Abstract: Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.

Abstract: Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.

Abstract: A method for treating hair including providing a caustic as well as an acidic crosslinking composition, wherein the caustic crosslinking composition comprises an at least bi-functional Brønsted-base and the acidic crosslinking composition comprises includes an at least bi-functional organic acid, and a cosmetically acceptable carrier; applying the caustic as well as the acidic crosslinking composition to keratin fibres; and optionally mixing the caustic crosslinking composition into a commercially available hair colouring or hair bleaching composition; and a kit thereof.

Abstract: The invention relates to the prevention and/or treatment of a severe broncho-pulmonary disease by administering a solution formulation from a pressurized metered dose inhaler capable of providing therapeutical doses of two or more active drug substances to the lung, wherein all the active drug substances are fully dissolved in the formulation as well as the two or more active drug substances are delivered with substantially the same particle size distribution.

Abstract: A powder injection of a donepezil semi palmoxiric acid salt, a composition containing the same and a preparation method therefor. The powder injection contains donepezil semi palmoxiric acid salt crystals, and the average grain size of the crystals ranges from 0.5 ?m to 100 ?m.

Abstract: Pharmaceutical compositions having enhanced active component permeation properties are described.

Abstract: A microcapsule composition comprising at least one polymer substantially disposed as a semipermeable shell around an aqueous buffered solution and at least one agent, wherein the agent permeates the shell, and wherein the composition is suitable for delivery to a mammal.

Abstract: A microcapsule composition comprising at least one polymer substantially disposed as a semipermeable shell around a buffered solution and at least one therapeutic agent, wherein the therapeutic agent permeates the shell, and wherein the composition is suitable for topical epithelial cells of mammal.

Abstract: Gastro-intestinal release capsule intended for oral use in a method for desensitizing and/or inducing tolerance in a peanut-allergic subject or, alternatively, for diagnosing a peanut allergy in a subject. The capsule has a shell and a core, the core has a composition of peanut including peanut, at least one oil, at least one first pulverulent excipient and, optionally, at least one second prebiotic excipient. The capsule is provided and ingested in an unopened form.

Abstract: A microcapsule composition comprising at least one polymer substantially disposed as a semipermeable shell around a buffered solution and at least one therapeutic agent, wherein the therapeutic agent permeates the shell, and wherein the composition is suitable for delivery to a mammal. This invention also provides related compositions, products and methods.

Abstract: The present disclosure relates to a dissolvable thin oral tape, film or strip or segment thereof composition or device, including a film former, at least one cannabinoid, menthol, caffeine and vitamins.

Abstract: Methods for spray drying gram negative bacteria are provided. Such spray drying methods are performed under conditions that allow for the spray dried composition to retain the biological activity of interest of the gram-negative bacteria. Further provided are compositions comprising a spray dried gram-negative bacteria, where the spray dried formulation comprises at least 105 CFU/gram of said gram-negative bacteria. The gram-negative bacteria employed in the various methods and compositions can comprise a biological activity of interest which, in specific embodiments, controls one or more pathogens that cause plant disease and/or improve at least one agronomic trait of interest. The spray dried formulation can be used as an inoculant for plants. Methods for growing a plant susceptible to plant disease and methods and compositions for controlling plant disease are also provided. Further provided are methods and compositions of increasing disease resistance in plants.

Abstract: The present invention is directed toward respirable dry powders and particles for systemic delivery of pharmaceutically active agents or delivery to the respiratory tract. The dry powders contain one or more monovalent metal cations (such as Na+), are small and dispersible.

Abstract: Pharmaceutical compositions having enhanced active component permeation properties are described.

Abstract: A personal care composition is disclosed comprising abrasive particles. The personal care composition may take a variety of forms such as a leave-on composition or an emulsion and/or may comprise one or more actives or agents.

Abstract: Effective delivery of an insecticide to a growing plant can sometimes be problematic. Topical delivery of an insecticide at the post-emergence stage of growth can sometimes be ineffective. It can also be difficult to deliver an insecticide to the roots of a growing plant, such as to combat a subsurface insect infestation. Accordingly, soil blends having insecticidal activity can comprise a soil medium, a porous soil additive, and an insecticide dispersed within the soil medium. Such soil blends may be used in conjunction with cultivating a variety of plants. Methods for producing the soil blends can comprise providing a soil medium and a porous soil additive, and dispersing the porous soil additive and an insecticide within the soil medium.

Abstract: The present disclosure relates to compositions methods of use and methods of manufacturing, hydrous hydrogel compositions useful as topical oral analgesics including cannabinoids and menthol.

Abstract: Provided herein are pharmaceutically acceptable sodium thiosulfate and pharmaceutical compositions thereof. Also provided herein are methods for determining the total non-purgeable organic carbon in a sodium thiosulfate-containing sample. Further provided herein are methods for producing pharmaceutically acceptable sodium thiosulfate. Still further provided herein are methods of treatment comprising the administration of pharmaceutically acceptable sodium thiosulfate.

Abstract: A cosmetic composition includes a non-acid-resistant-grade ultramarine dye, a stabilizing agent, at least one additive, and water. The ultramarine dye may be present at a concentration of about 0.1% to about 0.4%, by weight, of the cosmetic composition and may include a trisulfur radical anion. The stabilizing agent may include baicalin and may be at a concentration of about 0.2% or less, by weight, of the cosmetic composition. The cosmetic composition may have a pH in the range of 6.5 to 8.0. A method of stabilizing a cosmetic composition includes forming a cosmetic composition including a non-acid-resistant-grade ultramarine dye, a stabilizing agent, at least one additive, and water. The method also includes adjusting a pH of the cosmetic composition to a predetermined value. The stabilizing agent inhibits degradation of the ultramarine dye, thereby stabilizing the cosmetic composition and inhibiting generation of an odor caused by degradation of the ultramarine dye.

Abstract: The invention provides an herbicide composition, which contains as active ingredients a Component A selected from the group consisting of an oxopyrazine derivative represented by the following Formula X and salts thereof, and a Components B described in the Specification, and which is capable of controlling effectively the growth of an plant undesirable for a useful plant, is highly safe to a useful plant, and exerts high effect at a low dosage: where R represents a lower alkyl group having 1 to 6 carbon atoms, and X represents a halogen atom, respectively.