Patents Examined by Phuong Huynh
  • Patent number: 10557783
    Abstract: The method for determining equilibrium wettability of an interface between a void space and a solid phase of a rock sample comprises obtaining a three-dimensional image of the internal structure of the sample. On the obtained image of the internal structure of the sample, a void space and a solid phase are differentiated. An interface between the void space and the solid phase of the sample and distribution of minerals on this surface are determined. Wettability of the solid phase at each point of the interface between the void space and the solid phase of the rock sample is determined. A process of oil migration to the void space filled with stratum water at the initial stage of formation of an oil and gas field is numerically simulated, and finally, the equilibrium wettability of the interface between the void space and the solid phase of the rock sample is determined.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: February 11, 2020
    Assignee: SCHLUMBERGER TECHNOLOGY CORPORATION
    Inventors: Evgeny Nikolaevich Dyshlyuk, Oleg Yurievich Dinariev, Ivan Victorovich Yakimchuk, Nikolay Vyacheslavovich Evseev
  • Patent number: 10556969
    Abstract: The present invention relates to multi-functional proteins which comprise (i) a signal peptide, (ii) a target specific recognition domain, (iii) a linker region, connecting domain (ii) and domain (iv) which comprises a specific modified hinge region of the human CD8 alpha-chain, and (iv) an effector domain. The present invention furthermore relates to nucleic acids encoding the proteins, expression constructs for expressing the protein in a host cell and host cells. The proteins of the invention are chimeric antigen receptors with an optimized linker or hinge region that are suitable for generating target-specific effector cells, for use as a medicament, in particular in the treatment of cancer and in adoptive, target-cell specific immunotherapy.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: February 11, 2020
    Assignee: CHEMOTHERAPETICSHES FORSHUNGSINSTITUT GEORG-SPEYER-HAUS
    Inventors: Kurt Schönfeld, Christiane Schönfeld, Winfried Wels
  • Patent number: 10556949
    Abstract: The present inventors have discovered that in living organisms that have received an antigen-binding molecule containing an antigen-binding domain whose binding activity to an antigen changes depending on ion concentration conditions and containing an FcRn-binding domain having FcRn-binding activity in a neutral pH range, immune responses to the antigen are induced. Furthermore, the present inventors have discovered that in living organisms that have received an antigen-binding molecule containing an antigen-binding domain whose binding activity to an antigen changes depending on ion concentration conditions and containing an FcRn-binding domain having FcRn-binding activity in a neutral pH range, immune responses to the antigen are induced, and also the antigen-binding molecule has cytotoxicity or antiproliferative action against cancer cells, foreign biological species, or such that express the antigen to which the antigen-binding molecule binds.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: February 11, 2020
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tomoyuki Igawa, Atsuhiko Maeda, Kenta Haraya, Tatsuhiko Tachibana
  • Patent number: 10548521
    Abstract: A method of monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a medium with time-varying optical properties is provided that includes providing a measurement data set that includes a plurality of measurement entries that include at least two measurements obtained from a patient before and after administration of the fluorescent agent. The measurements may include one or more of: a DRex signal detected by an unfiltered light detector during illumination by excitatory-wavelength light from first region adjacent to the diffuse reflecting medium; a Flr signal detected by a filtered light detector during illumination by excitatory-wavelength light; and a DRem signal detected by the unfiltered light detector during illumination by emission-wavelength light.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: February 4, 2020
    Assignee: MediBeacon Inc.
    Inventors: Kimberly Schultz, Jennifer Keating, Edward Solomon, Kate Bechtel
  • Patent number: 10548989
    Abstract: Disclosed herein are nanoparticle immunoconjugates useful for therapeutics and/or diagnostics. The immunoconjugates have diameter (e.g., average diameter) no greater than 20 nanometers (e.g., as measured by dynamic light scattering (DLS) in aqueous solution, e.g., saline solution). In certain embodiments, the conjugates are silica-based nanoparticles with single chain antibody fragments attached thereto.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: February 4, 2020
    Assignees: Memorial Sloan Kettering Cancer Center, Cornell University, The Curators of the University of Missouri
    Inventors: Michelle S. Bradbury, Thomas P. Quinn, Feng Chen, Barney Yoo, Jason Lewis, Ulrich Wiesner, Kai Ma
  • Patent number: 10538595
    Abstract: Novel multispecific antibody platform, multispecific antibodies and a method to make the antibodies is disclosed here. The CH3 domain harboring polypeptide chains of the Fc-regions are modified by increasing the positive charge of one chain and negative charge of another chain. Heterodimer formation in cotransfection with the modified chains is comparable to formation of wild type antibodies when same cell line is transfected with wild type polypeptides. Moreover, the modification provides a simple one step purification of the heterodimers.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: January 21, 2020
    Assignee: BISON THERAPEUTICS, INC.
    Inventor: Wenjun Zhang
  • Patent number: 10539541
    Abstract: A method and apparatus are provided for characterizing a product sample for example in comparison to a reference sample using a sensor such as a gas chromatograph or a MOS sensor. This characterization may comprise an indication of whether or not the product sample conforms to a quality criterion. The comparison of the sensor output measurements for the product sample is compared to maximum and minimum value curves, which may be derived from measurements of the reference sample, whereby adjacent samples outside the envelope defined by these maximum and minimum values are grouped together. A dissimilarity index may be determined for the anomalous values as a whole, or on a per group basis. The groups may be classified depending on the shape they describe, in particular the presence, or not, of peaks, and correspondingly the shape of the corresponding part of the envelope.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: January 21, 2020
    Assignee: ALPHA M.O.S.
    Inventor: Saïd Labreche
  • Patent number: 10540992
    Abstract: A system processes data signals consisting of sums of independent signal terms, zero or more of which signal terms may already have been identified, in order to generate one or more additional terms. Deflated versions of the data signals are created by subtracting from the data signals any previously identified signal terms. Additional independent signal terms are computed using a set of reference signals organized into mutually independent partioning support sets. The images of each support set are computed on the data signals. Computed images on a data signal that are non-zero are identified as additional independent signal terms of that data signal.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: January 21, 2020
    Assignees: Speech Technology & Applied Research Corporation
    Inventors: Richard S. Goldhor, Keith Gilbert, Joel MacAuslan
  • Patent number: 10539621
    Abstract: A method, an apparatus, and a system for determining a state of a battery are provided. The method includes acquiring battery information from a sensor associated with the battery. The battery information includes at least terminal voltage and a terminal current. The method further includes estimating degradation information based on a first principle degradation model and the battery information. The first principle degradation model is a three dimensional model that includes a plurality of layers having one or more attributes representative of physical parameters of the battery. The method further includes identifying a circuit model based on the degradation information and the battery information, determining the state of the battery using the identified circuit model, and implementing a control action or a notification based on the determined state of the battery.
    Type: Grant
    Filed: August 2, 2017
    Date of Patent: January 21, 2020
    Assignees: TOTAL SOLAR INTERNATIONAL, NORTH CAROLINA STATE UNIVERSITY
    Inventors: Mo-Yuen Chow, Bharat Balagopal, Wente Zeng
  • Patent number: 10534354
    Abstract: A device maintenance apparatus, includes: a communication control part configured to control a communication with a device; a device information acquisition part configured to acquire device information of the device via the communication; a storage configured to store maintenance process information, the maintenance process information including device specifying information for specifying a maintenance target device and process specifying information for specifying details of a maintenance process; and an information processing part configured to compare the acquired device information to the stored maintenance process information, and to execute a maintenance process on the device based on the result of the comparison.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: January 14, 2020
    Assignee: Yokogawa Electric Corporation
    Inventor: Kazutoshi Kodama
  • Patent number: 10527468
    Abstract: Two control strategies may be implemented to optimize mud circulation in a drilling mud circulation system. In a networked control strategy, the mud circulation system does not involve any centralized controller yet all the local controllers can exchange information in real-time via a central data storage. The master-slave control strategy involves a centralized optimizer, and the subsystems are treated as slave systems and are driven by a visual master control system.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: January 7, 2020
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Jason D. Dykstra, Zhijie Sun, Xiaoqing Ge
  • Patent number: 10527650
    Abstract: A measurement system is provided that has a digital edge trigger circuit that is capable of operating at the full signal bandwidth of the measurement system. The digital edge trigger circuit comprises a plurality of processors that process time-interleaved digital data samples output from respective time-interleaved ADCs to perform edge trigger detection. The processors share edge detection information with one another to increase the speed at which edge trigger detection is performed to enable the digital edge trigger circuit to operate at the full signal bandwidth of the measurement system.
    Type: Grant
    Filed: January 1, 2017
    Date of Patent: January 7, 2020
    Assignee: Keysight Technologies, Inc.
    Inventor: Allen Montijo
  • Patent number: 10520418
    Abstract: The present set of embodiments relates to systems and methods for diagnosing a fluidics system and determining data processing settings for a flow cytometer. Systems and methods for diagnosing a fluidics system require accurate measurement and interpretation of fluctuations within the fluid delivery system. Systems and methods for determining data processing settings require an accurate measurement of peak times among various channels and being able to adjust time delay settings wherein peak time is the measurement of time elapsed from the beginning of the data collection time window to the highest peak in the window.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: December 31, 2019
    Assignee: Life Technologies Corporation
    Inventors: Gregory Kaduchak, Jace Akerlund, Jason Malkin, Michael Ward
  • Patent number: 10519234
    Abstract: Multispecific proteins that bind and specifically redirect NK cells to lyse a target cell of interest are provided without non-specific activation of NK cells in absence of target cells. The proteins have utility in the treatment of disease, notably cancer or infectious disease.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: December 31, 2019
    Assignee: INNATE PHARMA
    Inventors: Laurent Gauthier, Nadia Anceriz, Ariane Morel, Benjamin Rossi
  • Patent number: 10517945
    Abstract: Herein is reported a conjugate comprising an antigen and an antibody that specifically binds to the antigen wherein a covalent bond is formed between the antigen and an amino acid residue in the CDR2 of the antibody, an antibody comprising a cysteine residue at amino acid position 53 (according to Kabat) in the heavy chain CDR2 and uses thereof.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: December 31, 2019
    Assignee: HOFFMAN-LA ROCHE INC.
    Inventors: Joerg Benz, Ulrich Brinkmann, Stefan Dengl, Sebastian Dziadek, Guy Georges, Michael Grote, Alexander Haas, Eike Hoffmann
  • Patent number: 10520530
    Abstract: Examples disclosed herein relate to determining a power sense output based on a current sense line and a voltage sense line. A first stage circuit has a first voltage input of the current sense line of a server. The first stage circuit also has a feedback voltage input based on an output voltage of the first stage circuit and a variable resistance value based on the voltage sense line of the server. A second stage circuit is used to buffer the first output voltage to yield a second output voltage. A third stage circuit yields a power sense output based on a difference between the second output voltage and the first voltage input.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: December 31, 2019
    Assignee: HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP
    Inventors: Vincent W. Michna, Peter Hansen, Julie Victoria Tan
  • Patent number: 10521553
    Abstract: A method, system and computer program are provided for determining the porosity of a flexible porous structure when it is subjected to deformation. The method performs the following steps by processing representative data of the flexible porous structure: a) generates a first function (Fs) defining how the flexible porous structure changes shape when it is subjected to deformation; b) generates a second function (Fp) defining how a covered surface of the flexible porous structure changes when it is subjected to changes in shape, wherein the second function (Fp) is directly linked with porosity of the flexible porous structure; c) obtains reference porosity values of a reference region (CU-R) of the flexible porous structure in a reference configuration via the first function (Fs); and d) calculates the porosity of at least one deformed region (CU-D) of the flexible porous structure, from said reference porosity values and from the second function (Fp).
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: December 31, 2019
    Assignee: GALGO MEDICAL, S.L.
    Inventors: Luis Serra del Molino, Ignacio Larrabide Fernandez, Héctor Fernandez Martinez
  • Patent number: 10509060
    Abstract: Disclosed herein are methods, systems, and devices for identifying computational operations based on power measurements. Disclosed herein are systems that may include a phase measurement unit configured to generate a first measurement based on a power signal, the first measurement characterizing a phase angle of the power signal. The systems may also include a power measurement unit configured to generate a second measurement based on the power signal, the second measurement characterizing an amplitude of one or more aspects of the power signal. The systems may further include a processing unit configured to identify a computational operation implemented by a target processing device, the identifying of the computational operation being based on a comparison of the first measurement and the second measurement with reference measurements.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: December 17, 2019
    Assignee: The Regents of the University of California
    Inventors: Sean Peisert, Charles McParland
  • Patent number: 10508153
    Abstract: The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: December 17, 2019
    Assignee: Amgen Fremont Inc.
    Inventors: Richard F. Weber, Xiao Feng, Orit Foord, Larry L. Green, Jean M. Gudas, Bruce A. Keyt, Ying Liu, Palaniswami Rathanaswami, Robert Raya, Xiao Dong Yang, Jose R. F. Corvalan, Ian Foltz, Xiao-Chi Jia, Jaspal Singh Kang, Chadwick Terence King, Scott L. Klakamp, Qiaojuan Jane Su
  • Patent number: 10501558
    Abstract: Provided herein are modified Fc proteins comprising non-natural amino acid residues at site-specific positions, conjugates of the modified Fc proteins for therapy or diagnosis, compositions comprising the modified Fc proteins and conjugates thereof, methods of their production and methods of their use. The modified Fc proteins and conjugates are useful for methods of treatment and prevention, methods of detection and methods of diagnosis.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: December 10, 2019
    Assignee: Sutro Biopharma, Inc.
    Inventors: Christopher D. Thanos, Leslie McEvoy, Gang Yin, Kalyani Penta, Ramesh Baliga, Sunil Bajad, Sonia Pollitt, Chris Murray, Alex Steiner, Avinash Gill