Abstract: Novel organoselenium selective ligands are presented and designed to determine metal ions in a sample. These ligands are used as complexing agents in a dispersive liquid-liquid microextraction procedure of copper and zinc ions. The procedure has a shortened extraction time, minimal organic solvent types, and lower amounts of solvents, as well as easy operation and high enrichment efficiency.
Type:
Grant
Filed:
September 12, 2023
Date of Patent:
May 7, 2024
Assignee:
KING FAISAL UNIVERSITY
Inventors:
Hany Mohamed Abd El-Lateef Ahmed, Saadeldin Elsayed Ibrahim Shabaan, Mai Mustafa Khalaf Ali, Mohamed Gouda, Wael I. Mortada
Abstract: Methods, apparatuses, and kits for detection of substances in water by forming a complex with an indicator reagent and filtering the complex on a filter or membrane are described. The concentrated indicator on the filter, membrane or other capture device provides a colorimetric readout that can determine the amount of substance present in a water sample. A computer-implemented method for determining the concentration of substances in water based on color data from the colorimetric readout is also described.
Abstract: Novel organoselenium selective ligands are presented and designed to determine metal ions in a sample. These ligands are used as complexing agents in a dispersive liquid-liquid microextraction procedure of copper and zinc ions. The procedure has a shortened extraction time, minimal organic solvent types, and lower amounts of solvents, as well as easy operation and high enrichment efficiency.
Type:
Grant
Filed:
September 11, 2023
Date of Patent:
April 9, 2024
Assignee:
KING FAISAL UNIVERSITY
Inventors:
Hany Mohamed Abd El-Lateef Ahmed, Saadeldin Elsayed Ibrahim Shabaan, Mai Mustafa Khalaf Ali, Mohamed Gouda, Wael I. Mortada
Abstract: Provided are a stable triazolinedione adduct, a method for producing the same, a method for producing an ene compound, and a method for analyzing an ene compound. A triazolinedione adduct that is stable until the time of use and can be reacted while reverting to a triazolinedione compound at the time of use. Specifically, a triazolinedione adduct represented by formula (1). (In the formula, R1 is an organic group, and A is a fused ring of three or more rings including at least one aromatic ring.
Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
Type:
Grant
Filed:
February 7, 2019
Date of Patent:
March 26, 2024
Assignee:
Meso Scale Technologies, LLC.
Inventors:
Charles M. Clinton, Eli N. Glezer, Sharon West, George Sigal, Carl Stevens, Michael L. Vock
Abstract: A standard calibration solution includes water, a non-alcoholic solvent that is mixed with water, and a steroid hormone, and a content of the non-alcoholic solvent is 10% by volume or more and 50% by volume or less. The standard calibration solution is used for quantitative measurement using a mass spectrometry device.
Abstract: Novel organoselenium selective ligands are presented and designed to determine metal ions in a sample. These ligands are used as complexing agents in a dispersive liquid-liquid microextraction procedure of copper and zinc ions. The procedure has a shortened extraction time, minimal organic solvent types, and lower amounts of solvents, as well as easy operation and high enrichment efficiency.
Type:
Grant
Filed:
February 23, 2023
Date of Patent:
March 5, 2024
Assignee:
KING FAISAL UNIVERSITY
Inventors:
Hany Mohamed Abd El-Lateef Ahmed, Saadeldin Elsayed Ibrahim Shabaan, Mai Mostafa Khalaf Ali, Mohamed Gouda, Wael I. Mortada
Abstract: A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample.
Type:
Grant
Filed:
February 28, 2022
Date of Patent:
March 5, 2024
Assignees:
bioMérieux, Inc., BioFire Defense, LLC
Inventors:
John D. Walsh, Christopher S. Ronsick, Mark S. Wilson, Kirk Ririe, Ryan T. Hill
Abstract: Systems and methods for concentrating an analyte preparatory to analysis thereof include processing the effluent of an analyte concentrator to produce an eluent for eluting an analyte retained in the same or separate concentrator, and systems implementing the same. The analyte concentrator system connects the effluent outlet of an analyte concentrator column to an eluent generation module such that the substantially analyte-free effluent discharged from the analyte concentrator column passes fluidly into the eluent generation module. Eluent generated from the substantially analyte-free effluent in the eluent generation module is likewise substantially free of the analyte. The systems and methods can minimize and/or (substantially) eliminate background signal during analysis of the concentrated analyte.
Abstract: Provided is a method for analyzing a diene compound including: a triazolinedione adduct heating step of heating a triazolinedione adduct to produce a triazolinedione compound; an ene compound formation step of reacting the triazolinedione compound with a diene compound to obtain an ene compound; and an ene compound analysis step of analyzing the ene compound to quantitative determine the diene compound. Also provided is a method for producing an ene compound, including: a triazolinedione adduct heating step of heating a triazolinedione adduct to produce a triazolinedione compound; and an ene compound formation step of reacting the triazolinedione compound with a diene compound to obtain an ene compound.
Abstract: A diketopyrrolopyrrole pigment compound having high weather resistance, a preparation method therefor and a use thereof, which relate to the technical field of organic pigments. The diketopyrrolopyrrole pigment compound has the structural formula (I). The described diketopyrrolopyrrole pigment compound may be directly used as a wet filter cake, or may be further formed into a flowing solid powder or granulated into a granulated preparation. In the various applications described, the diketopyrrolopyrrole pigment compound exhibits high saturation, good rheology, hiding power, and gloss, high tint strength, and particularly high weather resistance. The diketopyrrolopyrrole pigment compound having high weather resistance, the preparation method therefor and the use thereof have good market prospects.
Abstract: According to the present teachings, systems, compositions, kits and methods for protein melt analysis are provided that utilizing a dye that is a dipyrrometheneboron difluoride compound. In some embodiments, a method comprises preparing a sample by mixing at least one protein with a dye, and applying a controlled heating, while recording the fluorescence emission of the sample.
Abstract: A colorimetric sensor for detecting an analyte of interest in a fluid sample includes a lamellar photonic material having alternating layers of a first polymer layer and a second polymer layer. Each first polymer layer can be a molecularly imprinted polymer defining a cavity shaped to receive an analyte of interest. The photonic material is configured such that, when an analyte contacts the photonic material and becomes disposed within a cavity of the molecularly imprinted polymer, a refractive property of the photonic material changes, causing a detectable color change in the sensor.
Abstract: An inner diameter of an opening of the flow path is larger than a particle diameter of an adsorbent. Therefore, in a state where the flow path 33 is disposed in the container 31, the adsorbent 40 enters the flow path 33 via the opening 33B of the flow path 33. That is, in the adsorption apparatus, the adsorbent is disposed in a region between a side surface portion of the container and the flow path and inside the flow path. Further, in the adsorption apparatus 3, the air flows the region between the container 31 and the flow path 33 and in the flow path 33. Therefore, when the air is flown into the adsorption apparatus 3, the air can be sufficiently brought into contact with the adsorbent 40, and moisture contained in the air can be sufficiently adsorbed.
Abstract: This invention relates to the preparation of N-(phosphonomethyl)glycine (“glyphosate”) from N-(phosphonomethyl)iminodiacetic acid (“PMIDA”), and more particularly to methods for control of the conversion of PMIDA, for the identification of reaction end points relating to PMIDA conversion and the preparation of glyphosate products having controlled PMIDA content.
Type:
Grant
Filed:
June 15, 2021
Date of Patent:
October 31, 2023
Assignee:
Monsanto Technology LLC
Inventors:
Donald D. Soleta, Peter E. Rogers, Eduardo A. Casanova, Robert E. Byrd, Eric A. Haupfear
Abstract: Described is an electrochemiluminescence method of detecting an analyte in a liquid sample using a measuring cell having a working electrode for detecting the analyte using an electrochemiluminescence measurement cycle, involving a. carrying out the measurement cycle in a calibration process using a liquid sample without analyte and performing a first electrochemical impedance spectroscopy, EIS, at a given point of the measurement cycle, the first EIS being performed using the working electrode, b. carrying out the measurement cycle in an analysis process using the liquid sample containing the analyte and performing a second EIS at the given point of the measurement cycle, the second EIS being performed using the working electrode, c. comparing the result of the first EIS and the second EIS, providing an indication indicating if the comparison results show a deviation between the first EIS and the second EIS exceed a predefined threshold.
Abstract: Methods for quantifying the amount of drug present in a crosslinked hyaluronic acid-linker-peptide (xHA-L-P) prodrug composition are provided. Disclosed are steps of contacting a sample of the xHA-L-P prodrug formulation with a hyaluronoglucosidase to generate oligomeric hyaluronic acid-linker-peptide drug (oHA-L-P), contacting the oHA-L-P with a second enzyme to generate peptide digest products of the drug, and detecting the peptide digest products to determine the amount of the drug present in the xHA-L-P prodrug formulation.
Abstract: The present disclosure relates to a method for detecting a prostate cancer related biomarker, including contacting the diluted sample with a modulating agent selected from a group consisting of sodium; 3-hydroxy-4-[(2-hydroxynaphthalen-1-yl)diazenyl]naphthalene-1-sulfonate, sodium; 3-hydroxy-4-[(1-hydroxynaphthalen-2-yl)diazenyl]-7-nitronaphthalene-1-sulfonate, triisopropylsilane, and iron(III) chloride, and a luminescent label to obtain a measurement sample. Then, the measurement sample is incubated for a period of time and excited thereafter. Time-resolved luminescence signal of the label in the measurement sample is measured, leading to an increased likelihood of prostate cancer of the human subject if the luminescence signal is at least 50% higher than for a control sample from a human subject without prostate cancer.
Type:
Grant
Filed:
May 4, 2021
Date of Patent:
October 24, 2023
Assignee:
Aqsens Health Oy
Inventors:
Janne Kulpakko, Jouko Vepsäläinen, Susanna Paavilainen
Abstract: The present disclosure relates to a novel probe compound, i.e., 1-(ortho-benzophenylaminoalkyl)-phenylboronic acid, or its derivative for a fluorescence and/or circular dichroism (CD) sensor for amine compounds containing aminoalcohols. Also, the present disclosure relates to a simultaneous fluorescence and CD analysis method of of amine compounds containing aminoalcohols using the novel probe compound to obtain concentration and optical purity of the amine compounds.
Type:
Grant
Filed:
April 17, 2020
Date of Patent:
October 10, 2023
Assignee:
EWHA UNIVERSITY—INDUSTRY COLLABORATION FOUNDATION
Inventors:
Kwan Mook Kim, Juyoung Yoon, Eknath Shirbhate Mukesh, Ah-Young Song