Patents Examined by Phuong Huynh
  • Patent number: 10590197
    Abstract: The present disclosure relates to antibody molecules comprising a binding domain specific to CD22, said binding domain comprising SEQ ID NO: 1, 2, 3, 4, 5 and 6 or 7. The disclosure also extends to pharmaceutical compositions comprising said antibody molecules and use of the antibody molecules/compositions in treatment.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: March 17, 2020
    Assignee: UCB BIOPHARMA SPRL
    Inventors: Helene Margaret Finney, Stephen Edward Rapecki, Kerry Louise Tyson, Michael John Wright
  • Patent number: 10591282
    Abstract: A method of generating and storing three-dimensional digital data indicative of a sporting trophy is provided. The method may be implemented in relation to a wide variety of sporting trophy applications. A sportsman can provide a sporting trophy to a scanning system to obtain three-dimensional image data relative to the sporting trophy. Sporting-relevant measurements can be computed based on the stored three-dimensional image data.
    Type: Grant
    Filed: December 12, 2012
    Date of Patent: March 17, 2020
    Assignee: Plainsmen Outdoors, LLC
    Inventor: David Krien
  • Patent number: 10590202
    Abstract: A bispecific antibody format, which comprises a) a Fab fragment comprising a first binding site for a first antigen; b) an scFv fragment comprising a second binding site for a second antigen; and c) a CH2 domain, wherein the Fab fragment and the scFv fragment are linked via the CH2 domain, wherein the first antigen is CD95 and the second antigen is CD20; or the first antigen is CD20 and the second antigen is CD95.
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: March 17, 2020
    Assignee: BALIOPHARM AG
    Inventors: Andreas Herrmann, Ludger Grosse-Hovest
  • Patent number: 10588986
    Abstract: The present invention relates to biofunctionalized nanoparticles and uses thereof in adoptive cell therapy. In particular, the present invention relates to a nanoparticle comprising an amount of at least one antigen and an amount of at least one antibody having specificity for a B cell receptor wherein the antigen and antibody are attached to the surface of the nanoparticle.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: March 17, 2020
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), ENS-ECOLE NORMALE SUPERIEURE DE LYON, UNIVERSITE CLAUDE BERNARD-LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), HOSPICE CIVILS DE LYON
    Inventors: Antoine Sicard, Olivier Thaunat
  • Patent number: 10590193
    Abstract: The present invention relates to soluble and stable anti-VEGF imunobinders comprising CDRs from rabbit monoclonal antibodies. Said antibodies are designed for the diagnosis and/or treatment of VEGF-mediated disorders. The hybridomas, nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
    Type: Grant
    Filed: November 16, 2017
    Date of Patent: March 17, 2020
    Assignee: Novartis AG
    Inventors: Leonardo Borras, David Urech, Tea Gunde
  • Patent number: 10584964
    Abstract: A slope monitoring system includes an analysis formula variable measuring means 81 which measures values of respective analysis formula variables that are obtained when a state of a test layer has been changed from a test environment in which there exist at least an arbitrary test layer or a test layer identical to a material layer forming a monitoring target slope, and a value of a predetermined first observable amount, and an analysis formula variable modeling means 831 which constructs, based on various values obtained from the test environment, for each of the analysis formula variables, a model defined a relationship of them with a second observable amount that is a predetermined observable amount being the same as the first observable amount, or having a known relationship with the first observable amount, or a predetermined third variable that can be calculated from the second observable amount.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: March 10, 2020
    Assignee: NEC CORPORATION
    Inventor: Shinji Kasahara
  • Patent number: 10583197
    Abstract: The invention provides protein-active agent conjugates having an amino acid motif that can be recognized by an isoprenoid transferase. The invention also provides compositions containing the conjugates. The invention further provides methods for using the conjugates to deliver the active agent to a target cell, as well as methods for using the conjugates to treat a subject in need thereof (e.g., a subject in need of the active agent).
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: March 10, 2020
    Assignee: LegoChem Biosciences, Inc.
    Inventors: Yongzu Kim, Taekyo Park, Sungho Woo, Hyangsook Lee, Sunyoung Kim, Jongun Cho, Doohwan Jung, Youngun Kim, Hyunjin Kwon, Kyuman Oh, Yunseo Chung, Yun-Hee Park
  • Patent number: 10585120
    Abstract: An arrangement for signal analysis provides at least one central data-processing unit and a screen unit connected to the at least one central data-processing unit, wherein the central data-processing unit calculates a spectrum and a spectrogram from a digitised signal. The at least one central data-processing unit is embodied in such a manner that it controls the screen unit in such a manner that the spectrogram of the digitised signal, the characteristic of the spectrum of the digitised signal and the characteristic of the digitised signal present in the time domain can be displayed together on the screen unit.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: March 10, 2020
    Assignee: ROHDE & SCHWARZ GMBH & CO. KG
    Inventor: Luke Cirillo
  • Patent number: 10576161
    Abstract: The invention provides methods of preventing and treating graft-versus-host-disease and autoimmune diseases, such as those arising from transplant therapy, by selective depletion of hematopoietic cells through the use of antibody-drug conjugates and ligand-drug conjugates that specifically bind CD137. The compositions and methods described herein can be used to treat a variety of pathologies, including stem cell disorders and other blood conditions.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: March 3, 2020
    Assignee: Magenta Therapeutics, Inc.
    Inventors: Adam Hartigan, Anthony Boitano, Michael Cooke, Megan D. Hoban, Rahul Palchaudhuri
  • Patent number: 10577918
    Abstract: A system and method for providing information regarding the tortuosity of a wellbore path is provided. The method includes receiving data from a plurality of survey stations of a wellbore survey. The method further includes determining a plurality of tortuosity parameter values for the wellbore path within a corresponding plurality of analysis windows, wherein each analysis window has at least one tortuosity parameter value.
    Type: Grant
    Filed: September 30, 2017
    Date of Patent: March 3, 2020
    Assignee: Gyrodata, Incorporated
    Inventors: Jon Bang, Onyemelem Jegbefume, Adrián Guillermo Ledroz, John Lionel Weston
  • Patent number: 10571495
    Abstract: A system includes a plurality of power monitors that, in operation, monitor parameters of power in an automation system at points between loads and/or power sources. Each of the power monitors includes sensing circuitry to sense the power parameters, peer-to-peer communications circuitry to communicate with other power monitors via peer-to-peer communication, network communications circuitry to communicate with automation devices via a network, and functional circuits to perform analysis of monitored power parameters in a cooperative manner based upon the power parameters monitored by the respective power monitor and power parameters monitored by other power monitors communicated via peer-to-peer communication.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: February 25, 2020
    Assignee: Rockwell Automation Technologies, Inc.
    Inventors: Benfeng Tang, Linglai Li, Xuyuan Xiao, Kun Wei, Phillip Bush, David Bradly Berman, Sean Charles Schmelzer, Steven A. Lombardi
  • Patent number: 10570197
    Abstract: It is an object of the present invention to provide a method for producing a low-molecular-weight antibody such as a Fab-type antibody, using yeast as a host, wherein the method is able to produce the low-molecular-weight antibody with high productivity. According to the present invention, there is provided a gene comprising a nucleotide sequence encoding an amino acid or an amino acid sequence capable of increasing the secretion amount of a Fab-type antibody at the 3?-terminus of a nucleotide sequence encoding the amino acid sequence of the Fd chain or L chain of an antibody.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: February 25, 2020
    Assignee: KANEKA CORPORATION
    Inventor: Tozo Nishiyama
  • Patent number: 10568977
    Abstract: The invention relates generally to antibodies and antigen-binding fragments thereof that bind activatable antibodies and/or conjugated activatable antibodies and methods of making and using these antibodies that bind activatable antibodies and/or conjugated activatable antibodies.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: February 25, 2020
    Assignee: CytomX Therapeutics, Inc.
    Inventors: Luc Roland Desnoyers, Tony W. Liang, Annie Yang Weaver
  • Patent number: 10564053
    Abstract: Embodiments disclosed herein generally relate to a method for monitoring optical power in a HAMR device. In one embodiment, the method includes enhancing a thermal sensor bandwidth through advanced electrical detection techniques. The advanced electrical detection techniques include obtaining calibration waveform data for a thermal sensor by calibrating the thermal sensor, obtaining real-time waveform data for the thermal sensor that may deviate from the calibration waveform data, updating the calibration waveform data to include the real-time waveform data, repeating obtaining real-time waveform data and updating the calibration waveform data during writing operations. By updating the calibration waveform data, the bandwidth of the thermal sensor is determined by a fixed sampling time interval, and the thermal sensor rise time to steady state would not be a limitation to its response time.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: February 18, 2020
    Assignee: WESTERN DIGITAL TECHNOLOGIES, INC.
    Inventors: John T. Contreras, Lidu Huang, Shen Ren, Erhard Schreck, Rehan Ahmed Zakai
  • Patent number: 10561726
    Abstract: Described herein are methods, formulations and kits for treating a patient with cancer with anti-VEGF antibodies and albumin-bound chemotherapeutic/anti-VEGF antibody nanoparticle complexes.
    Type: Grant
    Filed: April 6, 2016
    Date of Patent: February 18, 2020
    Assignees: Vavotar Life Sciences LLC, Mayo Foundation for Medical Education and Research
    Inventors: Gerald F. Swiss, Svetomir N. Markovic, Wendy K. Nevala
  • Patent number: 10557783
    Abstract: The method for determining equilibrium wettability of an interface between a void space and a solid phase of a rock sample comprises obtaining a three-dimensional image of the internal structure of the sample. On the obtained image of the internal structure of the sample, a void space and a solid phase are differentiated. An interface between the void space and the solid phase of the sample and distribution of minerals on this surface are determined. Wettability of the solid phase at each point of the interface between the void space and the solid phase of the rock sample is determined. A process of oil migration to the void space filled with stratum water at the initial stage of formation of an oil and gas field is numerically simulated, and finally, the equilibrium wettability of the interface between the void space and the solid phase of the rock sample is determined.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: February 11, 2020
    Assignee: SCHLUMBERGER TECHNOLOGY CORPORATION
    Inventors: Evgeny Nikolaevich Dyshlyuk, Oleg Yurievich Dinariev, Ivan Victorovich Yakimchuk, Nikolay Vyacheslavovich Evseev
  • Patent number: 10556949
    Abstract: The present inventors have discovered that in living organisms that have received an antigen-binding molecule containing an antigen-binding domain whose binding activity to an antigen changes depending on ion concentration conditions and containing an FcRn-binding domain having FcRn-binding activity in a neutral pH range, immune responses to the antigen are induced. Furthermore, the present inventors have discovered that in living organisms that have received an antigen-binding molecule containing an antigen-binding domain whose binding activity to an antigen changes depending on ion concentration conditions and containing an FcRn-binding domain having FcRn-binding activity in a neutral pH range, immune responses to the antigen are induced, and also the antigen-binding molecule has cytotoxicity or antiproliferative action against cancer cells, foreign biological species, or such that express the antigen to which the antigen-binding molecule binds.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: February 11, 2020
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Tomoyuki Igawa, Atsuhiko Maeda, Kenta Haraya, Tatsuhiko Tachibana
  • Patent number: 10556969
    Abstract: The present invention relates to multi-functional proteins which comprise (i) a signal peptide, (ii) a target specific recognition domain, (iii) a linker region, connecting domain (ii) and domain (iv) which comprises a specific modified hinge region of the human CD8 alpha-chain, and (iv) an effector domain. The present invention furthermore relates to nucleic acids encoding the proteins, expression constructs for expressing the protein in a host cell and host cells. The proteins of the invention are chimeric antigen receptors with an optimized linker or hinge region that are suitable for generating target-specific effector cells, for use as a medicament, in particular in the treatment of cancer and in adoptive, target-cell specific immunotherapy.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: February 11, 2020
    Assignee: CHEMOTHERAPETICSHES FORSHUNGSINSTITUT GEORG-SPEYER-HAUS
    Inventors: Kurt Schönfeld, Christiane Schönfeld, Winfried Wels
  • Patent number: 10548989
    Abstract: Disclosed herein are nanoparticle immunoconjugates useful for therapeutics and/or diagnostics. The immunoconjugates have diameter (e.g., average diameter) no greater than 20 nanometers (e.g., as measured by dynamic light scattering (DLS) in aqueous solution, e.g., saline solution). In certain embodiments, the conjugates are silica-based nanoparticles with single chain antibody fragments attached thereto.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: February 4, 2020
    Assignees: Memorial Sloan Kettering Cancer Center, Cornell University, The Curators of the University of Missouri
    Inventors: Michelle S. Bradbury, Thomas P. Quinn, Feng Chen, Barney Yoo, Jason Lewis, Ulrich Wiesner, Kai Ma
  • Patent number: 10548521
    Abstract: A method of monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a medium with time-varying optical properties is provided that includes providing a measurement data set that includes a plurality of measurement entries that include at least two measurements obtained from a patient before and after administration of the fluorescent agent. The measurements may include one or more of: a DRex signal detected by an unfiltered light detector during illumination by excitatory-wavelength light from first region adjacent to the diffuse reflecting medium; a Flr signal detected by a filtered light detector during illumination by excitatory-wavelength light; and a DRem signal detected by the unfiltered light detector during illumination by emission-wavelength light.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: February 4, 2020
    Assignee: MediBeacon Inc.
    Inventors: Kimberly Schultz, Jennifer Keating, Edward Solomon, Kate Bechtel