Patents Examined by Raymond Covington
  • Patent number: 9227947
    Abstract: The invention relates to a process for the manufacture of epichlorohydrin (“ECH”) by catalytic oxidation of allyl chloride (“AC”) with an oxidant wherein the catalytic oxidation is performed in an aqueous reaction medium, wherein a water-soluble manganese complex is used as oxidation catalyst, followed by the isolation of epichlorohydrin.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: January 5, 2016
    Assignee: HEXION INC.
    Inventors: Ron Postma, Prasad Muppa
  • Patent number: 9227986
    Abstract: A compound according to Formula IA and IB, reversibly convertible under photochromic and electrochromic conditions between a ring-open isomer A and a ring-closed isomer B is provided. For substitutent groups, Z is N, O or S; each R1 is independently selected from the group consisting of H, or halo; each R2 is independently selected from the group consisting of H, halo, a polymer backbone, alkyl or aryl; or, when both R2 together form —CH?CH— and form part of a polymer backbone; each R3 is independently selected from the group consisting of H, halo, alkyl, alkoxy, thioalkyl or aryl; each R4 is aryl; and each R5 is independently selected from the group consisting of H, halo, alkyl, alkoxy, thioalkyl or aryl.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: January 5, 2016
    Assignee: Switch Materials, Inc.
    Inventors: Neil Robin Branda, Jeremy Graham Finden, Simon James Gauthier, Ali Hayek, Kyle Andrew Hope-Ross, James Daniel Senior, Andreea Spantulescu, Serguei Sviridov
  • Patent number: 9220790
    Abstract: Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.
    Type: Grant
    Filed: January 7, 2015
    Date of Patent: December 29, 2015
    Assignee: Naktar Therapeutics
    Inventors: Antoni Kozlowski, Samuel P. McManus, Jennifer Riggs-Sauthier, Xiaoming Shen, Wen Zhang
  • Patent number: 9206147
    Abstract: The present invention relates to a method for producing a furan-based compound using an ion exchange resin in the presence of an organic solvent. In the method for producing a furan-based compound according to the present invention, a furan-based compound is made from an aldose-type hexose compound in the presence of an organic solvent by using an anion exchange resin and a cation exchange resin. Thus, the aldose-type hexose compound obtained from biomass by simultaneously or consecutively using the anion/cation exchange resins as catalysts can be made into 5-hydroxymethyl-2-furfural (HMF) or alkyl ether derivatives thereof such as 5-alkoxymethyl-2-furfural (AMF) without using an expensive reagent. Also, since the selection of an organic solvent is not limitative and a heterogeneous catalyst can be used, separation and purification is easy and chemically stable AMF can be directly obtained.
    Type: Grant
    Filed: July 9, 2012
    Date of Patent: December 8, 2015
    Assignee: KOREA INSTITUTE OF INDUSTRIAL TECHNOLOGY
    Inventors: Jin Ku Cho, Sang Yong Kim, Jae Hoon Cho, Bo Ra Kim, Paul Joo
  • Patent number: 9199954
    Abstract: The invention relates to (among other things) non-ring hydroxy substituted taxanes and methods for synthesizing the same. The invention further relates to conjugating the non-ring hydroxyl substituted taxanes to a water-soluble, non-peptidic polymer.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: December 1, 2015
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Samuel P. McManus
  • Patent number: 9198895
    Abstract: Novel chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and chemotherapeutic selective agents are described.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: December 1, 2015
    Assignee: MEI Pharma, Inc.
    Inventors: Andrew Heaton, Alan Husband
  • Patent number: 9199923
    Abstract: In recognition of the need to develop novel therapeutic agents, the present invention provides novel histone deacetylase inhibitors. These compounds include an ester bond making them sensitive to deactivation by esterases. Therefore, these compounds are particularly useful in the treatment of skin disorders. When the compounds reaches the bloodstream, an esterase or an enzyme with esterase activity cleaves the compound into biologically inactive fragments or fragments with greatly reduced activity Ideally these degradation products exhibit a short serum and/or systemic half-life and are eliminated rapidly. These compounds and pharmaceutical compositions thereof are particularly useful in treating cutaneous T-cell lymphoma, neurofibromatosis, psoriasis, hair loss, skin pigmentation, and dermatitis, for example. The present invention also provides methods for preparing compounds of the invention and intermediates thereto.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: December 1, 2015
    Assignees: President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.
    Inventors: James Elliot Bradner, Ralph Mazitschek
  • Patent number: 9187491
    Abstract: Gambogenic acid derivatives having a structure shown as Formula (I) or (II), salts, preparation method and application thereof in the treatment of tumor. Compared with gambogenic acid, the gambogenic acid derivatives exhibit more potent anti-tumor activities.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: November 17, 2015
    Assignee: Ninth People's Hospital, School Medicine Shanghai Jiao Tong University
    Inventors: Wantao Chen, Xu Wang, Zhiyuan Zhang, Chenping Zhang, Li Mao, Ping Zhang, Qin Xu, Ming Yan, Jianjun Zhang, Jinsong Pan, Yan Lv, Rongxin Deng, Weiliu Qiu
  • Patent number: 9186599
    Abstract: A process which isolates tetrahydrofuran from a stream of tetrahydrofuran, alkanol and high boilers, by: (a) separating off a first stream of tetrahydrofuran and alkanol as azeotrope in a first distillation stage; (b) feeding part of the first stream into a reactor for esterifying maleic anhydride, giving a second stream of tetrahydrofuran and monoalkyl maleate; (c) separating the second stream into a third stream of monoalkyl maleate and a fourth stream of tetrahydrofuran in a second distillation stage; (d) feeding the fourth stream of tetrahydrofuran from the second distillation stage and the part of the first stream from (a) which is not fed to the reactor into a third distillation stage to obtain a product stream of tetrahydrofuran and a sixth stream of tetrahydrofuran and alkanol; (e) recirculating the sixth stream from the third distillation stage into the first distillation stage or the reactor in (b).
    Type: Grant
    Filed: September 18, 2011
    Date of Patent: November 17, 2015
    Assignee: BASF SE
    Inventors: Maria Guixa Guardia, Rolf Pinkos, Nadja Pollmer, Wolf-Steffen Weissker, Hugues Vandenmersch
  • Patent number: 9181211
    Abstract: Furfural is produced by mixing an aqueous feedstock solution containing C5 sugar and/or C6 sugar with a heated high boiling, water-miscible solvent, such as sulfolane, and a solid acid catalyst. Furfural product and water can be distilled off, leaving non-volatile solvent behind. Furfural yields of over 70% at as high as 99% conversion have been obtained with this process with sulfolane as the reaction solvent and zeolite beta as the solid acid catalyst. Also, certain by-products (e.g., humins) solubilized in the reaction solvent can be precipitated by addition of water or aqueous feedstock solution and then removed by filtration, thereby providing a convenient and effective way of removing these undesirable byproducts from the reaction mixture.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: November 10, 2015
    Assignee: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: David Richard Corbin, Paul Joseph Fagan, Ronnie Ozer, Bhuma Rajagopalan, Eric J. Till
  • Patent number: 9181484
    Abstract: There is provided a compound having a good miscibility with another liquid crystal compound and having a combination of a low viscosity (?), high storage stability, and high T?i even after being used to produce a liquid crystal composition. In particular, it is a compound having a 2-fluorophenyloxymethane structure is provided. Since the compound having a 2-fluorophenyloxymethane structure is highly miscible with another liquid crystal compound, using the compound having a 2-fluorophenyloxymethane structure as a component of a liquid crystal composition enables a production of a liquid crystal composition which exhibits a liquid crystal phase at low viscosity and in a wide temperature range and which has a high storage stability and enables production of a liquid crystal display device which responds fast and which has excellent display characteristics.
    Type: Grant
    Filed: April 24, 2013
    Date of Patent: November 10, 2015
    Assignee: DIC CORPORATION
    Inventors: Kenta Tojo, Tetsuo Kusumoto, Masashi Osawa, Masakazu Kaneoya, Kiyofumi Takeuchi
  • Patent number: 9181210
    Abstract: Processes for making furfural and 5-hydroxymethylfurfural from sugars are provided. The processes can be carried out using a batch process or a continuous mode of operation. An aqueous sugar solution is pressurized with CO2, thereby producing carbonic acid in situ that catalyzes the dehydration reaction to produce furfural from C5 sugars and 5-methylhydroxyfurfural from C6 sugars.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: November 10, 2015
    Assignee: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Keith W Hutchenson, Michael Stephen McKinnon, Bhuma Rajagopalan
  • Patent number: 9169277
    Abstract: The present invention generally relates to methods for the synthesis of catalysts, including epoxidation catalysts, and related compounds and catalyst compositions. Embodiments described herein may provide efficient processes for providing catalysts (e.g., epoxidation catalysts) in large quantities and using simplified methods.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: October 27, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Timothy F. Jamison, Yutaka Ikeuchi
  • Patent number: 9162934
    Abstract: The object of the present invention is to solve the problems in the prior arts, and to find more improved reaction conditions for suppressing the racemization of the product and obtaining an optically active alcohol at a high optical purity. The inventors achieved to solve the above problems by using a solvent system that is capable of resolving both an asymmetric catalyst and a formate salt, allowing the hydrogen source and the asymmetric catalyst to be present in the same phase.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: October 20, 2015
    Assignee: Kanto Kagaku Kabushiki Kaisha
    Inventors: Taito Hatakeyama, Kunihiko Murata, Kunihiko Tsutsumi, Noriyuki Utsumi
  • Patent number: 9145422
    Abstract: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: September 29, 2015
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Alfredo C. Castro, Michael J. Grogan, Karen J. McGovern, Martin R. Tremblay
  • Patent number: 9140706
    Abstract: The present disclosure is directed to a reactive ester agent capable of conjugating a reporter molecule to a carrier molecule or solid support. The reactive ester agent has the general formula: wherein the variables are described throughout the application.
    Type: Grant
    Filed: August 21, 2013
    Date of Patent: September 22, 2015
    Assignee: Life Technologies Corporation
    Inventors: Evan Antoulinakis, Kyle Gee, Aleksey Rukavishnikov
  • Patent number: 9133176
    Abstract: Methods for the synthesis, isolation, and purification of procyanidin B2 are disclosed. The synthetic methods utilize epicatechin as a starting material and produce procyanidin B2 in high yields. The isolation methods extract procyanidin B2 from a sample of bark powder from plant matter of the genus Uncaria. The isolated and/or synthesized procyanidin B2 is used to treat amyloid disease, such as Alzheimer's disease and Parkinson's disease as well as improve cognitive performance and increase learning and memory in Alzheimer's patients. Pharmaceutical compositions containing the synthesized and/or isolated procyanidin B2 are also disclosed.
    Type: Grant
    Filed: May 12, 2008
    Date of Patent: September 15, 2015
    Assignee: PROTEOTECH INC.
    Inventors: Gerardo Castillo, Beth Nguyen, Paula Choi, Lesley Larsen, Stephen Lorimer, Alan Snow
  • Patent number: 9127018
    Abstract: The present invention relates to solid forms of 13-(N-Boc-?-isobutylserinyl)-14-? hydroxybaccatin III 1, 14-carbonate (Ortataxel). Amorphous Form A, crystalline Form B, mixtures thereof and processes for preparing them are disclosed. Amorphous Form A is prepared by fast precipitation of Ortataxel from a mixture of acetone and water. Form A transforms in Form B when suspended and stirred in a mixture of ethanol and water for 4-8 hours. If the suspension is stirred for less than 4 hours, mixtures of Form B and Form A are obtained. Form B or mixtures of Forms A and B can also be obtained dissolving Ortataxel in a protic organic solvent, followed by addition of water.
    Type: Grant
    Filed: December 10, 2013
    Date of Patent: September 8, 2015
    Assignee: Indena S.p.A.
    Inventors: Daniele Ciceri, Nicola Sardone, Bruno Gabetta, Maurizio Ricotti
  • Patent number: 9126963
    Abstract: The present invention relates to a method for producing tetrahydrofuran comprising: feeding raw material 1,4-butanediol containing gamma butyrolactone to a reaction tank, and performing a dehydration cyclization reaction in the presence of a homogeneous acid catalyst having a pKa of 4 or less and being dissolvable in 1,4-butanediol to produce tetrahydrofuran, wherein a gas containing tetrahydrofuran, gamma butyrolactone and water in the reaction tank is introduced into a heat exchanger and when obtaining a condensate from the outlet of the heat exchanger, the ratio of the concentration of gamma butyrolactone in the condensate based on the concentration of gamma butyrolactone in the raw material 1,4-butanediol is from 20 to 100%.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: September 8, 2015
    Assignee: MITSUBISHI CHEMICAL CORPORATION
    Inventors: Yusuke Izawa, Masaru Utsunomiya, Eiji Hattori
  • Patent number: 9126967
    Abstract: A process for the production of dioxolane compounds of formula (I): wherein R1 and R2 independently represent hydrogen or an alkyl chain from 1 to 10 carbon atoms; R3 and R4 independently represent hydrogen, an alkyl chain from 1 to 5 carbon atoms, or an alkyl chain from 1 to 5 carbon atoms which is endowed with one or more hydroxyl groups, such process comprising a reaction between crude glycerol and an aldehyde or a ketone, with a molar ratio of aldehyde:glycerol or ketone:glycerol from 3:1 to 20:1.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: September 8, 2015
    Assignee: RHODIA POLIAMIDA E ESPECIALIDADES LTDA
    Inventors: Edson Rodrigues, Arthur Malheiro