Patents Examined by Raymond Covington
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Patent number: 9227986Abstract: A compound according to Formula IA and IB, reversibly convertible under photochromic and electrochromic conditions between a ring-open isomer A and a ring-closed isomer B is provided. For substitutent groups, Z is N, O or S; each R1 is independently selected from the group consisting of H, or halo; each R2 is independently selected from the group consisting of H, halo, a polymer backbone, alkyl or aryl; or, when both R2 together form —CH?CH— and form part of a polymer backbone; each R3 is independently selected from the group consisting of H, halo, alkyl, alkoxy, thioalkyl or aryl; each R4 is aryl; and each R5 is independently selected from the group consisting of H, halo, alkyl, alkoxy, thioalkyl or aryl.Type: GrantFiled: September 28, 2012Date of Patent: January 5, 2016Assignee: Switch Materials, Inc.Inventors: Neil Robin Branda, Jeremy Graham Finden, Simon James Gauthier, Ali Hayek, Kyle Andrew Hope-Ross, James Daniel Senior, Andreea Spantulescu, Serguei Sviridov
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Patent number: 9227947Abstract: The invention relates to a process for the manufacture of epichlorohydrin (“ECH”) by catalytic oxidation of allyl chloride (“AC”) with an oxidant wherein the catalytic oxidation is performed in an aqueous reaction medium, wherein a water-soluble manganese complex is used as oxidation catalyst, followed by the isolation of epichlorohydrin.Type: GrantFiled: May 22, 2014Date of Patent: January 5, 2016Assignee: HEXION INC.Inventors: Ron Postma, Prasad Muppa
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Patent number: 9220790Abstract: Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.Type: GrantFiled: January 7, 2015Date of Patent: December 29, 2015Assignee: Naktar TherapeuticsInventors: Antoni Kozlowski, Samuel P. McManus, Jennifer Riggs-Sauthier, Xiaoming Shen, Wen Zhang
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Patent number: 9206147Abstract: The present invention relates to a method for producing a furan-based compound using an ion exchange resin in the presence of an organic solvent. In the method for producing a furan-based compound according to the present invention, a furan-based compound is made from an aldose-type hexose compound in the presence of an organic solvent by using an anion exchange resin and a cation exchange resin. Thus, the aldose-type hexose compound obtained from biomass by simultaneously or consecutively using the anion/cation exchange resins as catalysts can be made into 5-hydroxymethyl-2-furfural (HMF) or alkyl ether derivatives thereof such as 5-alkoxymethyl-2-furfural (AMF) without using an expensive reagent. Also, since the selection of an organic solvent is not limitative and a heterogeneous catalyst can be used, separation and purification is easy and chemically stable AMF can be directly obtained.Type: GrantFiled: July 9, 2012Date of Patent: December 8, 2015Assignee: KOREA INSTITUTE OF INDUSTRIAL TECHNOLOGYInventors: Jin Ku Cho, Sang Yong Kim, Jae Hoon Cho, Bo Ra Kim, Paul Joo
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Patent number: 9199923Abstract: In recognition of the need to develop novel therapeutic agents, the present invention provides novel histone deacetylase inhibitors. These compounds include an ester bond making them sensitive to deactivation by esterases. Therefore, these compounds are particularly useful in the treatment of skin disorders. When the compounds reaches the bloodstream, an esterase or an enzyme with esterase activity cleaves the compound into biologically inactive fragments or fragments with greatly reduced activity Ideally these degradation products exhibit a short serum and/or systemic half-life and are eliminated rapidly. These compounds and pharmaceutical compositions thereof are particularly useful in treating cutaneous T-cell lymphoma, neurofibromatosis, psoriasis, hair loss, skin pigmentation, and dermatitis, for example. The present invention also provides methods for preparing compounds of the invention and intermediates thereto.Type: GrantFiled: March 6, 2014Date of Patent: December 1, 2015Assignees: President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.Inventors: James Elliot Bradner, Ralph Mazitschek
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Patent number: 9199954Abstract: The invention relates to (among other things) non-ring hydroxy substituted taxanes and methods for synthesizing the same. The invention further relates to conjugating the non-ring hydroxyl substituted taxanes to a water-soluble, non-peptidic polymer.Type: GrantFiled: December 22, 2011Date of Patent: December 1, 2015Assignee: Nektar TherapeuticsInventors: Antoni Kozlowski, Samuel P. McManus
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Patent number: 9198895Abstract: Novel chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and chemotherapeutic selective agents are described.Type: GrantFiled: January 5, 2015Date of Patent: December 1, 2015Assignee: MEI Pharma, Inc.Inventors: Andrew Heaton, Alan Husband
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Patent number: 9187491Abstract: Gambogenic acid derivatives having a structure shown as Formula (I) or (II), salts, preparation method and application thereof in the treatment of tumor. Compared with gambogenic acid, the gambogenic acid derivatives exhibit more potent anti-tumor activities.Type: GrantFiled: September 28, 2012Date of Patent: November 17, 2015Assignee: Ninth People's Hospital, School Medicine Shanghai Jiao Tong UniversityInventors: Wantao Chen, Xu Wang, Zhiyuan Zhang, Chenping Zhang, Li Mao, Ping Zhang, Qin Xu, Ming Yan, Jianjun Zhang, Jinsong Pan, Yan Lv, Rongxin Deng, Weiliu Qiu
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Patent number: 9186599Abstract: A process which isolates tetrahydrofuran from a stream of tetrahydrofuran, alkanol and high boilers, by: (a) separating off a first stream of tetrahydrofuran and alkanol as azeotrope in a first distillation stage; (b) feeding part of the first stream into a reactor for esterifying maleic anhydride, giving a second stream of tetrahydrofuran and monoalkyl maleate; (c) separating the second stream into a third stream of monoalkyl maleate and a fourth stream of tetrahydrofuran in a second distillation stage; (d) feeding the fourth stream of tetrahydrofuran from the second distillation stage and the part of the first stream from (a) which is not fed to the reactor into a third distillation stage to obtain a product stream of tetrahydrofuran and a sixth stream of tetrahydrofuran and alkanol; (e) recirculating the sixth stream from the third distillation stage into the first distillation stage or the reactor in (b).Type: GrantFiled: September 18, 2011Date of Patent: November 17, 2015Assignee: BASF SEInventors: Maria Guixa Guardia, Rolf Pinkos, Nadja Pollmer, Wolf-Steffen Weissker, Hugues Vandenmersch
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Patent number: 9181210Abstract: Processes for making furfural and 5-hydroxymethylfurfural from sugars are provided. The processes can be carried out using a batch process or a continuous mode of operation. An aqueous sugar solution is pressurized with CO2, thereby producing carbonic acid in situ that catalyzes the dehydration reaction to produce furfural from C5 sugars and 5-methylhydroxyfurfural from C6 sugars.Type: GrantFiled: December 28, 2012Date of Patent: November 10, 2015Assignee: E I DU PONT DE NEMOURS AND COMPANYInventors: Keith W Hutchenson, Michael Stephen McKinnon, Bhuma Rajagopalan
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Patent number: 9181484Abstract: There is provided a compound having a good miscibility with another liquid crystal compound and having a combination of a low viscosity (?), high storage stability, and high T?i even after being used to produce a liquid crystal composition. In particular, it is a compound having a 2-fluorophenyloxymethane structure is provided. Since the compound having a 2-fluorophenyloxymethane structure is highly miscible with another liquid crystal compound, using the compound having a 2-fluorophenyloxymethane structure as a component of a liquid crystal composition enables a production of a liquid crystal composition which exhibits a liquid crystal phase at low viscosity and in a wide temperature range and which has a high storage stability and enables production of a liquid crystal display device which responds fast and which has excellent display characteristics.Type: GrantFiled: April 24, 2013Date of Patent: November 10, 2015Assignee: DIC CORPORATIONInventors: Kenta Tojo, Tetsuo Kusumoto, Masashi Osawa, Masakazu Kaneoya, Kiyofumi Takeuchi
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Patent number: 9181211Abstract: Furfural is produced by mixing an aqueous feedstock solution containing C5 sugar and/or C6 sugar with a heated high boiling, water-miscible solvent, such as sulfolane, and a solid acid catalyst. Furfural product and water can be distilled off, leaving non-volatile solvent behind. Furfural yields of over 70% at as high as 99% conversion have been obtained with this process with sulfolane as the reaction solvent and zeolite beta as the solid acid catalyst. Also, certain by-products (e.g., humins) solubilized in the reaction solvent can be precipitated by addition of water or aqueous feedstock solution and then removed by filtration, thereby providing a convenient and effective way of removing these undesirable byproducts from the reaction mixture.Type: GrantFiled: December 28, 2012Date of Patent: November 10, 2015Assignee: E I DU PONT DE NEMOURS AND COMPANYInventors: David Richard Corbin, Paul Joseph Fagan, Ronnie Ozer, Bhuma Rajagopalan, Eric J. Till
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Patent number: 9169277Abstract: The present invention generally relates to methods for the synthesis of catalysts, including epoxidation catalysts, and related compounds and catalyst compositions. Embodiments described herein may provide efficient processes for providing catalysts (e.g., epoxidation catalysts) in large quantities and using simplified methods.Type: GrantFiled: February 6, 2014Date of Patent: October 27, 2015Assignee: Massachusetts Institute of TechnologyInventors: Timothy F. Jamison, Yutaka Ikeuchi
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Patent number: 9162934Abstract: The object of the present invention is to solve the problems in the prior arts, and to find more improved reaction conditions for suppressing the racemization of the product and obtaining an optically active alcohol at a high optical purity. The inventors achieved to solve the above problems by using a solvent system that is capable of resolving both an asymmetric catalyst and a formate salt, allowing the hydrogen source and the asymmetric catalyst to be present in the same phase.Type: GrantFiled: May 10, 2011Date of Patent: October 20, 2015Assignee: Kanto Kagaku Kabushiki KaishaInventors: Taito Hatakeyama, Kunihiko Murata, Kunihiko Tsutsumi, Noriyuki Utsumi
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Patent number: 9145422Abstract: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:Type: GrantFiled: October 15, 2013Date of Patent: September 29, 2015Assignee: Infinity Pharmaceuticals, Inc.Inventors: Alfredo C. Castro, Michael J. Grogan, Karen J. McGovern, Martin R. Tremblay
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Patent number: 9140706Abstract: The present disclosure is directed to a reactive ester agent capable of conjugating a reporter molecule to a carrier molecule or solid support. The reactive ester agent has the general formula: wherein the variables are described throughout the application.Type: GrantFiled: August 21, 2013Date of Patent: September 22, 2015Assignee: Life Technologies CorporationInventors: Evan Antoulinakis, Kyle Gee, Aleksey Rukavishnikov
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Patent number: 9133176Abstract: Methods for the synthesis, isolation, and purification of procyanidin B2 are disclosed. The synthetic methods utilize epicatechin as a starting material and produce procyanidin B2 in high yields. The isolation methods extract procyanidin B2 from a sample of bark powder from plant matter of the genus Uncaria. The isolated and/or synthesized procyanidin B2 is used to treat amyloid disease, such as Alzheimer's disease and Parkinson's disease as well as improve cognitive performance and increase learning and memory in Alzheimer's patients. Pharmaceutical compositions containing the synthesized and/or isolated procyanidin B2 are also disclosed.Type: GrantFiled: May 12, 2008Date of Patent: September 15, 2015Assignee: PROTEOTECH INC.Inventors: Gerardo Castillo, Beth Nguyen, Paula Choi, Lesley Larsen, Stephen Lorimer, Alan Snow
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Patent number: 9126967Abstract: A process for the production of dioxolane compounds of formula (I): wherein R1 and R2 independently represent hydrogen or an alkyl chain from 1 to 10 carbon atoms; R3 and R4 independently represent hydrogen, an alkyl chain from 1 to 5 carbon atoms, or an alkyl chain from 1 to 5 carbon atoms which is endowed with one or more hydroxyl groups, such process comprising a reaction between crude glycerol and an aldehyde or a ketone, with a molar ratio of aldehyde:glycerol or ketone:glycerol from 3:1 to 20:1.Type: GrantFiled: September 30, 2011Date of Patent: September 8, 2015Assignee: RHODIA POLIAMIDA E ESPECIALIDADES LTDAInventors: Edson Rodrigues, Arthur Malheiro
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Patent number: 9127018Abstract: The present invention relates to solid forms of 13-(N-Boc-?-isobutylserinyl)-14-? hydroxybaccatin III 1, 14-carbonate (Ortataxel). Amorphous Form A, crystalline Form B, mixtures thereof and processes for preparing them are disclosed. Amorphous Form A is prepared by fast precipitation of Ortataxel from a mixture of acetone and water. Form A transforms in Form B when suspended and stirred in a mixture of ethanol and water for 4-8 hours. If the suspension is stirred for less than 4 hours, mixtures of Form B and Form A are obtained. Form B or mixtures of Forms A and B can also be obtained dissolving Ortataxel in a protic organic solvent, followed by addition of water.Type: GrantFiled: December 10, 2013Date of Patent: September 8, 2015Assignee: Indena S.p.A.Inventors: Daniele Ciceri, Nicola Sardone, Bruno Gabetta, Maurizio Ricotti
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Patent number: 9127208Abstract: The present invention is related to a thermal extract of a plant material and methods of extraction thereof. The method of producing a thermal extract from a plant starting material by means of a thermal extraction of the starting material wherein the improvement consists in requiring smaller amounts of costly and/or toxic organic solvents for the extraction and partitioning steps.Type: GrantFiled: April 2, 2007Date of Patent: September 8, 2015Assignee: Pharmatherm Chemicals, Inc.Inventors: David Boulard, Robert G. Graham, Barry Freel