Patents Examined by Phuong Huynh
  • Patent number: 11905042
    Abstract: A signal associated with a motor is obtained where the motor is included in a aircraft that has flight capabilities. A motor wear metric that represents an amount of wear experienced by the motor is determined based at least in part on the signal. It is determined, at a flight computer that is included in the aircraft, whether to restrict the flight capabilities of the aircraft based at least in part on the motor wear metric. The flight capabilities of the aircraft are restricted in the event it is so determined.
    Type: Grant
    Filed: July 15, 2021
    Date of Patent: February 20, 2024
    Assignee: Kitty Hawk Corporation
    Inventors: Dennis Young Kwon, Alexander David Selwa
  • Patent number: 11899439
    Abstract: A method includes acquiring data indicating a plurality of sensor detection values arranged in order along a specific variable axis, detecting, in the data, a plurality of change points that are data points at which the sensor detection value on the specific variable axis changes by a predetermined value or more, and calculating, for a target change point that is one change point among the plurality of change points, an index value representing a degree of abnormality using the target change point and a reference change point that is another change point.
    Type: Grant
    Filed: April 11, 2022
    Date of Patent: February 13, 2024
    Inventor: Shinji Magara
  • Patent number: 11892828
    Abstract: Personal dependency related to fault tree construction is reduced, and the reliability of an operating machine is improved by improving the accuracy of a fault diagnosis.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: February 6, 2024
    Assignee: Hitachi, Ltd.
    Inventors: Yohei Tanno, Yuuki Shimizu
  • Patent number: 11891434
    Abstract: An objective of the present invention is to provide methods for promoting antigen uptake into cells by antigen-binding molecules, methods for increasing the number of times of antigen binding by one antigen-binding molecule, methods for promoting reduction of the antigen concentration in plasma by administering antigen-binding molecules, and methods for improving the plasma retention of an antigen-binding molecule, as well as antigen-binding molecules that allow enhanced antigen uptake into cells, antigen-binding molecules having an increased number of times of antigen binding, antigen-binding molecules that can promote reduction of the antigen concentration in plasma when administered, antigen-binding molecules with improved plasma retention, pharmaceutical compositions comprising the above antigen-binding molecules, and methods for producing them. The present inventors revealed that the above objective can be achieved by using antigen-binding molecules that show calcium-dependent antigen-antibody reaction.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: February 6, 2024
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tomoyuki Igawa, Shinya Ishii, Miho Funaki, Naoka Hironiwa, Atsuhiko Maeda, Junichi Nezu, Yoshinao Ruike, Takeshi Baba, Shun Shimizu
  • Patent number: 11885720
    Abstract: A time series data processing apparatus according to the present invention includes an extracting unit configured to extract, from normal period time series data that is time series data of a period during which a measurement target is determined to be in a normal state of time series data including a plurality of parameters based on data measured from the measurement target, a combination of the plurality of parameters in which a value of another parameter with respect to a value of a predetermined parameter is maximum among combinations of the plurality of parameters, as a normal period maximum value.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: January 30, 2024
    Inventor: Naoki Yoshinaga
  • Patent number: 11885721
    Abstract: An abnormality determination method includes: a first distance calculation step of calculating, based on measurement data of an object, a first Mahalanobis distance in a first unit space corresponding to a normal mode of the object; a second distance calculation step of calculating, based on the measurement data, an (i+1)-th Mahalanobis distance in an (i+1)-th unit space corresponding to an i-th abnormal mode of the object for each integer i greater than or equal to 1 and less than or equal to N, N being an integer greater than or equal to 2; and an abnormality determination step of determining, based on the second to (N+1)-th Mahalanobis distances, one of the first to N-th abnormal modes where the object is when the first Mahalanobis distance exceeds a threshold value.
    Type: Grant
    Filed: March 28, 2022
    Date of Patent: January 30, 2024
    Inventor: Kenta Sato
  • Patent number: 11885719
    Abstract: Provided is a measurement data recording apparatus including: an acquisition portion configured to acquire time-series measurement data obtained by measuring a state of a target; a recording portion configured to record the acquired measurement data; a measurement data transmission portion configured to transmit the measurement data recorded in the recording portion to a generation apparatus configured to generate a determination model for determining a quality of the state of the target; a model reception portion configured to receive the determination model generated by the generation apparatus; and a determination portion configured to determine the quality of the state of the target from newly acquired measurement data using the received determination model.
    Type: Grant
    Filed: February 23, 2022
    Date of Patent: January 30, 2024
    Assignee: Yokogawa Electric Corporation
    Inventor: Jun Tsuduki
  • Patent number: 11879760
    Abstract: A meter electronics (20) for determining a decay characteristic of a meter assembly (10) of a flow meter (5) is provided. The meter electronics (20) includes an interface (201) for receiving a vibrational response from a meter assembly (10), the vibrational response comprising a response to an excitation of the meter assembly (10) at a substantially resonant frequency, and a processing system (203) in communication with the interface (201). The processing system (203) is configured to receive the vibrational response from the interface (201), determine a response voltage (V) of the vibrational response, determine a decay characteristic (?) of the meter assembly (10) based on the response voltage (V), and compensate the decay characteristic (?) by using a previously determined decay characteristic-to-response voltage relationship.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: January 23, 2024
    Assignee: MICRO MOTION, INC.
    Inventors: Craig B. McAnally, Bert J. Downing
  • Patent number: 11879004
    Abstract: Engineered antibodies that are stable and can be conjugated to a ligand or drug at a ligand/drug to antibody ratio of above 3, making these conjugates suitable for treatment of a variety of indications, are provided. Methods of producing these engineered antibodies are also provided.
    Type: Grant
    Filed: February 26, 2021
    Date of Patent: January 23, 2024
    Inventors: Qun Zhou, Sunghae Park, Huawei Qiu, Marie-Priscille Brun, Francis Duffieux
  • Patent number: 11880011
    Abstract: The present method predicts and separates dispersive surface waves from seismic data using dispersion estimation and is completely data-driven and computer automated and no human intervention is needed. The method is capable of predicting and suppressing surface waves from recorded seismic data without damaging the reflections. Nonlinear signal comparison (NLSC) is used to obtain a high resolution and accurate dispersion. Based on the dispersion, surface waves are predicted from the field recorded seismic data. The predicted surface waves are then subtracted from the original data.
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: January 23, 2024
    Inventors: Yingcai Zheng, Hao Hu
  • Patent number: 11878063
    Abstract: Described herein are engineered ligand that binds a cell surface receptor (e.g., GPCR), with improved affinity, potency, and specificity. By conjugating a sub-optimal ligand for a cell surface receptor (e.g., GPCR) to a targeting molecule that binds an epitope (natural or exogenous epitope) in the extracellular portion of the cell surface receptor (e.g., GPCR), the affinity, potency, and/or specificity of the sub-optimal ligand is enhanced.
    Type: Grant
    Filed: March 5, 2020
    Date of Patent: January 23, 2024
    Assignees: Children's Medical Center Corporation, The General Hospital Corporation
    Inventors: Ross Cheloha, Hidde L. Ploegh, Thomas J. Gardella
  • Patent number: 11867594
    Abstract: An evaluation method and an evaluation device for evaluating a health state of well site equipment, and a storage medium are provided. The evaluation method for evaluating the health state of the well site equipment includes: obtaining operating parameters of a component to be tested of equipment to be tested in at least one dimension, the at least one dimension including an operating data dimension, an environmental data dimension, and a maintenance data dimension; obtaining evaluation values of a health state of the component to be tested in various dimensions based on the operating parameters of the various dimensions; obtaining a comprehensive evaluation value of the health state of the component to be tested based on the evaluation values of the health state of the component to be tested in the various dimensions.
    Type: Grant
    Filed: May 18, 2022
    Date of Patent: January 9, 2024
    Inventors: Kaishen Liu, Yuanjie Xie, Shouzhe Li, Zhuqing Mao, Hao Yang, Weiwei Liu, Kai Wang, Shuzhen Cui
  • Patent number: 11868431
    Abstract: According to one embodiment, an information processing apparatus includes: a processor configured to select a first case based on subject data including at least one feature, and acquire a first prediction value that is a value of an objective variable included in the first case; a first estimator configured to estimate frequency data indicating frequencies of observation values of the objective variable, based on a history of observation values of the objective variable; a second estimator configured to estimate first frequency data indicating frequencies of first prediction values, based on a history of first prediction values acquired before the first prediction value is acquired; and a corrector configured to correct the first prediction value acquired by the processor, based on the frequency data and the first frequency data.
    Type: Grant
    Filed: March 10, 2021
    Date of Patent: January 9, 2024
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Mitsuru Kakimoto, Hiromasa Shin, Yoshiaki Shiga, Fang Ni
  • Patent number: 11858991
    Abstract: The present invention is directed to the anti-LAG-3 antibodies: LAG-3 mAb 1, LAG-3 mAb 2, LAG-3 mAb 4, LAG-3 mAb 5, and LAG-3 mAb 6, and to humanized and chimeric versions of such antibodies. The invention additionally pertains to LAG-3-binding molecules that comprise LAG-3 binding fragments of such anti-LAG-3 antibodies, immunoconjugates, and to bispecific molecules, including diabodies, BiTEs, bispecific antibodies, etc., that comprise (i) such LAG-3-binding fragments, and (ii) a domain capable of binding an epitope of a molecule involved in regulating an immune check point present on the surface of an immune cell. The present invention also pertains to methods of detecting LAG-3, as well as methods of using molecules that bind LAG-3 for stimulating immune responses.
    Type: Grant
    Filed: January 12, 2021
    Date of Patent: January 2, 2024
    Assignee: MacroGenics, Inc.
    Inventors: Ross La Motte-Mohs, Kalpana Shah, Douglas H. Smith, Leslie S. Johnson, Paul A. Moore, Ezio Bonvini, Scott Koenig
  • Patent number: 11851489
    Abstract: The present invention provides a protein complex comprising heterodimerizing regions HRI and HRII, each comprised of antiparallel ?-strands and intervening regions wherein HRI and HRII are each interspersed fusion proteins of two human constant regions of an immunoglobulin or immunoglobulin-like proteins. The present invention also provides nucleic acid molecules comprising a sequence encoding said protein complexes and vectors comprising the nucleic acid. The present invention also provides the protein complex, the nucleic acid and the vector for use as a medicament. The present invention further provides a method of determining the amino acid sequence of HRI and/or of the amino acid sequence of HRII. The present invention also provides a method of producing amino acid chains of HRI and/or amino acid chains of HRII. The present invention further provides the protein complex for use in the N prophylaxis, treatment or diagnosis of a disorder or a disease.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: December 26, 2023
    Inventors: Fabian Richter, Oliver Seifert, Roland Kontermann
  • Patent number: 11845795
    Abstract: Multispecific proteins that bind and specifically redirect NK cells to lyse a target cell of interest are provided without non-specific activation of NK cells in absence of target cells. The proteins have utility in the treatment of disease, notably cancer or infectious disease.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: December 19, 2023
    Assignee: INNATE PHARMA
    Inventors: Laurent Gauthier, Nadia Anceriz, Ariane Morel, Benjamin Rossi
  • Patent number: 11844839
    Abstract: The present invention provides improved processes for the preparation of auristatin drug-linkers with a PEG unit, as well as intermediates thereof.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: December 19, 2023
    Assignee: Seagen Inc.
    Inventors: Yunyu Mao, Philip Moquist, Anusuya Choudhury, Wendel Doubleday
  • Patent number: 11840569
    Abstract: Polypeptides are provided that bind CD123 on a target cell and the constant domain of TCR on a T cell. The polypeptides can be used in methods for treatment of CD123 associated cancers or inflammatory conditions.
    Type: Grant
    Filed: November 16, 2017
    Date of Patent: December 12, 2023
    Assignee: Ablynx N.V.
    Inventors: Diane Van Hoorick, Annelies Roobrouck, Catelijne Stortelers, João Vieira, Edward McGowan
  • Patent number: 11841295
    Abstract: Various embodiments described herein relate to an anomaly detection framework adaptable to different asset types. In this regard, a data stream associated with a first asset is received. The data stream is then processed to generate output data by encoding the data stream based on historical data associated with the first asset, the historical data comprising clustered data representative of fault states and one or more non-fault states. Furthermore, in accordance with a determination that the generated output data is indicative of a potential fault of the first asset, fault data indicative of the potential fault is generated and caused to be transmitted to an administrative device for display.
    Type: Grant
    Filed: November 15, 2021
    Date of Patent: December 12, 2023
    Assignee: Honeywell International Inc.
    Inventors: Vijay Kumar Ravi, Jan Zirnstein, Amit Pandey, Milad Makkie
  • Patent number: 11841753
    Abstract: An operating temperature of a memory sub-system is identified. It is determined whether the operating temperature satisfies a first temperature condition associated with a threshold temperature. Upon determining that the operating temperature satisfies the first temperature condition, one or more operations are performed on at least one data block at a memory component of the memory sub-system until the operating temperature changes to satisfy a second temperature condition associated with the threshold temperature. The one or more operations are selected to be performed based on a difference between the operating temperature and the threshold temperature.
    Type: Grant
    Filed: September 3, 2021
    Date of Patent: December 12, 2023
    Inventors: Shane Nowell, Sivagnanam Parthasarathy