Abstract: The present invention relates to a formulation that can be utilised to facilitate expression of natural behaviour in pigs, and in particular sows and weaners and a method which utilises the formulation for the same.
Type:
Grant
Filed:
January 22, 2016
Date of Patent:
September 28, 2021
Assignee:
AUSTRALASIAN PORK RESEARCH INSTITUTE LTD
Inventors:
Matthew John Callaghan, Robert John Van Barneveld
Abstract: Methods of modifying the rate of systemic absorption of a drug administered to a subject by a pulmonary route, the method comprising covalently conjugating a hydrophilic polymer to a drug, wherein the drug has a half-life of elimination from the lung of less than about 180 minutes, to form a drug-polymer conjugate, wherein the drug-polymer conjugate has a net hydrophilic character and a weight average molecular weight of from about 50 to about 20,000 Daltons, and wherein the half-life of elimination from the lung of the drug-polymer conjugate is at least about 1.5-fold greater than the half-life of elimination from the lung of the drug, wherein the half-life of elimination from the lung is measured by bronchioalveolar lavage followed by assaying residual lung material.
Type:
Grant
Filed:
June 27, 2018
Date of Patent:
September 28, 2021
Assignee:
Nektar Therapeutics
Inventors:
C. Simone Jude-Fishburn, David Lechuga-Ballesteros, Tacey X. Viegas, Mei-Chang Kuo, Hema Gursahani, Chester Leach, Yuan Song
Abstract: Health concerns of the vector-borne diseases, such as, yellow fever, malaria, dengue fever and general discomfort due to insect bites, has encouraged the development of insecticides to kill insects and insect repellents to keep insects away from treated human skin. Annatto extracts as a natural insect repellent and insecticide have many advantages over synthetic such as lower harmful side effects, low resistance, and more environmentally friendly. Annatto extracts containing ishwarane (C15) and geranyl-?-terpinene (C20) have strong mosquito repellency. Annatto extracts containing geranyl-?-terpinene (C20) and geranylgeraniol (C20) have strong larvicidal activity. Annatto extracts with approximately equal C15 and C20 composition have insect repellency, and annatto extracts with mainly C20 composition have larvicidal activity. Annatto extracts have synergistic effects with other natural extracts.
Abstract: Described herein are transdermal formulations of phytocannabinoids and methods of using the same in the treatment of pain and/or inflammation.
Abstract: A method of treating Atrial Fibrillation or a pre-Atrial Fibrillation condition in a mammal, preferably a human, comprising administering a therapeutically effective amount of one of organic or inorganic sulfide, organic or inorganic nitrite, both organic or inorganic sulfide and organic or inorganic nitrite, or pharmacologically acceptable salts, solvates, esters, amides, clathrates, stereoisomers, enantiomers, prodrugs or analogs thereof, or a combination thereof.
Abstract: The present invention is silver (I) periodate compounds and their use in preventing or reducing microbial contamination. The invention includes gels, coatings, and articles of manufacture having a surface contacted or coated with a gel comprising an antimicrobial silver (I) compound. Methods of treatment are also disclosed.
Type:
Grant
Filed:
August 22, 2019
Date of Patent:
September 14, 2021
Assignee:
Innovotech, Inc.
Inventors:
Merle E. Olson, Patricia L. Nadworny, Graeme Prosperi-Porta
Abstract: This document provides methods and materials for treating lung conditions induced by inhalable insulin therapy. For example, compositions including a dried amnion tissue preparation and/or a dried stem cell preparation as well as methods for using such compositions to treat inhalable insulin induced lung conditions are provided.
Abstract: The present invention relates to particles and to methods of making particles. In particular, the invention relates to methods of making composite active particles comprising a pharmaceutically active material for pulmonary inhalation, the method comprising a jet milling process.
Abstract: A spray dried-powder composition for inhalation comprising particles (X) containing (a) between 5 and 50% by weight of at least one azole derivative in amorphous state but not in crystalline structure and (b) at least one matricial agent to the composition selected from a group consisting of polyol such as sorbitol, mannitol and xylitol; a monosaccharides such as glucose and arabinose; disaccharide such as lactose, maltose, saccharose and dextrose; cholesterol, and any mixture thereof, wherein the composition provides a dissolution rate of said azole derivative of at least, 5% within 10 minutes, 10% within 20 minutes and 40% within 60 minutes when tested in the dissolution apparatus type 2 of the United States Pharmacopoeia at 50 rotation per minute, 37° C. in 900 milliliters of an aqueous dissolution medium adjusted at pH 1.2 and containing 0.3% of sodium laurylsulfate.
Type:
Grant
Filed:
October 3, 2017
Date of Patent:
August 31, 2021
Inventors:
Arthur Deboeck, Francis Vanderbist, Philippe Baudier, Thami Sebti, Christophe Duret, Karim Amighi
Abstract: Film coatings comprising protein and lipid, and methods of using the film coatings to coat biological surfaces. For example, when applied to the surface of plant seeds, the film coating adheres to and reinforces the outer seed coat or hull to maintain seed viability.
Abstract: The present invention relates to the use of the compounds of formula (I) wherein the variables are defined according to the description, for controlling unwanted vegetation Further the invention relates to novel compounds of the formula (I), compositions comprising them a method for controlling unwanted vegetation which comprises allowing a herbicidal effective amount of at least one azine of the formula I to act on plants, their seed and/or their habitat.
Type:
Grant
Filed:
May 23, 2017
Date of Patent:
July 20, 2021
Assignee:
BASF SE
Inventors:
Matthias Witschel, Thomas Mietzner, Manuel Johannes, Thomas Seitz, Trevor William Newton, Gerd Kraemer, Stefan Tresch
Abstract: An emulsion polymer system suitable for use in agrochemical formulations for coating seeds. The emulsion polymer system comprises a core polymer and stabiliser polymer where the core is a polymer with a low glass transition temperature (?100° C. to 10° C.) and the stabiliser has a high glass transition temperature (30° C. to 300° C.). There is also provided a method of making the core-stabiliser system. The core-stabiliser system is suitable for seed coating formulations provided dust off, germination, and good flow.
Type:
Grant
Filed:
May 25, 2017
Date of Patent:
June 29, 2021
Inventors:
Howard Dungworth, James Wickson, Kathryn Knight, James Flavell
Abstract: Provided herein are catheter lock solutions having anticoagulation and antimicrobial properties, the catheter lock solutions including citrate salts. The citrate salt can be trisodium citrate, and the catheter lock solution can further include a diluted acid for adjusting the pH of the catheter lock solution.
Abstract: The present disclosure concerns herbicide granules and powders containing a high-load of fluroxypyr-meptyl. The granules exhibit good storage stability and good herbicidal efficacy when added to water and applied by spray application to control unwanted plant growth.
Type:
Grant
Filed:
July 2, 2018
Date of Patent:
June 22, 2021
Assignee:
Corteva Agriscience LLC
Inventors:
Ashish Batra, David J. Adrian, Raymond E. Boucher, Jr., Joseph C. Hercamp, Hiteshkumar Dave, Hao Shen
Abstract: Stabilized liquid cyclopropane compositions are provided which compromise flowable, non-aqueous dispersion concentrates comprising a) a continuous substantially water-immiscible liquid phase and b) a dispersed solid phase comprising cured polymer particles prepared from a polymerizable thermoset resin which particles contain at least one cylcopropene complex, optionally a non-porous particulate mineral, and optionally a non-cross-linkable mobile chemical distributed therein, and wherein the outside surfaces of the particles comprise a colloidal solid material. The compositions of the invention can be used directly or with dilution to combat pests or as plant growth regulators.
Abstract: The present invention provides a stable fat-soluble active ingredient composition, microcapsule and process for preparation and use thereof. The fat-soluble active ingredient composition comprises tocopherol, vitamin C palmitate and a fat-soluble active ingredient; wherein the weight ratio of tocopherol to vitamin C palmitate is 2-8:1, the weight ratio of a combination of tocopherol with vitamin C palmitate to the fat-soluble active ingredient is 7-13:100. The present invention obtains a novel antioxidant composition without hidden dangers for improving the stability of the fat-soluble active ingredient by screening a combination of antioxidants and adjusting their proportion and dose.
Type:
Grant
Filed:
January 19, 2018
Date of Patent:
May 25, 2021
Assignees:
ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY, ZHEJIANG MEDICINE CO., LTD. VITAMIN FACTORY
Inventors:
Guoquan Mao, Hongming Zhu, Wenxin Ma, Zhiping Liang, Li Qian, Fritz Bernhard Lubbe, Siping Hu, Chun Li, Shanping Wen, Qinlan Wang, Huajuan Kong
Abstract: The present disclosure is directed to floating gastroretentive dosage forms with prolonged gastric residence time. The disclosure also provides rapidly expanding sustained release or combined immediate release and sustained release formulations comprising drugs that require targeted release in the proximal gastrointestinal tract for maximum therapeutic benefit. The rapidly expanding floating gastroretentive dosage forms comprise a permeable elastic membrane providing desired characteristics for drug release and mechanical strength to maintain tablet integrity.
Type:
Grant
Filed:
October 7, 2020
Date of Patent:
May 18, 2021
Assignee:
KASHIV SPECIALTY PHARMACEUTICALS, LLC
Inventors:
Kanji Meghpara, Jaydeep Vaghashiya, Navnit H. Shah, Dipen Desai, Wantanee Phuapradit, Harpreet Kaur Sandhu, Siva Ram Kiran Vaka, Namdev B. Shelke, Ashish Chatterji
Abstract: Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.
Type:
Grant
Filed:
August 7, 2020
Date of Patent:
May 4, 2021
Assignee:
The Johns Hopkins University
Inventors:
Alexey Popov, Elizabeth M. Enlow, Hongming Chen, James Bourassa
Abstract: Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
Type:
Grant
Filed:
January 17, 2019
Date of Patent:
April 27, 2021
Assignee:
Horizon Orphan, LLC
Inventors:
Mark W. Surber, Keith A. Bostian, Michael N. Dudley, Olga Rodny, David C. Griffith