Abstract: An indicator generating method for generating an indicator which is suitable for maintenance prediction of a water heating system is proposed. A power state indication device generates a high power consumption signal if a heating device of the water heating system is activated. The time duration of the activation is such an indicator, if no water flow is present. Furthermore, the time interval between subsequent activations is such an indicator. A predictive maintenance method processes these condition-based indicators and determines a remaining useful lifetime according to a predictive maintenance model. The predictive maintenance device outputs a maintenance signal indicating required maintenance, if the remaining useful lifetime drops below a predetermined threshold. The methods may be performed by water heating systems or beverage makers.

Abstract: CD37-specific bispecific antibody molecules binding to different epitopes of the human CD37 antigen which bispecific antibody molecules have enhanced Fc-Fc interactions upon binding to CD37 on the cell surface. The invention also relates to the monoclonal parental antibodies from which the first or the second binding region of the bispecific antibody molecules is obtained. The invention also relates to pharmaceutical compositions containing these molecules and the treatment of cancer and other diseases using these compositions.

Abstract: A method for improving a performance of a metal detector, including: determining positions of a sensor head of the metal detector with respect to a coordinate system as the sensor head is moved on top of a ground; processing a receive signal received by the sensor head to produce a substantially ground balanced signal that is substantially insensitive to signals due to the ground; and actively controlling the step of processing based on one or more of the determined positions as the metal detector is moved on top of the ground; wherein, during a continuous use of the metal detector, the determined positions are processed to control, without any instruction or indication from an operator of the metal detector to do so, the step of processing the receive signal to produce the substantially ground balanced signal.

Abstract: A temperature control method for vehicle seat heating includes: when turning on or switching to a heating level, determining a heating period at present according to a temperature value corresponding to a current Negative Temperature Coefficient (NTC) sensor, the heating period including an initial heating stage, an approaching stage and a steady stage; and segmentally controlling the on-off of a seat heating apparatus according to a heating strategy corresponding to each heating period, so that the seat surface temperature reaches to and stabilizes at an expected target temperature of the level. Further disclosed are a corresponding temperature control apparatus for the vehicle seat heating and a temperature control system for the vehicle seat heating. By adopting the temperature control method for the vehicle seat heating, the seat surface temperature can quickly reach to and stabilize at the expected temperature value, and thus the use experience of a user is improved.

Abstract: Disclosed herein are agonistic anti-CD137 antibodies and methods of using such for eliciting CD137 signaling, thereby enhancing immune responses such as T cell functions. The antibodies disclosed within may be used to treat diseases, such as cancer and immune disorders.

Abstract: The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

Abstract: The present invention relates to an in vitro method for production of heterodimeric proteins.

Abstract: A method of predicting a remaining battery life in a device is provided. The method includes obtaining battery state information indicative of a current state of a charge of a battery, the battery being configured to supply power to a device; predicting, by using a machine learning algorithm, a remaining battery life of the device on which a specific application is to be executed, based on the obtained battery state information; and providing, to a user, an indication of the predicted remaining battery life.

Abstract: A method of assessment of renal function by monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties is provided that includes using a renal monitoring system comprising at least one light source, at least one light detector, at least one optical filter, and at least one controller to provide a measurement data set comprising a plurality of measurement entries, each measurement data entry comprising at least two measurements obtained at one data acquisition time from a patient before and after administration of the fluorescent agent.

Abstract: In some embodiments, marrow-infiltrating lymphocytes (“MILs”) comprising a chimeric antigen receptor (“CAR”) are provided. In some aspects, the embodiments relate to a method for making a recombinant MIL, comprising obtaining bone marrow comprising MILs; and transfecting, transforming, or transducing the MILs with a nucleic acid encoding a chimeric antigen receptor. In some aspects, the embodiments relate to a method for treating a condition in a subject, comprising administering to the subject a MIL comprising a CAR.

Abstract: The present invention relates to compounds for treatment of a disease or disorder associated with excessive vascularisation of the eye, such as for instance corneal neovascularisation, neovascularisation of the iris, neovascularisation of the ciliary body, corneal pannus, choroidal neovascularisation, retinal neovascularisation, wet age-related macular degeneration, proliferative diabetic retinopathy, retinopathy of prematurity, and ischemic retinopathy.

Abstract: Provided herein is an applicable bio-conjugation process for preparing antibody-drug conjugates (ADCs) with improved homogeneity. As compared with conventional conjugation process, the homogeneity of antibody-drug conjugate (ADC) products generated from the bio-conjugation process can be dramatically improved. Specifically, in the ADCs prepared by the process disclosed herein, the content of D0+D8 is less than 10 wt % and the content of D6 is less than 10 wt %. Moreover, the content of D4 is generally more than 65 wt %, for example, more than 70 wt %, and more than 77 wt %, while the content of D4 is normally less than 40 wt % in the ADCs prepared by conventional conjugation processes.

Abstract: A method for testing at least one energy micro-storage device includes an anode made of metallic lithium formed by electrodeposition of ions on a metal inert to lithium ions, the method comprising a succession of steps during the manufacture of said anode: a step of measuring the initial voltage OCV of the energy micro-storage device; a first charging step, comprising applying a current, measuring the voltage and the internal resistance of the device in order to verify the compliance of the measurements on a very low lithium layer thickness formed at the anode; a second charging stabilization step, comprising applying a current and measuring the voltage of the device in order to verify the compliance of the measurements on a low lithium layer thickness formed at the anode; a retention step with a zero current applied and measuring the voltage in order to confirm the compliance of the energy micro-storage device. A system for implementing the method is also provided.

Abstract: A method for determining a health status of a system of interest is proposed. The method comprises acquiring (S1) a time series, extracting (S2) subsequences, selecting (S3) a set of subsequences, classifying (S4) the subsequences of the set into several groups on the basis of at least one criterion of resemblance to at least one reference subsequence, and constructing (S5) a normal operating model of the system of interest. The construction includes, for each group, a modeling (S51) of a representative subsequence and a determination (S52) of an associated weight. The normal model is defined by the modeled subsequences and the associated weights. The method further includes an attribution (S6) of a normality score to each subsequence extracted by comparison with the normal model, an identification (S7) of at least one abnormal subsequence, and a determination (S8) of the health status of the system of interest.

Abstract: Disclosed are a system, apparatus and techniques for evaluating a dataset to confirm that the data in the dataset satisfies a data quality metric. A machine learning engine or the like may evaluate text strings within the dataset may be of arbitrary length and encoded according to an encoding standard. Data vectors of a preset length may be generated from the evaluated text strings using various techniques. Each data vector may be representative of the content of the text string and a category may be assigned to the respective data vector. The category assigned to each data vectors may be evaluated with respect to other data vectors in the dataset to determine compliance with a quality metric. In the case that a number of data vectors fail to meet a predetermined quality metric, an alert may be generated to mitigate any system errors that may result from unsatisfactory data quality.

Abstract: The present disclosure relates to antibody molecules comprising a binding domain specific to CD22, said binding domain comprising SEQ ID NO: 1, 2, 3, 4, 5 and 6 or 7. The disclosure also extends to pharmaceutical compositions comprising said antibody molecules and use of the antibody molecules/compositions in treatment.

Abstract: Antibodies that include a sulfatase motif-containing tag in a constant region of an immunoglobulin (Ig) heavy chain polypeptide are disclosed. The sulfatase motif can be converted by a formylglycine-generating enzyme (FGE) to produce a formylglycine (fGly)-modified Ig heavy chain polypeptide. An fGly-modified Ig heavy chain polypeptide of the antibody can be covalently and site-specifically bound to a moiety of interest to provide an antibody conjugate. The disclosure also encompasses methods of production of such tagged Ig heavy chain polypeptides, fGly-modified Ig heavy chain polypeptides, and antibody conjugates, as well as methods of use of same.

Abstract: An advanced driver assistance system (ADAS) and method for a vehicle utilize a light detection and ranging (LIDAR) system configured to emit laser light pulses and capture reflected laser light pulses collectively forming three-dimensional (3D) LIDAR point cloud data and a controller configured to receive the 3D LIDAR point cloud data, convert the 3D LIDAR point cloud data to a two-dimensional (2D) birdview projection, detect a set of lines in the 2D birdview projection, filter the detected set of lines to remove lines having features that are not indicative of traffic signs to obtain a filtered set of lines, and detect one or more traffic signs using the filtered set of lines.

Abstract: Disclosed herein are methods of engineering a bi-specific T-cell expressing chimeric antigen receptors for promoting the in vivo expansion and activation of an effector cell and a second chimeric antigen receptor or TcR specific for a ligand on a tumor. Methods of administering to subjects in need, bi-specific chimeric antigen receptor bearing cells are also provided.

Abstract: The present invention relates to fully human antibodies and conjugates thereof, which specifically bind to the extracellular domain of receptor tyrosine kinase-like orphan receptor 2 (ROR2).