Patents Examined by Mina Haghighatian
  • Compositions and methods for ophthalmic and/or other applications
    Patent number: 10864219
    Abstract: Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: December 15, 2020
    Assignee: The Johns Hopkins University
    Inventors: Alexey Popov, Elizabeth M. Enlow, Hongming Chen, James Bourassa
  • Tobramycin magnesium stearate microparticles for inhalation, compositions thereof, and methods of making and using the same
    Patent number: 10857169
    Abstract: Powder formulations for inhalation which comprise microparticles containing an antibiotic and magnesium stearate are useful for the treatment of bacterial infections associated with certain pulmonary diseases.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: December 8, 2020
    Assignee: CHIESI FARMACEUTICI S.p.A.
    Inventors: David Morton, Qi Zhou, Rossella Musa
  • Gastroretentive dosage forms for sustained drug delivery
    Patent number: 10857098
    Abstract: The present disclosure is directed to floating gastroretentive dosage forms with prolonged gastric residence time. The disclosure also provides rapidly expanding sustained release or combined immediate release and sustained release formulations comprising drugs that require targeted release in the proximal gastrointestinal tract for maximum therapeutic benefit. The rapidly expanding floating gastroretentive dosage forms comprise a permeable elastic membrane providing desired characteristics for drug release and mechanical strength to maintain tablet integrity.
    Type: Grant
    Filed: May 6, 2020
    Date of Patent: December 8, 2020
    Assignee: KASHIV SPECIALTY PHARMACEUTICALS, LLC
    Inventors: Kanji Meghpara, Jaydeep Vaghashiya, Navnit H. Shah, Dipen Desai, Wantanee Phuapradit, Harpreet Kaur Sandhu, Siva Ram Kiran Vaka, Namdev B. Shelke, Ashish Chatterji
  • Compositions and methods for ophthalmic and/or other applications
    Patent number: 10857096
    Abstract: Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.
    Type: Grant
    Filed: June 8, 2020
    Date of Patent: December 8, 2020
    Assignee: The Johns Hopkins University
    Inventors: Alexey Popov, Elizabeth M. Enlow, Hongming Chen, James Bourassa
  • Formulation for treating chronic wounds
    Patent number: 10849868
    Abstract: Inventive subject matter disclosed herein includes a method of treating a chronic wound. The method includes mechanically debriding a chronic wound; and applying a formulation to the wound for 5 to 60 seconds, the formulation including: phenolsulfonic acid—37% by weight; guaiacolsulfonic acid—24% by weight; free sulfuric acid—29% by weight; and water—10% by weight.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: December 1, 2020
    Assignee: EPIEN Medical, Inc.
    Inventors: Michael Basara, Matthew J. Watkins, James Bracke
  • Tablet
    Patent number: 10835541
    Abstract: The present invention provides a tablet showing high stability of the active ingredients (potassium-competitive acid blocker and acetylsalicylic acid) and stably and rapidly expressing the pharmacological effects of the active ingredients after administration. The present invention provides a tablet containing an inner core and an outer layer, wherein the inner core is an enteric-coated tablet containing acetylsalicylic acid, and the outer layer contains a potassium-competitive acid blocker free of enteric coating.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: November 17, 2020
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Arisa Maeda, Yuichi Sugiyama, Yoshihiro Uchiyama
  • Highly alkaline detergent composition
    Patent number: 10836982
    Abstract: Present invention relates to a detergent composition and a method for preparing the composition. The composition may be a compressed tablet, a coated tablet, in form of small granules or pearls packed in a dose unit. The composition may also be formulated so as to be an effervescent composition. The detergent composition may conveniently be used in the food industry for cleaning of appliances in food processing and preparation or in the metal industry for cleaning of appliances with respect to soot or oil residues.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: November 17, 2020
    Assignee: Graff Pehrson Vesterager GMBH
    Inventor: Niels Ole Vesterager
  • Systems, methods and products for minimizing tissue reactions and tissue injury at an infusion site
    Patent number: 10821156
    Abstract: Products, systems and methods are disclosed for lowering the concentrations of at least one of preservatives and fibrils in a liquid insulin composition. One method comprises replacing at least a portion of at least one of phenol and m-cresol with at least one of cyclodextrins, cyclodextrin polymers, cyclodextrin beads, and an ion exchange resin.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: November 3, 2020
    Assignee: Cell and Molecular Tissue Engineering, LLC
    Inventors: Ulrike W. Klueh, Donald L. Kreutzer
  • Heterocycle-substituted bicyclic azole pesticides
    Patent number: 10822351
    Abstract: Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein Q is and A, R1, m, X1, X2, X3, X4, Y1, Y2 and Y3 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: November 3, 2020
    Assignee: FMC Corporation
    Inventors: David Alan Clark, Breena Gloriana Fraga, Wenming Zhang
  • Cannabinoid and menthol compositions and methods
    Patent number: 10813889
    Abstract: The present disclosure relates to compositions, including, hydrogel compositions useful as topical analgesics including cannabinoids and menthol where the menthol component can be a stabilized menthol composition comprising menthol and at least one menthol stabilizer compound including undecylenic acid methyl ester, undecylenic acid or a salt of undecylenic acid. The present disclosure also disclosure relates to compositions, including, hydrogel compositions useful as topical analgesics including cannabinoids and menthol as well as carboxymethyl cellulose, carrageenan and a cross-linking agent.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: October 27, 2020
    Inventor: Babak Ghalili
  • Memory shape sunscreen composition
    Patent number: 10813875
    Abstract: A memory-shape skin-care composition, in the form of an oil-in-water emulsion, including a UV filter system, including avobenzone, octocrylene, and homosalate. The composition additionally includes a thickening emulsifier including a co-polymer including a stearate derivative and a polyethylene glycol derivative, a non-thickening emulsifier including a polyglyceryl stearate co-polymer, and a memory-shape material including a polyethylene glycol/hexamethylene diisocyanate co-polymer.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: October 27, 2020
    Assignee: L'OREAL
    Inventors: Jonathan James Faig, David Chan
  • Engineered metal nanoparticles and methods thereof
    Patent number: 10806754
    Abstract: A pharmaceutical composition comprises a metal nanoparticle having an average diameter of about 0.5 nm to about 5 nm. The composition may be used to treat cancer or an anosmia-related disease.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: October 20, 2020
    Assignee: Auburn University
    Inventors: Vitaly Vodyanoy, Oleg Pustovyy, Ludmila Globa, Mahmoud Mansour, Iryna Sorokulova
  • Aerosol formulation for COPD
    Patent number: 10806701
    Abstract: Stable aerosol solution formulations comprising glycopyrronium bromide are useful for administration to patients with COPD and other respiratory conditions.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: October 20, 2020
    Assignee: CHIESI FARMACEUTICI S.p.A.
    Inventors: Sauro Bonelli, Francesca Usberti, Enrico Zambelli
  • High-strength testosterone undecanoate compositions
    Patent number: 10799513
    Abstract: The present disclosure is drawn to pharmaceutical compositions and oral dosage capsules containing testosterone undecanoate, as well as related methods. The capsule includes a capsule shell and a capsule fill. The capsule fill can include a solubilizer and about 14 wt % to about 35 wt % testosterone undecanoate based on the total capsule fill. The oral dosage capsule is such that when a single oral administration to a male subject of one or more capsules with a total testosterone undecanoate daily dose of about 350 mg to about 650 mg it provides a ratio of serum testosterone Cmax to serum testosterone Cave of about 2.7 or less. In yet another embodiment, a method for providing a serum concentration of testosterone within a target serum testosterone concentration Cave range for a male subject is provided.
    Type: Grant
    Filed: April 17, 2018
    Date of Patent: October 13, 2020
    Assignee: Lipocine Inc.
    Inventors: Chandrashekar Giliyar, Basawaraj Chickmath, Nachiappan Chidambaram, Mahesh V. Patel, Srinivansan Venkateshwaran
  • Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
    Patent number: 10799599
    Abstract: An inhalable formulation containing SAE-CD and corticosteroid is provided. The formulation is adapted for administration to a subject by nebulization with any known nebulizer. The formulation can be included in a kit. The formulation is administered as an aqueous solution, however, it can be stored as a dry powder, ready-to-use solution, or concentrated composition. The formulation is employed in an improved nebulization system for administering corticosteroid by inhalation. SAE-CD present in the formulation significantly enhances the chemical stability of budesonide. A method of administering the formulation by inhalation is provided. The formulation can also be administered by conventional nasal delivery apparatus.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: October 13, 2020
    Assignee: CyDex Pharmaceuticals, Inc.
    Inventors: James D. Pipkin, Rupert O. Zimmerer, Diane O. Thompson, Gerold L. Mosher
  • Functional coating
    Patent number: 10786606
    Abstract: The present invention relates to the coating of a range of functional heparins onto the surface of a substrate for which hemocompatibility is a key functional characteristic, such that the functionality of the functional heparin is maintained. The approach employs a metal coordination complex to bind to the substrate with the functional heparin binding to the metal coordination complex to thereby impart hemocompatibility.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: September 29, 2020
    Assignee: ANTEO TECHNOLOGIES PTY LTD.
    Inventors: Nobuyoshi Joe Maeji, Chang-Yi Huang
  • Process for preparing a dry powder formulation comprising an anticholinergic, a corticosteroid and a beta-adrenergic
    Patent number: 10786450
    Abstract: A process for preparing a dry powder formulation for inhalation comprising a combination of an anti-cholinergic, a long-acting beta2-adrenoceptor agonist, and a corticosteroid is provided.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: September 29, 2020
    Assignee: CHIESI FARMACEUTICI S.p.A.
    Inventors: Alessandro Cavecchi, Cristiana Merusi, Fausto Pivetti, Francesca Schiaretti
  • Compositions and methods for improving plant health
    Patent number: 10772335
    Abstract: Disclosed are compositions and methods for preparing compositions that improve plant health and reduce fungal infestations. Also disclosed are methods of using the compositions described herein to improve plant health by applying the compositions directly to plants, and/or applying the compositions to substrates used for plant growth. The compositions include a synergistic ratio of composting bacteria, bio-surfactant producing bacteria, bio-remediating bacteria, bovine feces, and humic acid. The compositions reduce fungal growth and fungal infestation the infected area. Methods of reducing brown patch and/or dollar spot infestations to a plant such as turf grass or crop are also described herein.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: September 15, 2020
    Assignee: HSC Organics LLC
    Inventors: Gregory R. H. Smith, Eric Davies
  • Herbicide composition containing isopropylamine caprylate
    Patent number: 10772327
    Abstract: Provided is a herbicidal composition comprising a compound of Formula (I) as a herbicidally active ingredient, and an agronomically acceptable additive, Also provided is a method of controlling undesirable vegetation using the herbicide composition.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: September 15, 2020
    Assignee: HUNAN AGRICULTURAL BIOTECHNOLOGY RESEARCH INSTITUTE
    Inventors: Lianyang Bai, Zuren Li, Xile Deng, Dingfeng Luo, Xiaogang Li, Xiaomao Zhou
  • Hybrid hydrogel and method of fabricating the same
    Patent number: 10772844
    Abstract: A hybrid hydrogel including a hydrogel material and a plurality of first hybrid nanoparticles is provided. The plurality of first hybrid nanoparticles are conjugated to the hydrogel material, wherein each of the first hybrid nanoparticles includes a first positive-charged polysaccharide and a first negative-charged polysaccharide. The first positive-charged polysaccharide is located at an inner core of the first hybrid nanoparticles. The first negative-charged polysaccharide is located at an outer shell of the first hybrid nanoparticles and carries a plurality of first growth factors. The first negative-charged polysaccharide and the first positive-charged polysaccharide are electrostatically attracted to form the first hybrid nanoparticles. A method of fabricating the hybrid hydrogel is also provided.
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: September 15, 2020
    Assignee: National Tsing Hua University
    Inventors: Tzu-Wei Wang, Wei-Hong Jian