentation of the denaturated first fragment sample in a digestion step to a completely fragmented sample; and (4) Analytical analysis of the completely fragmented sample for the determination of fragments characteristic of having been the result both the limited proteolysis of step 1 as well as of the complete fragmentation in the digestion step 3. for the determination of the conformational state.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: May 21, 2019
    Assignee: ETH ZURICH
    Inventors: Paola Picotti, Yuehan Feng, Giorgia De Franceschi
  • Patent number: 10272427
    Abstract: Techniques are provided for a completely programmable fluidic manipulation without requiring any external control elements or electricity. A chip includes multiple microfluidic channels separated from an outside of the chip by an outer flexible substrate. An apparatus includes a plurality of actuators rotatably connected to a support structure with a recess for receiving the chip. Each actuator includes a plurality of teeth protruding outward, and is positioned so that at least in some angle of rotation a tooth of the actuator extends sufficiently into the recess to compress a microfluidic channel in a chip disposed in the recess. An optional punch card guide is included for guiding a card to contact the actuators. A system or kit includes a punch card on which is formed a plurality of punch features, each configured to engage a tooth of an actuator. Different microfluidic protocols are executed by simply changing the punch card.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: April 30, 2019
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Manu Prakash, George Korir
  • Patent number: 10254291
    Abstract: The disclosure provides quaternary ammonium containing isobaric tag reagents useful in the analysis of biomolecules and methods of making and using the quaternary ammonium containing isobaric tag reagents. The quaternary ammonium containing isobaric tag reagents are particularly useful for glycan analysis, especially quantitative glycan profiling such as glycan quantitation by tandem mass spectrometry.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: April 9, 2019
    Assignees: UNIVERSITY OF MARYLAND, COLLEGE PARK, THE JOHNS HOPKINS UNIVERSITY
    Inventors: Shuwei Li, Hui Zhang, Shuang Yang
  • Patent number: 10247646
    Abstract: A self-contained biological sample processing cartridge includes top and bottom portions that close together to form a sealed chamber therein. The chamber is configured to enable one of one or more biological sample staining procedures appropriate for a biological sample. The top portion includes a chamber top section and valve control elements. The bottom portion includes a chamber bottom section and fluidic valves. One of the fluid valves evacuates the contents of the chamber. One of the valve control elements couples to a respective fluidic valve to control fluid flow for the chamber. The cartridge includes a preloaded reagent component to supply the chamber with the reagent component appropriate for a particular biological sample staining procedure. A user desiring to conduct a particular biological sample staining procedure may select a particular cartridge that is preloaded with the preloaded reagent fluidic valves component appropriate for the particular biological sample staining procedure.
    Type: Grant
    Filed: March 9, 2015
    Date of Patent: April 2, 2019
    Assignee: SYFR, INC.
    Inventors: Shazi S Iqbal, Steven M Montgomery, Ronald Chang, Gregory E Mote, Douglas B Dority, Jeffrey S Ross
  • Patent number: 10234440
    Abstract: A method and system for testing soil includes wetting a selected soil sample to obtain a soil solution and measuring an initial pH of the soil solution. A buffer solution is then applied to the soil solution to displace alkaline anions from soil colloids of the soil solution with a displacement agent and to neutralize the alkaline anions with a neutralization agent in a buffer having a buffer pH of between 4.38 and 4.42. A resultant pH of the soil solution is then measured. A target pH for the soil sample is selected, and using mathematical relationships of the disclosure, an acidic amendment recommendation is obtained as a function of the initial pH, the resultant pH, and the target pH.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: March 19, 2019
    Inventor: Gobena Huluka
  • Patent number: 10233551
    Abstract: A method for concentrating an aqueous caustic alkali produced by a membrane cell process by using a single or multiple effect evaporator system in which the vapor flows in a counter direction to the aqueous caustic alkali flow and the heat recovered from the catholyte circulation line is used as part of the concentration process. In one embodiment, a catholyte heat recovery heat exchanger and flash evaporation chamber are located after the last effect of a multiple effect evaporator system. In another embodiment, the catholyte heat recovery heat exchanger and flash evaporation chamber are located prior to the single or multiple effect evaporator system. In yet another embodiment, the catholyte heat recovery process is used in conjunction with additional heat exchanger processes to further concentrate the final product as desired.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: March 19, 2019
    Assignee: WESTLAKE VINYL CORPORATION
    Inventors: Anthony B. Davis, Thomas H. Yohe, Russell F. Dunn
  • Patent number: 10232374
    Abstract: Methods are provided for the preparation of a sample using a digital microfluidic platform and the optional subsequent mass analysis of an extracted analyte. A sample is dried, optionally on a solid phase support, and contacted with digital microfluidic array. An analyte present within the dried sample is extracted into an extraction solvent by electrically addressing the digital microfluidic array to transport a droplet of extraction solvent to the dried sample spot. The extracted sample may be dried and subsequently processed on the digital microfluidic array for derivatization. The digital microfluidic device may further include an integrated microfluidic channel having an output aperture, and the method may further include contacting a droplet containing extracted analyte with the microfluidic channel and applying a suitable electric field for generating nano-electrospray, thereby enabling the device to be directly interfaced with a mass analysis device.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: March 19, 2019
    Assignee: mirOculus Inc.
    Inventors: Mais J. Jebrail, Hao Yang, Aaron R. Wheeler
  • Patent number: 10220390
    Abstract: A device for collecting, transferring and/or conserving samples of biological material, comprising at least: a support body having at least a housing seating for a conserving element for samples, the housing seating being configured for enabling removably housing the conserving element for samples of biological material, the support body being configured for maintaining at least a conserving portion of the conserving element accessible for depositing a sample when the conserving element is housed in the housing seating; an operating portion, movable between a first closed position in which it is arranged in proximity of said housing seating and at least an open position in which it is arranged in a distanced position from the housing seating; and engaging portion configured for selectively and removably engaging a sampling element for samples, in particular an element for buccal sampling, to the support body and/or to the operating portion.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: March 5, 2019
    Assignee: Copan Italia S.p.A.
    Inventor: Daniele Triva
  • Patent number: 10215727
    Abstract: Embodiments of the invention are directed to a solid-state zinc sensor. A non-limiting example of the sensor includes a semiconductor substrate. The sensor can also include an assembly surface on the semiconductor substrate. The sensor can also include a zinc detection monolayer chemically bound to the assembly surface. The sensor can also include a power supply electrically connected to the semiconductor substrate.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: February 26, 2019
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Ali Afzali-Ardakani, Abram L. Falk, Bharat Kumar
  • Patent number: 10203286
    Abstract: We describe a method for conducting an assay in a multi-well assay plate using an apparatus comprising a light detection subsystem, a liquid handling subsystem, and a plate handling subsystem. This is particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, it may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
    Type: Grant
    Filed: April 10, 2009
    Date of Patent: February 12, 2019
    Assignee: Meso Scale Diagnostics, LLC
    Inventors: Charles M. Clinton, Eli N. Glezer, Sharon West, George Sigal, Carl Stevens, Michael L. Vock
  • Patent number: 10156573
    Abstract: The present disclosure relates to an optical fluorescence sensor comprising a probe for sensing glucose, an intra-reference probe, and a matrix. The present disclosure also relates to an optical fluorescence dual sensor comprising a probe for sensing glucose having two boronic acid moieties, a probe for sensing oxygen comprising modified porphyrin, an intra-reference probe that is rhodamine-based, and a matrix. The present disclosure additionally relates to methods of preparing these sensors and methods of using them.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: December 18, 2018
    Assignee: Arizona Board of Regents, a body corporate of the State of Arizona, acting for and on behalf of Arizona State University
    Inventors: Yanqing Tian, Liqiang Zhang, Fengyu Su, Deirdre Meldrum, Sean Buizer
  • Patent number: 10101354
    Abstract: A method is provided for disposing of a liquid within an automated analytical system for processing a fluid biological sample, wherein a contamination prevention shield including channels for pipets or pipet tips is reversibly docked to a container for liquid waste in order to reduce the risk of cross-contamination. A tip rack assembly is provided for processing a fluid sample, the assembly including a rack for pipet tips and the contamination prevention shield. An analytical system is provided using the tip rack assembly, wherein cross-contamination is avoided.
    Type: Grant
    Filed: January 24, 2017
    Date of Patent: October 16, 2018
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Renato Belz, Christian Thalmann