Abstract: A second n-fold angle signal is calculated using a first sine wave signal and a second sine wave signal obtained from a first n-fold angle signal that is an angle signal multiplied by n (n is a real number other than 1), offset correction values of the first sine wave signal and the second sine wave signal respectively are calculated from the second n-fold angle signal, the first sine wave signal is corrected by the calculated offset correction value of the first sine wave signal being added to the first n-fold angle signal, and the second n-fold angle signal is corrected by the calculated offset correction value of the second sine wave signal being added to the second sine wave signal.

Abstract: The present disclosure relates to fusion molecules and chimeric molecules which comprise two components: an Ang-2 antagonist peptide linked to a VEGF-binding moiety. Further disclosed are methods of using said chimeric molecules to treat a patient cancer, proliferative retinopathy, neovascular glaucoma, macular edema, wet age-related macular degeneration (wAMD), macular edema following retinal vein occlusion (RVO), diabetic macular edema (DME), or diabetic retinopathy (DR).

Abstract: Systems and methods for monitoring emissions of a combusted gas are provided. The method includes determining a first net heating value of a flare gas. The method also includes determining a second net heating value of a combustion gas including the flare gas. The second net heating value can be determined based upon the first net heating value and a volumetric flow rate of the flare gas. Based upon the value of the second net heating value, an empirical model or a non-parametric machine learning model can be selected. A combustion efficiency of the combustion gas can be determined using the selected model, the second net heating value, and selected ones of the process conditions and the environmental conditions. Total emissions of the combustion mixture can be further determined from the combustion efficiency and a volumetric flow rate of the combustion gas.

Abstract: Disclosed is a method of predicting a lifespan of a material by using a material parameter and by using Equation described below. y = ? × exp [ - ( x ? ) ? ] in which y is the physical property retention rate, x is the aging time, ? is a scale parameter, ? is a shape parameter, and ? is the material parameter.

Abstract: According to one embodiment, a load estimation apparatus includes processing circuitry. The processing circuitry acquires sensor data from a measurement target, estimates an operation of a body part of the measurement target, based on the sensor data, estimates an operation load of the body part, based on information on the operation, estimates a posture of the body part, based on the sensor data, estimates a posture load of the body part, based on information on the posture, estimates a first cumulative load, based on the operation load, and estimates a second cumulative load, which requires a longer load elimination time than the first cumulative load, based on the operation load and the posture load.

Abstract: The present invention relates to an early warning method before the occurrence of aflatoxin contamination.

Abstract: Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes located on a single molecule or located on different molecules.

Abstract: Herein are provided bispecific anti-human CD20/human transferrin receptor antibodies and methods of using the same.

Abstract: Herein is reported a conjugate comprising an antigen and an antibody that specifically binds to the antigen wherein a covalent bond is formed between the antigen and an amino acid residue in the CDR2 of the antibody, an antibody comprising a cysteine residue at amino acid position 53 (according to Kabat) in the heavy chain CDR2 and uses thereof.

Abstract: The present application discloses high-concentration monoclonal antibody formulations suitable for subcutaneous administration, e.g. via a pre-filled syringe. In particular, it discloses a formulation comprising a spray dried monoclonal antibody at a concentration of about 200 mg/mL or more suspended in a non-aqueous suspension vehicle where the viscosity of the suspension vehicle is less than about 20 centipoise. Also disclosed are: a subcutaneous administration device with the formulation therein, a method of making the formulation, a method of making an article of manufacture comprising the suspension formulation, use of the formulation in the preparation of a medicament, and a method of treating a patient with the formulation.

Abstract: The invention provides a strategy for site specific covalent modification of antibodies using a specialized targeting covalent heterobivalent ligand (cHBL), and corresponding design for a covalent heterobivalent inhibitor (cHBI) that can be used to prevent Immunoglobulin E (IgE) mediated allergic reactions triggered by drug molecules, according to one embodiment. These molecules contain four important components: (1) an IgE antigen binding site (ABS) ligand that can be a mimotope for the allergen protein, a small molecule, or a peptidomimetic, (2) an appropriate linker, which can be any flexible or rigid chemical linker, providing spacing between the ABS binder and the other moieties, (3) a nucleotide binding site (NBS) ligand, and (4) a reactive moiety to form a covalent link with an amino acid side chain of target IgE antibodies.

Abstract: A compound for the sequestration of undesirable antibodies (e.g. related to an autoimmune disease) in a patient. The compound includes an inert biopolymer scaffold and at least a first peptide n-mer of the general formula P(—S—P)(n?1) and a second peptide n-mer of the general formula P(—S—P)(n?1); wherein, independently for each occurrence, P is a peptide with a sequence length of 2-13 amino acids and S is a non-peptide spacer, wherein, independently for each of the peptide n-mers, n is an integer of at least 1, wherein each of the peptide n-mers is bound to the biopolymer scaffold. Also provided are pharmaceutical compositions including the compound, as well as a method of sequestering one or more antibodies present in an individual and a method of inhibiting an immune reaction to a treatment with an active agent.

Abstract: Embodiments of the present disclosure provide a method and an Internet of Things (IoT) system for diagnosing accuracy of a smart gas ultrasonic meter. The method is implemented by a smart gas device management platform of the IoT system for diagnosing accuracy of the smart gas ultrasonic meter. The method includes: acquiring gas attribute data of gas passing through a metering device based on a distributed sensor deployed in a gas pipeline network; determining a first accuracy risk of the metering device through performing pre-diagnosis on the metering device based on the gas attribute data and metering device information; determining a second accuracy risk of the metering device through performing precision diagnosis on the metering device based on a pre-diagnosis result; and displaying detection indication information to the smart gas device management platform based on a precision diagnosis result.

Abstract: A classical computer outputs a Hamiltonian and initial information of a parameter expressing a quantum circuit. The classical computer, according to a parameter expressing a first quantum circuit that was output from a quantum computer and was generated by quantum computation employing a Variational Quantum Eigensolver (VQE) based on the Hamiltonian and the initial information, generates a parameter expressing a second quantum circuit including a rotation gate and outputs the parameter expressing the second quantum circuit. The classical computer, based on measurement results of quantum computation that were output from the quantum computer and computed according to the parameter expressing the second quantum circuit, based on the Hamiltonian, and based on a derivative function of the Hamiltonian, generates a derivative function of energy corresponding to the Hamiltonian and outputs the derivative function of energy.

Abstract: The invention provides compositions including a fusion polypeptide and methods for making a fusion polypeptide that includes a COF1/CRBN-binding polypeptide, COF2/CRBN-binding polypeptide, or COF3/CRBN-binding polypeptide and a heterologous polypeptide of interest.

Abstract: A method is provided for remote monitoring, decision making and operation of one or more parameters of on-site well operation equipment. The method includes collecting data corresponding to the at least one parameter by one or more on-site sensor modules assigned to the equipment for monitoring joint make-up of tubing and casing connections; transmitting the collected data to an on-site make-up monitoring system; transmitting said collected data from the on-site make-up monitoring system to a cloud or edge-based system for storage, display and analysis; accessing collected day by one or more users via one or more dedicated remote portals for review or analysis; and transmitting instructions from any one or more users via the remote portal and cloud or edge-based system back to the on-site make-up monitoring system for modifying the operation of the equipment within predefined limits.

Abstract: Methods to create chemically-induced dimerizing (CID) protein systems and uses thereof are described. The methods utilize antibody binding domain dimerizing proteins. The created systems can be used to regulate cellular events such as gene expression, receptor signaling and cell death to effectuate a variety of clinically relevant treatment outcomes.

Abstract: The invention provides bifunctional molecules including an antibody specifically binding to CD122 and an extracellular domain of CTLA-4. The bifunctional molecules specifically bind to CD122 and CTLA-4 ligands, CD80 and CD86 and inhibit their function in immune activation. The bifunctional molecules can inhibit interaction of CD122 with its ligands IL-2 and IL-15 and inhibit interaction of CD80 and CD86 with their counter-receptor, CD28. These bifunctional molecules can suppress Signals 2 and 3 of immune responses as a single therapeutic agent for treatment of immune disorders.

Abstract: The invention relates generally to compositions and methods for conjugating antibodies and activatable antibodies, and methods of partially reducing antibodies and/or activatable antibodies prior to conjugation, e.g., thiol-based conjugation, with an agent, e.g., a therapeutic and/or diagnostic agent.

Abstract: A method for borehole measurements may comprise receiving one or more signals from a linear receiver array, computing an arctan of a Hilbert Transform, isolating a first arriving energy, selecting a reference instantaneous phase on a reference receiver, finding the reference instantaneous phase for the linear receiver array, computing a relative travel time shift, combining a reference pick time with a relative time, and determining a travel time. A system for borehole measurements comprise a conveyance, a bottom hole assembly attached to the conveyance, a linear receiver array, wherein the linear receiver array is disposed on the bottom hole assembly, and a computer system connected to the linear receiver array.