Patents Examined by Raymond Covington
  • Patent number: 8901325
    Abstract: A method for producing furfural from lignocellulosic biomass material is provided, comprising (a) contacting the lignocellulosic biomass material with a mixture comprising water and an organic acid at a temperature of at least 100° C. and a pressure of at most 10 bar (absolute) to obtain a first liquid stream comprising hydrolyzed hemicellulose and a second stream comprising lignin and cellulose; (b) maintaining the first liquid stream comprising hydrolyzed hemicellulose at a temperature of at least 130° C. to obtain a second liquid stream comprising furfural; and (c) separating the furfural obtained in step b) from the second liquid stream.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: December 2, 2014
    Assignee: Shell Oil Company
    Inventors: Evert Van Der Heide, Ting Zhang
  • Patent number: 8901322
    Abstract: The present invention provides Crystalline Forms of 4-acetoxy-2?-benzoyloxy-5?-20-epoxy-1-hydroxy-7?,10?-dimethoxy-9-oxotax-11-en-13?-yl(2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate, i.e Cabazitaxel. The present invention also discloses methods for the preparation of Crystalline Forms of Cabazitaxel and pharmaceutical compositions thereof.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: December 2, 2014
    Assignee: Fresenius Kabi Oncology Limited
    Inventors: Saswata Lahiri, Rajesh Srivastava, Bhuwan Bhaskar Mishra, Shatrughan Sharma, Vijay Ojha, Nilendu Panda, Sandeep Kumar, Sonu Prasad
  • Patent number: 8895762
    Abstract: The present invention is directed to an improved process for the preparation of sulfamide derivatives.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: November 25, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: Stefan Horns, Roger Faessler
  • Patent number: 8895576
    Abstract: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: November 25, 2014
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Alfredo C. Castro, Michael J. Grogan, Karen J. McGovern, Martin R. Tremblay
  • Patent number: 8884032
    Abstract: Monomeric and dimeric trioxane fluoroaryl amides, 5-carbon-linked, C-10 non-acetal trioxane dimer esters; trioxane silylamides; and trioxane dimer orthoesters and methods of their use for treating subjects infected with malaria or other parasitic infectious diseases including, but not limited to, toxoplasmic infection; subjects afflicted with psychiatric conditions associated with toxoplasmic infection; and subjects afflicted with cancer.
    Type: Grant
    Filed: May 19, 2010
    Date of Patent: November 11, 2014
    Assignee: The Johns Hopkins University
    Inventors: Gary H. Posner, Lauren E. Woodard, David R. Levine, Deuk Kyu Moon, Bryan T. Mott
  • Patent number: 8883824
    Abstract: Disclosed is a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof: wherein R1 is 1: a C3-8 cycloalkyl C1-4 alkyl group, 2: a C7-14 aralkyl group, in which the aryl moiety thereof is optionally substituted with the same or different 1 to 3 groups selected from the group consisting of: (a) halogen, (b) C1-4 alkyl, which is optionally substituted with 1 to 3 fluorine atoms, (c) C1-4 alkoxy, which is optionally substituted with 1 to 3 fluorine atoms, and (d) C1-4 alkylcarbonyl, which is optionally substituted with C1-4 alkoxy, 3: a five-to ten-membered heteroaryl-C1-4 alkyl group, in which the heteroaryl moiety thereof is optionally substituted with the same or different 1 to 3 groups selected from the group consisting of: (a) halogen, and (b) C1-4 alkyl, or 4: a C6-10 aryl C2-6 alkenyl group; and R2 is a cyano group or a nitro group.
    Type: Grant
    Filed: May 12, 2010
    Date of Patent: November 11, 2014
    Assignee: Sumitomo Dainippon Pharma Co., Ltd.
    Inventors: Akihito Fujii, Kazumi Niidome, Chiaki Migihashi, Toshiyuki Kamei, Takafumi Matsumoto, Tomoyuki Hirata
  • Patent number: 8884033
    Abstract: The disclosure relates to a process for preparing 5-aminobenzoylbenzofuran derivatives of formula I: in which R1 and R2 are as defined in the disclosure; by reduction of a 5-nitrobenzofuran derivative of formula II: using a hydrogen transfer agent, in the presence of palladium-on-charcoal as catalyst and in an ether or an ether mixture as solvent.
    Type: Grant
    Filed: January 16, 2013
    Date of Patent: November 11, 2014
    Assignee: Sanofi
    Inventors: Xavier Bon, Christine Biencourt, Corinne Leroy, Julia Mateos-Caro, Philippe Vayron
  • Patent number: 8871954
    Abstract: The present invention is directed to a process for the preparation of 1,3:2,4-bis (4-methylbenzylidene) sorbitol (MDBS) and 1,3:2,4-bis (4-dimethylbenzylidene) sorbitol (DMDBS) by dehydrocondensating an aldehyde and an alditol using a hydrophobic ionic liquid as an acid catalyst. The ionic liquid used in the accordance with the process of the present invention is a phosphonium ion based ionic liquid.
    Type: Grant
    Filed: July 8, 2013
    Date of Patent: October 28, 2014
    Assignee: Reliance Industries Limited
    Inventors: Pavankumar Aduri, Parasu Veera Uppara
  • Patent number: 8871956
    Abstract: The invention relates to a method for preparing 3-keto-benzofurane derivatives of the general formula: Formula (I), where R is an alkyl or aryl group, R1 is hydrogen or an alkyl or aryl group, and R2 is a substituted alkyl or phenyl group. Said preparation method involves coupling a derivative of Formula III, where X is chlorine, bromine, or iodine or a sulfonate grouping: Formula (III) with a sulfonamide derivative of the formula R—SO2—NH2 in the presence of a basic agent and a catalytic system formed of a complex between a palladium compound and a ligand.
    Type: Grant
    Filed: March 30, 2011
    Date of Patent: October 28, 2014
    Assignee: Sanofi
    Inventors: Fréderic Bailly, Thomas Priem, Philippe Vayron
  • Patent number: 8859789
    Abstract: A method for producing an optically active fluorine-containing oxeten, the method being provided to include the steps of causing a fluorine-containing ?-ketoester and an internal alkyne to react with each other in the presence of a transition metal complex that has an optically active ligand.
    Type: Grant
    Filed: November 16, 2011
    Date of Patent: October 14, 2014
    Assignee: Tokyo Institute of Technology
    Inventors: Koichi Mikami, Kohsuke Aikawa, Yuta Hioki
  • Patent number: 8859790
    Abstract: Apparatus and processes are provided for forming epoxide compounds. In one embodiment, a process for the manufacture of an epoxide is provided including adding an oxidant, a water-soluble manganese complex and a terminal olefin to form a multiphasic reaction mixture, reacting the terminal olefin with the oxidant in the multiphasic reaction mixture having at least one organic phase in the presence of the water-soluble manganese complex, separating the reaction mixture into the at least one organic phase and an aqueous phase, and reusing at least part of the aqueous phase. The invention is also related to a device for performing the above process.
    Type: Grant
    Filed: January 26, 2011
    Date of Patent: October 14, 2014
    Assignee: Momentive Specialty Chemicals Inc.
    Inventors: Prasad Muppa, Ron Postma, Bart Van Den Berg, Juergen Stock, Holger Wiederhold, Hans Rausch, Jorg Schallenberg, Stefan Bernhardt
  • Patent number: 8846644
    Abstract: A phosphate-containing nanoparticle delivery vehicle includes nanoparticle, an active ingredient, and a phosphodiester moiety connecting the nanoparticle and the active ingredient and forms a prodrug. The nanoparticle delivery vehicle achieves the function of increasing hydrophilicity of the active ingredient and specificity against tumor cells. Advantages of the nanoparticle material include biocompatibility, magnetism and/or controllable drug release.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: September 30, 2014
    Assignee: National Cheng-Kung University
    Inventors: Jih Ru Hwu, Yu-Sern Lin, Chen-Sheng Yeh, Dar-Bin Shieh, Wu-Chou Su
  • Patent number: 8835655
    Abstract: The present invention relates to a process for the preparation of olopatadine and, more particularly, to an improved method of synthesizing olopatadine which comprises reacting a dibenz[b,e]oxepin-11-one derivative of formula (III) and a suitable reagent under Witting condition, and to the intermediate 11-[(Z)-3-(dimethylamino)-propylidene]-6-11-dihydrodibenz[b,e]-oxepin-2-acet-amide p-toluensulfonate salt.
    Type: Grant
    Filed: February 1, 2010
    Date of Patent: September 16, 2014
    Assignee: Zach System S.p.A
    Inventors: Alberto Guidi, Filippo Chiarello, Gianmauro Orru', Massimo Verzini, Livius Cotarca, Jean-Claude Kizirian, Elisenda Trepat Guixer, Francisco Marquillas Olondriz
  • Patent number: 8835489
    Abstract: This invention belongs to the chemical-pharmaceutical field. New compounds of pterocarpanquinone family presented in formula (I) according to this invention are capable to be activated by reduction generating alkylating species intracellularly. It presents selective cytotoxic effects particularly on mammalian human and nonhuman cells that divide constantly and are useful in treating diseases and dysfunctions related to the phenomenon of undesired cell proliferation. Such compounds are also effective for the treatment of diseases or dysfunctions related to high levels of TNF-? in human and nonhuman mammals.
    Type: Grant
    Filed: November 5, 2009
    Date of Patent: September 16, 2014
    Assignee: Universidade Federal Do Rio de Janeiro
    Inventors: Alcides Jose Monteiro Da Silva, Vivian Mary Barral Dold Rumjanek, Bartira Rossi Bergmann, Eduardo Salustiano Jesus Dos Santos, Paulo Roberto Ribeiro Costa, Chaquip Daher Netto, Wallace Pacienza Lima, Eduardo Caio Torres Dos Santos, Moises Clemente Marinho Cavalcante, Sergio Henrique Seabra, Ingred Goretti Rica
  • Patent number: 8835658
    Abstract: The present invention relates to a type of norcantharidin analogues and a method to synthesis such norcantharidin analogues by transition metal-catalyzed alkynylation of 7-oxabenzonorbornadienes. The present invention also relates to the use of such norcantharidin analogues in manufacture of a medicament for the treatment of cancer tumors.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: September 16, 2014
    Assignees: Hong Kong Baptist University, Yunnan University of Nationalities
    Inventors: Albert Sun-Chi Chan, Baomin Fan, Jun Wang, Chengyuan Lin, Chao Huang, Qingjing Yang, Jianbin Xu, Zhaoxiang Bian, Aiping Lu, Jun Hu
  • Patent number: 8829206
    Abstract: A process for making a cyclic compounds such as cyclic acetal or cyclic ketones by feeding aldehyde or ketone compounds and polyhydroxyl compounds to a reaction zone at a molar ratio of polyhydroxyl compounds to aldehyde or ketone compounds of at least 3:1, reacting these compounds in the presence of a solid acid such as an acidic ion exchange resin, to generate a liquid reaction mixture without separating water from the reaction mixture as it is being formed in the reaction mixture, withdrawing the liquid reaction mixture from the reaction zone as a liquid product stream, and feeding the liquid reaction product stream to a distillation column to separate cyclic acetal compounds from unreacted polyhydroxyl compounds, and optionally recycling back the unreacted polyhydroxyl compounds to the reaction zone. The process produces cyclic acetal compounds in yields of at least 90% with long catalyst life. The process is also suitable to make cyclic ketals from ketone compounds.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: September 9, 2014
    Assignee: Eastman Chemical Company
    Inventors: Daniel Latham Terrill, Brian David McMurray, Damon Ray Billodeaux, James Lon Little, Adam Scott Howard
  • Patent number: 8828975
    Abstract: A phosphate-containing nanoparticle delivery vehicle includes a nanoparticle, an active ingredient, and a phosphodiester moiety connecting the nanoparticle and the active ingredient and forms a prodrug. The nanoparticle delivery vehicle achieves the function of increasing hydrophilicity of the active ingredient and specificity against tumor cells. Advantages of the nanoparticle material include biocompatibility, magnetism and/or controllable drug release.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: September 9, 2014
    Assignee: National Cheng-Kung University
    Inventors: Jih Ru Hwu, Yu-Sern Lin, Chen-Sheng Yeh, Dar-Bin Shieh, Wu-Chou Su
  • Patent number: 8816102
    Abstract: A method of modulating the flavor of an orally-receivable product, such as a foodstuff, beverage, dentifrice or medicine, comprising the addition thereto of a flavor-modulating proportion of at least one compound of the formula I in which X is selected from CHOH, C?O, CH2—CO and CH?C(OH), Y is selected from C1-C7 linear and branched alkyl and CH2CH2OH, Z is selected from CH3 and a moiety of the formula II in which the wavy bond represents bond linking Z to X and R1 and R2 are selected from the possibilities (i) both hydrogen; (ii) independently OH and OCH3; and (iii) R1 and R2 together with their bonds to the phenyl ring form a ring of the formula —O—CH2—O—; such that, when Z is CH3, X is C?O and Y is CH2CH2OH.
    Type: Grant
    Filed: June 24, 2010
    Date of Patent: August 26, 2014
    Assignee: Givaudan S.A.
    Inventors: Abdelmajid Kaouas, Harry Renes, Alexander P. Tondeur, Cornelis Winkel
  • Patent number: 8809555
    Abstract: Provided is an anti-leishmanial compound represented by formula (1):
    Type: Grant
    Filed: October 13, 2011
    Date of Patent: August 19, 2014
    Assignee: Aoyama Gakuin Educational Foundation
    Inventors: Junji Kimura, Shohei Horie, Harumi Marushima, Yoshitsugu Matsumoto, Chizu Sanjoba, Yasutaka Osada
  • Patent number: 8809553
    Abstract: The application discloses a process for the preparation of 5-deoxy-L-arabinose of formula (VI); comprising the conversion of a compound of formula (XII); wherein n is 0, 1 or 2; which can be used as intermediate for the synthesis of sapropterin.
    Type: Grant
    Filed: June 13, 2011
    Date of Patent: August 19, 2014
    Assignee: Dipharma Francis S.r.l.
    Inventors: Emanuele Attolino, Mario Michieletti, Davide Rossi, Pietro Allegrini