Abstract: The present disclosure relates to antibody-drug conjugates comprising ALK5 inhibitors and their uses.

Abstract: The present invention provides antagonizing antibodies that bind to complement factor D (CFD), conjugates thereof, and methods of using same. The anti-CFD antibodies can be used therapeutically alone or in combination with other therapeutics to treat age related macular degeneration and other diseases.

Abstract: The present invention relates to compositions and methods employing conjugates that include a self-assembly and disassembly (SADA) polypeptide and a binding domain. The present invention encompasses the recognition that conjugates with a SADA polypeptide have certain improved biological properties. SADA-conjugates are described, along with uses thereof (e.g., as therapeutic or diagnostic agents) and methods of manufacture.

Abstract: Bispecific antibodies which comprise one antigen-binding region binding to an epitope of human epidermal growth factor receptor 2 (HER2) and one antigen-binding region binding to human CD3, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods for preparing and using the antibodies are also disclosed.

Abstract: A system and method including receiving sets of sensor data associated with sensors configured to monitor one or more systems. Sensor fingerprints are generated for each set of sensor data based on the sensor data. At least one proximity value is computed for each sensor by comparing the fingerprint of that sensor with another fingerprint. Clusters of similar sensors are identified based at least upon the proximity values of the sensors.

Abstract: A spatial recognition device provided with an analysis unit configured to acquire, from an optical device which receives reflected light obtained by radiating light onto a reflective plate provided on a moving body positioned within a detection area, reflected light information obtained based on the reflected light in accordance with a radiation direction of the light, and analyze a state of the moving body on which the reflective plate is provided, based on a distribution of the reflected light information at coordinates within the detection area.

Abstract: The invention provides novel peptides (e.g., linkers) and polypeptide compositions comprising the linkers (e.g., fusion proteins) and methods of using the polypeptide compositions. Peptides (e.g., linkers) are useful as tags and for engineering fusion proteins (e.g., antigen binding molecules, scFv). Polypeptide linkers described herein facilitate flexibility of linked peptides allowing for proper folding, conformation and reduced immunogenicity.

Abstract: Methods, systems, and devices for analyzing vibration data to determine and mitigate an occurrence of an anomaly at an industrial asset. A device may obtain and preprocess vibration data, which may include grouping the vibration data according to respective time intervals, and the device may filter the grouped data to obtain the most recent measurement readings. The device may use an anomaly detection algorithm to detect outliers in the datasets for each group of vibration data and compare an amplitude of the outliers to a threshold for the respective group. The device may determine that the vibration data includes an anomaly based on quantities of outliers in first and second subsets of the vibration data that are within a detection window. The device may generate a report including an indication of the anomaly and transmit the report to an operator or engineer for the facility.

Abstract: An electronic apparatus and a control method thereof are provided. The electronic apparatus may include an interface; and a processor configured to obtain, via the interface, information related to values, which occur in time series, of a plurality of factors regarding a prediction object, identify, based on the information related to the values of the plurality of factors, at least one factor, from among the plurality of factors, having a time series change of values that corresponds to a time series change of reference values of the prediction object, and output information related to a predicted value of the prediction object based on the time series change of the values of the at least one factor.

Abstract: To detect connection between a secondary battery and a charger, determine whether or not a state of the secondary battery is stabilized in a case of detecting the connection, measure a first open circuit voltage that is an open circuit voltage before charging of the secondary battery in a case of determining that a state of the secondary battery is stabilized, instruct the charger to start charging of the secondary battery, detect end of charging of the secondary battery, determine whether or not a state of the secondary battery is stabilized in a case of detecting end of charging of the secondary battery, measure a second open circuit voltage that is an open circuit voltage after charging of the secondary battery in a case of determining that a state of the secondary battery is stabilized, and notify the user of end of charging of the secondary battery.

Abstract: The present invention relates to isolated monoclonal antibodies (mAbs) and/or antigen-binding fragments thereof that specifically recognize indoxyl sulfate, a protein-bound uremic toxin, and uses of such isolated anti-IS mAbs and/or antigen-binding fragments thereof to create immunoassay methods applied in theragnosis of IS-related diseases.

Abstract: A device may receive a classification model generated based on a set of spectroscopic measurements performed by a first spectrometer. The device may store the classification model in a data structure. The device may receive a spectroscopic measurement of an unknown sample from a second spectrometer. The device may obtain the classification model from the data structure. The device may classify the unknown sample into a Kosher or non-Kosher group or a Halal or non-Halal group based on the spectroscopic measurement and the classification model. The device may provide information identifying the unknown sample based on the classifying of the unknown sample.

Abstract: A fault finding support system is a fault finding support system for instructing a maintenance worker of an appropriate examination location and examination contents using fault knowledge data in which a causal relationship of fault of a target machine is described, the system including: an examination procedure creation unit that creates an examination procedure with respect to the examination location and the examination contents of the target machine using the fault knowledge data, an examination result storage unit that stores an examination history of performing examination using the examination procedure created by the examination procedure creation unit, an update target extraction unit that recommends an update location of the fault knowledge data using the examination history stored in the examination result storage unit, and a user interface that provides a function of displaying a location extracted by the update target extraction unit and updating the fault knowledge data.

Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a canine and methods of their use. The compositions involve variant canine IgG Fc regions.

Abstract: The present invention concerns binding molecules that comprise an IgM, IgA, IgG/IgM or IgG/IgA antibody with a J-chain modified to include an ADME-modulating moiety, and their uses.

Abstract: A method for performing technical diagnostics of machines is carried our by means of a diagnostic system of machines that employs at least two sensors to be placed on the machines, wherein the sensors are selected from the group of vibration sensors, strain sensors, position sensors, and distance sensors, and wherein measured data is evaluated by an evaluation process comprising a step of pairing the measured data and a step of comparing processed data with model states.

Abstract: A computer-implemented method for detecting anomalies in sensor recordings of a technical system. The method including: ascertaining a first anomalous value which, with regard to all sensor recordings, characterizes whether or not an anomaly is present; ascertaining a plurality of second anomalous values, a second anomalous value from the second anomalous values corresponding to a sensor recording, and the second anomalous value, with regard to the sensor recording and under the condition of the occurrence of the other sensor recordings, characterizing whether or not an anomaly is present in the sensor recording; detecting an anomaly in a sensor recording of the sensor recordings if the first anomalous value characterizes the presence of an anomaly, and the second anomalous value corresponding to the sensor recording characterizes an anomaly, and the second anomalous value differs beyond a predefined extent from other second anomalous values of the second anomalous values.

Abstract: A multifunctional polypeptide chain or a protein. A polypeptide chain X, comprising an antigen 1 binding domain R1, an auxiliary peptide chain linking domain R2 and an antigen 2 binding domain R3. The auxiliary peptide chain linking domain R2 is a cytokine or a cytokine binding domain in a cytokine receptor. A protein, which is a heterodimer composed of the polypeptide chain X as a main peptide chain and an auxiliary peptide chain Y. The auxiliary peptide chain Y comprises an antigen 3 binding domain R4 and a main peptide chain X linking domain R5, or the auxiliary peptide chain Y is the main peptide chain linking domain R5. The multifunctional protein mediates specific cell killing by binding to different tumor antigens with the two antigen binding domains of tumor-associated antigens therein. The multifunctional protein can function as a cytokine by introducing a cytokine or a cytokine receptor complex.

Abstract: A system for controlling supply of a device. The device can be a power retention device that requires to be permanently powered. To this end, it can be alternatively powered by a power supply, in a first mode, or by a battery, in a second mode. At least one sensor of the system acquires data related to the battery, such as environmental data, the voltage of the battery or the discharge current of the battery. Based on the data and at least one characteristic curve of the battery, a battery monitoring module is configured to switch between the first and second modes to improve the lifetime of the battery.

Abstract: An aggregation system comprises a server holding the survey results of crops and a management apparatus, wherein the management apparatus acquires, from the server, survey data indicating results of a survey of crops performed in the farm field in a set period, and containing information of at least a date of the survey and survey contents, edits the information of the acquired survey data, and transmits the edited survey data to the server, and wherein the server manages survey data, transmits survey data to the management apparatus, updates, when edited survey data is received from the management apparatus, managed survey data by the edited survey data, and aggregates survey data containing the updated survey data, and indicating results of a survey of crops performed in the farm field in the set period.