Patents Examined by P. K. Sripada
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Patent number: 6187910Abstract: The present invention provides for substituted metal chelating compounds in which at least two of the chelating atoms are nitrogen which are directly attached to aromatic rings and one or more of those nitrogen atoms has attached thereto a substituent other than hydrogen, and methods for making and using these compounds.Type: GrantFiled: May 12, 1999Date of Patent: February 13, 2001Assignee: NeoRx CorporationInventor: Sudhakar Kasina
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Patent number: 5929105Abstract: New compounds useful in photodynamic therapy are of the formula ##STR1## and their 1,4-diene isomers and the metallated and/or labeled and/or conjugated forms thereofwherein each R.sup.1 is independently alkyl (1-6C);each n is independently an integer of 0-6; andR.sup.2 is vinyl or a derivative form thereof.Type: GrantFiled: June 1, 1998Date of Patent: July 27, 1999Assignees: QLTPhoto Therapeutics, Inc., The University of British ColumbiaInventors: Ethan Sternberg, David Dolphin, Julia G. Levy, Anna M. Richter, David W. C. Hunt, Ashok Jain
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Patent number: 5770734Abstract: R.sup.2 is H, alkyl of 1 to 6 carbon atoms, cyano, halo, nitro, amino or mono or dialkylamino in which the alkyl groups have 1 to 6 carbon atoms;R.sup.3 is H or alkyl of 1 to 6 carbon atoms;n is 1 to 5and R.sup.4 and R.sup.5 taken with the nitrogen atom to which they are attached are polymethylene of 4 to 6 carbon atoms, morpholino, pyrrolidin-2-on-1-yl, or a piperazin-1-yl moiety in the 4-position of which is H, alkyl of 1 to 6 carbon atoms or unsubstituted or substituted pyrimidinyl, pyridinyl, or pyrazinyl wherein the substituents are alkyl of 1 to 6 carbon atoms, alkoxyl of 1 to 6 carbon atoms, halo, cyano, nitro or trifluoromethyl and the pharmaceutically acceptable salts, hydrates and solvates thereof are M.sub.1 receptor agonists useful in treatment of dementias involving the cholinergic system.Type: GrantFiled: June 22, 1992Date of Patent: June 23, 1998Assignee: American Home Products CorporationInventor: Annmarie Louise Sabb
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Patent number: 5750686Abstract: A novel .beta.-lactam compound of the formula ?1!: ##STR1## or a pharmaceutically acceptable salt thereof, which shows an excellent antibacterial activity against Gram-positive bacteria, especially against methicillin-resistant staphylococci and methicillin-resistant coagulase-negative staphylococci, and a process for producing the same. R.sub.1, R.sub.2, X, Y, Z are as defined in the specifacation.Type: GrantFiled: December 14, 1995Date of Patent: May 12, 1998Assignee: Sumitomo Pharmaceuticals Company, LimitedInventors: Makoto Sunagawa, Hiroshi Yamaga, Yoshihiro Sumita
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Patent number: 5747484Abstract: Novel crystalline cephem acid addition salts and processes for their preparationCompounds of the formula I ##STR1## in which n is equal to 1 or 2 andm is 0.4-2.6, and where X is the anion of a carboxylic acid, have antibacterial activity.Type: GrantFiled: November 1, 1995Date of Patent: May 5, 1998Assignee: Hoechst AktiengesellschaftInventors: Rudolf Lattrell, Walter Durckheimer, Peter Schmid
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Patent number: 5693636Abstract: This invention relates to compounds of the formula: ##STR1## wherein A.sup.1 to A.sup.5 form an accessible substituted seven-membered ring, which may be saturated or unsaturated, optionally containing up to two heteroatoms chosen from the group of O, S and N wherein S and N may be optionally oxidized;D.sup.1 to D.sup.4 form an accessible substituted six membered ring, optionally containing up to two nitrogen atoms;R is at least one substituent chosen from the group of R.sup.7, or Q--C.sub.1-4 alkyl, Q--C.sub.2-4 alkenyl, Q--C.sub.2-4 alkynyl, preferably substituted by an acidic function;R* is H, Q--C.sub.1-6 alkyl, Q--C.sub.1-6 oxoalkyl, Q--C.sub.2-6 alkenyl or Q--C.sub.2-4 alkynyl, C.sub.3-6 cycloalkyl, Ar or Het, optionally substituted by one or more substitutents; andR.sup.Type: GrantFiled: June 26, 1992Date of Patent: December 2, 1997Assignee: SmithKline Beecham CorporationInventors: William Edward Bondinell, James Francis Callahan, William Francis Huffman, Richard McCulloch Keenan, Thomas Wen-Fu Ku, Kenneth Allen Newlander
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Patent number: 5556968Abstract: Macrocyclic chelating agents, optionally possessing more than one macrocyclic ring having at least two peptide linkages within the macrocyclic skeleton. The chelating agents are used for the preparation of paramagnetic metal chelates for use as MRI contrast agents.Type: GrantFiled: May 7, 1993Date of Patent: September 17, 1996Assignee: Nycomed Salutar, Inc.Inventors: Joan F. Carvalho, Shaun P. Crofts, John Varadarajan
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Patent number: 5514794Abstract: Derivatized drugs are prepared with a linker consisting of a malonate, wherein the drug is linked through a methylene to the 2-position carbon of the malonate.Type: GrantFiled: January 22, 1991Date of Patent: May 7, 1996Assignee: Eli Lilly and CompanyInventor: Russell L. Barton
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Patent number: 5506708Abstract: Phthalocyanine of formula (I), wherein M is a metal or is 2H, bonded at 29 and 31 positions shown, R.sub.1 to R.sub.8 are the same or different and are independently selected from C.sub.1 to C.sub.20 alkyl, C.sub.1 -C.sub.20 alkenyl, --X--COO--X.sup.1, --X--O--Y, a, and --X--COZ where X is independently selected from a chemical bond, (CH.sub.2).sub.n where n-0-20 or (CH.sub.2).sub.a CH--CH (CH.sub.2).sub.b where a and b are independently selected from 0-20 and a+b is in the range 0-20, X.sup.1 is independently selected from C.sub.1 -C.sub.20 alkyl or C.sub.2 -C.sub.20 alkenyl, Y is independently selected from C.sub.1 -C.sub.20 alkyl, C.sub.2 -C.sub.20 alkenyl or H and Z is selected from OH or NR.sup.1 R.sup.11 are independently selected from H, C.sub.1 -C.sub.20 alkyl and C.sub.2 -C.sub.20 alkenyl. These phthalocyanines may exhibit discotic liquid crystal phases, absorb infra-red radiation and make good Langmuir-Blodgett films.Type: GrantFiled: July 17, 1989Date of Patent: April 9, 1996Assignee: The Secretary of State for Defence in Her Majesty's Government of the United Kingdom of Great Britain and Northern IrelandInventors: Kenneth J. Harrison, Michael J. Cook, Andrew J. Thomson, Neil B. McKeown, Mervyn F. Daniel, Adrian J. Dunn
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Patent number: 5502077Abstract: Fatty acid composition comprising at least 80% by weight of omega-3-fatty acids, salts or derivatives thereof, wherein (all-Z)-5,8,11,14,17-eicosapentaenoic acid (EPA) and (all-Z)-4,7,10,13,16,19-docosahexaenoic acid comprises at least 75% by weight of the total fatty acids. The compositions can be used for the treatment or prophylaxis of multiple risk factors for cardiovascular diseases.Type: GrantFiled: June 23, 1992Date of Patent: March 26, 1996Assignee: Norsk Hydro A.S.Inventors: Harald Breivik, Bernt Borretzen, Knut H. Dahl, Hans E. Krokan, Kaare H. Bonaa
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Patent number: 5473070Abstract: There is disclosed compounds and pharmaceutical compositions comprising compounds of the formula: ##STR1## wherein each of one or two R is independently ##STR2## wherein n is an integer from 7 to 20, at least one of X or Y is --OH and if one of X or Y is --OH then the other X or Y is H, CH.sub.3, CH.sub.3 --CH.sub.2, CH.sub.3 --(CH.sub.2).sub.2 --, or (CH.sub.3).sub.2 --CH.sub.2 --, and W.sub.1, W.sub.2, and W.sub.3 is independently H, CH.sub.3, CH.sub.3 --CH.sub.2, CH.sub.3 --(CH.sub.2).sub.2 --, or (CH.sub.3).sub.2 --CH.sub.2 --, and wherein the alkyl groups may be substituted by a hydroxyl, halo or dimethylamino group and/or interrupted by an oxygen atom, H or alkyl (1-4C), including resolved enantiomers and/or diastereomers, salts and mixtures thereof. In particular, the compounds lower elevated levels of unsaturated, non-arachidonate phosphatidic acid (PA) and diacylglycerol (DAG) derived from said PA within seconds of the primary stimulus and their contact with said cells.Type: GrantFiled: November 16, 1992Date of Patent: December 5, 1995Assignee: Cell Therapeutics, Inc.Inventors: Gail Underiner, David Porubek, J. Peter Klein, Paul Woodson
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Patent number: 5470858Abstract: A compound represented by the following formula I:(HET)Ar--X--CH.sub.2 --Y--CH.sub.2 --O--R (I)wherein:(HET)Ar represents a bicyclic hetero aryl nucleus which is unsubstituted or is substituted;X represents --S--;Y represents --CO--, --C.dbd.N--R.sub.2, in which R.sub.2 is hydrogen or a linear or branched alkyl having 1 to 10 carbon atoms, OH, an alkoxy having 1 to 10 carbon atoms, aryloxy, arylalkoxy, --NH.sub.2, --NHCONH.sub.2, --NHCSNH.sub.2 ; and R represents a phenyl substituted at para position with a carboxyl or a (C.sub.1 -C.sub.20) alkoxycarbonyl group in which the alkoxy group is linear or branched.Type: GrantFiled: June 19, 1992Date of Patent: November 28, 1995Assignee: Pierrel SpAInventors: Cristina Fraire, Massimo Bani, Ermes Vanotti, Vincenzo Olgiati
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Patent number: 5459263Abstract: The medicinal product comprises as active principle a melarsomine hydrochloride preparation having a purity of between 98.5 and 100%. The process for obtaining this preparation is stated essentially as follows:step 1, trichlorotriazine (TCT) is converted to diaminochlorotriazine (DCT) in an ammoniacal medium;step 2, the DCT is converted to melarsen acid hydrochloride (MAH) in the presence of arsanilic acid;step 3, the MAH is reduced to melarsen oxide dihydrate; andstep 4, the melarsen oxide dihydrate is converted to melarsomine dihydrochloride in the presence of cysteamine hydrochloride. In each step, a purified preparation of the corresponding intermediate product, or final product in step 4, is obtained.Type: GrantFiled: December 2, 1992Date of Patent: October 17, 1995Assignee: Rhone MereiuxInventors: Robert Floc'H, Jean-Pierre Etchegaray, Gerard Wolf, Patrick Lubert, Regine J. A. Mazars
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Patent number: 5457195Abstract: The present invention provides various covalently modified sapphyrin derivatives and conjugates, and also, polymers including sapphyrin or derivatives thereof. Disclosed are water soluble sapphyrins, including polyhydroxysapphyrins and sapphyrin-sugar derivatives; sapphyrin-metal chelating conjugates; sapphyrin nucleobase conjugates; and polymer supported sapphyrins. Novel sapphyrin dimers, trimers, oligomers and polymers are also described, which polymers may include repeating units of sapphyrin or sapphyrin derivatives alone, or may further incorporate other units such as nucleobases.Type: GrantFiled: October 21, 1992Date of Patent: October 10, 1995Assignee: Board of Regents, The University of Texas SystemInventors: Jonathan L. Sessler, Brent L. Iverson, Vladimir Kral, Kevin Shreder, Hiroyuki Furuta
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Patent number: 5451599Abstract: New complex salts of hematoporphyrin and of its derivatives have the general Formula 1 (FIG. 1). The method of preparation of new complex salts of Formula 1 consists of reacting, with a basic amino acid, hematoporphyrin derivatives of general Formula 4 (FIG. 4). The new complex salts are used as a therapeutic agent for detection and treatment of neoplasms.Type: GrantFiled: October 29, 1992Date of Patent: September 19, 1995Assignee: Wojskowa Akademia Techniczna im. Jaroslawa DabrowskiegoInventors: Alfreda Graczyk, Jerzy Konarski
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Patent number: 5447933Abstract: A novel xanthine derivative of the formula (I): ##STR1## wherein one of R.sup.1 and R.sup.2 represents substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl, substituted or unsubstituted alicyclic alkyl, substituted or unsubstituted phenyl, or substituted or unsubstituted benzyl; and the other represents--(CH.sub.2).sub.m --Xwherein m is 2 or 3, and X is amino substituted phenyl.Q represents ##STR2## (wherein R.sup.3 and R.sup.4 are the same or different and are substituted or unsubstituted alicyclic alkyl), ##STR3## or a pharmacologically accetable salt thereof is disclosed. This derivative has anti-dementia activity.Type: GrantFiled: November 9, 1992Date of Patent: September 5, 1995Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Fumio Suzuki, Junichi Shimada, Hiromasa Kato, Akio Ishii, Shizuo Shiozaki
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Patent number: 5446141Abstract: Near-infrared absorbers which contain phthalocyanine derivatives in which the four benzene rings contained in the molecule independently have 1 to 4 substituents are light and thermal resistant and possess high molar extinction coefficients. Such near-infrared absorbers are useful in optical recording media, near-infrared absorption filters, and liquid crystal display devices.Type: GrantFiled: September 17, 1992Date of Patent: August 29, 1995Assignees: Mitsui Toatsu Chemicals, Incorporated, Yamamoto Chemicals, IncorporatedInventors: Hisato Itoh, Katashi Enomoto, Takahisa Oguchi, Tsutomu Nishizawa
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Patent number: 5438135Abstract: Water-soluble tetraazaporphins with novel structure is suitable as a fluorochrome for labeling and provides a reagent usable for fluorescence analysis process.Type: GrantFiled: March 5, 1992Date of Patent: August 1, 1995Assignee: Hitachi Chemical CompanyInventors: Seiji Tai, Mitsuo Katayose, Hiroo Watanabe
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Patent number: 5434164Abstract: Carbostyril derivatives and salts thereof represented by the general formula (1a), including some known compounds, possess activities for inhibiting adhesion of thrombocytes. ##STR1## Z, A, X, R, R.sup.1 and R.sup.2 are defined in the specification. Some carbostyril derivatives having chemical structural formulas similar to those of carbostyril derivatives and salts thereof represented by the general formula (1a) have been known in prior art references, however the above-mentioned pharmacological activities have not been known to the present date.Type: GrantFiled: October 8, 1992Date of Patent: July 18, 1995Assignee: Otsuka Pharmaceutical Co. Ltd.Inventors: Takao Nishi, Tetsuyuki Uno, Yasuo Koga, Gil-Namg Chu
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Patent number: 5434262Abstract: A method for the synthesis of cyclic polyamines preceeds by reaction of a diamine with the acrylonitrile wherein the reduction steps are carried out with Raney alloy instead of using hydrogen under pressure in the presence of Raney nickel. Compounds so prepared have the formula: ##STR1## wherein A and B are: an alkyl chain --(CH.sub.2)-- in which x is an integer of 2 to 4, substituted or not by an alkyl group of 1 to 5 carbon atoms, which may be substituted or not by an aromatic ring, heterocyclic ring, amine ketone, carboxylic acid, amide, cyano, alkyl, alkoxy, hydroxy, nitro or halogen and R.sub.1 and R.sub.2 are the same moieties as those substituting the alkyl claim above.Type: GrantFiled: September 16, 1992Date of Patent: July 18, 1995Assignee: L'Air Liquide, Societe Anonyme pour l'Etude et l'Exploitation des Procedes Georges ClaudeInventors: Roger Guilard, Isabelle Meunier, Christophe Jean, Brigitte Boisselier-Cocolios