Abstract: Novel compounds, i.e. 3,5-bis(chloromethylthio)-4-cyanoisothiazole; 2,5-bis(chloromethylthio)-1,3,4-thiadiazole; and 3,5-bis(chloromethylthio)-1,2,4-thiadiazole are prepared by reacting an alkali metal aryl mercaptide with bromochloromethane in the presence of a quaternary ammonium salt. These novel compounds have microbiological activity and are also useful as intermediates in the preparation of the corresponding thiocyanomethylthio compounds which have antimicrobial activity.

Abstract: Compounds of the formula ##STR1## wherein X is cyano or ##STR2## Q is Cl, --OR.sub.1, --SR.sub.1 or --NR.sub.2 R.sub.3 ; R.sub.1 is hydrogen or alkyl of 1-2 carbon atoms,R.sub.2 is hydrogen or methyl; andR.sub.3 is hydrogen, alkyl of 1-4 carbon atoms or phenyl,With the proviso that (a) when R.sub.2 is hydrogen, R.sub.3 is hydrogen or alkyl of 1-3 carbon atoms or phenyl and (b) when Q is --SR.sub.1, R.sub.1 is not hydrogen, are useful as fungicides and reaction intermediates. These compounds may be prepared by reacting substituted 3,4-dimercaptoisothiazole salts with sulfur monochloride.

Abstract: The protected copolymer compositions of the present invention have the following structural formula: ##STR1## WHEREIN A is a cyclic or acyclic group having 1 to 12 carbon atoms, 2 to 26 - (j + m) hydrogen atoms, 0 to 4 oxygen atoms, and 0 to 2 nitrogen atoms,E is a group having the structure ##STR2## wherein n is 3 to 5, G is a group having the structure--C.sub.u H.sub.2u-2 (CO.sub.2 C.sub.v H.sub.2v + 1 --.sub.2Wherein u is 2 or 3 and v is an integer from 2 to 9,K is a radical selected from the group consisting ofR--, RCO--, RNHCO--, ROC(CH.sub.3)H--, ##STR3## wherein R is a cyclic or acyclic radical having 1 to 18 carbon atoms and x is 3 or 4, J IS AN INTEGER FROM 0 TO 8,m is an integer from 0 to 4,j + m is 1 to 8,s is an integer from 2 to 4,w is 1 to 200,p is 1 to 10,q is 1 to 10, andr is 1 to 50.The compositions of this invention have been found to be useful as stabilizers in the preparation of cellular foams.

Abstract: 2-Imino-3-aminothiazolidines are inhibitors of indoleamine-N-methyl transferase in vivo.

Abstract: Novel 8-aza-9-dioxothiaprostanoic acid compounds, their salts, and derivatives, are prepared from ethyl 7-(3-hydroxymethyl-2-isothiazolidinyl)-5-heptynoate S,S-dioxide by first hydrogenating the triple bond over a Lindlar catalyst, followed by mild oxidation, to produce the corresponding 3-formyl compound, which is condensed with the ylide prepared from dimethyl-(2-oxoheptyl)phosphonate to produce the .alpha.,.beta.-unsaturated ketone, followed by reduction to the corresponding carbinol, and ester hydrolysis. The compounds are useful especially for the treatment of patients with poorly functioning kidneys, as hypotensives, or as platelet aggregation inhibitors.

Abstract: This invention discloses new compounds of the formula ##STR1## WHEREIN X is selected from the group consisting of alkyl, haloalkyl, alkoxy and halogen,; n is an integer from 0 to 2; R.sup.1 is selected from the group consisting of alkyl, alkenyl, haloalkyl and ##STR2## wherein R.sup.3 and R.sup.4 are each selected from the group consisting of hydrogen and alkyl; p is an integer from 0 to 3; Y is oxygen or sulfur; R.sup.2 is selected from the group consisting of alkyl and halogen; and q is an integer from 0 to 2. Further disclosed is the herbicidal utility of the foregoing compounds.

Abstract: N,15-Didehydro-15-deoxo-3,15-epi(methano(alkylimino))rifamycins which can exist in either the quinone or hydroquinone form, are prepared from the corresponding Mannich base derivatives by an acid-catalyzed dehydration reaction.

Abstract: An intermediate represented by following formula for synthesizing 3-hydroxy-3-cephem compounds. ##STR1## wherein A and B each is a hydrogen or amino substituent; R is a hydrogen or thiol substituent; Hal is a halogen; X is a hydroxy or carboxy protecting group; the broken line between A and R shows that when R and B are hydrogens, and A is a carboxylic acyl, the substituents can be combined to form an azetidinothiazoline bicyclic ring; and the enamine derivatives thereof.

Abstract: A compound of the formula ##STR1## wherein Y represents an arylene group optionally substituted by a halogen atom, an arylsulfonyl group or an acyl group, Z represents a 1,2-naphthylene, 2,3-naphthylene, 1,8-naphthylene or 2, 2'-biphenylene group optionally substituted by a halogen atom, and either one or both of the rings A and B optionally contain a substituent. This compound can be obtained by reacting a quinoline derivative with an aryldicarboxylic acid or its reactive derivative, and if desired, halogenating the resulting product. A yellow organic pigment comprising this compound as a coloring ingredient is useful for coloring polymeric materials.

Abstract: A process for preparing the compound represented by the formula ##STR1## wherein the indicated carbon has the D-configuration which comprises dissolution of the compound in the L-configuration or as a mixture of the D and L-configurations in aqueous pyridine from which the compound having the D-configuration selectively crystallizes.

Abstract: Compounds having the formula ##STR1## ARE FOUND TO BE EFFECTIVE PLANT GROWTH REGULANTS.

Abstract: Metal complexes of N-trityl-azoles of the formula ##STR1## IN WHICH Me is a metal,X is halogen, nitro, cyano, hydroxyl, alkyl, alkoxy, alkylthio, alkoxycarbonyl, haloalkyl or alkylsulfonyl,Az is an imidazolyl radical or a 1,2,4-triazolyl radical,A is an anion of an inorganic acid,n is 0, 1, 2, 3 or 4,m is 1, 2, 3 or 4, andp is 1, 2, 3, 4, 5 or 6,Which possess fungicidal properties.

Abstract: (5-Alkylureido-1,3,4-thiadiazol-2-ylsulfonyl) acetic acid derivative of the formula ##STR1## in which R.sub.1 and R.sub.2 are hydrogen or alkyl and R.sub.3 is hydrogen, alkyl, univalent metal equivalent, an ammonium group or an alkyl ammonium group. The compositions are used for herbicidal purposes as the active agent in herbicide compositions.

Abstract: 2-Amino-(2)-thiazoline-4-carboxylic acid is prepared by dehydrochlorinating S-(.beta.-carboxy-.beta.-chloroethyl) isothiourea by adding it to an aqueous medium maintained at a pH ranging from 5.5 to 7.5 with an alkali.

Abstract: Benzene derivatives of the formula: ##STR1## wherein R.sup.1 is alkyl, R.sup.2 is a group --SR.sup.3, --SOR.sup.3, --SO.sub.2 R.sup.3 or --OR.sup.3, in which R.sup.3 is alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, aryl or cycloalkylalkyl, whose position on the benzene ring is either para to --NHCOAZ or para to the heterocyclo group, A is a C.sub.1-4 aliphatic hydrocarbon radical, B is a bivalent methylene or ethylene group, and Z is a primary, secondary or tertiary amino group, and acid addition salts and quaternary ammonium derivatives thereof, are new compounds useful as anthelmintics and antifungal agents.

Abstract: Anti-allergic 2-amino-quinolin-4-one-3-phosphonic acid esters are prepared by reacting an isatoic anhydride with the carbanion resulting from the treatment of an organo-methane phosphate with a proton abstracting agent.

Abstract: The present invention relates to 8-(1H-tetrazol-5-yl)-11H-pyrido[2,1-b]quinazolin-11-ones having the following structure: ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen, alkyl, alkyloxy, halogen, hydroxy and methylenedioxy; R.sub.3 is carboxamido, cyano or 5-tetrazolyl groupings and the pharmaceutically acceptable salts of acids and bases thereof.These compounds exhibit anti-allergic properties and are useful as anti-asthmatic agents.

Abstract: Novel polyoxyalkylene fluoroalkyltrimellitate compounds are disclosed that are useful for improving the soil release properties of textiles. These compounds may be conveniently prepared by reacting a fluorinated alkyl thiol or amine with trimellitic anhydride monoacid chloride to form a fluorinated trimellitic anhydride intermediate product which is then reacted with a polyoxyalkylene derivative.

Abstract: Diarylimidazothiazoles, such as 2,3-dihydro-5,6-bis(p-methoxyphenyl)imidazo[2,1-b]thiazole, useful as antiinflammatories.

Abstract: 1-Alkylamino-3-(5-alkynylaminocarbonylthiazol-2-yloxy)-2-propanol; 5-(5-alkynylaminocarbonyl-thiazol-2-yloxymethylene)-N-alkyloxazolidine and/or 2-substituted oxazolidine derivatives thereof, and methods of making such compounds. The compounds exhibit cardiovascular activity and are useful in the treatment of abnormal heart conditions in mammals. The compounds are also useful in the treatment of hypertension in mammals. The 5-(5-alkynyl-aminocarbonylthiazol-2-yloxymethylene)-N-alkyloxazolidines and derivatives are also intermediates for the 1-alkylamino-3-(5-alkynylaminocarbonylthiazol-2-yloxy)-2-propanols. The 1-alkylamino-3-(5-alkynylaminocarbonylthiazol-2-yloxy)-2-propanols can be prepared by base or acid hydrolysis of the corresponding 5-(5-alkynylaminocarbonylthiazol-2-yloxymethylene)-N-alkyloxazolidine or derivative; or by treatment of the corresponding 3-(5-alkynylaminocarbonylthiazol-2-yloxy)-2,3-epoxypropane with the desired alkylamine.