Abstract: Novel topical formulations an anti-microbially effective amount of povidone iodine and a water-washable emollient, as well as, methods for their preparation, are disclosed.

Abstract: Therapeutic anti-inflammatory and analgesic pharmaceutical compositions containing nimesulide for use transdermally. The pharmaceutical compositions comprise nimesulide, one or more percutaneous enhancers, one or more gelling agent/thickening agents, one or more vehicles/bases and water. The compositions may also contain one or more surfactants and a neutralizing/pH adjusting agent.

Abstract: A solid formulation which comprises polyvinylpyrrolidone and a pyrethroid insecticide, for example alpha-cypermethrin, is disclosed for use in the treatment of animals, for example cattle. Also disclosed are uses of the solid formulation and methods which use the solid formulation in the treatment of animals.

Abstract: A water dispersible solid formulation comprising an active ingredient, a surfactant of non-ionic type, a surfactant of anionic type and at least 30 wt % of urea is disclosed. A process of preparing the formulation and the use of the formulation for delivering an active ingredient, for example a pesticide or plant growth regulant to an agricultural or horticultural locus are also described.

Abstract: A tooth surface treating agent is provided which comprises a polymerization catalyst and an acidic compound, both water-soluble, the treating agent being capable of enhancing tooth adhesion. The tooth surface treating agent imparts strong adhesion to the enamel and dentin of teeth through simultaneous treatment thereof. The invention is mainly intended for use in the field of dentistry, but is also applicable as a treating agent for vital hard tissues in such fields as surgery, and orthopaedic or plastic surgery.

Abstract: There is disclosed an insect growth regulator composition comprising (a) an insect growth-regulating active ingredient and, if necessary, another insecticidal active ingredient, (b) an organic substance having a solubility of not greater than 2% in water at 20.degree. C. and a melting point of 35.degree. through 100.degree. C., and (c) a glycol selected from the group having a melting point of 35.degree. through 100.degree. C. and consisting of polyethylene glycol, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxybutylene glycol, and polyoxyethylene polyoxypropylene polyoxybutylene glycol, wherein the weight of the constituent (b) is equal to or greater than 3% based on the total weight, and a sum of the weight of the constituent (b) and the weight of the constituent (c) ranges from 20 to 98% based on the total weight, the constituent (b) and the constituent (c) being molten and then cooled to be solidified in manufacturing process of the insect growth regulator composition.

Abstract: The invention relates to a special process for the preparation of stable, solid medicament formulations of high bioavailability and with controlled release comprising sparingly soluble active compounds and polymeric auxiliaries, and to the formulations thus prepared.

Abstract: A hydromorphone composition, a hydromorphone dosage form and a method for administering hydromorphone are disclosed, indicated for the management of pain.

Abstract: A liquid composition comprising a transforming growth factor .beta.(TGF-/.beta. in a polyoxyalkylene block copolymer--containing liquid carrier which gels at about 37 C, promotes osseointegration of an implant in bone, when introduced into a bore in the bone, prior to the insertion of the implant in the bone.

Abstract: A processed product for hair and skin treatment, having binary and tertiary fluid phase levels prior to remixing and therapeutic use is disclosed. The invention discloses defined amounts of admixed components including an Iodine complex having tincture of iodine solution and povidone-iodine compound, a diluting fluid complex having a water and mineral oil constituent, and a cod liver oil component, which, after admixing, are ambiently exposed to a photon-light-energy component from sunlight or substantially equivalent artificial light to produce a processed product having at least binary product reaction fluid levels and containing a nucleophically iodinated cod liver oil compound.

Abstract: The present invention provides a novel antimicrobial polymer composition having superior weatherability and discoloration resistance to those of the prior art.The present invention provides an antimicrobial polymer composition comprising a polymer and an antimicrobial composition having an antimicrobial coat of an aluminosilicate on the surface of silica gel, wherein said aluminosilicate containing antimicrobial metal ions, characterized in that said antimicrobial polymer composition further comprises thiabendazole.

Abstract: Cholestyramine and starch containing, oil-free compositions with excellent organoleptic features are obtained by mixing cholestyramine and grain starch in a weight ratio of 1:1.8 to 2.9 with the addition of grain bran as a filler and optionally an aroma stuff with 10 to 35% by weight of water (calc. on the starting materials) into a homogenous moist mass, forming of the mass through extrusion into a string, whereby the temperature is 105.degree.-180.degree. C. (measured in the mass in the extrusion head) and the pressure is 30-70 bars (measured in the extrusion head), and subsequently drying at a temperature above 100.degree. C. to a remaining humidity of .ltoreq.3.5% by weight, whereby the extruded material before or after the drying is divided into bars or is grinded into a powder.

Abstract: Affinity bound collagen matrices for the delivery of biologically active agents, and methods for preparing such matrices, are disclosed. A preferred method for preparing the matrices of the invention comprises mixing a binding ligand and an active agent together, allowing the resulting binding ligand-active agent mixture to form an affinity bound complex, then combining the resulting affinity bound complex with collagen to form a matrix. Particular affinity bound matrices comprising collagen, heparin, and an active agent are also disclosed, as well as methods for using the matrices of the invention for delivery of biologically active agents.

Abstract: Novel acetylsalicylic acid derivatives having general formula (I) are provided, in which R.sup.1 is hydrogen or methyl; R.sup.2 is --O-- or --NH--; and W is hydroxy, halogen, lower alkoxy, lower alkenyloxy, lower alkynyloxy, cycloalkyloxy, aryloxy, aralkyloxy, acyloxy, or --N(R.sup.3)(R.sup.4) wherein the lower alkoxy, the lower alkenyloxy, the lower alkynyloxy, the cycloalkyloxy, the aryloxy, the aralkyloxy, and the acyloxy are optionally substituted with hydroxy, carboxyl, lower alkoxy, lower alkyl, halogen, nitro, and amino. The invention also pertains to a polymer made from such derivatives and a medical equipment containing the polymer. The polymer is useful in the prevention of platelet aggregation thereon.

Abstract: Described are preferred methods for promoting interfacial bonding between surfaces containing oxide, hydrous oxide or hydroxyl groups. The methods involve attaching silane coupling agents to the opposed surfaces and, in turn, bonding the opposed silane coupling agents to each other to thereby promote interfacial bonding between the surfaces. Also described are preferred compositions for promoting such interfacial bonding.

Abstract: The present invention provides a teeth-coating liquid comprising a color pigment represented by titanium oxide and a pearl pigment or an extender pigment represented by tricalcium phosphate, dispersed singly or in combination thereof in an alcohol series solvent, mainly ethanol with an N-methacryloylethyl-N,N-dimethylammonium..alpha.-N-methylcarboxybetaine.bu tyl methacrylate copolymer, and an applicator for the coating liquid described above.This teeth-coating liquid provides excellent dispersion stability, gloss, coating property and sticking performance by using the N-methacryloylethyl-N,N-dimethylammonium..alpha.-N-methylcarboxybetaine.bu tyl methacrylate copolymer singly or in combination with a shellac and a vinyl acetate resin.

Abstract: A polymeric composition capable of releasing nitric oxide comprises a polysaccharide including a nitric oxide-releasing N.sub.2 O.sub.2.sup.- functional group bound to the polymer; pharmaceutical compositions including the polymeric composition; and methods for treating biological disorders in which dosage with nitric oxide is beneficial. The compositions can be used as and/or incorporated into implants, injectables, condoms, prosthesis coatings, patches, and the like for use in a wide variety of medical applications.

Abstract: Methods for producing solutions of polybenzoxazol precursors that are soluble in alkali and resist solutions based on such precursors. A dicarboxylic acid halogenide is reacted with a bis-(o-aminophenol) in an organic solvent and in the presence of a polymer with a tertiary N atom, which is insoluble in the solvent. Excess polymer and hydrohalogenide are separated from the reaction solution. The reaction solution is optionally mixed with a photoactive component.

Abstract: Solutions of polyether polyurethane with benzoin gum in tetrahydrafuran applied to animal skin provide dry films that are elastic, vapor permeable, water proof, dirt proof, insect proof, aerobic bacteriostatic and adhere well under environmental conditions. Apparent application viscosity can be adjusted as required for specific needs.

Abstract: A method of treating canker sores is disclosed by which a fluoroquinolone is topically applied to the ulcerous area. The fluoroquinolone is shown to be applied in solution form, and also as a paste, ointment, or gel. The fluoroquinolone is preferably applied three to eight times a day until the lesion disappears.