Abstract: Solid catalyst components for olefin polymerization which comprise a solid carrier components comprising a solid substance having the general formulaMgX.sub.2.(E).sub.n ( 1)wherein X is a halogen atom, E is a monoether compound and n is 0.01.about.4, at least a portion of said E being replaced by an eletron donative compound different from said monoether compound (E), and a titanium compound and these catalyst components can produce an olefin polymer having a high stereoregularity in a high polymer yield per unit of a catalyst component in olefin polymerization.
Abstract: An under floor insect control method for structures in which an insect control chemical in a mixed resin foam coating is installed under the floor by forcefully mixing, at a nozzle part of the sprayer, and spraying on the soil surface the following: an aqueous emulsion, of which 15-20 percentage by weight is a solid copolymeric resin, based on vinyl acetate and alkyl methacrylate in a proportion ranging from 55-85 and 15-45 parts by weight, respectively; an inert organic solvent solution contains a mixture of diisocyanate and polypropylene glycol in a proportion ranging from 5-15 and 85-95 parts by weight, respectively. The two components make up an adjusted 60-80 percentage by weight as a total volume. An insect control chemical is also included. The proportion of organic solvent solution to the emulsion is in the range of 7-15 percentage by volume. The mixed resin foam insect control barrier formed provides superior insect control chemical immobilization, gas barrier and crack proof properties.
Abstract: Precipitated silica compositions, and methods for making the same, with improved dentifrice performance characteristics. In particular, precipitated silica compositions of the present invention have a 40% slurry viscosity build of less than approximately 20,000 centipoise and a 10% Brass Einlehner abrasion value of approximately 2.5 to 20.0 mg loss/100,000 rev. Precipitated silica compositions of the present invention also have reactor slurry average particle sizes (50%) of approximately 10 to 50 .mu.m. Methods for preparing precipitated silicas of the present invention include the steps of: (a) adding sodium silicate and a mineral acid to a reactor, thereby initiating a precipitation reaction between the reactor contents; and (b) subjecting the reactor contents to shearing forces as the reaction proceeds.
Abstract: Topical film-forming compositions for the prevention and treatment of prutitus containing an opiate that is substantially devoid of central nervous system effects.
Type:
Grant
Filed:
July 14, 1997
Date of Patent:
March 30, 1999
Assignee:
Adolor Corporation
Inventors:
John J. Farrar, Alan L. Maycock, Virendra Kumar, Imre Jim Balogh
Abstract: A composition contains certain nutrients, active and protective substances, as well as an oxygen carrier, along with a process for preparing this composition and its use. The composition provides skin care preparation with a high oxygen content which also contain further nutrients, active and/or protective substances. The new functional oxygenated composition contains (a) phospholipids and oxygen-loaded fluorocarbon or fluorocarbon mixtures. The proportion of fluorocarbon lies in the 0.2 to 100% by weight/volume range. The lipid fraction contains 30 to 99% by weight phosphatidylcholine in the form of asymmetric lamellar aggregates. The composition also contains (b) a product obtained by gentle disintegration of suspensions or dispersions of cells of plant substances, bacteria or yeasts by ultrasonic and/or high-pressure homogenization under up to 25 MPa; and (c) a cosmetic or dermatological carrier suitable for use on the skin.
Type:
Grant
Filed:
June 17, 1997
Date of Patent:
March 23, 1999
Assignee:
Lancaster Group GmbH
Inventors:
Leonhard Zastrow, Karin Golz, Klaus Stanzl
Abstract: A mixed feed or a feed additive, which comprises Cucurbita Seed, Plantago and Lornicera.Other crude drugs such as Safflower, Licorice, Mabiacao, Pugongying, Houttuynia and Juhua may be compounded in addition to the above crude drugs.For breeding cattle, swine, fowl, Hamachi, and the like, the above-described mixed feed, or the feed additive compounded with the marketed feed may be used.The resistance to diseases of the fed animals is improved, healthy candicidin can be maintained during the breeding, and the meat quality, egg quality, or the like is improved.
Abstract: Preparation of highly monodispersed polymeric hydrophilic nanoparticles having a size of up to 100 nm (in which may have drug substances encapsulated therein. The process comprises subjecting a mixture of an aqueous solution of a monomer or preformed polymer reverse micelles, a cross linking agent, initiator, and optionally, a drug or target substance to polymerization. The polymerized reaction product is dried for removal of solvent to obtain dried nanoparticles and surfactant employed in the process of preparing reverse micelles. The dry mass is dispersed in aqueous buffer and the surfactant and other toxic material are removed therefrom.
Type:
Grant
Filed:
January 7, 1997
Date of Patent:
February 23, 1999
Inventors:
Amarnath Maitra, Prashant Kumar Ghosh, Tapas K. De, Sanjeeb Kumar Sahoo
Abstract: A precipitated silica composition which, when incorporated into a suitable dentifrice composition, the dentifrice composition exhibits an mPCR of about 103 to 124 and an RDA of about 88 to 102. The invention also provides a precipitated silica composition which, when incorporated into a suitable dentifrice composition, the dentifrice composition exhibits an mPCR to RDA ratio of greater than about 1.1.
Abstract: A method of providing a patient needing clonidine with an extended dosage of clonidine over a prolonged period of time. Such method involves administering to the patient an oral dosage unit comprising a homogenous mixture of a therapeutically effective amount of clonidine, about 30 to about 70 percent by weight of one or more cellulose ethers such as hydroxypropyl methylcellulose, and about 30 to about 70 percent by weight of an inert substance such as cornstarch. The oral dosage unit may be contained in a gelatin capsule or in the form of a tablet.
Abstract: Skin irritation, such as diaper rash, appearing when the skin is allowed to remain in contact with proteolytic enzymes found in feces is prevented by inactivating the fecal proteolytic enzymes by contact with organophilic clays. The organophilic clays are applied to the skin in areas likely to come into contact with feces or to garments such as diapers. A composition suitable for practicing the method of the invention comprises an amount of an organophilic clay effective to inactivate irritating fecal proteolytic enzymes dispersed in a pharmaceutically acceptable non-toxic dermatological vehicle. A fabric incorporating organophilic clay, preferably dispersed in a matrix of a superabsorbent polymer is useful for preparing diapers for infants that can help to prevent skin irritation by fecal enzymes.
Abstract: Tissue infiltrating primer formulations and methods of using such formulations, e.g., in the dental or medical fields, are described. The formulations of the invention include an effective amount of a tissue infiltrating agent and a primer. The tissue infiltrating primer formulations provide enhanced penetration of a biomaterial into a target substrate, e.g. hard tissues, when compared to their non-tissue infiltrating primer formulation counterparts.
Type:
Grant
Filed:
December 5, 1995
Date of Patent:
February 2, 1999
Assignee:
The University of Toronto Innovations Foundation
Inventors:
Paul Joseph Santerre, Keith Titley, Robert Chernecky, Phillip Watson
Abstract: The present invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an ionene polymer and a salt of dodecylamine in a combined amount effective to inhibit bacterial adhesion to the submergible surface. The present invention also relates to a method for controlling biofouling of an aqueous system. This method adds an ionene polymer and a salt of dodecylamine in a combined amount effective to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the fouling organisms. The present invention also relates to compositions containing an ionene polymer and a salt of dodecylamine and useable in the above methods. The compositions comprise an ionene polymer and a salt of dodecylamine in a combined amount effective to inhibit bacteria from adhering to submergible or submerged surfaces.
Type:
Grant
Filed:
July 1, 1997
Date of Patent:
February 2, 1999
Assignee:
Buckman Laboratories International, Inc.
Inventors:
Percy A. Jaquess, Luis Fernando Del Corral, Richard A. Clark
Abstract: The hydrogel is a copolymer of an N-substituted methacrylamide or acrylamide, a cross-linking agent and a complex sugar or derivative, a tissue adhesion peptide or a polymer conjugate with antibodies, the polymer being heterogeneous, elastically deformable and having an equilibrium water content of at least about 80%. It can be used for tissue regeneration and for organ repair, for example, in the developing and adult nervous system.
Abstract: An ophthalmic composition and process for treating blepharitis employing the composition of 0.5-10% of available nonionic surfactant in water to emulsify and remove lipids from the corneal surface.
Abstract: A non-abusable, non-inflammatory, biocompatible, non-biodegradable, subcutaneous, polymeric implant for the prolonged, controlled release of hydromorphone with near zero-order kinetics is described. Methods of alleviating cancer pain and treating opioid drug addiction with the implant are also described.
Type:
Grant
Filed:
January 30, 1997
Date of Patent:
January 12, 1999
Assignee:
Axxia Technologies
Inventors:
Stuart A. Grossman, Kam W. Leong, Glenn J. Lesser, Hungnan Lo
Abstract: Compositions and methods for treating a contact lens very effectively and conveniently provide enhanced contact lens wearability by reducing the actual or perceived ocular sensitivity which results from exposing a contact lens to non-oxidative antimicrobial components. The present system takes advantage of inactivating or deactivating a non-oxidative antimicrobial component located on or in a contact lens to reduce the ocular sensitivity caused by placing the lens in the eye.
Abstract: An oral administration form with a carrier for acid active substances wherein the active substance has at least one free carboxyl group ionically bound to a polymer having tertiary amino groups is characterized by the fact that the polymer is colestipol or colestipol hydrochloride.
Abstract: Disclosed herein is an EHV-1 vaccine which provides protection against diseases associated with EHV-1 and EHV-4, and methods of preparing and using the same.
Type:
Grant
Filed:
August 16, 1996
Date of Patent:
December 29, 1998
Assignee:
Bayer Corporation
Inventors:
Joseph Macek, Karen K. Brown, Bobby O. Moore
Abstract: A drug formulation for producing sustained therapeutic efficacy, which releases at least one water-soluble drug over a prolonged period of time at a substantially constant rate wherein said drug formulation comprises(a) a nondisintegrating inner layer comprised of a biocompatible material that contains at least one uniformly dispersed water-soluble drug; and(b) an outer layer comprised of a biocompatible material that surrounds the circumference of the said inner layer, is impermeable to water, and is capable of controlling the swelling of the inner layer; wherein the ratio of the axial length of the drug formulation to the cross-sectional diameter of the inner layer is one or more and wherein one or both ends of the inner layer are open so as to come into direct contact with the external environment.
Abstract: The present invention provides a composition comprising an ion exchange resin and a therapeutically active biopolymer in a form for oral administration. The present invention also provides a composition comprising Amberlite.RTM. IRP-64 and a cytokine regulatory agent having the amino acid sequence:Ac-Nle-Gln-His-(D)Phe-Arg-(D)Trp-Gly-NH.sub.2,in a form for oral administration. The present invention further provides a method of protecting a therapeutically active biopolymer from degradation by forming a complex of the biopolymer and an ion exchange resin. In addition, the present invention provides a method of reducing or inhibiting the severity of a pathological condition by orally administering a therapeutically effective dose of the composition.