Abstract: Aspects of the disclosure relate to complexes comprising a muscle-targeting agent covalently linked to a molecular payload. In some embodiments, the muscle-targeting agent specifically binds to an internalizing cell surface receptor on muscle cells. In some embodiments, the molecular payload inhibits expression or activity of a DMPK allele comprising a disease-associated-repeat. In some embodiments, the molecular payload is an oligonucleotide, such as an antisense oligonucleotide or RNAi oligonucleotide.

Abstract: An adaptive method and device for predicting a weather-related characteristic of a surface of a segment of a road network. The method includes obtaining a location and of measuring a weather-related characteristic of the surface of the roadway of a road segment on which a measuring vehicle is traveling; predicting a weather-related surface characteristic of the road segment using a weather-observation history and a first prediction model associated with the road segment; associating a second prediction model with the road segment when a difference between the measured characteristic and the predicted characteristic is greater than a threshold; and transmitting to a vehicle a prediction made by applying the associated model to the weather-observation history.

Abstract: The present disclosure relates to compositions and methods of engineered IgG Fc constructs, wherein the Fc constructs include one or more Fc domains.

Abstract: A specific antigen-binding member (ABM) comprising a specific antigen-binding moiety and an antibody Fc region comprising a CH2 domain, which is engineered for a cysteine substitution at position 108 and/or 113, wherein numbering is according to the IMGT, and wherein the antibody Fc region does not comprise an antigen-binding CH3 domain; and an ABM conjugate (ABMC) comprising the ABM and at least one heterologous molecule covalently conjugated to one or both of the cysteines at positions 108 and 113 of the CH2 domain.

Abstract: An electronic apparatus includes a connection unit to which a battery device is connected, a calculation unit that calculates a remaining battery level of a battery of the battery device based on a full charge capacity of a battery of the electronic apparatus, and a display unit that displays information indicating a result of calculation made by the calculation unit.

Abstract: The present disclosure relates to anti-CD38 antibodies and their use as therapeutics and diagnostics. The present disclosure further relates to methods of treating autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis. The present disclosure further relates to diagnostic assay methods for identifying patients having autoimmune diseases for treatment.

Abstract: A system and method for predicting a crop yield for a type of seed in a location is described. The method includes receiving, at a client device, seasonal crop data for the type of seed, soil data associated with the location, and mapping data associated with the location. The soil data includes soil variables, and the location is represented by voxels. The seasonal crop data, the soil data and the mapping data are uploaded to a geospatial database associated with a crop prediction engine. A random forest prediction model is applied to the seasonal crop data, the soil data and mapping data in the geospatial database by the crop prediction engine, which then ranks covariates to determine one or more significant covariates. The crop prediction engine then re-applies the significant covariates to the random forest prediction model to predict the crop yield for the type of seed at the location.

Abstract: Isolated antigen binding molecules that specifically binds to a molecule comprising an amino acid sequence selected from the group consisting of GSTSGSGKPGSGEGSTKG (SEQ ID NO: 1), GSGKPGSGEG (SEQ ID NO: 2), GKPGSGEG (SEQ ID NO: 3), SGKPGSGE (SEQ ID NO: 499) and KPGSG (SEQ ID NO: 500) are provided. The antigen binding molecules can be used in the methods provided herein.

Abstract: Disclosed is a device and a method for measuring stream water depth in real-time through positioning data filtering to ensure the reliability of the measured water depth data even when the stream water depth measurement data is filtered and applied to a small stream having a small basin area and a steep slope. The device for measuring stream water depth in real-time through positioning data filtering includes: a measuring part for measuring the water depth of a stream to be measured; a positioning data filtering part for filtering the water depth data measured by the measuring means by a local linear regression-based bivariate scatterplot smoothing technique through elastic bandwidth application; and a water depth calculating part for calculating a water depth of the stream to be measured by using the positioning data filtered by the positioning data filtering part, and minimizing the uncertainty of the water depth measurement.

Abstract: Herein are provided bispecific anti-human CD20/human transferrin receptor antibodies and methods of using the same.

Abstract: Methods, systems, and techniques for determining the confidence that predicted demand charge savings resulting from deploying an energy management system at a site will match actual cost savings. A processor obtains predicted demand charge savings resulting from deploying the energy management system at the site, and also obtains demand-related data describing at least two of load predictability, load shape, and battery capacity of the energy management system. The processor determines a confidence score representing the confidence that the predicted demand charge savings will result in view of the demand-related data, and displays the confidence score on a display for subsequent use by a user.

Abstract: A server apparatus 10 is communicably connected to a terminal apparatus 20 that collects sensor data from an odor sensor 40. The server apparatus 10 includes an analyzer holding unit 11 that holds a plurality of analyzers for analyzing specific odor analysis targets, based on sensor data, an analyzer management unit 12 that determines preprocessing to be performed on the sensor data, by selecting an analyzer according to the environment of the odor sensor 40, and causes the terminal apparatus 20 to execute the preprocessing, an analysis execution unit 13 that executes analysis processing of the designated odor analysis target, by applying the selected analyzer to the preprocessed sensor data, and an analysis result transmission unit 14 that transmits information indicating a result of the analysis processing to the terminal apparatus 20.

Abstract: One embodiment of the present invention provides an apparatus and the like for improving the accuracy of deterioration estimation regarding a monitoring target. An information processing apparatus as one embodiment of the present invention includes a detector, a separator, a calculator, and an estimator. The detector detects a normal waveform pattern included in a waveform of time-series data of a target. The separator separates the waveform of the time-series data into components while removing the normal waveform pattern that is detected. The calculator calculates a feature of the time-series data based on at least one of the components. The estimator estimates deterioration of the target based on the feature.

Abstract: A computer implemented method processes time waveform machine vibration data that are indicative of operational characteristics of a machine. The data, which were measured on the machine over a period of time having a begin time and an end time, are accessed from a memory or storage device. An integer number M of waveform samples are determined from the data to be averaged, and an asymptotically decaying DC bias component in the data is derived using a moving average of the M number of waveform samples. The DC bias component is extrapolated from the begin time of the waveform back to an earlier time and from the end time of the waveform forward to a later time. The DC bias component is then subtracted from the time waveform data, and a Fast Fourier Transform is performed on the data to generate a spectrum.

Abstract: A system can assign a value to one or more sustainability factors for a wellbore operation based on historical data. The system can determine, for each of the one or more sustainability factors, a weight. The system can determine a sustainability index corresponding to a predicted carbon footprint for the wellbore operation based on the weight and the value for each of the one or more sustainability factors. The system can output a command for adjusting the wellbore operation based on the sustainability index.

Abstract: The present invention provides specific sites for modifying antibodies or antibody fragments by replacing at least one native amino acid in the constant region of a parental antibody or antibody fragment with cysteine, which can be used as a site of attachment for a payload or linker-payload combination.

Abstract: Methods for developing disease-related nanobodies and related products and kits are provided. The disease-specific proteins are extracellular matrix (ECM) proteins, domains or epitopes that are associated with various aspects of disease and are not present, or are present in very low quantities, in non-diseased individuals. Highly effective nanobodies capable of specifically binding to these ECM protein epitopes useful in in vivo imaging assays, the detection, diagnosis and treatment of diseases as well as monitoring therapeutic progress in a patient with a disease are provided herein.

Abstract: A method for testing a technical system. Tests are carried out with the aid of a simulation of the system. The tests are evaluated with respect to a fulfillment measure of a quantitative requirement on the system and different error measures of the simulation. On the basis of the fulfillment measure and each of the error measures, a classification of the tests is carried out as either reliable or unreliable case by case. A selection among the error measures is made on the basis of a number of the tests classified as reliable.

Abstract: The present disclosure provides a chimeric receptor binding protein (RBP) resistant to proteolytic digestion wherein said RBP comprises a portion of a receptor binding protein derived from a bacteriophage fused through a designed linker region consisting of 1 to 70 amino acids, to a portion of a receptor binding protein derived from a different bacteriophage, wherein said linker region is designed to be resistant to proteolytic digestion.

Abstract: The present disclosure relates to antibody-drug conjugates comprising ALK5 inhibitors and their uses.