Abstract: Substituted N-aminoalkylpyrroles of the formula: ##STR1## IN WHICH X, Z, R.sub.1, -R.sub.5 and n are as defined below, and their physiologically tolerable acid addition salts are disclosed to have antiarrhythmic, central nervous system depressant, antiinflammatory and antihypertensive activity. A process for their preparation is also disclosed.

Abstract: This invention discloses the compound 1-(5-t-butyl-1,3,4-thiadiazol-2-yl)-3-methyl-5-acetyloxy-1,3-imidazolidin- 2-one and its utility as a herbicide.

Abstract: Compounds of the formula I: ##SPC1##whereinR.degree. is lower alkyl,n is 0, 1 or 2,R is lower alkyl,R' is a radical of the formula ##SPC2##In which Y and Y' are the same or different and represent hydrogen, lower alkyl, lower alkoxy, halo of atomic weight of 19 to 36 or one of Y and Y' is trifluoromethyl while the other is hydrogen, or a radical of the formula ##SPC3##In which Y" is hydrogen, fluorine, chlorine or alkyl of 1 to 3 carbon atoms,Are prepared by cyclizing a compound of formula II ##SPC4##in which R, R', R.degree. and n are as defined above, with phosgene, or,Where R is not a tertiary alkyl group in which the tertiary carbon atom is directly attached to the ring nitrogen atom, with a C.sub.1 -C.sub.2 alkyl chlorocarbonate or 1,1'carbonyldiimidazole. The compounds of formula I possess pharmaceutical activity in animals.

Abstract: 4,4-Spiro-oxazolinium halides, named systematically as 1-oxo-3-azaspiro[4.4]nonane hydrohalides or 1-oxo-3-azaspiro[4.5]decane hydrohalides, and 4,4-dimethyl oxazolinium halides, useful as intermediates in the synthesis of hypotensive azetidinones.

Abstract: Catalysts having the following formula, prepared in the absence of water, are stable to heat and storage and show high activity in reactions involving organic isocyanates, such as in the production of polyurethane and polyisocyanurate resins: ##EQU1## wherein: A is a mono- or bicyclic tertiary amine having at least 4 carbon atoms in an azine ring,R.sup.1 is H or an alkyl group of 1 to 10 carbon atoms,R.sup.2 is H or an alkyl or aryl group of 1 to 10 carbon atoms, and.phi. is a phenyl group, which may be further substituted by one or more hydroxyl or alkyl groups.Typical compounds, for example, are those corresponding to the formula ##EQU2## wherein: R is H or methyl.

Abstract: 6-AMINO AND 6-(N-protected amino)-2,2-dimethyl-3-cyanopenams, intermediates therefor, and a process for the conversion of the 3-cyano penams, by reaction with a source of azide ion in a reaction inert solvent, to 6-amino- and 6-(N-protected amino)-2,2-dimethyl-3(5-tetrazolyl)penams, intermediates for the preparation of antibacterial agents.

Abstract: 2-amino-5-(substituted or unsubstituted phenylalkyl)-thiadiazoles, e.g., 2-amino-5-(4-[phenylbutyl])-thiadiazole, prepared, e.g., by ring closure, of corresponding 1-(substituted or unsubstituted phenylalkanoyl)-thiosemicarbazide in a strong acid medium. The compounds are useful as minor tranquilizers and sedative hypnotics.

Abstract: This invention relates to novel substituted benzo[c][2,7]naphthyridines and their preparation. The compounds of this invention are active as bronchodilators.

Abstract: New derivatives of pyrido[2,3-b]pyrazine carboxylic acids and esters and their acid addition salts have the general formula ##SPC1##They are useful as anti-inflammatory agents and central nervous system depressants.

Abstract: (1-ALKYL-5-NITRO-IMIDAZOLYL-2-ALKYL)-HETEROARYL COMPOUNDS AND A PROCESS FOR THEIR MANUFACTURE ARE DESCRIBED. The new compounds are well compatible and are effective against bacteria and protozoa as well as against fungi. They are especially active against trichomonads and amebae.

Abstract: Novel 2-substituted-1,2,4-thiadiazolo-[2,3-a]-imidazoles of the formula ##SPC1##And the pharmaceutically acceptable salts thereof; and process for their preparation. These 2-substituted-1,2,4-thiadiazolo-[2,3-a]-imidazoles are useful as fungistatic and fungicidal agents.

Abstract: A process is disclosed which comprises reacting hydrogen sulfide with azolesulfonates and sulfinates to give 2-mercaptoazoles. One embodiment of the invention describes removal of oxidized forms of 2-mercaptobenzothiazole including benzothiazole-2-sulfonates from effluent by treatment with hydrogen sulfide.

Abstract: 1-(1,2,4-TRIAZOLYL-1')-2-PHENOXY-4,4-DIMETHYL-PENTAN-3-ONES OF THE FORMULA ##SPC1##In whichn is an integer from 0 to 5,X is halogen, halogenoalkyl, alkyl, alkoxy, alkylthio, alkylsulfonyl, nitro, nitrile, carbalkoxy or phenyl, andY is a keto group or a functional derivative of a keto group,Or a salt thereof,Which possess fungicidal properties.

Abstract: The D-form of an optically active protected penicillamine is prepared by treating a solution of D,L protected penicillamine of the formula: ##EQU1## wherein Ac is formyl, and R.sub.1 and R.sub.2 are both methyl or are joined together to form the pentamethylene group.

Abstract: Nitrogen-heterocyclic phosphonic acids and derivatives thereof characterized by aminomethyl (or substituted methyl) phosphonic acids or derivatives thereof bonded directly or indirectly, i.e., through a N-side chain to the nitrogen atom in the heterocyclic ring, for example those containing in the molecule at least one of the following units: ##EQU1## where N represents a heterocyclic ring having a nitrogen atom on the ring; --R'N-- represents an amino-terminated side chain attached directly to the ring nitrogen (which side chain may or may not be present); and ##EQU2## represents a methyl (or substituted methyl) phosphonic acid group where M is hydrogen, an alcohol or a salt moiety, and X and Y are hydrogen or a substituted group such as alkyl, aryl, etc., of which one or two units may be present depending on the available nitrogen bonded hydrogens, and to uses for these compounds, for example, as scale inhibitors, corrosion inhibitors, etc.

Abstract: In accordance with the present invention there are provided N-(m-trifluoromethylthio-phenyl)-piperazine and its salts. These compounds are intermediates for synthesis.

Abstract: D,L-penicillamine is converted to D-penicillamine with the aid of 1-pseudonorephedrine.

Abstract: This invention provides aminopyridazine derivatives of formula I, ##SPC1##whereinR.sub.1 is amino, or an ##EQU1## group, wherein each of R.sub.3 and R.sub.4 is alkyl of 1 to 4 carbon atoms, orR.sub.3 and R.sub.4 together with the carbon atom to which they are bound, form a cycloalkylidene radical of 5 to 12 carbon atoms,R.sub.2 is hydrogen or methyl,A is a --(CH.sub.2).sub.n -- group,Whereinn is 0 or an integer from 1 to 7, or an >N--CO--R.sub.5 group,WhereinR.sub.5 is alkyl or alkenyl of 1 to 16 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, 1-adamantyl, or a --(CH.sub.2).sub.m --R.sub.6 group,Whereinm is 0 or an integer from 1 to 4, andR.sub.

Abstract: Naphthalimides of the formula ##SPC1##In which R is substituted alkyl or heteroaralkyl and R' is alkyl or alkyl bearing alkoxy or hydroxy as a substituent. The compounds are eminently suitable for the optical brightening of synthetic fibers, particularly acrylonitrile polymers, on which outstanding brightening effects are obtained.

Abstract: Trifluoromethyl substituted analogs of quinine and quinidine are prepared by reacting a 4-quinolyllithium compound with a 4,5-erythro-5-ethyl-(or vinyl)-quinuclidine-2 .xi.-carboxaldehyde or the corresponding quinuclidine-2 .xi.-carboxylic acid alkyl ester. The end products are useful as antimalarial agents.