Patents Examined by Phuong Huynh
  • Patent number: 10723791
    Abstract: The present invention relates to isolated monoclonal antibodies (mAbs) and/or antigen-binding fragments thereof that specifically recognize indoxyl sulfate, a protein-bound uremic toxin, isolated polynucleotide segment encoding the isolated antibodies and/or antigen-binding fragments thereof, and uses of such isolated anti-IS mAbs and/or antigen-binding fragments thereof to create immunoassay methods, device compositions, and pharmaceutical compositions applied in theragnosis of IS-related diseases.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: July 28, 2020
    Inventors: Yung-Chun Chuang, Yu-Wei Cheng, Chih-Hui Kao
  • Patent number: 10712375
    Abstract: In order to solve the above-described problem, there is provided a data processing device (1) including a measurement data acquisition unit (10) that acquires measurement data indicating a temporal change in at least one of current consumption and power consumption of an electrical apparatus, a fluctuation component extraction unit (20) that extracts a fluctuation component related to fluctuation in the current consumption and a fluctuation component related to fluctuation in the power consumption from the measurement data, and a feature value acquisition unit (30) that acquires a feature value of the fluctuation component.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: July 14, 2020
    Inventors: Takahiro Toizumi, Eisuke Saneyoshi, Ryota Suzuki, Shigeru Koumoto
  • Patent number: 10710568
    Abstract: An apparatus is described that receives a brake control signal from the brake controller of a tow vehicle, and displays characteristics of that brake control signal including commanded brake force. The apparatus includes a data processor, brake simulation circuitry, brake integration circuitry, and display circuitry. The brake simulation circuitry sequentially applies several parallel resistors to the brake control signal in response to commands received from the data processor. These parallel resistors cause the load current on the brake controller to ramp up, mimicking the electrical signature of electric trailer brakes. At the same time, the brake integration circuitry integrates the brake control signal. Lastly, the display circuitry displays an indication of a value of the integrated brake control signal.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: July 14, 2020
    Inventors: Ian R. Vinci, Peter Vinci
  • Patent number: 10704989
    Abstract: A method of monitoring a gas turbine engine includes the steps of: (a) receiving information from actual flights of an aircraft including an engine to be monitored, and including at least one of the ambient temperature at takeoff, and internal engine pressures, temperatures and speeds; (b) evaluating the damage accumulated on an engine component given the data received in step (a); (c) storing the determined damage from step (b); (d) repeating steps (a)-(c); (e) recommending a suggested future use for the component based upon steps (a)-(d). A system is also disclosed.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: July 7, 2020
    Assignee: Raytheon Technologies Corporation
    Inventors: Frederick M. Schwarz, Marnie A. Rizo, David P. Houston, David M. Nissley, Paul J. Hiester, Timothy Dale, Timothy B. Winfield, Madeline Campbell, James R. Midgley
  • Patent number: 10705095
    Abstract: The invention relates to methods and products for the identification of a clinically significant immune response in subjects treated with a therapeutic protein. Aspects of the invention relate to methods and compositions for identifying a clinically significant immune response in patients treated with therapeutic amounts of a VLA4 binding antibody (e.g., natalizumab).
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: July 7, 2020
    Assignee: BIOGEN MA INC.
    Inventors: Meena Subramanyam, Lakshmi Amaravadi, Eric Wakshull, Frances Lynn, Michael Panzara, Robin McDaid Barbour, Julie Elizabeth Taylor
  • Patent number: 10703824
    Abstract: The present disclosure provides antibodies and antigen-binding fragments capable of penetrating cells via an ENT transporter, such as humanized antibodies. The disclosure also provides conjugates comprising the antibodies or antigen-binding fragments and a heterologous agent. The disclosure further provides methods for making and using the antibodies, antigen-binding fragments and conjugates, including humanized antibodies.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: July 7, 2020
    Assignee: Valerion Therapeutics, LLC
    Inventors: Dustin D. Armstrong, Jeffrey C. Way
  • Patent number: 10702543
    Abstract: Provided herein are conjugate molecules containing a substrate for a nucleoside transport pathway linked to an active agent, wherein the conjugate can be transported into a cell or into the nucleus of a cell via a cellular nucleoside transport pathway. Further provided are methods of delivering a conjugate molecule to a target cell expressing a nucleoside transport pathway, wherein the conjugate contains a substrate for the nucleoside transport pathway linked to an active agent. Also provided are methods for screening for conjugates that are transported by nucleoside transport pathways. Further provided are methods of treating a patient having a disease or disorder affecting tissues expressing nucleoside transport pathways, in which a conjugate containing an agent effective in treating the disorder is administered to the patient. Also provided are methods of treating a patient having an autoimmune disorder involving administering to the patient a compound that inhibits a nucleoside transport pathway.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: July 7, 2020
    Assignee: The United States Government as Represented by the Department of Veterans Affairs
    Inventor: Richard H. Weisbart
  • Patent number: 10691116
    Abstract: An intelligent processing modulation system comprises: a detector detecting the condition of the processing equipment before the process for processing a raw material into a product begins; a data storage recording the information of the product; a basic database storing the information of the detector and the data storage corresponding to the product and the condition of the product for each time the process is completed; a mode database receiving the information of the detector, the data storage and the basic database and setting up the processing model; a processing equipment operating according to the parameters of the processing model received by the processing information manager; a processing information manager modifying the processing model promptly according to the result of the product in order to improve the yield rate of the product.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: June 23, 2020
    Inventor: Chi-Hung Lin
  • Patent number: 10689423
    Abstract: Provided herein are recombinant CTLA-4 binding proteins, which are, inter alia, useful for the treatment of cancer. The recombinant proteins provided herein are, inter alia, capable of binding CTLA-4 proteins on a tumor cell. In a first aspect, there is provided a recombinant CTLA-4 binding protein including (i) a CTLA-4 binding domain; (ii) a CTLA-4 binding domain masking peptide; and (iii) a cleavable peptide linker connecting the CTLA-4 binding domain masking peptide to the CTLA-4 binding domain. In another aspect, there is provided a dimerizing domain covalently attached to the CTLA-4 binding domain, wherein the binding protein domains are bound together.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: June 23, 2020
    Assignees: City of Hope, Thomas Jefferson University and Health System Innovation Pillar
    Inventors: John Williams, Ulrich Rodeck
  • Patent number: 10690795
    Abstract: This disclosure is directed to utility locating systems, devices, and methods using frequency suites of simultaneously processed signals emitted from buried utilities to locate the buried utilities or other hidden or buried conductors.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: June 23, 2020
    Assignee: SEESCAN, INC
    Inventors: Mark S. Olsson, Stephanie M. Bench, Michael J. Martin, Ray Merewether, Paul Wisecaver, Austin Rutledge
  • Patent number: 10683345
    Abstract: The present invention relates to bispecific antibody against human vascular endothelial growth factor (VEGF/VEGF-A) and against human angiopoietin-2 (ANG-2) of human IgG1 or IgG4 subclass with mutations I253A, H310A, and H435A, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: June 16, 2020
    Assignee: Roche Glycart AG
    Inventors: Harald Duerr, Frank Herting, Christian Klein, Joerg Thomas Regula, Matthias Rueth, Kay-Gunnar Stubenrauch
  • Patent number: 10685322
    Abstract: The system includes an apparatus which automatically measures an inventory of a consumable good and tracks the inventory as it is used. The system may include a signaling device which creates a signal when a defined minimum amount of the consumable good has been reached. The apparatus may also send the user an electronic message that the defined minimum has been reached. The system may then automatically submit an order to a supplier for a replacement supply of the consumable good. This system may be used to track supply and reorder animal food, food staples, production supplies, manufacturing parts, or virtually any consumable good. Accordingly, a user may avoid the inconvenience and loss of time and money due to failure to timely replace a consumable good.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: June 16, 2020
    Assignee: Hall Labs LLC
    Inventors: David R. Hall, Ben Swenson, Jared Eggett, Hugo Tapia
  • Patent number: 10685408
    Abstract: A device includes an image data receiving component, a vegetation index generation component, a crop data receiving component, a masking component and a multivariate regression component. The image data receiving component receives image data of a geographic region. The vegetation index generation component generates an array of vegetation indices based on the received image data, and includes a plurality of vegetation index generating components, each operable to generate a respective individual vegetation index based on the received image data. The crop data receiving component receives crop data associated with the geographic region. The masking component generates a masked vegetation index based on the array of vegetation indices and the received crop data. The multivariate regression component generates a crop parameter based on the masked vegetation index.
    Type: Grant
    Filed: September 5, 2015
    Date of Patent: June 16, 2020
    Assignee: OmniEarth, Inc.
    Inventors: David Murr, Shadrian Strong, Kristin Lavigne, Lars P Dyrud, Jonathan T Fentzke
  • Patent number: 10675352
    Abstract: Extracellular drug conjugates (EDCs) targeting CD38 are useful in the treatment of diseases such as cancer and immune disorders, including asthma.
    Type: Grant
    Filed: February 17, 2015
    Date of Patent: June 9, 2020
    Assignee: Centrose, LLC
    Inventor: James R. Prudent
  • Patent number: 10675579
    Abstract: A method for predicting the residual useful life of an air filter arrangement is described. The method includes the following steps: providing a plurality of predetermined reference degradation curves; measuring a degradation parameter of the filter arrangement; and estimating the residual useful life of the filter arrangement by comparing the predetermined reference degradation curves and an actual degradation curve defined by measured values of the degradation parameter.
    Type: Grant
    Filed: November 26, 2015
    Date of Patent: June 9, 2020
    Inventors: Carmine Allegorico, Claudio Antonini, Marco Santini, Giorgio Marchetti
  • Patent number: 10675359
    Abstract: The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: June 9, 2020
    Assignees: Innate Pharma, Paul Scherrer Institut
    Inventors: Patrick Dennler, Delphine Bregeon, Laurent Gauthier, François Romagné, Christian Belmant, Eliane Fischer, Roger Schibli
  • Patent number: 10677907
    Abstract: A method to determine the heading or orientation of a target vehicle by a host vehicle, said host vehicle equipped with a lidar or radar system, said system including a sensor unit adapted to receive signals emitted from said host vehicle and reflected by said target vehicle, comprising: a) determining at least one reference angle being an initial estimate of target heading or orientation (?); b) emitting a signal from said system and determining a plurality of point radar or lidar detections belonging to said a target vehicle, said point detections having co-ordinates in the horizontal plane; c) formulating an initial rectangular boundary box from said point detections, where the bounding box is formulated such that such that two edges of the boundary box are drawn parallel to the reference angle and two sides are perpendicular to the reference angle and such that all the detections are either on the bounding box sides or lay within the bounding box and each edge has at least one detection point on it; d) fo
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: June 9, 2020
    Assignee: Aptiv Technologies Limited
    Inventors: Mateusz Orlowski, Dariusz Cieslar, Mateusz Stachnik
  • Patent number: 10669347
    Abstract: Provided herein are antibodies comprising non-natural amino acid residues at site-specific positions, compositions comprising the antibodies, methods of their production and methods of their use. The antibodies are useful for methods of treatment and prevention, methods of detection and methods of diagnosis.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: June 2, 2020
    Inventors: Christopher D. Thanos, Leslie McEvoy, Gang Yin, Kalyani Penta, Ramesh Baliga, Sunil Bajad, Sonia Pollitt, Chris Murray, Alex Steiner, Avinash Gill
  • Patent number: 10670498
    Abstract: A risk assessment device includes a parameter storage unit that calculates, based on data for calculation, one or more parameters for calculating a target malfunction curve and stores the calculated parameters, the parameters relating to piping system-related items, the data for calculation being stored in a storage unit in which the piping system-related items and a number of years passed before malfunction are stored as the data for calculation with respect to each of a plurality of process devices; a calculation condition acquisition unit that acquires the piping system-related items with respect to a target process device; a parameter acquisition unit that acquires a calculation parameter for obtaining the target malfunction curve based on the piping system-related items acquired with respect to the target process device and the stored parameters; and a malfunction curve calculation unit that calculates the target malfunction curve based on the calculation parameter.
    Type: Grant
    Filed: February 14, 2018
    Date of Patent: June 2, 2020
    Assignee: TLV Co., Ltd.
    Inventors: Tetsuya Mita, Guoxian Hou
  • Patent number: 10662254
    Abstract: The instant disclosure provides antibody fragments (e.g., Fab and F(ab?)2) having reduced or no reactivity towards pre-existing anti-hinge antibodies (AHA) and compositions comprising such antibody fragments, as well as methods of making and using such antibody fragments and compositions.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: May 26, 2020
    Assignee: Genentech, Inc.
    Inventors: Yu-Ju G. Meng, Hok Seon Kim, Ingrid Kim, Christoph Spiess