Patents Examined by P. K. Sripada
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Patent number: 5302709Abstract: A layered double hydroxide intercalated with a metal complex of a polyaryl compound is described. A preferred complex is porphin or phthylocyanine. The metals are preferably selected from Group VII-B and Group VIII cobalt and iron triads. The resulting LDH metal complexes are useful for the oxidation of oxidate compounds such as thiols and phenols.Type: GrantFiled: November 25, 1992Date of Patent: April 12, 1994Assignee: Board of Trustees operating Michigan State UniversityInventors: Thomas J. Pinnavaia, Elena M. Perez-Bernal, Ricardo Ruarno-Casero, Malama Chibwe
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Patent number: 5302586Abstract: A class of phosphonomethyl-imidazo[1,2-a]pyrimidine-2-carboxylic acid compounds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest, hypoglycemia or perinatal asphyxia. The treatment includes administration of a compound of this class alone or in a composition in an amount effective as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites. Compounds of most interest are those of the formula: ##STR1## wherein each of R.sup.1, R.sup.2 and R.sup.6 is independently selected from hydrido, alkyl, allyl, cycloalkyl, cycloalkylalkyl, phenyl and benzyl; wherein Y.sub.m is --CH.sub.2 -- or --CH.sub.2 --CH.sub.Type: GrantFiled: November 30, 1992Date of Patent: April 12, 1994Assignee: G. D. Searle & Co.Inventors: Alexis A. Cordi, Eric T. Sun
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Patent number: 5300497Abstract: A penam derivative represented by the following general formula or a salt thereof: ##STR1## wherein R.sup.1 represents a hydrogen atom, an amino-protecting group or an acyl group; R.sup.2 represents a hydrogen atom or a lower alkyl group; R.sup.3 represents a hydrogen atom, a lower alkoxy group, a lower alkylthio group or a formamido group; R.sup.4 represents an protected or unprotected carboxyl group or a carboxylato group; R represents a group of the formula, --NHR.sup.5 or --NR.sup.5 R.sup.6 (in which R.sup.5 and R.sup.6, which may be the same or different, represent protected or unprotected hydroxyl groups, cyano groups, sulfo groups, or unsubstituted or substituted lower alkyl, aryl, acyl, carbamoyl, sulfamoyl, lower alkylsulfonyl or heterocyclic groups) or a group of the formula, --N.dbd.CR.sup.7 R.sup.8 (in which R.sup.7 and R.sup.Type: GrantFiled: October 7, 1992Date of Patent: April 5, 1994Assignee: Toyama Chemical Co., Ltd.Inventors: Hirokazu Ochiai, Yasuo Watanabe, Yoshiharu Murotani, Hirohiko Fukuda, Osamu Yoshino, Shinzaburo Minami, Toshio Hayashi, Kaishu Momonoi
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Patent number: 5298620Abstract: Process for the reliable and quantitative destruction of the residual cyanuric fluoride which still remains in residues from the cyanuric fluoride preparation by reaction of cyanuric chloride with alkali metal fluorides in dipolar aprotic solvents such as sulfolane, nitrobenzene, or benzonitrile after distillative removal of the majority of cyanuric fluoride; which comprises reacting the residue with an alkali metal hydroxide, bicarbonate or carbonate which is anhydrous apart from any water of crystallization present, or any desired mixture of these compounds, in an amount which is at least equivalent to the residual cyanuric fluoride at temperatures of about 20.degree. to about 180.degree. C.Type: GrantFiled: February 19, 1992Date of Patent: March 29, 1994Assignee: Hoechst AktiengesellschaftInventor: Georg Grotsch
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Patent number: 5298618Abstract: Macrocyclic oxamides may be made easily, in good yield and in one step by reacting an oxalic compound, such as oxalic acid or oxalic esters, with a diamine, where the amine groups are separated by at least five atoms. The oxalic compounds may include, but are not limited to such materials as dimethyl oxalate and diethyl oxalate. The diamines may include, but are not limited to such materials as alkylenediamines; polyalkylene glycol diamines; alkyl-bis-(aminoalkyl)amines; imino bis-(alkyl)amines; and N,N' bis-(aminoalkyl)-N,N'-dialkylalkylenediamines and bis-(aminoalkyl)piperazines; and mixtures thereof. The macrocyclic oxamides made by this process may be used to selectively separate metal ions from solution, or complexed together with a metal ion act as a catalyst.Type: GrantFiled: November 23, 1992Date of Patent: March 29, 1994Assignee: Texaco Chemical CompanyInventors: George P. Speranza, Donald H. Champion, Martin J. Plishka
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Patent number: 5296482Abstract: The compounds are 3-[ (benzocycloalkyl)alkyl amino alkyl] -1,3,4,5-te trahydro 2H- 3-benzazepin-2 ones useful in cardiovascular field.A compound disclosed is (R,S)-7,8-dimethoxy-3-{3-{N-[(4,5-dimethoxybenzocyclobut-1-yl) methyl]-N-methyl amino}propyl}-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one.Type: GrantFiled: September 25, 1992Date of Patent: March 22, 1994Assignee: Adir et CompagnieInventors: Jean-Louis Peglion, Joel Vian, Jean-Paul Vilaine, Nicole Villeneuve, Philip Janiak, Jean-Pierre Bidouard
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Patent number: 5292768Abstract: A compound having the formula (I): ##STR1## wherein A is --CH.sub.2 --, --O--, or --S--; R.sup.1 is CH.sub.3 or OCH.sub.3 ; R.sup.2 is hydroxy or carboxy which may be optionally esterized or amidated; R.sup.3 is H or a lower alkyl; and n is 0 or an integer of 1 to 6 or a pharmaceutically acceptable salt thereof.Type: GrantFiled: November 23, 1992Date of Patent: March 8, 1994Assignee: Suntory LimitedInventors: Toshio Tatsuoka, Kenji Suzuki, Fumio Satoh, Seiji Miyano, Kunihiro Sumoto
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Patent number: 5292729Abstract: Vitamin and mineral absorption in warm-blooded animals is promoted by means of a class of vitamin chelates where at least one of the bonds between the metal ion and the vitamin ligand is formed between the ion and an electron rich .pi.-cloud of an aromatic ring of the water soluble vitamin. The chelate, containing a total of from one to three ligands, may contain from one up to three vitamin ligands which form a .pi.-bond with the mineral and, when present, one or two amino acid, dipeptide or tripeptide ligands. The mineral is selected from the group consisting of Fe, Cu, Zn, Mg, Mn and Ca. The water soluble vitamin ligand is preferably a residue of nicotinamide, nicotinic acid, pyridoxine, thiamine, riboflavin and folic acid. The amino acid may be any of the naturally occurring .alpha.-amino acids such as glycine. The .pi.-bond vitamin chelates are absorbed more readily from both the gastric and intestinal areas of the GI tract than vitamins or minerals administered separately or as mixtures.Type: GrantFiled: August 14, 1992Date of Patent: March 8, 1994Assignee: Albion International, Inc.Inventor: Harvey H. Ashmead
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Patent number: 5290771Abstract: The novel compounds of the invention are 19 nor-steroids of the formula: ##STR1## Where A, B, C, D, X, Y, Z, R.sub.17, and R.sup.1 are as defined in the specification, having hormonal properties and their preparation and intermediates.Type: GrantFiled: April 29, 1992Date of Patent: March 1, 1994Assignee: Roussel UclafInventors: Andre Claussner, Lucien Nedelec, Daniel Philibert, Patrick Van de Velde
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Patent number: 5290928Abstract: A process for preparing an oxytitanium phthalocyanine hydrate crystal which, when dried at 100.degree. C. and 0.1 mmHg for 8 hours and then allowed to stand in air at room temperature for 12 hours, has a structural formula of TiOPc.multidot.(H.sub.2 O).sub.n, wherein Pc represents a phthalocyanine nucleus, and n represents a number of from 0.15 to 1, and elemental analysis values of C: 65.0 to 66.3%, H: 2.5 to 3.1%, and N: 18.5 to 19.3% is disclosed, which process comprises the steps of: mechanically grinding a mixture of oxytitanium phthalocyanine and an inorganic salt to convert the crystal form of the oxytitanium phthalocyanine to a crystal form showing a distinct peak in its X-ray diffraction pattern at a Bragg angle (2.theta..+-.0.2.degree. ) of 27.3.degree. and treating the resulting oxytitanium phthalocyanine crystal with a mixed solvent of water and a water-insoluble organic solvent.Type: GrantFiled: August 12, 1992Date of Patent: March 1, 1994Assignee: Fuji Xerox Co., Ltd.Inventors: Katsumi Nukada, Masakazu Iijima, Akira Imai, Katsumi Daimon
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Patent number: 5288721Abstract: Compounds of the formula ##STR1## including the resolved enantiomers and/or diastereomers and mixtures thereof wherein each of one or two R is independently ##STR2## wherein n is 1-16 and R' is H or alkyl(1-4C); and wherein each remaining R is independently H, alkyl(1-6C), alkenyl(1-6C) or benzyl; an wherein said alkyl or alkenyl may be substituted by a hydroxyl, halo, or dimethylamino group, and/or interrupted by an oxygen atom, are useful in modulating the effects of internal and external stimuli on cells by reversing the effects of these stimuli on the short-term secondary messenger pathways. In particular, the compounds lower elevated levels of unsaturated, non-arachidonate phosphatidic acid (PA) and diacylglycerol (DAG) derived from said PA within seconds of the primary stimulus and their contact with said cells. The modulatory effect depends on the nature of the target cell and the stimulus applied.Type: GrantFiled: September 22, 1992Date of Patent: February 22, 1994Assignee: Cell Therapeutics, Inc.Inventors: J. Peter Klein, David Porubek, Glenn C. Rice, Paul Woodson
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Patent number: 5286723Abstract: The present invention relates to spiro compounds of general formula I: ##STR1## wherein the substituents are herein below defined. The present invention relates to antibacterial spiro compounds which are of value as drugs for humans, veterinary drugs or drugs for use in fish culture or as preservatives, and to antibacterial compositions containing one or more of the same compounds as active ingredients.Type: GrantFiled: June 22, 1992Date of Patent: February 15, 1994Assignee: Daiichi Seiyaku Co., Ltd.Inventors: Isao Hayakawa, Shohgo Atarashi, Masazumi Imamura, Youichi Kimura
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Patent number: 5284647Abstract: Porphyrin complex compounds, consisting of a mesotetraphenylporphyrin ligand, optionally at least one ion of an element with atomic numbers 13, 21, 32, 37-39, 42-44, 49, 50 or 57-83 as well as optionally cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable diagnostic and therapeutic agents.Type: GrantFiled: January 9, 1992Date of Patent: February 8, 1994Assignee: Schering AktiengesellschaftInventors: Ulrich Niedballa, Hanns-Joachim Weinmann, Heinz Gries, Jurgen Conrad, Sabina Hofmann, Ulrich Speck
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Patent number: 5279622Abstract: Solid dyestuff preparations of reactive phthalocyanine dyestuffs of the formula ##STR1## in which the substituents have the meaning given in the description, have improved solubility in water if they contain 5 to 15% by weight of an acid-binding agent.Type: GrantFiled: April 28, 1992Date of Patent: January 18, 1994Assignee: Bayer AktiengesellschaftInventors: Josef-Walter Stawitz, Frank-Michael Stohr, Joachim Wolff
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Patent number: 5280121Abstract: Compounds of formula ##STR1## wherein R is C.sub.7 -C.sub.21 alkyl, C.sub.4 -C.sub.18 alkenyl, C.sub.5 -C.sub.12 cycloalkyl or C.sub.5 -C.sub.6 cycloalkyl-substituted C.sub.1 -C.sub.4 alkyl,R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently of one another hydrogen, chloro, bromo, methyl or methoxy,Z is a direct bond or --O--, --S--, --NH--, --CO--, --SO.sub.2 -- or --NHCO--, andn is 0 or 1.These compounds have excellent suitability as pigments for coloring organic material of high molecular weight, especially polyvinyl chloride, polyolefins and paints.Type: GrantFiled: June 30, 1992Date of Patent: January 18, 1994Assignee: Ciba-Geigy CorporationInventor: Stefan Hari
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Patent number: 5280010Abstract: A compound of the formula: ##STR1## wherein R is lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy(lower)alkyl, halo(lower)alkyl or halo(lower) alkenyl, X is chlorine or bromine, and Y is methyl optionally substituted with halogen, which is useful as an active ingredient of herbicides.Type: GrantFiled: June 5, 1992Date of Patent: January 18, 1994Assignee: Sumitomo Chemical Company, LimitedInventors: Masayuki Enomoto, Susumu Takemura, Masaharu Sakaki, Shinsuke Shojima, Eiki Nagano
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Patent number: 5276025Abstract: Compounds of general formula: ##STR1## are topically effective carbonic anhydrase inhibitors useful in the treatment of ocular hypertension and related disorders such as glaucoma.Type: GrantFiled: September 9, 1992Date of Patent: January 4, 1994Assignee: Merck & Co., Inc.Inventors: John J. Baldwin, Jacob M. Hoffman, Jr., James H. Jones, Clarence S. Rooney, Anthony M. Smith
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Patent number: 5273974Abstract: A condensed heterocyclic derivative of the formula (I): ##STR1## wherein X is an oxygen atom, a sulfur atom or R.sup.1 --N< wherein R.sup.1 is a hydrogen atom, a hydrocarbon group which may be substituted or an acyl group which may be substituted; R.sup.2 is a hydrogen atom or a hydrocarbon group which may be substituted; ring A is a benzene ring which may be substituted, k is a whole number of 0 to 3; m is a whole number of 1 to 8; and n is a whole number of 1 to 6, or a pharmaceutically acceptable salt thereof exhibiting high colinesterase inhibitory activity, and a method for producing the same.Type: GrantFiled: November 22, 1991Date of Patent: December 28, 1993Assignee: Takeda Chemical Industries, Ltd.Inventors: Giichi Goto, Yuji Ishihara, Masaomi Miyamoto
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Patent number: 5273998Abstract: The present invention provides an industrially valuable method for preparing an optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compound which is useful as a starting material for an optically active benzopyran compound with antihypertensive, coronary blood flow-increasing activities and the like, provides a diastereomeric ester compound which is useful as an intermediate for said epoxy compound and also provides a use of said diastereomeric ester compound in making of said epoxy compound, and further an optically active benzopyran compound which is useful as medicine.Type: GrantFiled: October 19, 1992Date of Patent: December 28, 1993Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventor: Tsutomu Yamanaka
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Patent number: 5247082Abstract: There is disclosed an imine compound of the general formula: ##STR1## wherein R.sup.1 and R.sup.2 are, the same or different, each a C.sub.1 -C.sub.5 alkyl group, or R.sup.1 and R.sup.2 are combined together to form a C.sub.4 -C.sub.5 alkylene group; R.sup.3 is a C.sub.1 -C.sub.5 alkyl group, a C.sub.3 -C.sub.4 alkenyl group or a C.sub.3 -C.sub.4 alkynyl group, which is useful as an intermediate for production of agrochemicals and the like. Also disclosed are an amide compound useful as a raw material of the imine compound and production processes for these compounds.Type: GrantFiled: September 29, 1992Date of Patent: September 21, 1993Assignee: Sumitomo Chemical Company LimitedInventors: Mitsuhiro Matsumoto, Yuji Funaki