Abstract: Amines are prepared by reacting ammonia, a primary amine or a secondary amine with an olefin, carbon monoxide and water in the presence of a rhodium catalyst which is rhodium oxide or a rhodium compound capable of forming a rhodium carbonyl and iron carbonyl.

Abstract: Compounds of the formula: ##SPC1##Wherein R is hydrogen, lower alkyl, halogen, nitro, trifluoromethyl, or lower alkoxy; and n is 2, 3, or 4; and the non-toxic pharmaceutically acceptable acid addition salts thereof; have CNS-depressant activity.

Abstract: Salts of p-dihydroxy benzene disulfonic acids having the general formula: ##SPC1##Wherein B is an alkali metal or an equivalent of an alkaline-earth metal, or BH is the cation of ammonia or a nitrogen containing basic organic compound, are useful for reducing the average bleeding time and for combating capillary fragility.

Abstract: 5H-Aminoacetamido-10,11-dihydrodibenz[b,f]azepines and their physiologically tolerable acid addition salts are disclosed to be useful as central nervous system depressant agents with anticonvulsant and muscle relaxing activity and as antihypertensive agents. A process for their preparation and for the preparation of their novel precursors is also described.

Abstract: Compounds of the formula ##SPC1##WhereinR.sub.1 and R.sub.2 each represent hydrogen or a straight-chained or branched C.sub.1.sub.-3 alkyl group,R stands for hydrogen or a straight-chained or branched C.sub.1.sub.-4 alkyl group,R.sub.3 stands for hydrogen or a straight-chained or branched C.sub.1.sub.-4 alkyl group.The new compounds of formula (I) possess valuable pharmacological properties, and act, primarily, on the central nervous system. Thus they can be used in the therapy first of all as the active agents of anticonvulsive medicines.

Abstract: Ketones are converted by hydrogenation to the corresponding secondary alcohols, in the presence of a soluble catalyst which is obtained by contacting a metal compound, for example a cobalt, nickel or iron salt, with a reducing agent, preferably a trialkylaluminum compound, the reaction being carried out with added metal alcoholate, preferably an alkali metal alcoholate.

Abstract: An improved process for the production of 2-mercaptoarylthiazoles comprising reacting a primary aryl amine and sulfur with selected nitrogen-containing compounds including thiourea, urea, cyanamide, metal cyanamide salts, dicyanodiamide, ammonium thiocyanate, and the like, in the presence or absence of carbon disulfide.

Abstract: 4-Desacetoxy-3'-hydroxyvinblastine, a novel indoledihydroindole alkaloid obtained in small quantities from Vinca rosea, intermediate for the preparation of antimitotic compounds.

Abstract: N-(7- or 8-substituted-quinolyl-4)-anthranilates of the formula ##SPC1##Wherein X in the 7 or 8 position is trihalomethyl or trihalomethylthio, Z is --(CH.sub.2).sub.n -- or --(CH.sub.2).sub.m --O--(CH.sub.2).sub.p --, n is a whole number from 2 to 6, m and p are whole numbers from 2 to 3 and Y.sub.1 and Y.sub.2 are alkyl having 1 to 6 carbon atoms, as well as their non-toxic, pharmaceutically acceptable acid addition salts having analgesic and anti-inflammatory activity and their preparation.

Abstract: Vitamin E orotate which is useful in medicines and cosmetics, is produced by esterifying vitamin E with an orotyl halide or orotic anhydride or with orotic acid in the presence of phosphorous oxychloride.

Abstract: 3-Hydroxy-3-(substituted-aminoalkyl-3,4-dihydro-2H-1,5-benzodioxepin products are described that exhibit .sym.-advenergic stimulating properties and are therefore suitable for use as bronchodilating agents. The products are prepared essentially by four principal routes from 3-oxo-3,4-dihydro-2H-1,5-benzodioxepins. By one route the 3-oxobenzodioxepin is treated with a nitroalkane to give a 3-hydroxy-3-nitroalkyl-benzodioxepin the nitro group of which is reduced to an amine and the resulting compound reacted with an aldehyde or ketone under hydrogenating conditions to introduce the desired substituent into the amino function.

Abstract: New 1,2,4-thiadiazoles substituted with a phosphorus containing radical and corresponding to the formula ##EQU1## are disclosed. In this formula R.sub.1 is alkyl or alkoxy, R.sub.2 represents alkoxy, alkylthio, amino, alkylamino, or dialkylamino, R.sub.3 stands for hydrogen, alkyl, aralkyl or cyclo-alkyl, and X is oxygen or sulphur. Such compound may be manufactured according to known methods and exibit a pesticidal especially an insecticidal and acaricidal activity.

Abstract: Charge transfer complexes composed of 7,7,8,8-tetracyanoquinodimethane and a quaternary nitrogen-containing heterocyclic compound, the hydrogen at N-position of the heterocyclic compound being substituted by a group such as an alkyl group, an alkylene group or a cycloalkyle group. The complex may be either an abnormal one which contains neutral 7,7,8,8,-tetracyanoquinodimethane in an amount deviated from 1 mole per 1 mole of the complex, or a normal one which contains 1 mole of neutral 7,7,8,8-tetracyanoquinodimethane per 1 mole of the complex.

Abstract: Disclosed are new chemical compounds namely 1,4-dialkanols of octahydrothieno[3,4-b]pyrazine 6,6-dioxides and 4-alkanols of octahydrothieno[3,4-b]pyrazine 6,6-dioxides, the use of such compounds in the production of polyurethanes, and methods of making such compounds.

Abstract: The invention is directed to 4-amino-2-phenyl-6-thiopyrimidine compounds having the formula ##SPC1##Where R.sup.1 -R.sup.3 are as defined in the specification. The compounds have pharmacodynamic activity as central nervous system depressants. That is, they produce a calming effect in the host.

Abstract: A method is provided for the direct production of the gamma crystalline phase of quinacridone. The method comprises ring closing a mixture of dianilinoterephthalic acid and 10 - 20 weight percent of di-(ortho substituted) anilinoterephthalic acid in polyphosphoric acid and thereafter diluting the product with water.

Abstract: Antimicrobially active ceph-3-ems having in the 3-position a benzyl or mono-halobenzyl group, preferably with the mono-halo group in the para-position of the phenyl part of the benzyl group.

Abstract: A novel process for the preparation of s-triazolo[3,4-b]benzothiazole compounds comprises reacting a molar equivalent of base in an amide solvent at a temperature from 60.degree.C. to 200.degree.C. with (a) a 1-acyl-4-(o-halophenyl)thiosemicarbazide compound or (b) a 4-(o-halophenyl)-1,2,4-triazole-3-thiol compound and recovering the product. The s-triazolo[3,4-b]benzothiazole compounds are useful for the control of plant pathogens.

Abstract: In the production of an aryl lactamhydrazone of the formula ##SPC1##In whichA represents optionally substituted alkylene, aralkylene or cycloalkylene, each with up to 20 carbon atoms, andQ represents optionally substituted, mononuclear to trinuclear aryl or an optionally alkylsubstituted mononuclear or binuclear heterocyclic aromatic system with 1 to 3 hetero atoms,In which a lactim-ether of the formula ##SPC2##In which R is aryl or alkyl of 1 to 6 carbon atoms,Is reacted with an arylhydrazine or heteroarylhydrazine of the formulaH.sub.2 N--NH--Q (III)the improvement which comprises effecting the reaction at a temperature of about -20.degree. to 150.degree.C and in the presence of at least a catalytic amount of acid, whereby the yield is markedly increased. Those compounds wherein A is --(CH.sub.2).sub.2-11 -- and Q is pyridyl or phenyl substituted by at least one nitro, sulfo, sulfonamido or carboxy group are new and exhibit fungicidal activity.

Abstract: Substituted piperazine dione oxyls and hydroxides are stabilizers for synthetic polymeric materials normally subject to deterioration caused by ultraviolet light. The compounds may be prepared by first preparing a substituted piperazine dione with subsequent oxidation of the piperazine dione to yield the oxyl and reduction of the oxyl to yield the hydroxide derivative. Polymeric compositions containing these stabilizers may also contain a hindered phenolic compound. A typical embodiment is 15-n-octadecyl-7-oxyl-7,15-diazadispiro[5,1,5,3]hexadecane-14,16-dione.