Patents Examined by P. K. Sripada
-
Patent number: 5424423Abstract: The preparation of compounds of formula (I), wherein R and R.sub.1 have the meanings specified in claim 1, is disclosed compounds (I) are useful intermediates for the preparation of chelating agents.Type: GrantFiled: February 26, 1993Date of Patent: June 13, 1995Assignee: Dibra S.p.A.Inventors: Fulvio Uggeri, Pier L. Anelli, Marcella Murru, Mario Virtuani
-
Patent number: 5422371Abstract: Disclosed are a novel class of anti-androgenic compounds including saturated and unsaturated fatty acids, their derivatives, and synthetic analogs, according to the following formula:CH.sub.3 --(CH.sub.2).sub.a --(CR.sub.1 R.sub.2 CH.dbd.CH).sub.b --(CH.sub.2).sub.c --COOH,wherein R.sub.1 and R.sub.2 are each either hydrogen or a halogen; wherein a and c are integers from 0-9; wherein b is an integer from 1-6, provided that12<a+c+(3.times.b).ltoreq.22.Also disclose are methods of synthesis of these compounds, and their use in treating disorders associated with androgenic activities. Also disclosed is the use of known compounds not previously known for their anti-androgenic activity in treating disorders related to androgenic activities.Type: GrantFiled: July 1, 1992Date of Patent: June 6, 1995Assignee: Arch Development Corp.Inventors: Shutsung Liao, Tehming Liang
-
Patent number: 5409935Abstract: The use of xanthine derivatives for the treatment of secondary nerve cell damage and functional disorders after cranio-cerebral traumas (CCT)The use of xanthine derivatives of the formula I ##STR1## and of their physiologically tolerable salts, in which R.sup.1 is oxoalkyl, hydroxyalkyl or alkyl, R.sup.2 is hydrogen or alkyl and R.sup.3 is hydrogen, alkyl, oxoalkyl or an alkyl having up to 6 carbon atoms, whose carbon chain is interrupted by an oxygen atom, for the production of pharmaceuticals for the treatment of disorders which can occur after cranio-cerebral traumas is described.Type: GrantFiled: July 9, 1992Date of Patent: April 25, 1995Assignee: Hoechst AktiengesellschaftInventors: Hans-Peter Schubert, John J. Grome, Barbara Kittner, Karl Rudolphi, Ulrich Gebert
-
Patent number: 5409893Abstract: The invention concerns a coordination complexes with R.sup.111 as central metal attached to a heterocyclic ligand in the apical position trans to a sulfoxide and their pharmaceutical compositions useful in antitumor therapy either alone or in combination with platinum complexes.Type: GrantFiled: December 13, 1991Date of Patent: April 25, 1995Assignee: Boehringer Mannheim Italia, S.p.A.Inventors: Enzo Alessio, Giovanni Mestroni, Sabrina Pocar, Gianni Sava, Silvano Spinelli
-
Patent number: 5403928Abstract: Marker components are provided which are compatible with aqueous solutions, exhibit favorable fluorescence properties and exhibit decreased non-specific binding to macromolecules in solution. These marker components are useful in applications such as fluorescence immunoassays, in vivo imaging and in vivo tumor therapy.Type: GrantFiled: May 15, 1991Date of Patent: April 4, 1995Assignee: Diatron CorporationInventor: Peter O. G. Arrhenuis
-
Patent number: 5385899Abstract: The invention relates to aminoalkyl-substituted 5,6-dihydro-dibenz[b,e]azepine-6,11-dione-11-oximes, to processes for their preparation and to their use as antiretroviral agents.Type: GrantFiled: November 17, 1992Date of Patent: January 31, 1995Assignee: Bayer AktiengesellschaftInventors: Hanno Wild, Wolfgang Roeben, Gerd Aichinger, Arnold Paessens, Jorg Petersen-von Gehr
-
Patent number: 5382661Abstract: Disclosed are amino substituted steroids (XI) which contain a pyrazinylpiperazinyl group attached to the terminal carbon atom of the C.sub.17 -side chain which are useful as pharmaceutical agents for treating a number of conditions.Type: GrantFiled: December 1, 1992Date of Patent: January 17, 1995Assignee: The Upjohn CompanyInventor: John M. McCall
-
Patent number: 5382662Abstract: New compositions of matter comprising cyano-substituted metal complexes of porphyrins are catalysts for the oxidation of alkanes. The metal is iron, chromium, manganese, ruthenium, copper or cobalt. The porphyrin ring has cyano groups attached thereto in meso and/or .beta.-pyrrolic positions.Type: GrantFiled: December 29, 1992Date of Patent: January 17, 1995Assignee: Sun Company, Inc. (R&M)Inventors: Paul E. Ellis, Jr., James E. Lyons
-
Patent number: 5380842Abstract: Phthalocyanine compounds represented by the below-described formula are suitable for use in the fabrication of color filters. ##STR1## wherein R.sup.1, R.sup.4, R.sup.5, R.sup.8, R.sup.9, R.sup.12, R.sup.13 and R.sup.16 represent a group represented by the below-described formula, H or a halogen atom, R.sup.2, R.sup.3, R.sup.6, R.sup.7, R.sup.10, R.sup.11, R.sup.14 and R.sup.15 represent an alkyl, alkoxyl, alkylthio, alkylamino, dialkylamino or aryloxyl, arylthio group or --COOR.sup.17, R.sup.17 being a particular monovalent group, H or a halogen atom; and Met represents a metal atom. ##STR2## wherein X and Z represent O or S, R.sup.18, R.sup.19 and R.sup.20 represent H or an alkyl group, A, B and D represent a connecting group, n and l is an integer of 0-10, m, q, t, u, r and w are an integer of 0-2, and p is 0 or 1.Type: GrantFiled: June 22, 1992Date of Patent: January 10, 1995Assignees: Mitsui Toatsu Chemicals, Incorporated, Yamamoto Chemicals, IncorporatedInventors: Hisato Itoh, Akio Karasawa, Kenichi Sugimoto, Takahisa Oguchi, Shin Aihara
-
Patent number: 5380840Abstract: Disclosed are amino substituted steroids (XI) which contain 4-[1,3,5-triazin-2-yl]- or 4-[1,2,4-triazin-3-yl]- 1-piperazinyl group attached to the terminal carbon atom of the C.sub.17 -side chain which are useful as pharmaceutical agents for treating a number of conditions.Type: GrantFiled: December 1, 1992Date of Patent: January 10, 1995Assignee: The Upjohn CompanyInventors: John M. McCall, Donald E. Ayer, E. Jon Jacobsen, Frederick J. Van Doornik, John R. Palmer, Harold A. Karnes
-
Patent number: 5380714Abstract: Compounds of the formula I: ##STR1## wherein: X is O, S or NH;n is O or an integer of from 1 to 3;R.sup.1 is hydrogen, (1-6C)alkyl, or (1-4C)alkanoyl;R.sup.2 is CH.sub.2 R.sup.3, NHR.sup.4, SO.sub.2 NR.sup.5 YNR.sup.6 R.sup.7 or R.sup.8, in which R.sup.3 is hydroxy, (1-4C)alkoxy or (1-4C)alkylsulphonyl; R.sup.4 is (1-4C)alkylsulphonyl, (1-4C)haloalkylsulphonyl, formyl, carbamoyl or 2,6-dichloro-4-(2-(1,1-dimethylethyl)amino-1-hydroxyethyl)phenyl; R.sup.5 is hydrogen or (1-4C)alkyl; Y is CO or (1-6C)alkylene; R.sup.6 and R.sup.7 are independently (1-4C)alkyl, or R.sup.6 is hydrogen and R.sup.7 is (1-4C)alkyl, (1-4C)haloalkyl, phenyl(1-4C)alkyl or, when Y is (1-6C)alkylene, is (1-4C)alkylaminocarbonyl or (5-6C)cycloalkylaminocarbonyl; and R.sup.8 is a sugar residue of formula II in which R.sup.Type: GrantFiled: November 20, 1992Date of Patent: January 10, 1995Assignee: Imperial Chemical Industries PLCInventors: Geraint Jones, Roger James, Rodney B. Hargreaves
-
Patent number: 5380839Abstract: Disclosed are amino substituted steroids (XI) which contain a phenylpiperazinyl group attached to the terminal carbon atoms of the C.sub.17 -side chain, which are useful as pharmaceutical agents for treating a number of conditions.Type: GrantFiled: December 1, 1992Date of Patent: January 10, 1995Assignee: The Upjohn CompanyInventors: John M. McCall, E. Jon Jacobsen, Frederick J. VanDoornik
-
Patent number: 5380841Abstract: Disclosed are amino substituted steroids (XI) which contain a pyridinylpiperazinyl group group attached to the terminal carbon atom of the C.sub.17 -side chain of the steroid which are useful as pharmaceutical agents for treating a number of conditions.Type: GrantFiled: December 1, 1992Date of Patent: January 10, 1995Assignee: The Upjohn CompanyInventors: John M. McCall, Donald E. Ayer, E. Jon Jacobsen, Frederick J. VanDoornik, John R. Palmer, Harold A. Karnes
-
Patent number: 5372996Abstract: A method of treatment of androgen-related diseases such as prostate cancer in susceptible male animals, including humans, comprises administering novel antiandrogens and/or novel sex steroid biosynthesis inhibitors as part of a combination therapy. Sex steroid biosynthesis inhibitors, especially those capable of inhibiting conversion of dehydroepiandrosterone (DHEA) or 4-androstenedione (.DELTA..sup.4 -dione) to natural sex steroida (and testosterone into dihydrotestosterone) in peripheral tissues, are used in combination with antiandrogens usually after blockade of testicular hormonal secretions. Antiestrogens can also be part of the combination therapy. Pharmaceutical compositions and two, three, four and five component kits are useful for such combination treatment.Type: GrantFiled: October 19, 1992Date of Patent: December 13, 1994Assignee: Endorecherche, Inc.Inventor: Fernand Labrie
-
Patent number: 5371218Abstract: Salts of triazine compounds with cyanuric acid, of general formula (I): ##STR1## obtained by salifying 2,4,6-triamino-1,3,5-triazine derivatives with cyanuric acid. The new salts of general formula (I) are used in particular as flame retardant additives.Type: GrantFiled: December 1, 1992Date of Patent: December 6, 1994Assignee: Ministero Dell'Universita' e Della Ricerca ScientificaInventors: Roberto Cipolli, Roberto Oriani, Gilberto Nucida, Enrico Masarati
-
Patent number: 5371199Abstract: Porphyrins substituted with, for example, vinyl and acetylene groups are provided, along with polymers containing the same. In preferred embodiments, the substituted porphyrins are prepared by coupling halogenated porphyrins with carbon-centered anionic groups via metal-mediated crosscoupling reactions under stoichiometric or catalytic conditions.Type: GrantFiled: August 14, 1992Date of Patent: December 6, 1994Assignee: The Trustees of the University of PennsylvaniaInventors: Michael J. Therien, Stephen G. DiMagno
-
Patent number: 5369103Type: GrantFiled: June 19, 1992Date of Patent: November 29, 1994Assignee: John Wyeth & Brother, LimitedInventors: Ian A. Cliffe, Alan C. White, Anderson D. Ifill
-
Patent number: 5366969Abstract: Compounds of the formula I ##STR1## in which R can be hydrogen or C.sub.1 -C.sub.4 -alkyl, R.sup.1 hydrogen, C.sub.1 -C.sub.6 -alkyl, aryl, aryl-C.sub.1 -C.sub.4 -alkyl, amino-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkylamino-C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.6 -dialkylamino-C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy-C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkylthio-C.sub.1 -C.sub.4 -alkyl, C.sub.3 -C.sub.7 -alkenyl, R.sup.2 R.sup.1 or C.sub.2 -C.sub.7 -alkenyl, C.sub.1 -C.sub.6 -alkylmercapto, C.sub.1 -C.sub.6 -alkoxy, phenoxy-C.sub.1 -C.sub.4 -alkyl,amino, C.sub.1 -C.sub.4 -alkylamino, di-C.sub.1 -C.sub.4 -alkylamino, morpholino, thiomorpholino, pyrrolidino, piperidino, hexamethyleneimino, pyrasolino, imidazolino, n 0, 1 or 2 and R.sup.1 and R.sup.Type: GrantFiled: March 6, 1992Date of Patent: November 22, 1994Assignee: Boehringer Mannheim GmbHInventors: Elmar Bosies, Harald Zilch
-
Patent number: 5359056Abstract: A novel fluorine-containing phthalocyanine compound represented by the following formula (I): ##STR1## wherein Y is ##STR2## wherein R.sub.1 and R.sub.2 are independently a hydrogen atom or a C1-C8 alkyl group; R.sub.3 and R.sub.4 are independently a C1-C8 alkyl group; X is a hydrogen atom, a C1-C4 alkyl group, a C1-C4 alkoxyl group or a halogen atom; Z is a hydrogen atom, a C1-C4 alkyl group, a C1-C4 alkoxyl group, a C1-C4 alkoxycarbonyl group or a halogen atom; W is a C1-C4 alkoxyl group; e, f, g, h and j are independently an integer of 1 or 2; n is an integer of 1 to 8; and p and q are independently an integer of 1 to 6; a to d are an integer of 0 to 2 with the proviso that the sum of a to d is 1 to 8; and M is a non-metal, a metal, a metal oxide, a metal carbonyl or a metal halide, and further, a method of producing a fluorine-containing phthalocyanine compound represented by the above formula (I).Type: GrantFiled: July 14, 1992Date of Patent: October 25, 1994Assignee: Nippon Shokubai Co., Ltd.Inventors: Osamu Kaieda, Takashi Yodoshi, Hideki Itoh, Miho Onozaki
-
Patent number: 5359072Abstract: Novel nonlinearly optically active compounds, well suited for electrooptical applications, have the following general formulae: ##STR1## wherein D is an electron donor group; A and A.sub.1, which may be identical or different, are each an electron acceptor group; and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each a lower alkyl radical or a hydrogen atom.Type: GrantFiled: June 13, 1991Date of Patent: October 25, 1994Assignee: Rhone-Poulenc ChimieInventors: Gerard Mignani, Gerard Soula, Remi Meyrueix