Patents Examined by Phuong Huynh
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Patent number: 12214050Abstract: Provided herein are conjugated immunoglobulins and methods for generating conjugated immunoglobulins using a microbial transglutaminase.Type: GrantFiled: August 20, 2021Date of Patent: February 4, 2025Assignee: Eisai R&D Management Co., Ltd.Inventors: Jared Spidel, Earl Albone
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Patent number: 12209138Abstract: Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies, and therapeutic and diagnostic methods for using the disclosed antibodies.Type: GrantFiled: August 31, 2022Date of Patent: January 28, 2025Assignee: Takeda Pharmaceutical Company LimitedInventors: Kathleen Ann Elias, Gregory Landes, Shweta Singh, Wouter Korver, Andrew Walling Drake, Mary Haak-Frendscho, Gyorgy Pal Snell, Vinay Bhaskar
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Patent number: 12209109Abstract: The present invention provides a method for preparing a composition comprising highly concentrated antibodies by ultrafiltration in batch concentration mode having a first constant feed rate step and a second controlled feed rate step.Type: GrantFiled: February 5, 2020Date of Patent: January 28, 2025Assignees: Chugai Seiyaku Kabushiki Kaisha, Genentech, Inc.Inventors: Kelby Lau, Jean Bender, Saeko Tanaka, Rumiko Wakayama, Hidenari Yamada, Tomonori Isoda, Masayoshi Oh-Eda
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Patent number: 12208091Abstract: The present invention relates to compounds for treatment of a disease or disorder associated with excessive vascularisation of the eye, such as for instance corneal neovascularisation, neovascularisation of the iris, neovascularisation of the ciliary body, corneal pannus, choroidal neovascularisation, retinal neovascularisation, wet age-related macular degeneration, proliferative diabetic retinopathy, retinopathy of prematurity, and ischemic retinopathy.Type: GrantFiled: September 7, 2022Date of Patent: January 28, 2025Assignee: Active Biotech ABInventors: Helena Eriksson, Joel Kaye, Marie Törngren
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Patent number: 12188343Abstract: A sensor device can be used to detect the presence of a cement composition in a reverse cementing operation. The sensor device can include a resistivity sensor, an acquisition and measurement apparatus, and an actuator. The actual derivative of resistivity of the drilling mud, spacer fluid, and cement composition to be used can be pre-determined. The acquisition and measurement apparatus can be pre-programmed with a slope change derivative of resistivity profile for the fluids. The resistivity sensor can measure the resistivity of the fluids as they flow past the resistivity sensor in the wellbore. When the acquisition and measurement apparatus receives a desired slope change reading within the slope change derivative of resistivity profile, instructions can be sent to the actuator to close a valve and block fluid flow through the casing or tubing string.Type: GrantFiled: July 27, 2022Date of Patent: January 7, 2025Assignee: Halliburton Energy Services, Inc.Inventors: Hector Jesus Elizondo, Ritesh Dharmendra Panchal, Jinhua Cao, Ishwar Patil, Paul J Jones
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Patent number: 12190647Abstract: Techniques regarding determining the operating condition of one or more mechanical parts are provided. For example, one or more embodiments described herein can comprise a system, which can comprise a memory that can store computer executable components. The system can also comprise a processor, operably coupled to the memory, and that can execute the computer executable components stored in the memory. The computer executable components can comprise a status component that can update a predictive failure algorithm by altering a vibration threshold based on a measured temperature of a mechanical part. Also, the vibration threshold can characterize an amount of vibration associated with a standard operating condition of the mechanical part.Type: GrantFiled: August 22, 2023Date of Patent: January 7, 2025Assignee: TPS IP, LLCInventors: Zachary A. Griffa, John Nathaniel Olson
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Patent number: 12187809Abstract: The invention relates to proximity-based sortase-mediated protein purification and ligation. Specifically, the invention relates to techniques that links protein expression/purification with conjugation to therapeutic agents, imaging agents, or linkers.Type: GrantFiled: January 28, 2022Date of Patent: January 7, 2025Assignee: The Trustees of the University of PennsylvaniaInventors: Andrew Tsourkas, Burcin Altun, Hejia Henry Wang, Feifan Yu
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Patent number: 12181529Abstract: A learning apparatus is provided, which comprises: a characteristic acquisition unit for acquiring one of a voltage and a capacity of a storage battery and a characteristic corresponding to a capacity change and a voltage change of the storage battery under a plurality of conditions during at least one of charging and discharging of the storage battery; and a learning unit for learning a relationship between one of the voltage and the capacity of the storage battery and the characteristic under each of the plurality of conditions to generate an estimation model for estimating at least one of a maximum capacity and a remaining capacity of the storage battery from one of the voltage and the capacity of the storage battery and the characteristic.Type: GrantFiled: June 28, 2021Date of Patent: December 31, 2024Assignee: Yokogawa Electric CorporationInventor: Soichiro Torai
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Patent number: 12182210Abstract: System and method for providing electric utilities and utility benchmarking organizations with an integrated real-time outage analytics and benchmarking solution. The system includes a powerful data importing apparatus that allows uploading of outage data from the utilities outage databases, confidential aggregation of utility outage data, real-time comparison of reliability metrics, real-time outage analytics and messaging capabilities. The system includes a communication link for receiving raw outage data uploaded from the outage management systems of participating utilities which couples the data to an analytics server which automatically recalculates standard reliability indices and analytics in real-time. A database server aggregates and stores the data and indices. The analytics server makes data and reports available to user utilities in real-time via the internet while using a unique ID for each user utility to maintain user anonymity and data confidentiality.Type: GrantFiled: November 11, 2021Date of Patent: December 31, 2024Assignee: AERINET SOLUTIONS, L.L.C.Inventors: Alvin M. Razon, Eduardo Ilao, John Ilao
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Patent number: 12181379Abstract: A system and method for predicting the failure and estimating the health of the industrial equipment or industrial measurement equipment and diagnosing the root cause of the incipient failures is provided. The system and method are applicable to different types of flow meters used in flow measurement applications and other industrial equipment or industrial measurement equipment. A means to detect anomalies in the industrial equipment or industrial measurement equipment diagnostic signals is provided and thereby allowing incipient failure prediction. The system and method provides the means to calculate the current state of health of the industrial equipment or industrial measurement equipment. Leading indicator/failed component in the industrial equipment or industrial measurement equipment can be tracked down in the event of a failure. The system and method provides the means to label the normal and abnormal periods in the historical data based on the available diagnostic alarms and signals.Type: GrantFiled: June 29, 2022Date of Patent: December 31, 2024Assignee: SPARTAN CONTROLS LTD.Inventors: Rahul Raveendran, Hailei Jiang
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Patent number: 12181396Abstract: A rheology device comprises an elongated body having a flow path defined therein, first and second pressure lines in communication with the first and second ends of the flow path, respectively, and a differential pressure sensor for measuring a difference in pressure between the first and second pressure lines. In embodiments, the pressure lines are filled with a spacer fluid different from the fluid in the flow path. Based on at least three measurements of difference in pressure and corresponding flow rates, a yield point, a consistency factor, and a power factor can be calculated, and a rheology model of the fluid can be generated. Related methods are described which allow fluid rheology models to be determined and updated frequently. The device and methods herein may be useful in oil and gas operations, for example for rheology and hydraulic modeling in drilling operations.Type: GrantFiled: July 1, 2021Date of Patent: December 31, 2024Assignee: Opla Energy Ltd.Inventors: Hossein Khorshidian, Elvin Mammadov, Saied Afshari, Ahmad Alizadeh
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Patent number: 12181502Abstract: An electrical meter including a housing including a socket interface operable to connect to a facility. The meter further including a sensor configured to sense a characteristic of the electrical meter. The meter further including a controller having an electronic processor and a memory. The electronic processor is configured to receive, from the sensor, a signal indicative of the electrical characteristic, determine, based on the signal, presence of a hot socket, and output an alert based on determining presence of the hot socket.Type: GrantFiled: October 16, 2023Date of Patent: December 31, 2024Assignee: Aclara Technologies LLCInventors: Thomas Lee McDougall, Jr., Curtis Whitmore Crittenden, Charles Andrew Waters
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Patent number: 12173076Abstract: As described herein are polypeptides and antibodies having an Fc region and an antigen binding region where the Fc region has an Fc-Fc-enhancing mutation and a C1q binding-enhancing mutation providing for polypeptides or antibodies with increased CDC activity and/or agonistic activity.Type: GrantFiled: February 12, 2018Date of Patent: December 24, 2024Assignee: GENMAB B.V.Inventors: Frank Beurskens, Marije Overdijk, Annieck M. Diks, Rob De Jong, Kristin Strumane, Janine Schuurman, Paul Parren
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Patent number: 12173072Abstract: Provided herein are antibodies that selectively bind to complex comprising a non-classical HLA-I (e.g. HLA-E) and a neoantigen having variable heavy chain domains (VH), variable light chain domains (VL), and complementarity determining regions (CDRs) as disclosed herein, as well as methods and uses thereof.Type: GrantFiled: May 13, 2022Date of Patent: December 24, 2024Assignee: Boehringer Ingelheim International GmbHInventors: Jon Weidanz, Katherine Upchurch-Ange
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Patent number: 12176098Abstract: A non-transitory computer readable medium (107, 127) stores instructions readable and executable by at least one electronic processor (101, 113) to perform a suspect device configuration detection method (200).Type: GrantFiled: June 18, 2020Date of Patent: December 24, 2024Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Tiblets Zeray Demewez, Mauro Barbieri, Johannes Henricus Maria Korst, Serverius Petrus Paulus Pronk
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Patent number: 12168684Abstract: The present invention relates to the preparation of an antibody analogue capable of being activated reversibly, and uses thereof, and provides a fusion protein comprising an inactive first fragment of an antibody analogue is fused to a stimulus-induced dimerization protein.Type: GrantFiled: September 7, 2021Date of Patent: December 17, 2024Assignee: INSTITUTE FOR BASIC SCIENCEInventors: Won Do Heo, Yun Ju Lee, Daseuli Yu, Byung Ouk Park
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Patent number: 12168700Abstract: The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.Type: GrantFiled: September 1, 2023Date of Patent: December 17, 2024Assignees: Children's Medical Center Corporation, Beth Israel Deaconess Medical Center, Inc.Inventors: James D. McCully, Sidney Levitsky, Douglas B. Cowan, Pedro J. del Nido, Sitaram M. Emani
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Patent number: 12162953Abstract: A platform technology provides particle and nucleic acid conjugates, and compositions thereof, with enhanced targeting to cells, tissues, organs. The particles and nucleic acids and other deliverables contain a synthetic binding protein such as a polypeptide monobody covalently conjugated to the surface of the particle or the nucleic acid, for linking a targeting agent to the particle's surface or the nucleic acid. The particles and nucleic acids and other deliverables optionally contain an antibody non-covalently conjugated to the binding protein, via an Fc domain of the antibody. The particles can include therapeutic agents, diagnostic agents, prophylactic agents, or a combination thereof, to be delivered to desired cells, tissues, and/or organs. The particles and nucleic acids and other deliverables can be used in a wide array of applications including, but not limited to, ex vivo perfusion of mammalian organs and in vivo disease treatment.Type: GrantFiled: December 4, 2020Date of Patent: December 10, 2024Assignees: YALE UNIVERSITY, NEW YORK UNIVERSITYInventors: W. Mark Saltzman, Gregory T. Tietjen, Shohei Koide, Claire Albert, Jordan Pober, Akiko Koide, Laura Bracaglia
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Patent number: 12162372Abstract: It is an object to provide a charging station reliability assessment device and a charging station reliability assessment method. According to an embodiment, a method comprises obtaining a history information of an electric vehicle, EV, charging station. A first and a second reliability index may be calculated based on the history information. Based on the first and the second reliability index, a third reliability index may be calculated. A method, a device, and a computer program product are provided.Type: GrantFiled: November 3, 2020Date of Patent: December 10, 2024Assignee: Liikennevirta Oy / Virta LTDInventor: Jussi Ahtikari
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Patent number: 12161059Abstract: The invention(s) include systems and methods for receiving and processing agriculture-associated samples with sample processing architecture structured to rapidly return outputs characterizing effects of agriculture inputs and practices over time. Control instructions based upon outputs of the systems and methods are then executed for maintaining or improving performance of crops and agriculture sites (e.g., in relation to yield, in relation to nutrient characteristics) in a sustainable manner (e.g., environmentally sustainable manner). System and method outputs can further be used to affect modifications to product treatments generated by associated manufacturers.Type: GrantFiled: March 24, 2022Date of Patent: December 10, 2024Assignee: Biome Makers Inc.Inventors: Alberto Acedo, Nabeel Imam, Felipe Engelberger, Ariel Romeo-Cares, Héctor Ortega-Arranz, Eneas Marin, Daniel Almonacid, Adrian Ferrero, Beatriz Garcia-Jimenez, Lisa Röttjers