Patents Examined by Phuong Huynh
  • Patent number: 10387694
    Abstract: Systems, methods, and electronic circuits facilitating embedded sensor chips in polymer-based coatings are provided. In one example, a method comprises fabricating an electronic circuit, the electronic circuit comprising one or more semiconductor devices, one or more sensors, and a communication element; encapsulating the electronic circuit within an insulator, resulting in an encapsulated circuit; and dispersing the encapsulated circuit into a lacquer solution comprising a polymer carrier and a solvent.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: August 20, 2019
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Ali Afzali-Ardakani, Homa Alemzadeh, Maryam Ashoori, Bahman Hekmatshoartabari, Elham Khabiri
  • Patent number: 10378349
    Abstract: An embodiment of an apparatus for estimating and displaying formation and formation fluid properties includes a sampling device coupled to borehole fluid, the borehole fluid including hydrocarbons released from a region of the formation surrounding an interval of the borehole. The apparatus also includes an analysis unit configured to analyze the sample of the borehole fluid at each of a plurality of sample times and estimate amounts of hydrocarbons in the borehole fluid, and a processing device configured to estimate one or more ratios of an amount of at least one hydrocarbon gas to an amount of at least another hydrocarbon gas at each sample time, analyze the one or more ratios to estimate a type of hydrocarbon fluid associated with the ratio, and automatically generate a fluid log that displays an indication of the type at each of the plurality of sample times.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: August 13, 2019
    Assignee: BAKER HUGHES, A GE COMPANY, LLC
    Inventors: Nicklas Jeremias Ritzmann, Stefan Schimschal
  • Patent number: 10379098
    Abstract: A rating evaluation method for groundwater pollution source intensity, including: determining pollution source characteristic indices, and weights and scores thereof, according to the type, the discharge mode, the existence time, and the like of a groundwater pollution source; determining an vadose zone antifouling property index and an vadose zone vulnerability index and scores thereof according to vadose zone characteristics; determining a rating evaluation index system for groundwater pollution sources by combining the pollution source characteristic indices with the vadose zone antifouling property index and the vadose zone vulnerability index; and establishing a rating evaluation method for groundwater pollution source intensity and evaluating the groundwater pollution source intensity.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: August 13, 2019
    Assignee: Chinese Research Academy of Environmental Sciences
    Inventors: Beidou Xi, Juan Li, Ningqing Lv, Da An, Yang Yang, Yue Wang, Jun Tang
  • Patent number: 10378997
    Abstract: A method includes capturing multivariate time-series data comprising two or more data sets from a system captured over a past time period and a present time period, applying at least two sliding time windows to the multivariate time-series data in determining respective data matrices, computing an orthonormal matrix for each of the data matrices, wherein the orthonormal matrix is a signature of fluctuation patterns of a respective data matrix, computing a difference between at least two of the data sets in the past and the present time periods through the orthonormal matrices, and detecting a fault in at least one of the systems by comparing the difference to a threshold.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: August 13, 2019
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Tsuyoshi Ide, Jayant R. Kalagnanam, Dung T. Phan
  • Patent number: 10371522
    Abstract: A method for determining centripetal accelerations of pivotally coupled rigid bodies arranged in a series, where the series includes a rigid body arranged between a previous rigid body and a next rigid body, includes determining the centripetal acceleration of the next rigid body and the centripetal acceleration at an inertial measurement unit (IMU) coupled to the next rigid body based on measurements and calculated parameters from the rigid body and the next rigid body. The centripetal acceleration of the next rigid body and the centripetal acceleration at the IMU coupled to the next rigid body are determined without using measurements or calculated parameters from the previous rigid body.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: August 6, 2019
    Assignee: Caterpillar Trimble Control Technologies LLC
    Inventor: Nima Alam
  • Patent number: 10370442
    Abstract: The present invention refers to the selection, isolation and purification of proteins belonging to variable regions named VHNAR or vNAR, originated from IgNAR-type immunoglobulins of elasmobranches with antigen receptor abilities. The clones from which they originate are named VEGFvNAR V32R and V19; and the antibodies are named V32R and V19. Their amino acid sequences and tertiary structures were elucidated, and their ability to neutralize the vascular endothelial growth factor (VEGF) activity was determined. During the development of the invention these proteins were optimized for expression in a production model of E. coli at industrial level. The invention involves the use of these antibodies in general to treat conditions related to angiogenesis or neovascularization and in particular to treat neovascularization-related ophthalmic conditions by topical administration.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: August 6, 2019
    Assignee: TERACLON IDF, S.L.
    Inventors: Carolina Elosua Portugal, Maria Teresa Mata Gonzalez, Tanya Amanda Camacho Villegas, Araceli Olguin Jimenez, Alexei Fedorovish Licea Navarro, Jorge Fernando Paniagua Solis
  • Patent number: 10369197
    Abstract: The present invention relates to the use of a CD24 protein for lowering low-density lipoprotein cholesterol levels, treating and preventing atherosclerosis, and for reducing risk of cardiovascular disease.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: August 6, 2019
    Assignee: OncoImmune, Inc.
    Inventors: Yang Liu, Pan Zheng
  • Patent number: 10370458
    Abstract: The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: August 6, 2019
    Assignees: Children's Medical Center Corporation and Beth Israel, Deaconess Medical Center, Inc.
    Inventors: James D. McCully, Sidney Levitsky, Douglas B. Cowan, Pedro J. del Nido, Sitaram M. Emani
  • Patent number: 10370447
    Abstract: The present disclosure relates to multispecific molecule comprising a binding domain specific to the antigen CD22 and a binding domain specific to the antigen CD79a and/or CD79b, compositions comprising the same and use of both in treatment, for example the treatment of autoimmune disease.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: August 6, 2019
    Assignee: UCB BIOPHARMA SPRL
    Inventors: Helene Margaret Finney, Stephen Edward Rapecki, Michael John Wright, Kerry Louise Tyson
  • Patent number: 10363214
    Abstract: Compositions and methods for treating dry age related macular degeneration (dry AMO) by administration to an intraocular location of an anti-neovascular agent (such as bevacizumab) in either a liquid or solid polymeric vehicle (or both), such as a biodegradable hyaluronic acid or PLGA (or PLA).
    Type: Grant
    Filed: July 7, 2014
    Date of Patent: July 30, 2019
    Assignee: Allergan, Inc.
    Inventors: Scott M. Whitcup, Michael R. Robinson, Wendy M. Blanda, Patrick M. Hughes, James A. Burke
  • Patent number: 10365387
    Abstract: The present invention discloses a method for overall exploration of a mature exploration area of oil-rich sags, the method including the following steps: building an area-wide seismic sequence framework for a study area based on uniform 3D seismic data of the study area; determining the spatial distribution characteristics of sedimentary reservoirs in the study area by sequence based on the area-wide seismic sequence framework; grading source rocks in the study area by sequence based on the area-wide seismic sequence framework; counting the spatial distribution characteristics of caprocks in the study area; determining a transporting system for the study area based on the unified 3D seismic data of the study area; classifying potential trap areas in the study area based on the spatial distribution characteristics of the sedimentary reservoirs and the spatial distribution characteristics of the caprocks; and deploying the overall exploration of the study area based on the classification of the potential trap a
    Type: Grant
    Filed: January 8, 2019
    Date of Patent: July 30, 2019
    Assignee: DAGANG OIL FIELD OF CNPC
    Inventors: Xianzheng Zhao, Fengming Jin, Lihong Zhou, Wenya Jiang, Xiugang Pu
  • Patent number: 10365239
    Abstract: A system for in-situ identification of a working fluid disposed in at least one piece of equipment, the system including: a working fluid reservoir that contains the working fluid; an in-situ sensor disposed in the working fluid reservoir such that it detects properties of the working fluid or computes properties from the generated spectra of the working fluid; a transmitter that transmits the detected spectra of the working fluid and equipment identification information; and a cloud computing system that receives the detected spectra and the equipment identification information transmitted from the transmitter, wherein the cloud computing system compares the spectra and equipment identification information against a reference database to determine whether or not the spectra of the working fluid substantially matches the stored reference spectra associated with the expected or specified fluid for the equipment.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: July 30, 2019
    Assignee: EXXONMOBIL RESEARCH AND ENGINEERING COMPANY
    Inventors: Gregory K. Lilik, Spencer T. Stober, Alan M. Schilowitz, Michael L. Blumenfeld, Gary James Johnston, Samuel C. Bainbridge, Erik Herz
  • Patent number: 10357571
    Abstract: In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a masked monoclonal antibody (mAb) is provided, which includes a therapeutic mAb and a mask, the mask comprising protein A and protein L attached by a protease cleavable linker.
    Type: Grant
    Filed: November 23, 2015
    Date of Patent: July 23, 2019
    Assignees: Thomas Jefferson University, City of Hope
    Inventors: John C. Williams, Cindy Zer, Kendra N. Avery, Ulrich Rodeck, Joshua M. Donaldson, Csaba Kari
  • Patent number: 10353093
    Abstract: A method for analyzing acoustic/elastic waves to determine subsurface structure of the earth includes receiving a plurality of observations of a seismic acoustic/elastic wave-field from a plurality of sensors; generating a plurality of Bernstein grids of differing resolutions; calculating a data misfit of the plurality of observations with respect to an initial subsurface structure model defined in terms of conic combinations of Bernstein polynomials on a lowest resolution Bernstein grid, and mapping the data misfit from the Bernstein grid onto a Lagrangian grid; updating the subsurface structure model by minimizing the data misfit between the plurality of observations and observations obtained by a simulation; increasing resolution of the Bernstein grid and recomputing the updated subsurface structure model on the increased resolution Bernstein grid; and mapping the recomputed subsurface structure model onto the Lagrangian grid.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: July 16, 2019
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Albert Akhriev, Sean McKenna, Stephen Moore, Sergiy Zhuk
  • Patent number: 10343630
    Abstract: The present application discloses a monitoring method and apparatus.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: July 9, 2019
    Assignee: BEIJING BAIDU NETCOM SCIENCE AND TECHNOLOGY CO., LTD.
    Inventors: Wei He, Haifeng Wang, Yu Ma, Chengliang Deng, Weide Zhang, Zhuo Chen
  • Patent number: 10344050
    Abstract: The present invention relates to an in vitro method for production of heterodimeric proteins.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: July 9, 2019
    Assignee: GENMAB A/S
    Inventors: Michael Gramer, Amitava Kundu, Ewald T. J. Van Den Bremer, Muriel Van Kampen, Patrick Priem, Aran Frank Labrijn, Joyce I. Meesters, Joost J. Neijssen, Janine Schuurman, Paul Parren, Patrick Van Berkel, Werner L. Vos, Arnout Gerritsen
  • Patent number: 10345270
    Abstract: Methods for quantitatively determining the time (TNI) between (1) the application of this method and (2) the time at which an out-of-service internal inspection of a steel, field-erected, aboveground storage tank (AST) containing a petroleum product or water should be performed. These methods combine in-service measurements of the thickness, integrity, and corrosion rate of the tank bottom with an empirical corrosion rate cumulative frequency distribution (CFD) for the tank of interest to develop a Bayesian tank bottom survival probability distribution to determine TNI. During this entire TNI time period, the risk of tank bottom failure is less than at the time these methods were applied. If available, the results of a previous out-of-service API 653 internal inspection are also used.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: July 9, 2019
    Assignee: Vista Precision Solutions, Inc.
    Inventor: Joseph W. Maresca, Jr.
  • Patent number: 10345230
    Abstract: The present invention is a spectroscopic analyzer that when measuring the concentration of a predetermined component contained in sample gas in a reduced pressure state lower than atmospheric pressure, obtains the concentration of the predetermined component with accuracy. The spectroscopic analyzer is one that measures the absorbance of the predetermined component contained in the sample gas in a reduced pressure state lower than atmospheric pressure, and calculates the concentration of the predetermined component with use of a calibration curve indicating the relationship between the absorbance of the predetermined component and the concentration of the predetermined component and a relational expression between the pressure of the sample gas at the time of the measurement and the concentration of the predetermined component.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: July 9, 2019
    Assignee: HORIBA, LTD.
    Inventor: Katsumi Nishimura
  • Patent number: 10338244
    Abstract: A method, including performing, with a computer, up/down separation of geophysical data, which produces an approximate up-going wavefield and an approximate down-going wavefield; creating an areal source based at least in part on the down-going wavefield; and performing, with a computer, a full wavefield inversion process with the areal source, and an objective function measuring a misfit between modeled up-going wavefields and recorded up-going wavefields, wherein the full wavefield inversion process generates a final subsurface physical property model.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: July 2, 2019
    Assignee: ExxonMobil Upstream Research Company
    Inventors: Anatoly I Baumstein, Di Yang, Tetyana Vdovina, Yaxun Tang
  • Patent number: 10329357
    Abstract: Disclosed are methods for treating eye diseases or conditions characterized by vascular instability, vascular leakage and neovacularization such as diabetic macular edema, age-related macular edema, choroidal neovascularization, diabetic retinopathy, trauma, ocular ischemia, retinal angiomatous proliferation, macular telangiectasia and uveitis.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: June 25, 2019
    Assignee: AERPIO THERAPEUTICS, INC.
    Inventors: Kevin Peters, Robert Shalwitz