Abstract: The present invention deals with the composition, and application of novel compounds, useful as anti-tangle, and conditioning agents for use in personal care, on hair which has been processed. By processes is meant hair which has been subjected to the process of bleaching, relaxing, permanent waving, and/or coloring. These processes make the hair raspy and degrade the properties of the hair. The properties of these novel compounds remediates the damage done to hair and leaves it more manageable and less raspy. The compounds are truly multi-functional, providing softening conditioning, and gloss to treated hair.

Abstract: The present invention relates to a pharmaceutical composition in a unit dosage form for peroral administration in a human or lower animal, having a gastrointestinal tract comprising a small intestine and a colon with a lumen therethrough having an inlet to the colon from the small intestine, comprising:a. a safe and effective amount of rapidly dissolving bisacodyl incorporated into a compressed, bi-convex tablet, with a maximum diameter of about 4 mm to about 10 mm;b. a non-pH dependent smoothing coat applied to the tablet to provide a smooth tablet surface free from edges and sharp curves; andc. an enteric polymer coating material comprising at least one inner coating layer and only one outer coating layer;wherein the rapidly dissolving bisacodyl is released at a point near the inlet to, or within the colon; each of the inner coating layer(s) is an enteric polymer that begins to dissolve in an aqueous media at a pH between about 5 to about 6.

Abstract: The present invention is directed to a method of treating wounds and burns on the skin of a warm-blooded animal which comprises applying to the area of the skin that is injured a medicament containing cocoa butter or partially hydrolyzed cocoa butter.

Abstract: It has been found that by administering secoisolariciresinol ?2,3-bis(3-methyl-4-hydroxybenzyl)butane-1,4-diol! from flaxseed in substantially pure form to a human or non-human animal, lupus nephritis can be controlled. The secoisolariciresinol (Seco) may be used per se or in the form of secoisolariciresinol diglucoside (SDG). Both compounds may be extracted from flaxseed and the SDG converts to Seco in the gut of a human or animal.

Abstract: A sustained release drug delivery composition and a method of making same are provided which comprises microspheres containing a pharmaceutically active agent, a core of a ion-exchange resin and a polymeric coating completely surrounding the core wherein the coating is water-insoluble and hydrolytically stable in physiological environments. The coating is non-erodible in physiological environments and is characterized by a diffusion constant suitable for the pharmaceutical agent to diffuse from the core to an aqueous environment at a predetermined release rate.

Abstract: A water dispersible solid formulation comprising an active ingredient, a surfactant of non-ionic type, a surfactant of anionic type and at least 30 wt % of urea is disclosed. A process of preparing the formulation and the use of the formulation for delivering an active ingredient, for example a pesticide or plant growth regulant to an agricultural or horticultural locus are also described.

Abstract: An agricultural composition, for example, a herbicidal, insecticidal or fungicidal composition, comprising at least a first active pesticidal component, and at least one other active component, the other active component being physico-chemically, chemically, or biologically incompatible with the first pesticidal component. The composition is in the form of a latex dispersion, containing at least one emulsifying surfactant and having a continuous aqueous phase, and at least a first dispersed phase. The first dispersed phase contains particles derived from a latex, and the first pesticidal component is present in the composition substantially wholly within the first dispersed phase. The said other active ingredient is present within the continuous phase, or within a second dispersed phase.

Abstract: A water based solution consisting of extract of the plant Anaphalis magaritacea (Pearly Everlasting) and Prunus (Cherry tree). The solution provides an effective mask of human scent for use by deer hunters. The scent of the solution effectively prevents the deer from detecting the hunter's presence.

Abstract: The invention provides a substantially nonirritating oral composition containing a surfactant system comprised of a combination of an anionic surfactant, an amphoteric surfactant and a nonesterified alkyl polyglucoside surfactant.

Abstract: The present invention is described as a lipid-complexed topoisomerase I inhibitor (TII), for example camptothecin (CPT) preparation that allows for intravenous administration in vivo in clinically relevant lipid:drug ratios. The lipid formulation has in vitro antitumor activity similar to that of the base compound and displays similar cytotoxicity against both MDR-1 negative and positive tumor cells.

Abstract: A method of increasing the effective life of oxygen-delivery agents is described. The method involves administering an oxygen-enriched atmosphere to a subject that has received the oxygen-delivery agent at a predetermined time.

Abstract: A direct compression tablet exhibiting relatively low hardness provides a relatively rapid release of fluoxetine. The tablet has a hardness of no more than about 6 kilopascals and a dicalcium phosphate dihydrate-to-disintegrant weight ratio of about 3 to about 7.

Abstract: A unit dosage form is provided which comprises an effective amount of a radioisotope adsorbed onto activated charcoal, and which is preferably enterically coated. The unit dosage form is useful for the measurement of intestinal transit.

Abstract: Foamable dental fluoride compositions containing a water-soluble fluoride component in an amount sufficient to provide from about 0.5 to about 10% by weight available fluoride are disclosed. The compositions include an oil in water emulsion which is preferably dispensed in combination with an aerosol propellant to provide microcell-stable foam which exhibits enhanced foam retention properties. Methods of treating teeth with fluoride and methods of preparing the foam are also disclosed.

Abstract: The present invention provides a long-lasting hair colourant composition comprising an intimate admixture of a dye with a phsiologically acceptable compatible solid base. The stick has a hardness which is sufficiently high to provide substantial dimensional stability under light to moderate manual pressure under ambient temperatures and sufficiently low to allow easy gliding of the stick over a mass of damp hair and transfer of stick material thereto under light to moderate manual pressure. The stick also contains an effective lathering component and is substantially free of alkaline soap material.

Abstract: A method for forming polymer/drug microparticles comprising the steps of (1) forming a polymer solution/drug mixture comprising a polymer dissolved in an organic solvent and a suspended labile drug; (2) removing the solvent from the polymer solution/drug mixture, thereby forming a solid polymer/drug matrix; and (3) fragmenting the polymer/drug matrix at a temperature below the glass transition temperature of the polymer/drug matrix, thereby forming polymer/drug matrix microparticles.In one embodiment, the solvent is removed from a polymer solution/drug mixture by freezing the polymer solution/drug mixture and extracting the solvent from the resulting solid polymer solution/drug matrix. The polymer can be a biocompatible polymer, such as poly(lactic acid-co-glycolic acid). The drug can be a labile drug, such as a protein, or a polynucleotide. Another embodiment of the present invention includes the polymer/drug matrix microparticles which are formed by the method outlined above.

Abstract: Compounds and pharmaceutical compositions thereof comprise the formula:(R)j-(core moiety),including resolved enantiomers and/or diastereomers, hydrates, salts, solvates and mixtures thereof, wherein J is an integer from one to three, the core moiety is non-cyclic or comprises at least one, five- to seven-membered ring structure, R may be selected from the group consisting of hydrogen, halogen, hydroxyl, amino, substituted or unsubstituted benzyl, alkyl (C.sub.1-6) or alkenyl (C.sub.1-6), and at least one R has the formula I: ##STR1## wherein n is an integer from four to eighteen; each R'.sub.1 and R'.sub.2 is independently hydrogen, alkyl (C.sub.1-4) or alkenyl (C.sub.1-4), the alkyl or alkenyl groups being preferably substituted by a halogen, hydroxyl, ketone or dimethylamino group and/or may be interrupted by an oxygen or hydrogen atom or an alkyl (C.sub.1-4) group; and each R'.sub.3 and R'.sub.4 is independently hydrogen or methyl. Preferably, n is an integer from six to ten, R'.sub.1 and R'.sub.

Abstract: A process for inhibiting the growth of pathogenic bacteria and aiding in periodontal tissue healing within the oral cavity by binding therapeutic agents to surfaces is described. The process includes initial coating of hard surfaces in the oral cavity such as tooth roots, dental restorative materials, dental implants, and guided tissue regeneration surgery barrier membranes with a cationic surfactant, tridodecylmethylammonium chloride, and then binding antibiotics such as tetracycline, metronidazole or with Platelet Derived Growth Factor. These surfaces are thereby made unavailable for bacterial colonization. Tooth roots, barrier membranes and other materials used in regenerative periodontal surgery also may be coated with cationic surfactant to bind local or added platelet derived growth factors.

Abstract: This invention pertains to the vaginal delivery of pharmacologically active agents and to polymeric formulations that allow for a prolonged release of the active agents in the vaginal environment. More specically the invention pertains to compositions for the delivery of drugs intravaginally comprising a drug or a plurality of drugs to be delivered and a thermoplastic graft copolymer, said graft copolymer being the reaction product of a polystyrene macromonomer having an ethylenically unsaturated functional group and at least one hydrophilic monomer having an ethylenically unsaturated functional group.

Abstract: A pharmaceutical tablet composition for oral administration containing pseudoephedrine pellets admixed with a tablet mixture containing a second active drug substance, either alone or in combination with pseudoephedrine or a pharmaceutically acceptable salt thereof, is disclosed. The pellets provide an extended release of pseudoephedrine, whereas the tablet mixture provides an immediate release of the second active drug and any pseudoephedrine.