Abstract: New 9-alphahydroxy steroids are prepared by the introduction of substituents on the D-ring of 9-alpha-hydroxy-androst-4-ene-3,17-dione. The resulting compounds are useful intermediates in the synthesis of corticosteroids.

Abstract: A method for preparing a mixture of the halogenated alkoxyphthalocyanines represented by the formula (8) which comprises the step of reacting alkoxyphthalocyanines represented by the formula (7) and a mixture thereof with a halogenating agent in a mixed solvent of an organic solvent and water.

Abstract: This invention discloses a compound and pharmaceutically acceptable salts having the formula: ##STR1## wherein X and Y are the same or different and are selected from the group consisting of OH and NH.sub.2 ; wherein R.sub.1 is selected from the group consisting of hydrogen, a first lower alkyl group, a nitroso group and an aldehyde; and wherein R.sub.2 is selected from the group consisting of a second lower alkyl group which is the same as or different than the first lower alkyl group, an aryl group, an alkylaryl group, a substituted aryl group and a substituted alkylaryl group, and each substituent of the substituted aryl group or the substituted alkylaryl group is the same or different and is selected from the group consisting of a third lower alkyl group which is the same as or different than the first lower alkyl group or the second lower alkyl group, an alkoxy group, a substituted alkoxyaryloxy group and a halogen; and wherein R.sub.

Abstract: There is disclosed a novel phenothiazine derivative of the general formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and are a C.sub.1-6 alkyl group and at least one of them has as a substituent a group which can react with amino group, thiol group or carboxyl group, and X.sup.- is a counter ion of the phenazathionium. Their production and the intermediates used in the production are also disclosed. The compound (I) is a derivative of methylene blue and is applicable to photodynamic therapy of cancer or immunoassays utilizing chemiluminescence.

Abstract: The present invention relates to a composition having the general formula: ##STR1## wherein each of A, B, C, X, Y, and Z is independently O, NH, N(CH.sub.2).sub.m CH.sub.3 ], N(C.dbd.O) (CH.sub.2).sub.m CH.sub.3 ], CH.sub.2, S, or Se; each of R.sub.1, R.sub.2, and R.sub.3 is independently phenyl, 4-hydroxyphenyl, pyridyl, pyrrolyl, indolyl, naphthyl, thiophenyl, (C.dbd.O) (CH.sub.2).sub.p CH.sub.3, NH(C.dbd.O) (CH.sub.2).sub.p CH.sub.3 ], OH, COOH, NH.sub.2, or SH; and m, n, and p are integers between 0 and 5. The composition is a chiral receptor molecule useful for the purification of enantiomers of derivatives of amino acids and of compounds able to form hydrogen bonds. The preparation of the composition involves coupling a trifunctional aromatic molecule with three protected chiral molecules at the three aromatic groups, cleaving protecting groups, and joining adjacent chiral groups by multiple lactamizations.

Abstract: Compounds of the formula ##STR1## wherein each of one or two R is independently ##STR2## wherein n is an integer from 4 to 18, each R.sub.1 ' and R.sub.2 ' is independently H, alkyl (1-4C) or alkenyl (1-4C); and R.sub.3 ' and R.sub.4 ' are independently H or CH.sub.3 ; and wherein the alkyl or alkenyl may be substituted by a hydroxyl, halo or dimethylamino group and/or interrupted by an oxygen atom, H or alkyl (1-4C), including resolved enantiomers and/or diastereomers and mixtures thereof. Preferably, n is from 6 to 10, R.sub.1 ' and R.sub.2 ' are independently H or methyl and R.sub.3 ' and R.sub.4 ' are H. In particular, the compounds lower elevated levels of unsaturated, non-arachidonate phosphatidic acid (PA) and diacylglycerol (DAG) derived from said PA within seconds of the primary stimulus and their contact with said cells. The modulatory effect depends on the nature of the target cell and the stimulus applied.

Abstract: Substituted 3,5-dioxo-3,4,5,6-tetrahydrooxazines as herbicides.

Abstract: Provided are cyclic hydrocarbons of Formula I ##STR1## with an aminoalkyl sidechain that are useful for treating phospholipase A2 mediated conditions, diabetes, and obesity.

Abstract: Compounds of the general formula I ##STR1## wherein A is N; Ar is aryl, substituted aryl or benzofuranyl, wherein the substituents are selected from C.sub.1 -C.sub.8 alkoxy; B is CO or CH.sub.2 and HET is selected from any of piperizine, piperidine, hexahydroazepine, morpholine, thiomorpholine or pyrrolidine, which may be substituted with one of more oxo groups are disclosed as novel antipsychotic agents. Pharmaceutical compositions and methods of treating convulsions employing such compounds of formula I are also disclosed.

Abstract: Glycol aldehyde and lactic acid derivatives and their sulfur analogs of the formula I ##STR1## where R.sup.1 to R.sup.3 have the meanings given in the specification, X is oxygen, sulfur or a single bond, and Y is a C.sub.2 -C.sub.4 -alkylene or C.sub.2 -C.sub.4 -alkenylene chain where in each case a methylene group may be substituted by an oxo group (.dbd.O), environmentally compatible salts of the compounds I, methods of preparing the compounds I, and their use as herbicides.

Abstract: An optically active pyrimidine compound represented by general formula (I): ##STR1## wherein R represents a fluoroalkyl group having 1 or 2 carbon atom(s), R.sup.1 represents an alkyl group having 1-15 carbon atoms or an alkoxyalkyl group having 2-15 carbon atoms, both the alkyl and alkoxyalkyl groups being optionally substituted by halogen atom, Y represents --O--, --COO-- or --OCO--, A represents: ##STR2## wherein X represents a hydrogen atom or a halogen atom, m and s each represent 0 or 1, and the C* means an asymmetric carbon atom; a process for producing said pyrimidine compound; and a liquid crystal composition containing said pyrimidine compound.

Abstract: An improved process for preparing triazacyclo compounds and, in particular, 1,4,7-tritosyl-1,4,7-triazyacyclononane. The process involves reacting a diethylenetriamine triarylsulphonate with a cyclising agent selected from the group consisting of diaryl sulphonates, dialkyl sulphonates, ethylene dibromide, ethylene dichloride and diacetylglycol in the presence of ultrasound.

Abstract: The invention provides novel condensed macrocyclic chelants of formula [X(CR.sup.2 R.sup.3).sub.n ].sub.m, (wherein each X independently represents an oxygen or sulphur atom or a group of formula NH, N(CR.sup.2 R.sup.3).sub.p R.sup.4, N(CR.sup.2 R.sup.3).sub.p Y, or N(CR.sup.2 R.sup.3).sub.n- N((CR.sup.2 R.sup.3).sub.p Y).sub.2 ; each Y independently represents a group COZ, SO.sub.2 Z, POZ.sub.2, CON(OH)R.sup.2, CH.sub.2 SR.sup.2, CS.sub.2 R.sup.2 or CSZ; each Z independently represents a group OR.sup.2 or NR.sup.2 R.sup.2 ; n is an integer of 1 to 4; m is an integer of 3 to 8; p is an integer of 1 to 3; each R.sup.2 independently represents a hydrogen atom or a C.sub.1-8 alkyl group optionally mono- or poly-substituted by hydroxyl or C.sub.1-8 alkoxy groups and at least one pair of R.sup.2 groups, in each pair one being from a (CR.sup.2 R.sup.3).sub. n moiety and the other being from a (CR.sup.2 R.sup.3).sub.n or (CR.sup.2 R.sup.3).sub.

Abstract: The invention concerns a method for treating depression or senile dementia using a compound which acts selectively as an agohist of gamma aminobutyric acid (GABA) at GABA autoreceptors with the proviso that the compound is not fengabine and progabide.

Abstract: There are described water-soluble phthalocyanine dyes, in particular copper phthalocyanine and nickel phthalocyanine dyes, which have the formula (1) defined hereinafter and can be used for the dyeing and printing of hydroxy and/or carboxyamido-containing fiber material, such as cotton, wool and synthetic polyamide, by the techniques customary in the art for fiber-reactive dyes. ##STR1## in which Pc is a phthalocyanine radical, R.sup.1 and R.sup.2 are both hydrogen or alkyl, A is an aromatic carboxylic or heterocyclic radical, which may be substituted by substituents customary in dyes, or is an alkylene radical, which may be substituted by 1 or 2 hetero groups, X is a direct bond or a divalent organic binding link, such as an alkylene radical or an alkyleneamino group, Y is a direct bond or a group of the formula --CO--NH--alkylene-- or a methylamino or .beta.-cyanoethylamino group, Z is a fiber-reactive radical from the vinylsulfonyl series or is .beta.

Abstract: The pH controlled selectivity of the sulfomethylation reaction is used to prepare a series of di-, tri-, tetra- and hexaazacyclomacrocycles with specified patterns of pendent side-chain chelating groups. The prepared mono and diacetic acid derivatives, together with monomethylenephosphonate and monomethylenephosphinate derivatives of tetraazacyclododecane, and triazcyclododecane and [9]aneN3, make these types of ligands easily available by a synthetic pathway that avoids the use of protective groups. The invention thus comprises a variety of compounds, methods and uses characterized by relatively high synthetic yields of polyazamacrocyclic ligands exhibiting a wide and predictable choice of metal ion binding constants water and lipid solubilities by reason of their substituent pendent groups.

Abstract: Xanthine derivatives having antiasthmatic activity are disclosed which have the following formula: ##STR1## where R is a linear or branched alkyl chain group of from one to six carbon atoms, R.sub.1 is a linear or branched alkyl or hydroxyalkyl group of from one to six carbon atoms. However, if R is methyl, then R.sub.1 is not methyl, ethyl or propyl; if R is ethyl, then R.sub.1 is not methyl or ethyl; and if R is methyl or n-butyl, then R.sub.1 is not 2-hydroxypropyl. Also disclosed are pharmaceutical compositions containing such xanthine derivatives.

Abstract: A method is described for purifying iron oxide, for example, in the form of magnetite or hematite slime, which preferably contains quartz as the impurity. The method comprises calcinating the iron oxide together with alkali carbonate and thereafter leaching with a weak aqueous solution of an acid or a mixture of acids.

Abstract: Gallium is efficiently extracted from strongly basic solutions containing aluminates by extractants having the tris- and/or tetrakis(2-hydroxybenzyl)-1,2-diaminoethane chemical moiety. The diaminoethane derivative may be used together with a hydrocarbyl 8-hydroxyquinoline and/or with a tertiary carboxylic acid.

Abstract: Phthalocyanine dyes, in particular copper phthalocyanine and nickel phthalocyanine dyes which contain one or more groups of the formula given and defined below ##STR1## or one or more carboxy groups or both groups and which furthermore can contain one or more sulfo groups, customary sulfonamide groups and/or groups of the formula given and defined below ##STR2## dye hydroxy- and/or carboxamide-containing materials, in particular fiber materials, such as cellulose fiber materials, wool and polyamide fibers, in fast, predominantly green hues of high color strength.