Abstract: The invention relates to compounds of the general formula I: ##STR1## or a salt thereof, in which A represents a pyridine ring or a halogen substituted pyridine ring,R.sub.1 represents hydrogen, alkyl (1-6 C), alkoxy (1-6 C), alkylthio (1-6 C), halogen, OH, SH or CF.sub.3R.sub.2 represents hydrogen or a lower alkyl or aralkyl group andn and m may each be 1, 2 or 3 with the proviso that the sum of m and n must be 2, 3 or 4, having CNS activity, a pronounced antihistamine activity and little or no antiserotonin activity.

Abstract: Naphth-[2,1-d]-isothiazole, agents for combatting nematodes containing this active ingredient, and a method of combatting nematodes with this active ingredient.

Abstract: New 1,3,4-thiadiazoles substituted in the 2 and 5 positions for use as soil and seed fungicides, nematocides and the processes therefor.

Abstract: This invention relates to novel 8-aza-9-oxo-11-thia-, -11-oxothia-, and -11-dioxothia-prostanoic acid compounds, salts, and derivatives thereof and also to processes for the preparation of such compounds. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, for the treatment of certain autoimmune diseases, and in preventing thrombus formation.

Abstract: Herbicidal bromo- or chloroacetamides of the formula: ##STR1## where R is alkyl or alkoxy of 1 to 4 carbon atoms;X is chlorine or bromine; andY is S or N--CH.sub.3.

Abstract: Novel sulfonium compounds are described herein which correspond to the formula ##STR1## The sulfonium compounds are useful corrosion inhibitors in acidic cleaning solutions.

Abstract: Novel thiazole derivatives of the formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen or methyl, R.sub.3 is oxo, hydroxyl or acetoxy, have prostaglandin side chains and have an action that is more selective than that of natural prostaglandins. They inhibit the activity of enzymes inducing the decomposition of prostaglandins in the organism and thus they increase the endogenous level of prostaglandins. Various novel methods are provided for their production.

Abstract: 1,3,4-Thiadiazol-5-yl-ureas, i.e. N-[2-(alkyl, alkylmercapto, alkenylmercapto, alkynylmercapto, chloro-substituted benzylmercapto, carboxy-alkylmercapto, aminocarbonyl-alkylmercapto, chlorophenyl-aminocarbonyl-alkylmercapto, alkylsulfonyl, benzylsulfonyl and alkoxy)-1,3,4-thiadiazol-5-yl]-N-alkyl-[N'-mono- and N',N'-di- alkyl]-ureas, which possess herbicidal properties, and which may be produced by conventional methods.

Abstract: A novel process for preparing 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide (I), starting with 3-amino-5-methylisoxazole (II) is disclosed. Compound I exhibits anti-inflammatory properties and is useful for treating inflammation. In the process of the invention an intermediate obtained, 2,3-dihydro-N-(5-methyl-3-isoxazolyl)-3-oxo-1,2-benzisothiazole-2-acetamid e 1,1-dioxide (IV) undergoes rearrangement to provide 1-{[5-(4-hydroxy-2H-1,2-benzothiazin-3-yl)-1,2,4-oxadiazol-3-yl]methyl}eth anone S,S-dioxide (V), which is methylated, according to conventional procedures. The methylated intermediate VI, upon further treatment, undergoes a second rearrangement to obtain the desired anti-inflammatory compound I.

Abstract: Novel 2(2'-hydroxyaminophenyl)benzothiazoles and the Schiff Bases thereof having the formula: ##STR1## wherein X represents hydrogen, SO.sub.3 H, alkyl, aryl, cycloalkyl, or halogen; and wherein R.sub.1 and R.sub.2 represent X, amino or N.dbd.CHR.sub.3 and one of the radicals R.sub.1 and R.sub.2 must be amino or N.dbd.CHR.sub.3 ; R.sub.3 represents alkyl, aryl, cycloalkyl, arylalkyl or nitrogen heterocyclic radicals having 4 or 5 carbon atoms.

Abstract: This invention discloses new compounds of the formula ##STR1## wherein R.sup.1 is selected from the group consisting of alkyl, cycloalkyl, alkenyl, haloalkyl, alkoxy, alkylthio, alkylsulfonyl and alkysulfinyl; R.sup.2 is selected from the group consisting of alkyl, alkenyl, haloalkyl and ##STR2## wherein R.sup.3 and R.sup.4 are each selected from the group consisting of hydrogen and alkyl, and Y is selected from the group consisting of furfuryl and tetrahydrofurfuryl. Further disclosed is the herbicidal utility of the foregoing compounds.

Abstract: A process for the production of a 2-amino-benzothiazole having the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and are hydrogen, halogen, alkyl or alkoxy. A phenylthiourea having the formula: ##STR2## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are defined as above, is added to a cyclization agent in the absence of a solvent and allowing the phenylthiourea to cyclize to form 2-amino-benzothiazole in salt form. Filtering the salt of the 2-amino-benzothiazole out of the reaction mixture.

Abstract: 4H-Pyrano[4,3-d]thiazole derivatives characterized by having a 4H-pyrano[4,3-d]thiazole nucleus having a phenyl substituent at position 2 and a substituent at position 4, said substituent incorporating an acidic or basic function therein, are disclosed. The nucleus is further substituted at position 4 with a lower alkyl and may be optionally substituted in the phenyl ring. The foregoing compounds possess anti-inflammatory and antidepressant activity and methods for their preparation and use are described.

Abstract: A new class of herbicidal compounds consisting of N,N-dialkyl-N'-(substituted-5-isothiazolyl)-N'-acylureas in which the 3-substitutent on the isothioazole moiety consists of alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, and dialkylamino, and the 4-substituent on the isothiazole moiety consists of cyano, alkoxycarbonyl, and nitro; and in which the nitrogen atom of the N,N-dialkylurea to which the isothiazolyl moiety is bonded, is also bonded to an acyl moiety, exhibits outstanding preemergence and postemergence herbicidal activity, controlling effectively the growth of a wide spectrum of grassy and broad-leaved plant species. The synthesis of members of this class is described in detail and the utility of representative compounds is exemplified.

Abstract: Isothiazoles with an alkyl substituent in the 3-position, a cyano group in the 4-position, and a grouping --NHCONR.sup.3 R.sup.4 in the 5-position, R.sup.3 and R.sup.4 each being methyl or ethyl, possess herbicidal properties against dicotyledonous and monocotyledonous weeds.

Abstract: A new class of herbicidal compounds consisting of N'-(substituted-5-isothiazolyl)-N,N-dimethylformamidines in which the 3-substituent on the isothiazole moiety consists of alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino and dialkylamino, and the 4-substituent on the isothiazole moiety consists of cyano, carbamoyl, and nitro, and in which the hydrogen of the dimethylformamidine moiety may be substituted by fluorine, chlorine, bromine, or carbonitrile, exhibits preemergence and postemergence herbicidal activity, controlling effectively the growth of a wide spectrum of grassy and broad-leaved plant species. The synthesis of members of this class is described in detail, and the utility of representative compounds is exemplified.

Abstract: The invention discloses substituted 2H,3H-2,1-benzisothiazole-S-oxides having pharmacological activity in animals and useful as CNS depressant agents. The compounds may be prepared by reacting a substituted 2H,3H-2,1-benzisothiazole with an oxidizing agent. The substituted 2H,3H-2,1-benzisothiazole may be prepared by reacting a substituted .alpha.-methylthio-o-toluidine with one equivalent of an oxidizing agent, followed by treatment with base.

Abstract: The invention discloses compounds of the formula ##STR1## wherein R.sup.1 is selected from the group consisting of alkyl, alkenyl, haloalkyl, alkoxy, alkylthio, alkylsulfonyl and alkylsulfinyl; and R.sup.2 is selected from the group consisting of alkenyl, haloalkenyl and ##STR2## wherein R.sup.3 and R.sup.4 are selected from the group consisting of hydrogen and alkyl.

Abstract: The compounds are N,N'-substituted thioureas, ureas and guanidines which are H-2 histamine receptor inhibitors. Two compounds of this invention are N,N'-bis[2-((4-methyl-5-imidazolyl)methylthio)ethyl]thiourea and N,N'-bis[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-N"-cyanoguanidine.

Abstract: An improvement in a process for producing 2-methylthiazole or 2,4-dimethylthiazole by reacting diethylamine, ethylidene-ethylamine or diisopropylamine with sulfur, the improvement comprising conducting said reaction in a reactor wherein a carbon layer has been formed on the inner surface of the walls of said reactor.