Patents Examined by Natalia Harkaway
  • Process for preparing 1-aryl-3-amino-5-pyrazolones
    Patent number: 4281143
    Abstract: Disclosed is a process for the preparation of certain 1-aryl-3-amino-5-pyrazolones by reacting a 3-nitropropionic acid ester with certain aryldiazonium salts to produce intermediate .alpha.-nitrohydrazones and then reducing the intermediate to give the corresponding aminopyrazolones. The aryl group may be, for example, phenyl, 4-methoxyphenyl, or the like, the diazo anion can be, e.g., Br.sup.-, Cl.sup.-, BF.sub.4.sup.-, or SO.sub.4.sup..dbd., and the ester alcohol moiety can be any convenient, unreactive group, preferably alkyl. The aminopyrazolones are useful for the preparation of photographic couplers.
    Type: Grant
    Filed: September 4, 1979
    Date of Patent: July 28, 1981
    Assignee: Eastman Kodak Company
    Inventors: John A. Hyatt, Stephen E. French, Cataldo A. Maggiulli
  • Chirally substituted 2-imidazolin-5-ones
    Patent number: 4280008
    Abstract: Chirally substituted 2-imidazolin-5-ones and their use as intermediates for the preparation of optically active aminoacids, especially of optically active .alpha.-substituted aminoacids.
    Type: Grant
    Filed: December 16, 1977
    Date of Patent: July 21, 1981
    Assignee: BASF Aktiengesellschaft
    Inventors: Ulrich Schoellkopf, Hans-Heinrich Hausberg, Walter Boell, Hans-Joachim May, Horst Koenig
  • 1-[(Substituted-naphthyl)ethyl]-imidazole derivatives
    Patent number: 4277486
    Abstract: Compounds of the formula ##STR1## wherein m is the integer 1, 2 or 3; R is independently selected from the group C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.6 alkoxy, halo, trifluoromethyl and hydroxy when m is the integer 1, 2 or 3 and methylenedioxy when m is the integer 2; Z is hydroxymethylene, esterified hydroxymethylene, alkoxymethylene, alkylthiomethylene, carbonyl, or ketal-, thioketal- or hemithioketal- protected carbonyl, and the pharmaceutically acceptable acid addition salts thereof, are useful as anticonvulsants, anti-secretory agents and spermatocides.
    Type: Grant
    Filed: March 9, 1979
    Date of Patent: July 7, 1981
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Keith A. M. Walker
  • Imidazole alkylthiourea compounds
    Patent number: 4276301
    Abstract: The compounds are novel N-substituted-N'-heterocyclic alkylthioureas, guanidines and 1-nitro-2,2-diaminoethylene compounds which are histamine H.sub.2 -antagonists.
    Type: Grant
    Filed: August 27, 1979
    Date of Patent: June 30, 1981
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham J. Durant, Charon R. Ganellin, Geoffrey R. Owen, Rodney C. Young
  • Amino-substituted-4,5,6,7-tetrahydro-1H (or 2H)-indazoles
    Patent number: 4276300
    Abstract: Amino-substituted-4,5,6,7-tetrahydro-1H (or 2H)-indazoles, useful as prolactin inhibitors and in treatment of Parkinson's Syndrome. Intermediate 6-keto(or 6-alkoxy or benzyloxy)-4,5,6,7-tetrahydro-1H (or 2H)-indazoles are also disclosed.
    Type: Grant
    Filed: March 15, 1979
    Date of Patent: June 30, 1981
    Assignee: Eli Lilly and Company
    Inventors: Nicholas J. Bach, Edmund C. Kornfeld
  • Fungicidal compounds
    Patent number: 4275073
    Abstract: Pentathiepinopyrazoles and pyrazolotrithiocarbonates, such as 7-methyl-7H-1,2,3,4,5-pentathiepino[6,7-c]pyrazole, useful for the control of fungi.
    Type: Grant
    Filed: April 29, 1980
    Date of Patent: June 23, 1981
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: William K. Moberg
  • Process for preparing 7-(1-hydroxyethyl)-3-(2-aminoethylthio)-1-carbadethiaceph-3-em-3-carboxy lic acid and intermediate therefor
    Patent number: 4275207
    Abstract: Disclosed is a process for preparing 7-(1-hydroxethyl)-3-(2-aminoethylthio)-1-carbadethiaceph-3-em-3-carboxylic acid and its pharmaceutically acceptable salts and esters (I) by total synthesis starting with L-aspartic acid and proceeding via intermediate II: ##STR1## R=blocking group
    Type: Grant
    Filed: August 17, 1979
    Date of Patent: June 23, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Ronald W. Ratcliffe, Thomas N. Salzmann
  • N-Heterocyclic alkyl-N'-pyridyl alkylthioureas, ureas and guanidines
    Patent number: 4271169
    Abstract: The compounds are N,N'-substituted thioureas, ureas and guanidines which are H-2 histamine receptor inhibitors. A compound of this invention is N-[2-(2-pyridylmethylthio)ethyl]-N'-[2-(4-methyl-5-imidazolylmethylthio)et hyl]thiourea is N,N'-bis[2-((4-methyl-5-imidazolyl)methylthio)ethyl]thiourea and N,N'-bis[2-((methyl-5-imidazolyl)methylthio)ethyl]-N"-cyanoguanidine.
    Type: Grant
    Filed: December 20, 1979
    Date of Patent: June 2, 1981
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham J. Durant, Charon R. Ganellin
  • Pyridine derivatives
    Patent number: 4271304
    Abstract: Pyridine derivatives having the formula ##STR1## and their N-oxides and pharmaceutically acceptable acid addition salts, wherein R.sup.1 and R.sup.2 are independently aryl, R.sup.3 is hydrogen or lower alkyl and n is 0, 1 or 2, have CNS activity and may be used as antidepressants.
    Type: Grant
    Filed: May 9, 1979
    Date of Patent: June 2, 1981
    Assignee: John Wyeth & Brother, Ltd.
    Inventors: Edwin T. Edington, Alan C. White
  • Isoindoline colorants
    Patent number: 4271309
    Abstract: Isoindoline colorants of the formula ##STR1## where A is hydrogen or phenyl andR is hydrogen, C.sub.1 -C.sub.4 -alkyl or phenyl andthe phenyl radicals in A and R and the ring C,independently of one another, do not carry further substituents or are substituted by groups which do not confer solubility, the two A's being identical or different.In finishes, printing inks and plastics, the colorants give very deep black colorations which exhibit high lightfastness, fastness to weathering and fastness to overcoating, and have a very high infrared reflectance.
    Type: Grant
    Filed: March 4, 1980
    Date of Patent: June 2, 1981
    Assignee: BASF Aktiengesellschaft
    Inventor: Wolfgang Lotsch
  • 1-Acyl-2-imidazolines and their manufacture
    Patent number: 4269990
    Abstract: The invention relates to 1-acyl-2-imidazolines, processes for their manufacture, and their use as intermediates.
    Type: Grant
    Filed: December 5, 1979
    Date of Patent: May 26, 1981
    Assignee: BASF Aktiengesellschaft
    Inventors: Hans-Joachim May, Horst Koenig
  • [1]Benzothiopyrano[4,3-c]pyrazoles as immunoregulatory agents
    Patent number: 4268516
    Abstract: 1,2,3,4-Tetrahydrobenzothiopyrano[4,3-c]pyrazol-3-ones and 2,3-dihydro[1]benzothiopyrano[4,3-c]pyrazol-3-ones, of respective structure I and II, ##STR1## wherein n is an integer of value from 0 to 2;R is phenyl; phenyl monosubstituted with chloro, bromo, fluoro, methyl, methoxy, nitro or trifluoromethyl; or phenyl disubstituted with chloro; andX is hydrogen or chloro;are described.These novel compounds are immunoregulators which, through suppression of the immune response in mammals, are useful in inhibiting rejection of organ transplants, as well as in the therapy of auto-immune diseases.
    Type: Grant
    Filed: March 24, 1980
    Date of Patent: May 19, 1981
    Assignee: Pfizer Inc.
    Inventors: Joseph G. Lombardino, Ivan G. Otterness, James F. Muren
  • Imidazolinium compounds
    Patent number: 4267350
    Abstract: A novel imidazolinium salt is prepared by (1) reacting N-aminoalkyl-imidazoline, N-hydroxyalkyl-imidazoline, or N-substituted-imidazoline with an .alpha.,.beta.-unsaturated ester of a carboxylic acid, (2) reacting the resulting ester imidazoline with a primary or secondary amine and (3) quaternizing the resulting amido imidazoline product by reacting it with an alkylating agent. This imidazolinium salt is useful as a fabric softening agent.
    Type: Grant
    Filed: December 12, 1979
    Date of Patent: May 12, 1981
    Assignee: The Dow Chemical Company
    Inventors: Donald A. Tomalia, Fredric L. Buchholz
  • Imidazolemethylphosphonium salts
    Patent number: 4267337
    Abstract: A process for preparing 4-(oxy, thio or amino)methylimidazole compounds via displacement of the trisubstituted phosphonium group from 4-(trisubstituted phosphonium)methylimidazole compounds is disclosed.
    Type: Grant
    Filed: December 12, 1979
    Date of Patent: May 12, 1981
    Assignee: SK&F Lab Co.
    Inventors: Joseph J. Lewis, Robert L. Webb
  • Process for the production of 2-substituted pyrido[4,3-b]-indoles
    Patent number: 4267331
    Abstract: A process for production of certain 2-substituted-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole tranquilizing agents of the formula ##STR1## wherein X.sub.1 and Y.sub.1 are each hydrogen or fluoro; Z.sub.1 is hydrogen, fluoro or methoxy and n is 3 or 4 which comprises contacting an amine of the formula ##STR2## with an equimolar amount of a lactol of the formula ##STR3## wherein q is 1 or 2; in the presence of a reaction inert solvent under reductive alkylation conditions.
    Type: Grant
    Filed: January 15, 1980
    Date of Patent: May 12, 1981
    Assignee: Pfizer Inc.
    Inventor: Willard M. Welch, Jr.
  • N-Aryl-N'-imidazol-2-ylureas
    Patent number: 4265900
    Abstract: N-aryl-N'-imidazol-2-ylureas useful for their antihypertensive, antidiarrheal, anti-irritable bowel syndrome, and anti-secretory activities.
    Type: Grant
    Filed: October 29, 1979
    Date of Patent: May 5, 1981
    Assignee: McNeilab, Inc.
    Inventors: C. Royce Rasmussen, Henry I. Jacoby
  • Mercaptoacyldihydropyrazole carboxylic acid derivatives
    Patent number: 4266065
    Abstract: Compounds having the formula ##STR1## and basic salts thereof, wherein R.sub.1 is hydrogen, alkyl, aryl, arylalkyl or ##STR2## wherein R.sub.6 is alkyl or aryl; R.sub.2 is hydrogen, alkyl, trifluoromethyl or pentafluoroethyl;R.sub.3 is hydrogen or alkyl;R.sub.4 is hydrogen, alkyl or arylalkyl;R.sub.5 is hydrogen or alkyl; andn is 0, 1 or 2;have hypotensive activity.
    Type: Grant
    Filed: April 14, 1980
    Date of Patent: May 5, 1981
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: George C. Rovnyak
  • Pharmacologically active compounds
    Patent number: 4264608
    Abstract: the compounds are alkoxypyridine compounds which are histamine H.sub.2 -antagonists. Two specific compounds of the present invention are N-cyano-N'-methyl-N"-[2-((3-methoxy-2-pyridyl)methylthio)ethyl]guanidine and 1-methylamino-1-[2-((3-methoxy-2-pyridyl)methylthio)ethyl-amino]-2-nitroet hylene.
    Type: Grant
    Filed: November 15, 1979
    Date of Patent: April 28, 1981
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham J. Durant, Charon R. Ganellin, George S. Sach
  • Basic thio-indazoles
    Patent number: 4264618
    Abstract: Compound belonging to the class of 2-benzyl-3-(3-dimethylaminopropylthio)-2H-indazole, its sulfoxide and its sulfone and their pharmacologically acceptable salts, and process for obtaining such compounds having an antiinflammatory action in the common pathological conditions.
    Type: Grant
    Filed: December 11, 1979
    Date of Patent: April 28, 1981
    Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
    Inventors: Leandro Baiocchi, Bruno Silvestrini
  • N,N'-Bis(2,6-Bis(trifluoromethyl)-4-pyridinyl)ethanediamide and its use as a coccidiostat
    Patent number: 4264610
    Abstract: N,N'-Bis(2,6-Bis(trifluoromethyl)-4-pyridinyl)ethanediamide and its use in controlling coccidia is taught.
    Type: Grant
    Filed: June 17, 1980
    Date of Patent: April 28, 1981
    Assignee: Dow Chemical Company Limited
    Inventor: David P. Clifford