Abstract: A reservoir bank landslide susceptibility evaluation method. The method includes the following steps: S1, acquiring geophysical parameters; S2, calculating stability of a reservoir bank after impoundment through a static geological evaluation model according to the geophysical parameters; S3, obtaining an average displacement velocity in a geographic coordinate system according to single look complex (SLC) images after impoundment; and S4, according to the average displacement velocity in the geographic coordinate system and the stability of the reservoir bank after impoundment of the reservoir, obtaining a reservoir bank landslide susceptibility grade. According to the method, a problem that present landslide susceptibility evaluation methods all adopt a single model to evaluate landslide susceptibility, which has low evaluation accuracy of the landslide susceptibility is solved.

Abstract: A method for determining a usability of a household appliance includes scanning operating information of the household appliance, determining stresses of different components of the household appliance on the basis of the operating information, and of determining the usability of the household appliance on the basis of the stresses determined and of predetermined stress functions for the components. Wherein a stress function maps a stress determined to a remaining stress capacity.

Abstract: Techniques regarding determining the operating condition of one or more mechanical parts are provided. For example, one or more embodiments described herein can comprise a system, which can comprise a memory that can store computer executable components. The system can also comprise a processor, operably coupled to the memory, and that can execute the computer executable components stored in the memory. The computer executable components can comprise a status component that can update a predictive failure algorithm by altering a vibration threshold based on a measured temperature of a mechanical part. Also, the vibration threshold can characterize an amount of vibration associated with a standard operating condition of the mechanical part.

Abstract: The present disclosure provides for antibody-oligonucleotide conjugates, methods of preparation thereof, and methods of use thereof. Also provided are related compounds, compositions and kits.

Abstract: A monitoring method includes monitoring variables that change over time and are continuously measured during repeated executions of a dynamic process. The measurement data include training data in a training period and monitoring data measured subsequently to the training period. Vectors are continuously determined based on the measurement data, the vector components of which comprise respective rates of change of the measured values of the individual measured variables determined for a series of successive points in time on the basis of the measurement data, wherein the points in time of each series cover a time window of a duration and the time windows of successive vectors are shifted. The vectors are stored as a reference cluster. The vectors are compared with the reference cluster. An anomaly is determined when a vector is outside the reference cluster.

Abstract: The present invention relates to a monoclonal antibody or antibody fragment thereof as a human IgG antibody including at least one lysine derivative in a constant region of the human IgG antibody; a modified antibody or antibody fragment thereof, wherein the lysine derivative is modified; a nucleic acid including a nucleotide sequence encoding the antibody or antibody fragment thereof; a vector including the nucleic acid; a transformed cell obtained by introducing the vector into a host cell; a method for producing the antibody or antibody fragment thereof; and a composition containing the antibody or antibody fragment thereof.

Abstract: The present invention provides method of increasing the percentage of monomer in a composition of recombinantly expressed antibody molecules characterised in that the antibody molecule comprises at least one Fv with specificity for an antigen of interest comprising one VH and one VL wherein said VH and VL are connected directly or indirectly via one or more linkers and are stabilised by a disulfide bond therebetween, said method comprises: a) a conversion step of treating the composition with a denaturant selected from urea and/or Guanidine hydrochloride; b) wherein step a) is performed in the presence of a reducing agent or after treatment with a reducing agent.

Abstract: An electrical meter including a housing including a socket interface operable to connect to a facility. The meter further including a sensor configured to sense a characteristic of the electrical meter. The meter further including a controller having an electronic processor and a memory. The electronic processor is configured to receive, from the sensor, a signal indicative of the electrical characteristic, determine, based on the signal, presence of a hot socket, and output an alert based on determining presence of the hot socket.

Abstract: The disclosure relates to methods, treatment regimens, uses, kits and therapies for preventing graft rejection in solid organ transplantation, by employing anti-CD40 antibodies.

Abstract: The present invention relates to a modular multivalent antigen-binding protein complex, use of the antigen-binding protein complex in medicine and use of the antigen-binding protein complex in the prophylaxis, treatment or diagnosis of a disorder or disease.

Abstract: Disclosed are synthetic nanocarrier compositions, and related methods, comprising immunosuppressants and MHC Class II-restricted epitopes of an allergen that provide tolerogenic immune responses specific to the allergen.

Abstract: Fluid stream management systems and methods relating thereto are described. The fluid management system includes: (1) one or more storage chambers; (2) two or more flow condition attribute measuring devices configured to measures certain flow condition attribute values; (3) one or more flow controllers that are communicatively coupled to receive the flow condition attribute values and use them to establish certain cost functions; and (4) one or more flow-modifying devices, each of which is coupled to at least one of the flow controllers, and based upon instruction received from at least one of the flow controllers, the flow-modifying device is capable of modifying flow of fluid through one or more of the flow-modifying devices to minimize a difference between the established cost functions.

Abstract: The present disclosure discloses methods for purifying antibodies providing an air overlay or headspace to single-use storage bags containing the antibody during purification. In specific embodiments, the application relates to purification of antibodies to human TIGIT (T cell immunoreceptor with Ig and ITIM domains), such as antibody 22G2, which decrease unwanted disulfide bond reduction. The application further provides depth filtration at lower throughput and/or flux, which also minimizes unwanted disulfide bond reduction.

Abstract: Polypeptide compositions comprising a human immunoglobulin constant region with a modified IgG4 hinge region having an N-terminal deletion of 1, 2, 3, 4, 5 amino acids, relative to a native human IgG4 hinge sequence are provided. In some embodiments the hinge sequence further comprises the amino acid substitution S228P (Eu numbering). Polypeptides comprising the modified sequence optionally comprise a binding moiety specific for an epitope that is present on red blood cells; and can provide for reduced agglutination of hematopoietic cells compared to a comparable polypeptide with a native hinge region.

Abstract: The present disclosure provides a self-adaption faster-than-real-time method for estimating a working condition start-up state of a unit. Firstly, an event recording sequence, an analog measurement point ID, an analog measurement point first-level alarm value and a history scatter point distribution record are read from a time sequence event record table, an analog measurement point table, an alarm threshold table and a historical scatter record table. A measured value slope of the analog measurement point is calculated according to an event recording relative time. Then, an abnormal state estimated value is calculated based on the history scatter point distribution record, the analog measurement point first-level alarm value and the measured value slope of the analog measurement point. Finally, a pre-warning is sent to remind a watchman to perform a preventive operation when the abnormal state estimated value is above the threshold.

Abstract: The present disclosure relates to photo-immunoconjugate formulations comprising a nanoparticle carrier comprising first and second therapeutic agents coupled to the nanoparticle carrier, and a photosensitizer molecule coupled to the first therapeutic agent or the nanoparticle carrier, and methods of treating cancer via administration of the photo-immunoconjugate formulations.

Abstract: A process diagnosis system includes a digital twin calculation unit, a process diagnosis calculation unit, and a remote calculation analysis unit. The digital twin calculation unit obtains a vibration-related parameter and a cutting-related parameter of a processing device, and performs a simulation calculation for the vibration-related parameter, the cutting-related parameter and a three-dimensional model corresponding to the processing device to generate a three-dimensional calculation result. The process diagnosis calculation unit receives a three-dimensional calculation result and displays the three-dimensional calculation result. The remote calculation analysis unit receives the three-dimensional calculation result, and performs a simulation analysis for the three-dimensional calculation result to generate an analysis result.

Abstract: Disclosed herein are compositions and methods for reducing the antigenicity of molecules. The antigenicity of a molecule may be reduced or eliminated by conjugating at least one branched polymer to the molecule to form a molecule-polymer conjugate. The branched polymer may include a backbone and a plurality of side chains, each side chain covalently attached to the backbone.

Abstract: Described herein is a bispecific molecule containing an Fc polypeptide chain and immunoglobulin variable regions. Also provided are pharmaceutical formulations comprising such molecules, nucleic acids encoding such molecules, host cells containing such nucleic acids, methods of making such molecules, and methods of using such molecules.

Abstract: An HVAC system is provided. Embodiments of the present disclosure generally relate to HVAC systems in communication with a test engine configured to schedule maintenance and service calls. In one embodiment the test engine utilizes the ambient temperature and temperature setpoint to establish a maintenance schedule.