Patents Examined by Phuong Huynh
  • Patent number: 11408969
    Abstract: Object tracking anti-jitter filtering systems and methods. A plurality of raw location points for a tracking tag attached to a tracked object is received. The raw location points are stored within a raw location points buffer. Raw location points within an averaging window are averaged to generate an averaged location point. The averaged location point is stored within an averaged location points buffer for use within the object tracking system.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: August 9, 2022
    Assignee: ISOLYNX, LLC
    Inventors: Douglas J. DeAngelis, Gerard M. Reilly, Kirk M. Sigel, Edward G. Evansen
  • Patent number: 11401337
    Abstract: The disclosure provides modified human IgM heavy chain constant regions that include one or more amino acid substitutions, e.g., in the C?3 domain, where a modified human IgM antibody comprising the modified IgM constant region and a heavy chain variable region specific for a target antigen exhibits reduced complement-dependent cytotoxicity (CDC) of cells expressing the target antigen relative to a corresponding wild-type human IgM antibody.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: August 2, 2022
    Assignee: IGM Biosciences, Inc.
    Inventors: Ramesh Baliga, Dean Ng
  • Patent number: 11396553
    Abstract: CD37-specific bispecific antibody molecules binding to different epitopes of the human CD37 antigen which bispecific antibody molecules have enhanced Fc-Fc interactions upon binding to CD37 on the cell surface. The invention also relates to the monoclonal parental antibodies from which the first or the second binding region of the bispecific antibody molecules is obtained. The invention also relates to pharmaceutical compositions containing these molecules and the treatment of cancer and other diseases using these compositions.
    Type: Grant
    Filed: July 22, 2021
    Date of Patent: July 26, 2022
    Assignee: GENMAB HOLDING B.V.
    Inventors: Simone Oostindie, Frank Beurskens, Esther Breij, Edward Van Den Brink, Andreas Hollenstein, Marije Overdijk, Margaret Lindorfer, Ronald Taylor, Paul Parren, Hilma Van Der Horst, Martine E. D. Chamuleau, Tuna Mutis
  • Patent number: 11396547
    Abstract: An anti-Epidermal Growth Factor Receptor (EGFR) and anti-Cluster-of-Differentiation (CD3) bispecific antibody and uses thereof are provided. The bispecific antibody can specifically bind to antigen epidermal growth factor receptor (EGFR) on tumor cell surface and antigen CD3 molecule on immune cell surface. The single-chain antibody (ScFv) of an anti-CD3 antibody is located at the C terminal of the constant region of the anti-EGFR antibody. Further provided are a preparation method of the bispecific antibody and clinical applications of the bispecific antibody. The bispecific antibody has high affinity, and is used for treating tumor diseases caused by high expression or abnormal expression of the EGFR and other diseases caused by other overexpression of the EGFR.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: July 26, 2022
    Assignees: BEIJING DONGFANG BIOTECH CO., LTD., BEIJING JINGYITAIXIANG TECHNOLOGY DEVELOPMENT CO. LTD.
    Inventors: Yi Bai, Wen Zhang, Meng Xu, Shuang Pei, Yanlu Zan, Shengmei Wen
  • Patent number: 11389532
    Abstract: Compositions including a CD180 binding ligand and a linked Hepatitis B antigen and their use are disclosed. The Hepatitis B antigen includes Hepatitis B virus pre-S1 and/or pre-S2 region of the HBV envelope protein (HBVpreS1/S2Ag), L-HBsAg, MHBsAg, S-HBsAg, or antigenic fragments or mutants thereof.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: July 19, 2022
    Assignees: University of Washington, Abacus Bioscience, Inc.
    Inventors: Edward A. Clark, Che-Leung Law, Deborah Fuller, Michael Gale
  • Patent number: 11389068
    Abstract: An apparatus and method of assessing a narrowing in a fluid filled tube having a fluid flow pressure wave having a backward-originating pressure component and a forward-originating pressure component without taking a flow velocity measurement, comprising: taking pressure measurements in the tube; separating the pressure components into the backward-originating pressure component and the forward-originating pressure component; identifying a time window when the differential of flow velocity (dU) is minimal or absent; and deriving the backward and forward pressure components for pressure measurements taken in at least the time window.
    Type: Grant
    Filed: April 20, 2020
    Date of Patent: July 19, 2022
    Assignees: MEDSOLVE LIMITED, IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
    Inventors: Helen Davies, Justin Davies
  • Patent number: 11391766
    Abstract: Some embodiments of the invention include a method and system for metering an electrical grid comprising at least one processor executing instructions from a non-transitory computer-readable storage medium of an electrical grid fault detection system. In some embodiments of the system, the instructions cause a processor to calculate a prediction of whether power delivery to at least a portion of the electrical grid is functioning abnormally using voltage sensing devices coupled to at least one feeder, where one or more of the voltage sensing devices are responsive to a determination that the power delivery is functioning abnormally. Further in some embodiments, the determination includes the electrical grid fault detection system receiving at least one signal or voltage reading from the electrical grid based at least in part on a sensed or received voltage level or range of voltage level.
    Type: Grant
    Filed: December 28, 2020
    Date of Patent: July 19, 2022
    Assignee: PACIFIC GAS AND ELECTRIC COMPANY
    Inventors: Eric Michael Schoenman, Wei Li, Sophia Chen, Daniel Marlowe Partridge, James Louis Meadows, Thomas Frank Martin
  • Patent number: 11389508
    Abstract: Provided is a complex composition, of which positional isomers are minimized by using a N-terminus of an immunoglobulin Fc region as a binding site when the immunoglobulin Fc region is used as a carrier. Also provided are a protein complex which is prepared by N-terminal-specific binding of immunoglobulin Fc region, thereby prolonging blood half-life of the physiologically active polypeptide, maintaining in vivo potency at a high level, and having no risk of immune responses, a preparation method thereof, and a pharmaceutical composition including the same for improving in vivo duration and stability of the physiologically active polypeptide. The protein complex prepared by the present invention may be usefully applied to the development of long-acting formulations of various physiologically active polypeptide drugs.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: July 19, 2022
    Assignee: HANMI PHARM. CO., LTD.
    Inventors: Dae Jin Kim, Jong Soo Lee, Young Jin Park, Sung Hee Hong, Sung Min Bae, Se Chang Kwon
  • Patent number: 11390346
    Abstract: A shaft characterized by its length to diameter ratio being less than about 1.75 having a drive connection at one end where the wall thickness of the shaft is selected to be thick enough to avoid ellipticalization strain error in torsional measurement of less than 5%. One specific application is for a crankset spindle that can be used to measure a cyclist right, left, and total leg torque.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: July 19, 2022
    Inventor: Michael Grassi
  • Patent number: 11391783
    Abstract: Provided is a method for diagnosing a state of reusable (SOR) of a battery and, more specifically, to a method for diagnosing an SOR of a battery, the method being capable of diagnosing the overall state of a battery during battery reuse by separately diagnosing a state of health (SOH) and a state of power (SOP) of the battery. The method for diagnosing a state of reusable (SOR) of a battery according to the present invention includes: estimating a state of charge (SOC) according to a change in an open circuit voltage (OCV); estimating a state of health (SOH) by using the SOC; calculating a state of power (SOP) in consideration of an output of a current battery; and calculating the SOR by using the SOH and the SOP.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: July 19, 2022
    Assignee: Mintech Co., Ltd.
    Inventors: Hee Kyung Myung, Jun Hee Lee
  • Patent number: 11382976
    Abstract: A method comprising: providing aqueous antibodies; cationizing the aqueous antibodies by the addition of stoichiometric amounts of an excess of a positively-charged crosslinker in the presence of a coupling reagent; titrating the cationized antibodies with a counter anionic polymer until the antibody cation/anion pair solution becomes negative by zeta potential measurement, to create at least one antibody cation/anion pair in aqueous solution. The antibodies are one of anti-hemoglobin antibodies, anti-horse spleen ferritin IgG antibodies, or blood-typing IgM Anti-A antibodies, single-chain antibodies from camelids, monoclonal Anti-Flag antibodies, monoclonal Anti-HRP2 to Plasmodium falciparum, polyclonal Anti-neuropeptide Y, and polyclonal Anti-human troponin. The antibody cation/anion pair solution may be lyophilized to remove all of the water, forming a lyophilized solid, and the lyophilized solid may be heated to generate an antibody ionic liquid.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: July 12, 2022
    Assignee: United States of America as represented by the Secretary of the Air Force
    Inventors: Joseph M Slocik, Rajesh R. Naik, Patrick B Dennis
  • Patent number: 11385201
    Abstract: A method of forming a stable protein complex comprising: providing aqueous protein complexes, wherein the protein complexes are one or more of photosystem I complex from spinach, photosystem II complex from spinach, chlorophyll antennae, thylakoids, bacteriochlorophylls, chlorosomes, and photosystems from green algae, cyanobacteria, and plants; cationizing the aqueous protein complexes by the addition of stoichiometric amounts of a crosslinker in the presence of a coupling reagent; titrating the cationized protein complexes with a counter anionic polymer until the protein cation/anion pair solution becomes negative by zeta potential measurement, to create at least one antibody cation/anion pair in aqueous solution. The protein complexes cation/anion pair solution may be lyophilized to remove all of the water, forming a lyophilized solid. The lyophilized solid may be heated until a protein complex ionic liquid is generated.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: July 12, 2022
    Assignee: United States of America as represented by the Secretary of the Air Force
    Inventors: Joseph M Slocik, Rajesh R. Naik, Patrick B Dennis
  • Patent number: 11384142
    Abstract: This invention concerns methods of treating a patient diagnosed with a platinum-resistant ovarian cancer comprising administering to said patient an effective amount of an anti-VEGF antibody and a chemotherapeutic.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: July 12, 2022
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David Bollag, Corrado Bernasconi
  • Patent number: 11382963
    Abstract: Lipocalin muteins specific to a predetermined antigen can be transduced into a T cell to bring therapeutic benefits to patients in need. In one example, a lipocalin mutein specific to a predetermined antigen (e.g., a target differentially expressed on the surface of a tumor cell) can be transduced into a T cell membrane to serve as an antigen receptor, offering benefits over conventionally deployed antibody-derived protein moieties such as a single chain variable fragment (scFv). Benefits include a more stable structure, leading to superior target engagement, for example. Further, lipocalin muteins specific to a predetermined antigen (e.g. an immunomodulatory target such as an immune checkpoint or costimulatory molecule) can be transduced into a T cell for secretion thereby, bringing an added therapeutic benefit. Specific examples of such modified T cells and methods of making and using the same are provided herein.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: July 12, 2022
    Assignee: Pieris Pharmaceuticals GmbH
    Inventor: Marlon Hinner
  • Patent number: 11385122
    Abstract: The present disclosure provides a method and a device for detecting a fault of a monitoring device. The method includes: obtaining monitoring data at a preset sampling period, wherein the monitoring data comprises monitoring values respectively corresponding to a plurality of sampling points; calculating a monitoring value change rate between each monitoring value and a following monitoring value based on the preset sampling period; performing normalization processing on each monitoring value to obtain a normalized monitoring value corresponding to each monitoring value; determining a first number of monitoring values each having the monitoring value change rate greater than a preset change rate threshold and the normalized monitoring value greater than a preset monitoring value threshold; judging whether the first number is less than a first preset number threshold; and determining that the monitoring device has a fault if no.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: July 12, 2022
    Assignees: Hefei Institute for Public Safety Research, Tsinghua University, Hefei Zezhong City Intelligent Technology Co., Ltd., Operation and Monitorina Center for Hefei Urban Safety & Security
    Inventors: Hongyong Yuan, Ming Fu, Qiong Tan, Guofeng Su, Youping Zhu, Peng Wang
  • Patent number: 11378492
    Abstract: A method and a system for estimating the state of wear of a cutting tool mounted on a machine tool. The system includes an acquisition module configured to acquire, for a determined duration of machining, values of an operating signal specific to the cutting tool mounted on the machine tool, and a microprocessor configured for calculating current values of a set of wear indicators from the values of the operating signal, and determining the state of wear of the cutting tool as a function of the current values of the set of indicators using a predetermined wear model modeling the state of wear of the cutting tool in function of learning values of the set of wear indicators.
    Type: Grant
    Filed: February 2, 2021
    Date of Patent: July 5, 2022
    Assignee: Airbus Operations (S.A.S.)
    Inventors: Florian Versolato, Emeric Noirot-Nerin
  • Patent number: 11378493
    Abstract: A method for a motion test and a control host of a movable machinery are provided. The method includes: loading a first motion test program; generating, according to the first motion test program, a template file recording first coordinate information indicated by the first motion test program for the movable machinery to perform a physical motion; loading a second motion test program; reading the template file according to program information of the second motion test program and comparing second coordinate information indicated by the second motion test program for the movable machinery to perform the physical motion with the first coordinate information; and generating, according to a comparison result, a warning message reflecting that a control for the movable machinery by the second motion test program may be abnormal.
    Type: Grant
    Filed: February 8, 2021
    Date of Patent: July 5, 2022
    Assignee: Industrial Technology Research Institute
    Inventors: Ming-Chun Ho, Chin-Hui Chen, Chao-Chuang Mai, Hsin-Chang Chang
  • Patent number: 11377494
    Abstract: Provided are isolated antibodies and antigen-binding fragments thereof that specifically bind CEACAM1, including the IgV domain of CEACAM1, as well as pharmaceutical formulations, kits, and methods of use thereof.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: July 5, 2022
    Assignee: Albert Einstein College of Medicine
    Inventor: Xingxing Zang
  • Patent number: 11378452
    Abstract: A device may obtain a master calibration set, associated with a master calibration model of a master instrument, that includes spectra, associated with a set of samples, generated by the master instrument. The device may identify a selected set of master calibrants based on the master calibration set. The device may obtain a selected set of target calibrants that includes spectra, associated with the subset of the set of samples, generated by the target instrument. The device may create a transfer set based on the selected set of master calibrants and the selected set of target calibrants. The device may create a target calibration set, corresponding to the master calibration set, based on the transfer set. The device may generate, using an optimization technique associated with the transfer set and a support vector regression modeling technique, a transferred calibration model, for the target instrument, based on the target calibration set.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: July 5, 2022
    Assignee: VIAVI Solutions Inc.
    Inventors: Changmeng Hsiung, Lan Sun, Christopher G. Pederson
  • Patent number: 11378712
    Abstract: An apparatus for detecting a moving ferromagnetic target object in a protected area comprises a first magnetic sensor adapted to measure a magnetic field within a first localised volume of space defined by a first zone of sensitivity of the first magnetic sensor and to produce a corresponding first measurement signal, and a second magnetic sensor adapted to measure a magnetic field within a second localised volume of space defined by a second zone of sensitivity of the second magnetic sensor and to produce a corresponding second measurement signal. The two magnetic sensors are separated spatially by a baseline such that the overlap between the two zones of sensitivity defines both a protected zone and a non-protected zone.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: July 5, 2022
    Assignee: Metrasens Limited
    Inventors: Mark Keene, Paul A. Manning