Abstract: The invention provides a translucent, water-insoluble hydrogel composition and methods of making it. The hydrogel composition comprises a polyvinyl alcohol polymer and a complexing agent which are physically crosslinked to form a semi-crystalline polyvinyl alcohol-complexing agent polymer complex. This is achieved by:(i) combining a polyvinyl alcohol polymer with a suitable aprotic solvent;(ii) Adding a complexing agent to (i) to form a water soluble complex with the polyvinyl alcohol polymer; and(iii) Allowing the polyvinyl alcohol polymer and the complexing agent to form a water-insoluble, semi-crystalline structure.The formation of the semi-crystalline structure is assisted by freezing the polyvinyl alcohol/complexing agent/polar aprotic solvent mixture.

Abstract: A composition and method of moisturizing mammalian membranous tissue is disclosed. The composition utilized in this method includes water, a bioadhesive polymer as the moisturizing agent, and preferably, a consistency-enhancing agent. The bioadhesive is a water-swellable, but water-insoluble, particulate, fibrous, cross-linked carboxy-functional polymer containing (a) a plurality of repeating units of which at least about 80 percent contain at least one carboxyl functionality, and (b) about 0.05 to about 1.5 percent cross-linking agent substantially free from polyalkenyl polyether. The consistency-enhancing agent, when present, is a water-soluble or -dispersible anionic or non-ionic polymer. The composition is contacted with the tissue to be moisturized, and that contact is maintained for a time period sufficient to moisturize the contacted area.

Abstract: Method for the treatment of inflammation and pain associated with inflammatory dermatoses, gingivitis and acute injury with a composition of finely divided powder of safflower seed or its extract contained in a pharmaceutically acceptable carrier.

Abstract: Polymer compositions of the invention typically comprise a base polymer composition, a polymer cleavage agent, and a stabilizer composition. The preferred base polymer composition comprises an ethylene vinyl alcohol copolymer composition. Preferred cleavage agent is an alkaline earth or transition metal salt, preferably an acetate, or a salt of an acid having 8 to 20 carbon atoms. The stabilizer composition comprises an alkylated phenol or bisphenol. Preferred stabilizer composition comprises a tocopherol, preferably alpha tocopherol.

Abstract: The present invention describes a crosslinked aliphatic polyoxaamide polymer and blends thereof that may be used to produce hydrogels, surgical devices such as catheters, molded devices, and the like. The crosslinked aliphatic polyoxaamide of the present invention are formed by crosslinking an aliphatic polyoxaamide having a first divalent repeating unit of formula I:?X--C(O)--C(R.sub.1) (R.sub.2)--O--(R.sub.3)--O--C(R.sub.1) (R.sub.2)--C(O)--! Iand a second repeating unit selected from the group of formulas consisting of:?--Y--R.sub.17 --!.sub.T, II?--O--R.sub.5 --C(O)--!.sub.B, and III(?--O--R.sub.9 --C(O)!.sub.P --O--).sub.L G XIand combinations thereof, wherein X and Y are selected from the group consisting of --O-- and --N(R)--, provided both X and Y are not both --0-- and may be blended with a second polymer that is preferably biocompatable.

Abstract: The present invention deals with the composition, and application of novel compounds, useful as anti-tangle, and conditioning agents for use in personal care, on hair which has been processed. By processes is meant hair which has been subjected to the process of bleaching, relaxing, permanent waving, and/or coloring. These processes make the hair raspy and degrade the properties of the hair. The properties of these novel compounds remediates the damage done to hair and leaves it more manageable and less raspy. The compounds are truly multi-functional, providing softening conditioning, and gloss to treated hair.

Abstract: A cyanoacrylate ester composition comprising a corticosteroid is applied to skin lesions associated with dermatosis or dermatitis to protect and/or treat such lesions.

Abstract: A method for forming an iodine disinfecting solution that continuously generates free molecular iodine at a controlled average rate of at least 0.2 ppm per hour over a sustained and extended time period. The method involves combining persulfate anions and iodide anions in sufficient quantity in an aqueous medium having a resulting pH of less than about 6.5 so as to create an iodine generating capacity in said aqueous medium of between 1.5 and 6.5 with a generated concentration of at least 5 ppm of free molecular iodine and maintaining this concentration over the course of the extended time period.

Abstract: A composition comprisinga) about 40 to about 85 wt. % of water,b) about 12 to about 50 wt. % of talcc) an acrylate/C.sub.10 /C.sub.30 alkyl acrylate cross polymer, emulsifier and thickening agent in quantities effective to emulsify composition and provide increased viscosity to the aqueous composition, andd) a polyacrylamide in composition thickening and stabilizing quantities.

Abstract: A method of forming a diffusion barrier on an article of a polymer blend of (i) a high surface energy polymer and (ii) a low surface energy polymer. Most commonly the low surface energy polymer is an organosilicon polymer, as a polysilane or a polysiloxane. The surface of the article is exposed to ozone and ultraviolet radiation to form a diffusion barrier.

Abstract: Compositions and processes for medicating human skin disorders using hydrogen peroxide as an active antimicrobial agent. The composition includes essentially hydrogen peroxide, a non-volatile carrier-solvent, and water. A predetermined final hydrogen peroxide concentration is achieved through evaporation of water. In this manner, hydrogen peroxide concentration may be controlled to avoid deleterious effects. Other therapeutic agents such as alpha hydroxy acids may also be added to the composition for treating various skin ailments.

Abstract: The invention relates to a chain end functionalised polymer of formula: ##STR1## in which: the polymer chain (P) is a hydrophobic chain obtained by radical polymerisation of at least one monomer,R represents a hydrogen atom or a linear or branched hydrocarbon chain having 1 to 8 carbon atoms optionally substituted with at least one group selected from CO.sub.2, NH.sub.2, OH or a phenyl group, itself being optionally substituted,A and B, identical or different, each represent a single bond, a saturated or unsaturated linear or branched hydrocarbon chain having from 1 to 16 carbon atoms, it being possible for it to contain an amide bond or a peptide chain having 2 to 4 amino acids, particularly natural amino acids,the NH.sub.2 and/or COOH groups being free or salified.The invention also relates to the use of the above products as surfactants and more particularly as wetting agents, dispersing agents of solid particles and for preparing microdispersions of polymers, in particular microgels and microlatexes.

Abstract: The present invention relates to the use of poly(vinyl N-heterocycle)-block-poly(alkylene oxide) copolymers in micelle containing pharmaceutical formulations. The copolymers advantageously respond to pH differences in the environment to which they are exposed forming micelles at higher pH values. The micelles, which comprise a therapeutic compound and a copolymer, deliver drug in a pH dependent manner.

Abstract: Absorbable, segmented polymers of aliphatic polyesters based on lactone monomers glycolide, p-dioxanone and .epsilon.-caprolactone are described. The segmented polymers exhibit a broad range of properties, especially high strength, low modulus and fast in vivo absorption, useful in a variety of medical devices. The polymers of the present invention have such properties, making them useful in medical devices for plastic surgery indications.

Abstract: The present invention relates to cosmetic or dermatological compositions in the form of an ultrafine oil-in-water emulsion wherein the mean size of the particles or globules which form the fatty phase ranges from 50 nm to 1000 nm, and wherein the composition also contains at least one crosslinked poly(2-acrylamido-2-methylpropanesulphonic acid) polymer neutralized to at least 90%. These compositions may be obtained according to an emulsifying technique using phase inversion. These compositions are stable in all viscosity ranges with a large variety of possible emulsifiers and whatever oils are employed. They can contain a large variety of cosmetic active substances and adjuvants without disturbing their stability and they can be employed in many cosmetic and dermatological applications and adapted to all types of skin.

Abstract: An ophthalmic composition particularly in the form of eye-drops suitable for the treatment of diseases of the eye and surrounding areas. The composition contains a cyclosporin and a surfactant selected from polyoxyethylene fatty acid esters, polyoxyethylene alkylphenyl ethers and polyoxyethylene alkyl ethers, or mixtures thereof.

Abstract: A water-in-oil type make-up cosmetic composition having excellent water resistance, perspiration resistance, sebum resistance, and oil resistance and containing 1 to 54% by weight of an oil-soluble resin in an external phase and 0.0001 to 63% by weight of a coloring material in an internal phase.

Abstract: The present invention relates to delivery systems comprising a cationic polymer, optionally in conjunction with an anionic polymer, to deliver cationic therapeutic agents and their application to a mucosal surface. In particular, these delivery systems are well suited for the treatment of intraocular pressure and glaucoma by way of a sustained delivery system.

Abstract: An improved stable conditioning shampoo imparts improved physical and cosmetic properties to the hair such as wet and dry comb, wet and dry feel, gloss, static control and manageability, yet does not cause build-up and does not contain any polyhydric compounds. The shampoo includes an anionic surfactant, a water soluble cationic surfactant, a water-insoluble conditioning agent, and a suspending agent where the suspending agent is a mixture of a cellulose derivative and a PVM/MA Decadiene crosspolymer. The conditioning shampoo is stable for extended periods.

Abstract: Stable water-in-oil emulsion for cosmetic or pharmaceutical use.This emulsion comprises a fatty phase in a proportion of 15 to 40% consisting of at least one silicone in a proportion of 15 to 40% by weight relative to the total weight of the emulsion, and an aqueous phase containing at least one electrolyte-insensitive aqueous gelling agent, the emulsifying agent of the said emulsion being an alkyl- or alkoxydimethicone copolyol of general formula: ##STR1## in which: X is a hydrogen atom or a C.sub.1 -C.sub.16 alkyl, C.sub.1 -C.sub.16 alkoxy or C.sub.1 -C.sub.16 acyl,Y is a C.sub.8 -C.sub.22 alkyl or C.sub.8 -C.sub.22 alkoxy radical,n=0 to 200,m=1 to 40,q=1 to 100,the molecular weight of the residue (C.sub.2 H.sub.4 O--).sub.x (C.sub.3 H.sub.6 O--).sub.y --X being from 250 to 2000, and x and y being chosen in such a way that the weight ratio of oxyethylene to oxypropylene groups is between 100:0 and 20:80.Production of stable emulsions having excellent cosmetic properties.