Patents Examined by R. J. Gallagher
  • Patent number: 4094985
    Abstract: Compounds of the formula ##STR1## wherein X is cyano or ##STR2## Q is Cl, --OR.sub.1, --SR.sub.1 or --NR.sub.2 R.sub.3 ; R.sub.1 is hydrogen or alkyl of 1-2 carbon atoms,R.sub.2 is hydrogen or methyl; andR.sub.3 is hydrogen, alkyl of 1-4 carbon atoms or phenyl,With the proviso that (a) when R.sub.2 is hydrogen, R.sub.3 is hydrogen or alkyl of 1-3 carbon atoms or phenyl and (b) when Q is --SR.sub.1, R.sub.1 is not hydrogen, are useful as fungicides and reaction intermediates. These compounds may be prepared by reacting substituted 3,4-dimercaptoisothiazole salts with sulfur monochloride.
    Type: Grant
    Filed: March 17, 1977
    Date of Patent: June 13, 1978
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Susan Anne Vladuchick
  • Patent number: 4094880
    Abstract: Novel compounds, i.e. 3,5-bis(chloromethylthio)-4-cyanoisothiazole; 2,5-bis(chloromethylthio)-1,3,4-thiadiazole; and 3,5-bis(chloromethylthio)-1,2,4-thiadiazole are prepared by reacting an alkali metal aryl mercaptide with bromochloromethane in the presence of a quaternary ammonium salt. These novel compounds have microbiological activity and are also useful as intermediates in the preparation of the corresponding thiocyanomethylthio compounds which have antimicrobial activity.
    Type: Grant
    Filed: September 24, 1976
    Date of Patent: June 13, 1978
    Assignee: The Dow Chemical Company
    Inventors: Christian T. Goralski, George A. Burk
  • Patent number: 4091030
    Abstract: The protected copolymer compositions of the present invention have the following structural formula: ##STR1## WHEREIN A is a cyclic or acyclic group having 1 to 12 carbon atoms, 2 to 26 - (j + m) hydrogen atoms, 0 to 4 oxygen atoms, and 0 to 2 nitrogen atoms,E is a group having the structure ##STR2## wherein n is 3 to 5, G is a group having the structure--C.sub.u H.sub.2u-2 (CO.sub.2 C.sub.v H.sub.2v + 1 --.sub.2Wherein u is 2 or 3 and v is an integer from 2 to 9,K is a radical selected from the group consisting ofR--, RCO--, RNHCO--, ROC(CH.sub.3)H--, ##STR3## wherein R is a cyclic or acyclic radical having 1 to 18 carbon atoms and x is 3 or 4, J IS AN INTEGER FROM 0 TO 8,m is an integer from 0 to 4,j + m is 1 to 8,s is an integer from 2 to 4,w is 1 to 200,p is 1 to 10,q is 1 to 10, andr is 1 to 50.The compositions of this invention have been found to be useful as stabilizers in the preparation of cellular foams.
    Type: Grant
    Filed: June 1, 1976
    Date of Patent: May 23, 1978
    Assignee: Air Products and Chemicals, Inc.
    Inventor: Nelson N. Schwartz
  • Patent number: 4091105
    Abstract: 2-Imino-3-aminothiazolidines are inhibitors of indoleamine-N-methyl transferase in vivo.
    Type: Grant
    Filed: August 12, 1977
    Date of Patent: May 23, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Joshua Rokach, Clarence S. Rooney, Grant W. Reader, Edward J. Cragoe, Jr.
  • Patent number: 4087435
    Abstract: Novel 8-aza-9-dioxothiaprostanoic acid compounds, their salts, and derivatives, are prepared from ethyl 7-(3-hydroxymethyl-2-isothiazolidinyl)-5-heptynoate S,S-dioxide by first hydrogenating the triple bond over a Lindlar catalyst, followed by mild oxidation, to produce the corresponding 3-formyl compound, which is condensed with the ylide prepared from dimethyl-(2-oxoheptyl)phosphonate to produce the .alpha.,.beta.-unsaturated ketone, followed by reduction to the corresponding carbinol, and ester hydrolysis. The compounds are useful especially for the treatment of patients with poorly functioning kidneys, as hypotensives, or as platelet aggregation inhibitors.
    Type: Grant
    Filed: February 17, 1977
    Date of Patent: May 2, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., James H. Jones, John B. Bicking
  • Patent number: 4086344
    Abstract: N,15-Didehydro-15-deoxo-3,15-epi(methano(alkylimino))rifamycins which can exist in either the quinone or hydroquinone form, are prepared from the corresponding Mannich base derivatives by an acid-catalyzed dehydration reaction.
    Type: Grant
    Filed: September 13, 1976
    Date of Patent: April 25, 1978
    Assignee: The Dow Chemical Company
    Inventors: James R. McCarthy, Jimmie L. Moore
  • Patent number: 4086241
    Abstract: This invention discloses new compounds of the formula ##STR1## WHEREIN X is selected from the group consisting of alkyl, haloalkyl, alkoxy and halogen,; n is an integer from 0 to 2; R.sup.1 is selected from the group consisting of alkyl, alkenyl, haloalkyl and ##STR2## wherein R.sup.3 and R.sup.4 are each selected from the group consisting of hydrogen and alkyl; p is an integer from 0 to 3; Y is oxygen or sulfur; R.sup.2 is selected from the group consisting of alkyl and halogen; and q is an integer from 0 to 2. Further disclosed is the herbicidal utility of the foregoing compounds.
    Type: Grant
    Filed: June 14, 1976
    Date of Patent: April 25, 1978
    Assignee: Velsicol Chemical Corporation
    Inventors: Chin Ching Wu, John Krenzer
  • Patent number: 4079181
    Abstract: An intermediate represented by following formula for synthesizing 3-hydroxy-3-cephem compounds. ##STR1## wherein A and B each is a hydrogen or amino substituent; R is a hydrogen or thiol substituent; Hal is a halogen; X is a hydroxy or carboxy protecting group; the broken line between A and R shows that when R and B are hydrogens, and A is a carboxylic acyl, the substituents can be combined to form an azetidinothiazoline bicyclic ring; and the enamine derivatives thereof.
    Type: Grant
    Filed: February 17, 1976
    Date of Patent: March 14, 1978
    Assignee: Shionogi & Co., Ltd.
    Inventors: Teruji Tsuji, Yoshio Hamashima, Mitsuru Yoshioka, Masayuki Narisada, Hiroshi Tanida, Taichiro Komeno, Wataru Nagata
  • Patent number: 4077960
    Abstract: A compound of the formula ##STR1## wherein Y represents an arylene group optionally substituted by a halogen atom, an arylsulfonyl group or an acyl group, Z represents a 1,2-naphthylene, 2,3-naphthylene, 1,8-naphthylene or 2, 2'-biphenylene group optionally substituted by a halogen atom, and either one or both of the rings A and B optionally contain a substituent. This compound can be obtained by reacting a quinoline derivative with an aryldicarboxylic acid or its reactive derivative, and if desired, halogenating the resulting product. A yellow organic pigment comprising this compound as a coloring ingredient is useful for coloring polymeric materials.
    Type: Grant
    Filed: June 8, 1976
    Date of Patent: March 7, 1978
    Assignee: Teijin Limited
    Inventors: Keizo Shimada, Toshiaki Harada, Masahiro Koga
  • Patent number: 4075219
    Abstract: A process for preparing the compound represented by the formula ##STR1## wherein the indicated carbon has the D-configuration which comprises dissolution of the compound in the L-configuration or as a mixture of the D and L-configurations in aqueous pyridine from which the compound having the D-configuration selectively crystallizes.
    Type: Grant
    Filed: March 31, 1977
    Date of Patent: February 21, 1978
    Assignee: Eli Lilly and Company
    Inventor: Lawrence J. McShane
  • Patent number: 4075216
    Abstract: Compounds having the formula ##STR1## ARE FOUND TO BE EFFECTIVE PLANT GROWTH REGULANTS.
    Type: Grant
    Filed: October 26, 1976
    Date of Patent: February 21, 1978
    Assignee: Monsanto Company
    Inventor: John J. D'Amico
  • Patent number: 4073901
    Abstract: Metal complexes of N-trityl-azoles of the formula ##STR1## IN WHICH Me is a metal,X is halogen, nitro, cyano, hydroxyl, alkyl, alkoxy, alkylthio, alkoxycarbonyl, haloalkyl or alkylsulfonyl,Az is an imidazolyl radical or a 1,2,4-triazolyl radical,A is an anion of an inorganic acid,n is 0, 1, 2, 3 or 4,m is 1, 2, 3 or 4, andp is 1, 2, 3, 4, 5 or 6,Which possess fungicidal properties.
    Type: Grant
    Filed: January 14, 1976
    Date of Patent: February 14, 1978
    Assignee: Bayer Aktiengesellschaft
    Inventors: Karl H. Buchel, Paul-Ernst Frohberger, Helmut Kaspers
  • Patent number: 4073793
    Abstract: (5-Alkylureido-1,3,4-thiadiazol-2-ylsulfonyl) acetic acid derivative of the formula ##STR1## in which R.sub.1 and R.sub.2 are hydrogen or alkyl and R.sub.3 is hydrogen, alkyl, univalent metal equivalent, an ammonium group or an alkyl ammonium group. The compositions are used for herbicidal purposes as the active agent in herbicide compositions.
    Type: Grant
    Filed: January 14, 1977
    Date of Patent: February 14, 1978
    Assignee: Schering Aktiengesellschaft
    Inventors: Friedrich Arndt, Ludwig Nusslein
  • Patent number: 4072687
    Abstract: 2-Amino-(2)-thiazoline-4-carboxylic acid is prepared by dehydrochlorinating S-(.beta.-carboxy-.beta.-chloroethyl) isothiourea by adding it to an aqueous medium maintained at a pH ranging from 5.5 to 7.5 with an alkali.
    Type: Grant
    Filed: November 1, 1976
    Date of Patent: February 7, 1978
    Assignee: Ajinomoto Co., Inc.
    Inventors: Kazushi Togo, Fumihide Tamura, Naohiko Yasuda, Takehiko Ichikawa, Konosuke Sano, Keizo Matsuda, Koji Mitsugi
  • Patent number: 4071528
    Abstract: Benzene derivatives of the formula: ##STR1## wherein R.sup.1 is alkyl, R.sup.2 is a group --SR.sup.3, --SOR.sup.3, --SO.sub.2 R.sup.3 or --OR.sup.3, in which R.sup.3 is alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, aryl or cycloalkylalkyl, whose position on the benzene ring is either para to --NHCOAZ or para to the heterocyclo group, A is a C.sub.1-4 aliphatic hydrocarbon radical, B is a bivalent methylene or ethylene group, and Z is a primary, secondary or tertiary amino group, and acid addition salts and quaternary ammonium derivatives thereof, are new compounds useful as anthelmintics and antifungal agents.
    Type: Grant
    Filed: October 27, 1976
    Date of Patent: January 31, 1978
    Assignee: May & Baker Limited
    Inventors: Sally Elizabeth Dalton, William George Gingell, David Conwil Jenkins, Leslie George King, Glyn Evan Lee, Garth Molesdale Thompson
  • Patent number: 4070468
    Abstract: Anti-allergic 2-amino-quinolin-4-one-3-phosphonic acid esters are prepared by reacting an isatoic anhydride with the carbanion resulting from the treatment of an organo-methane phosphate with a proton abstracting agent.
    Type: Grant
    Filed: March 1, 1976
    Date of Patent: January 24, 1978
    Assignee: Sandoz, Inc.
    Inventors: Goetz E. Hardtmann, Gary M. Coppola
  • Patent number: 4066767
    Abstract: The present invention relates to 8-(1H-tetrazol-5-yl)-11H-pyrido[2,1-b]quinazolin-11-ones having the following structure: ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen, alkyl, alkyloxy, halogen, hydroxy and methylenedioxy; R.sub.3 is carboxamido, cyano or 5-tetrazolyl groupings and the pharmaceutically acceptable salts of acids and bases thereof.These compounds exhibit anti-allergic properties and are useful as anti-asthmatic agents.
    Type: Grant
    Filed: November 1, 1976
    Date of Patent: January 3, 1978
    Assignee: Warner-Lambert Company
    Inventors: Charles F. Schwender, Brooks R. Sunday
  • Patent number: 4065630
    Abstract: Novel polyoxyalkylene fluoroalkyltrimellitate compounds are disclosed that are useful for improving the soil release properties of textiles. These compounds may be conveniently prepared by reacting a fluorinated alkyl thiol or amine with trimellitic anhydride monoacid chloride to form a fluorinated trimellitic anhydride intermediate product which is then reacted with a polyoxyalkylene derivative.
    Type: Grant
    Filed: September 10, 1976
    Date of Patent: December 27, 1977
    Assignee: Pennwalt Corporation
    Inventor: Stanley Robert Sandler
  • Patent number: 4064257
    Abstract: 1-Alkylamino-3-(5-alkynylaminocarbonylthiazol-2-yloxy)-2-propanol; 5-(5-alkynylaminocarbonyl-thiazol-2-yloxymethylene)-N-alkyloxazolidine and/or 2-substituted oxazolidine derivatives thereof, and methods of making such compounds. The compounds exhibit cardiovascular activity and are useful in the treatment of abnormal heart conditions in mammals. The compounds are also useful in the treatment of hypertension in mammals. The 5-(5-alkynyl-aminocarbonylthiazol-2-yloxymethylene)-N-alkyloxazolidines and derivatives are also intermediates for the 1-alkylamino-3-(5-alkynylaminocarbonylthiazol-2-yloxy)-2-propanols. The 1-alkylamino-3-(5-alkynylaminocarbonylthiazol-2-yloxy)-2-propanols can be prepared by base or acid hydrolysis of the corresponding 5-(5-alkynylaminocarbonylthiazol-2-yloxymethylene)-N-alkyloxazolidine or derivative; or by treatment of the corresponding 3-(5-alkynylaminocarbonylthiazol-2-yloxy)-2,3-epoxypropane with the desired alkylamine.
    Type: Grant
    Filed: July 19, 1976
    Date of Patent: December 20, 1977
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Belig M. Berkoz, Brian Lewis, Stefan H. Unger
  • Patent number: 4064260
    Abstract: Diarylimidazothiazoles, such as 2,3-dihydro-5,6-bis(p-methoxyphenyl)imidazo[2,1-b]thiazole, useful as antiinflammatories.
    Type: Grant
    Filed: July 29, 1976
    Date of Patent: December 20, 1977
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Saul Carl Cherkofsky, Thomas Ray Sharpe