Patents Examined by Michelle Adams
-
Patent number: 11719684Abstract: Robust methods for quantitating the amount of elemental sulfur in a fluid whereby a caustic solution is mixed with the fluid, and the elemental sulfur present in the fluid reacts to form a colored solution that can be compared to a series of standards. The methods can be performed in a laboratory or the field and allow for real time feedback. Once the concentration of the elemental sulfur is known, appropriate methods of treatment can proceed. Test kits for performing the methods in the field are also described.Type: GrantFiled: October 2, 2020Date of Patent: August 8, 2023Assignee: CONOCOPHILLIPS COMPANYInventors: Jay Locklear, Clinton Crowe
-
Patent number: 11714091Abstract: The present invention relates to a method for determining the three dimensional structure of biomolecules, such as proteins, protein fragments, and peptides. The biomolecule is encapsulated in an amorphous silica matrix, from which a needle specimen is prepared. Atom probe tomography is then used to analyze the needle specimen and the data is used to reconstruct the three dimensional structure of the biomolecule. The present invention greatly facilitates determination of the three dimensional structure of biomolecules.Type: GrantFiled: July 4, 2018Date of Patent: August 1, 2023Assignee: Vitroprobe Analytics ABInventors: Martin Andersson, Mats Hulander, Gustav Sundell
-
Patent number: 11703456Abstract: A component measurement device for measuring a component of interest in blood on a basis of optical characteristics of a mixture containing a color component produced by a color reaction between the component of interest in the blood and a reagent includes: a first light source configured to emit first irradiation light of a first predetermined wavelength to the mixture; and a second light source configured to emit second irradiation light of a second predetermined wavelength to the mixture, the second irradiation light to be used for estimation of a noise amount contained in a measured value of absorbance of the mixture measured by using the first irradiation light of the first light source, the noise amount being derived other than from the color component.Type: GrantFiled: September 18, 2019Date of Patent: July 18, 2023Assignee: TERUMO KABUSHIKI KAISHAInventor: Ryokei Aikawa
-
Patent number: 11685835Abstract: Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I): or a stereoisomer, tautomer or salt thereof, wherein R1, R2, R3, R4, R5, L, L1, L2, L3, L4, M, M?, m1, m2, n, x, y and z are as defined herein. Methods associated with preparation and use of such compounds are also provided.Type: GrantFiled: May 11, 2017Date of Patent: June 27, 2023Assignee: SONY CORPORATIONInventor: Tracy Matray
-
Patent number: 11674965Abstract: Disclosed herein is a method for analyzing the concentration of a fluorescent compound in the plasma of a patient. The method includes collecting a sample of plasma from a patient, diluting the sample with a solvent and analyzing the diluted sample by HPLC. The sample does not need to be dried down during sample preparation nor is an internal standard required.Type: GrantFiled: November 15, 2018Date of Patent: June 13, 2023Assignee: MediBeacon Inc.Inventor: Jeng J. Shieh
-
Patent number: 11656213Abstract: A detection reagent is disclosed in the form of a dye having the basic structure of a 4-(phenylethynyl)-phenyl-amine, a 4-(phenylethenyl)-phenyl-amine and/or a biphenylamine derivative. The dye can be used as detection reagent for nitroaromatics, nitroalkanes, nitroamines, nitrates, nitric acid, nitrous acid, nitrogen oxides, and additionally for sulphur dioxide (which is produced with the degradation of black powder). The dye can be an asymmetric triphenylamine derivative, which can lead to a fluorescence quenching, which can be used analytically in the case of electron abstraction.Type: GrantFiled: November 16, 2016Date of Patent: May 23, 2023Assignee: Institut Dr. Foerster GmbH & Co. KGInventors: Mustafa Biyikal, Knut Rurack
-
Patent number: 11635442Abstract: A sample testing system comprising: a transporting apparatus; a testing apparatus for obtain a sample and performing testing on the obtained sample; and a controller. The controller executes operation of: controlling the transporting apparatus so as to transport the sample rack in first direction, such that each sample container held in a sample rack is transported to a obtaining position on which the testing apparatus obtains a sample and then the sample rack is transported toward the second position; changing, when retesting of a sample contained in a sample container is necessary, the transporting direction from the first direction to second direction, and then controlling the transporting apparatus so as to transport the sample container accommodating the sample, for which retesting is necessary, to the obtaining position again. Sample testing method and a computer program product are also disclosed.Type: GrantFiled: December 30, 2014Date of Patent: April 25, 2023Assignee: SYSMEX CORPORATIONInventors: Yuichi Hamada, Daigo Fukuma
-
Patent number: 11630115Abstract: A sample testing system comprising: a transporting apparatus; a testing apparatus for obtain a sample and performing testing on the obtained sample; and a controller. The controller executes operation of: controlling the transporting apparatus so as to transport the sample rack in first direction, such that each sample container held in a sample rack is transported to a obtaining position on which the testing apparatus obtains a sample and then the sample rack is transported toward the second position; changing, when retesting of a sample contained in a sample container is necessary, the transporting direction from the first direction to second direction, and then controlling the transporting apparatus so as to transport the sample container accommodating the sample, for which retesting is necessary, to the obtaining position again. Sample testing method and a computer program product are also disclosed.Type: GrantFiled: February 18, 2022Date of Patent: April 18, 2023Assignee: SYSMEX CORPORATIONInventors: Yuichi Hamada, Daigo Fukuma
-
Patent number: 11630089Abstract: Yttria containing hybrid organic-inorganic sol-gels may be used in coatings for capillary microextraction, optionally hyphenated to online HPLC analysis. The sol-gel reaction mixture can use an yttrium trialkoxyalkoxide, such as yttrium trimethoxyethoxide, and a [bis(hydroxyalkyl)-amino-alkyl]-terminated polydialkyl/arylsiloxane, such as [bis(hydroxyethyl)-amine] (BHEA)-terminated polydimethylsiloxane, that can undergo hydrolysis and polycondensation, to form coating materials. Capillaries coated with such sol-gels can have improved extraction efficiency compared, e.g., to pure yttria-based coatings. The CME-HPLC can analyze water samples containing analytes of varied polarity, with excellent extraction of amides, phenols, alcohols, ketones, aldehydes, and polyaromatic hydrocarbons and detection limits ranging from 0.18 to 7.35 ng/mL (S/N=3). Such capillaries can exhibit solvent stability at pH 0 to 14, RSD % between 0.6 to 6.8% (n=3), at a preparative reproducibility RSD between 4.1 and 9.9%.Type: GrantFiled: January 23, 2019Date of Patent: April 18, 2023Assignee: King Fahd University of Petroleum and MineralsInventors: Khalid Alhooshani, Shehzada Muhammad Sajid Jilani
-
Patent number: 11604141Abstract: The compounds relate to zinc-sensitive fluorescent probes, compositions and methods utilizing the same. Such compounds provide an emission-ratiometric fluorescence response upon binding of an analyte. In some embodiments, compounds can be used for two-photon excitation microscopy or conventional fluorescence microscopy. The compounds described herein can also contain one or more functional groups to improve the emission-ratiometric fluorescence response.Type: GrantFiled: June 12, 2018Date of Patent: March 14, 2023Assignee: Georgia Tech Research CorporationInventors: Christoph J. Fahrni, Adam M. McCallum, Michael Thomas Morgan
-
Patent number: 11604189Abstract: A detection device (10), comprising a sample detection layer (1) provided thereon with a detection reagent reacted with an analyte and a result display region (18), wherein the device further comprises a symbol display layer (2) on which an indicator (21) is processed; after the indicator contacts with a gas which can change the color of the indicator, the indicator changes from a first color to a second color.Type: GrantFiled: April 26, 2018Date of Patent: March 14, 2023Assignee: LEADWAY (HK) LIMITEDInventors: Feng qin Fei, Chunxia Zhang, Tao Shang
-
Patent number: 11585735Abstract: A detector inlet for providing a sample to an analytical apparatus for detecting an aerosol, the detector inlet comprising; an intake for inhaling a flow of gaseous fluid to be sampled by the analytical apparatus; a mixing region; a first conduit for carrying a first part of the flow of gaseous fluid from the intake to the mixing region; a second conduit for carrying a second part of the flow of gaseous fluid from the intake to the mixing region; and a heater configured to heat the first part more than the second part, and wherein the detector inlet is configured to combine the first part with the second part in the mixing region.Type: GrantFiled: September 30, 2016Date of Patent: February 21, 2023Assignee: Smiths Detection-Watford LimitedInventors: Oliver Kirkby, Alastair Clark, Bruce Grant
-
Patent number: 11567052Abstract: An embodiment provides a method for measuring nitrate in an aqueous sample, including: introducing an aqueous sample containing an amount of nitrate to a cation exchange resin; flowing the aqueous sample over copper metal; adding a reducing reagent to the aqueous sample; adding a colorimetric indicator to the aqueous sample; and measuring the amount of nitrate in the aqueous sample by measuring a change in intensity of the absorbance. Other aspects are described and claimed.Type: GrantFiled: October 29, 2019Date of Patent: January 31, 2023Assignee: HACH COMPANYInventor: Angella Nicholle Greenawalt
-
Patent number: 11559785Abstract: The present invention relates to monolithic bodies, uses thereof and processes for the preparation thereof. Certain embodiments of the present invention relate to the use of a monolithic body in the preparation of a radioactive substance, for example a radiopharmaceutical, as part of a microfluidic flow system and a process for the preparation of such a monolithic body.Type: GrantFiled: October 22, 2015Date of Patent: January 24, 2023Assignee: The University of HullInventors: Stephen James Archibald, Ping He, Stephen John Haswell, Nicole Pamme, Nathan Joel Brown, Mark Duncan Tarn, Richard Alexander, Mohammad Mehdi Nasr Esfahani
-
Patent number: 11549888Abstract: An embodiment provides a method for measuring total chlorine in a seawater sample, including: preparing a thiocarbamate-based indicator; introducing the thiocarbamate-based indicator to a seawater sample, wherein the seawater sample contains an amount of total chlorine; adding an additive to the seawater sample, wherein the additive accelerates the reaction rate between the thiocarbamate-based indicator and total chlorine and causes a change in fluorescence of the seawater sample; and measuring the amount of total chlorine in the seawater sample by measuring an intensity of the fluorescence. Other aspects are described and claimed.Type: GrantFiled: October 3, 2019Date of Patent: January 10, 2023Assignee: HACH COMPANYInventor: Amit Das
-
Carbonyl containing compound high-throughput quantitative analysis using isobaric multiplex reagents
Patent number: 11535576Abstract: The present invention provides a set of novel isobaric chemical tags, also referred herein as SUGAR (Isobaric Multiplex Reagents for Carbonyl Containing Compound). These labeling tags are compact and easy to synthesize at high yield and purity in just a few steps using commercially available starting materials. The tagging reagents of the present invention comprise: a) a reporter group, having at least one atom that is optionally isotopically labeled; b) a balancing group, also having at least one atom that is optionally isotopically labeled, and c) an aldehyde, ketone, or carboxylic acid reactive group. The multiplex SUGAR tags are able to react with an aldehyde, ketone, or carboxylic acid group of the molecule to be tagged, which offers the capability for labeling and quantitation of glycans, proteins/peptides, and fatty acids.Type: GrantFiled: January 18, 2019Date of Patent: December 27, 2022Assignee: Wisconsin Alumni Research FoundationInventors: Lingjun Li, Yu Feng, Bingming Chen, Qinying Yu, Xuefei Zhong, Miyang Li -
Patent number: 11519863Abstract: The invention relates to a method in the preparation of samples for microscopic examination onto which a coverslip is applied. The method is notable for the fact that the coverslipping quality is checked automatically and at least partly optically. The invention further relates to an apparatus for carrying out the method, and to an apparatus for checking the coverslipping quality of samples onto which a coverslip is applied.Type: GrantFiled: December 13, 2017Date of Patent: December 6, 2022Assignee: LEICA BIOSYSTEMS NUSSLOCH GMBHInventors: Bernhard Neef, Christian Wilke, Karl-Heinrich Westerhoff
-
Patent number: 11519859Abstract: Provided are novel rhodol-based compounds, the preparation method thereof, and use thereof in Tl+ flux assays. The fluorescent thallium ion sensor compounds have a rhodol fluorophore attached to an amino dicarboxylic acid metal binding moiety. The compounds are prepared in the “pro-dye” form, with the rhodol oxygen and the carboxylic acids of the metal binding unit masked by protecting groups. The disclosed compounds may be used as more red-shifted and less pH-sensitive variants of Thallos.Type: GrantFiled: April 9, 2019Date of Patent: December 6, 2022Assignee: Vanderbilt UniversityInventors: Charles David Weaver, Brendan F. Dutter, Gary A. Sulikowski
-
Patent number: 11506605Abstract: An embodiment provides a method for measuring total chlorine in a solution, including: preparing a thiocarbamate indicator; introducing the thiocarbamate indicator to a solution, wherein the solution contains an amount of monochloramine; adding an additive to the solution, wherein the additive accelerates the reaction rate between the thiocarbamate indicator and monochloramine and causes a change in fluorescence of the solution; and measuring the amount of monochloramine in the solution by measuring an intensity of the fluorescence. Other aspects are described and claimed.Type: GrantFiled: May 14, 2019Date of Patent: November 22, 2022Assignee: HACH COMPANYInventor: Amit Das
-
Patent number: 11474057Abstract: A thermochemical sensor is provided. The thermochemical sensor comprises: a substrate structure comprising a thermoelectric surface having concave portions and convex portions; a base fiber disposed on the thermoelectric surface of the substrate structure; and a catalyst layer that conformally covers the thermoelectric surface of the substrate structure and the base fiber.Type: GrantFiled: December 19, 2016Date of Patent: October 18, 2022Assignee: INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY ERICA CAMPUSInventors: Yong-Ho Choa, Seil Kim, Yoseb Song