Patents Examined by Raymond Covington
  • Patent number: 9127208
    Abstract: The present invention is related to a thermal extract of a plant material and methods of extraction thereof. The method of producing a thermal extract from a plant starting material by means of a thermal extraction of the starting material wherein the improvement consists in requiring smaller amounts of costly and/or toxic organic solvents for the extraction and partitioning steps.
    Type: Grant
    Filed: April 2, 2007
    Date of Patent: September 8, 2015
    Assignee: Pharmatherm Chemicals, Inc.
    Inventors: David Boulard, Robert G. Graham, Barry Freel
  • Patent number: 9120816
    Abstract: The present invention relates to chemical entities originated from natural sources and further synthesized for therapeutic uses. More particularly, the present invention relates to norcantharidin analogs synthesized by a transition metal-catalyzed alkynylation of oxanorbornadiene derivatives and their antitumor effects.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: September 1, 2015
    Assignee: HONG KONG BAPTIST UNIVERSITY
    Inventors: Zhaoxiang Bian, Chengyuan Lin, Baomin Fan, Huaixue Mu, Yongyun Zhou, Weimin Zeng, Aiping Lu, Albert Sun Chi Chan
  • Patent number: 9102640
    Abstract: Apparatus and processes are provided for forming epoxide compounds. In one embodiment, a process for the manufacture of an epoxide is provided including adding an oxidant, a water-soluble manganese complex and a terminal olefin to form a multiphasic reaction mixture, reacting the terminal olefin with the oxidant in the multiphasic reaction mixture having at least one organic phase in the presence of the water-soluble manganese complex, separating the reaction mixture into the at least one organic phase and an aqueous phase, and reusing at least part of the aqueous phase. The invention is also related to a device for performing the above process.
    Type: Grant
    Filed: February 19, 2014
    Date of Patent: August 11, 2015
    Assignee: Evonik Degussa GmbH
    Inventors: Prasad Muppa, Ron Postma, Bart Van Den Berg, Jürgen Stock, Holger Wiederhold, Hans Rausch, Jörg Schallenberg, Stefan Bernhardt
  • Patent number: 9096498
    Abstract: The present invention discloses a cheaper and practical protocol for the construction of a wide variety of o-cyanocinnamonitrile and their structural analogs that proceeds with good yields in a single step using CuCN as the only reagent.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: August 4, 2015
    Assignee: Council of Scientific & Industrial Research
    Inventors: Brij Bhushan Ahuja, Reddy S. Rekula, Arumugam Sudalai
  • Patent number: 9084766
    Abstract: The invention provides naphthofuran compounds, polymorphs of naphthofuran compounds, naphthofuran compounds in particle form, purified compositions that contain one or more naphthofuran compounds, purified compositions that contain one or more naphthofuran compounds in particle form, methods of producing these naphthofuran compounds, polymorphs, purified compositions and/or particle forms, and methods of using these naphthofuran compounds, polymorphs, purified compositions and/or particle forms to treat subjects in need thereof.
    Type: Grant
    Filed: March 21, 2011
    Date of Patent: July 21, 2015
    Assignee: Boston Biomedical, Inc.
    Inventors: Chiang Jia Li, David Leggett, Youzhi Li, Wei Li
  • Patent number: 9067910
    Abstract: Chemiluminescent compositions, methods, assays and kits for oxidative enzymes are described. Further disclosed are dioxetane compounds of the form: where R can independently be any branched alkyl or cycloalkyl group which provides stabilization for the dioxetane or where both R groups together form a cycloalkyl or polycycloalkyl moiety spiro bound to the dioxetane ring, wherein each R group or the spiro bound moiety can be unsubstituted or substituted with one or more electron-withdrawing groups or electron donating groups, or groups providing preferential oxidative isozyme substrate recognition, and wherein R1 is an aryl group, or an alkyl group of 1-20 carbon atoms, which can be optionally substituted with 1 or more halogen atoms, and wherein T is an aryl or heteroaryl ring capable of emitting light upon enzyme activated decomposition of the dioxetane I. Kits, methods and assays are also disclosed that comprise the dioxetane compounds.
    Type: Grant
    Filed: March 1, 2010
    Date of Patent: June 30, 2015
  • Patent number: 9062018
    Abstract: A crystalline from of 13-[(N-tert-butoxycarbonyl)-2?-O-hexanoyl-3-phenylisoserinyl]-10-deacetylbaccatin III.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: June 23, 2015
    Assignee: Indena S.p.A
    Inventors: Daniele Ciceri, Andrea Gambini, Maurizio Ricotti, Nicola Sardone
  • Patent number: 9056872
    Abstract: The present disclosure relates to novel organic compounds, to the processes for preparing same and to the uses thereof, firstly in the electronics field, in particular in the fields referred to as plastic electronics and molecular electronics, and, secondly, in the coatings field, in particular in the fields of adhesion primers and intelligent coatings. The disclosure also relates to a material comprising a novel compound according to the invention.
    Type: Grant
    Filed: May 19, 2011
    Date of Patent: June 16, 2015
    Assignees: UNIVERSITE PARIS DIDEROT—PARIS 7, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Gaëlle Trippé-Allard, Jean-Christophe Lacroix
  • Patent number: 9051259
    Abstract: A process for producing a perfluorinated functional compound comprises the steps of: A) converting an at least partially hydrogenated alcohol into an at least partially hydrogenated ester compound; and B) reacting said at least partially hydrogenated ester compound with fluorine in the presence of at least one (per)haloolefin comprising at least one carbon-carbon double bond and having at least one fluorine or chlorine atom on either one of the carbon atoms of said double bond, to obtain a perfluorinated ester compound.
    Type: Grant
    Filed: November 17, 2011
    Date of Patent: June 9, 2015
    Assignee: SOLVAY SPECIALTY POLYMERS ITALY S.P.A.
    Inventors: Vito Tortelli, Marco Galimberti
  • Patent number: 9040587
    Abstract: Aromatic N-halosulfonamide organic compounds have been known for over one hundred years. The ability of these compounds to release active halogen ions has been utilized in a range of biocidal and fungicidal applications. This disclosure deals with the use of halo active aromatic sulfonamide organic compounds as odor control and/or biocidal agents in a cleaning solution for use with bovines and other dairy animals.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: May 26, 2015
    Inventors: David J. Schneider, Charles A. Schneider
  • Patent number: 9040726
    Abstract: An improved process for the N-alkylation of tertiary morphinan alkaloid bases to form the corresponding quaternary morphinan alkaloid derivatives.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: May 26, 2015
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Gary L. Cantrell, Robert E. Halvachs, Kevin R. Roesch, Henry J. Buehler, Joseph P. Haar
  • Patent number: 9029579
    Abstract: The present invention relates to a method of making low colored bis(2-ethylhexyl) furan-2,5-dicarboxylate (BEHFD) plasticizer via mild hydrogenation of highly colored BEHFD.
    Type: Grant
    Filed: November 8, 2012
    Date of Patent: May 12, 2015
    Assignee: Eastman Chemical Company
    Inventors: Mesfin Ejerssa Janka, John Dayton Baker, Jr., Stephanie Nicole Rollins
  • Patent number: 9029575
    Abstract: A process for the preparation of 1,3:2,4-bis(4-methylbenzylidene)sorbitol (MDBS) and 1,3:2,4-bis(3,4-dimethylbenzylidene)sorbitol (DMDBS) via a dehydrocondensation reaction is disclosed. The reaction is carried out between an aldehyde and an alditol in a mole ratio of 2:1 wherein ionic fluid is used as the acidic catalyst and/or reaction medium. The ionic fluid used in accordance with the present invention is quaternary ammonium salt based ionic liquid.
    Type: Grant
    Filed: July 8, 2013
    Date of Patent: May 12, 2015
    Assignee: Reliance Industries Limited
    Inventors: Parasu Veera Uppara, Pavankumar Aduri, Mangesh Sakhalkar, Uday Ratnaparkhi
  • Patent number: 9029574
    Abstract: Provided is a compound which has strong and sustaining intraocular pressure lowering action and, further, has no fear of side effect on eyes. Since a compound represented by the formula (I): wherein definition of each group is as described in the specification, or a salt thereof, a solvate thereof, or a prodrug thereof has strong and sustaining intraocular pressure lowering action and, further, has no side effect on eyes such as ocular stimulating property (hyperemia, corneal clouding etc.), aqueous humor protein rise etc., it has high safety, and can be an excellent agent for preventing and/or treating glaucoma etc.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: May 12, 2015
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Tohru Kambe, Isamu Sugimoto
  • Patent number: 9024044
    Abstract: Compounds represented by the following formula (I), are useful as hyperglycemic inhibitors having a serine protease inhibitory action and as prophylactic or therapeutic drugs for diabetes.
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: May 5, 2015
    Assignee: Ajinomoto Co., Inc.
    Inventors: Takahiro Koshiba, Munetaka Tokumasu, Taisuke Ichimaru, Koji Ohsumi, Tadakiyo Nakagawa, Tatsuhiro Yamada, Kayo Matsumoto, Tamotsu Suzuki
  • Patent number: 9024046
    Abstract: The invention relates to a novel process for preparation of drohedarone of formula (I) and pharmaceutically acceptable salts thereof characterized in that a compound of formula (II) is reacted in the presence of a reductive agent with butyraldehyde and/or butanoic acid, and isolating the obtained product and, if desired, converting it into a pharmaceutically acceptable salt thereof. The invention also relates to some hovel intermediary compounds and the preparation thereof.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: May 5, 2015
    Assignee: Sanofi
    Inventors: Antal Friesz, Csaba Huszar
  • Patent number: 9018414
    Abstract: The present application relates to novel 3-phenylpropionic acid derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.
    Type: Grant
    Filed: October 3, 2013
    Date of Patent: April 28, 2015
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Thomas Lampe, Michael Hahn, Johannes-Peter Stasch, Karl-Heinz Schlemmer, Frank Wunder, Sherif El Sheikh, Volkhart Min-Jian Li, Eva-Maria Becker-Pelster, Friederike Stoll, Andreas Knorr
  • Patent number: 9012665
    Abstract: The present invention is directed to an amorphous form of cabazitaxel, which can be prepared by dissolving a solid form of cabazitaxel in an organic solvent, and removing the organic solvent to dryness. The amorphous form of cabazitaxel is characterized by DSC as in FIG. 1 and/or X-ray powder diffraction pattern as in FIG. 2.
    Type: Grant
    Filed: July 26, 2013
    Date of Patent: April 21, 2015
    Assignee: Yung Shin Pharm. Ind. Co., Ltd.
    Inventors: Liang-Rern Kung, Yi-Ting Hung, Tung-Shen Fang, Po-Wei Chang, Tsang-Miao Huang
  • Patent number: 9006470
    Abstract: The present invention relates to a method of synthesizing a low colored furan-2,5-dicarboxylate derivative plasticizer by utilizing purified FDCA (pFDCA), which has very low level 5-formyl furan-2-carboxyic acid (FFCA) and very low level colored bodies, and an alcohol.
    Type: Grant
    Filed: November 8, 2012
    Date of Patent: April 14, 2015
    Assignee: Eastman Chemical Company
    Inventors: Mesfin Ejerssa Janka, John Dayton Baker, Jr., Stephanie Nicole Rollins
  • Patent number: 9006465
    Abstract: An epoxy group-containing a fluorene compound has a methallyl group at the end thereof and is represented by the following general formula (1): wherein R represents a hydrogen atom or a methyl group. The compound gives a compound excellent in regioselectivity at the time of hydrosilylation with a Si—H containing organosilicon compound, with a less formed amount of an internally added ? adduct, as compared with the conventionally known fluorene compound having an allyl group, so that heat resistance of the resulting organosilicon compound is expected to be improved whereby it is a useful compound.
    Type: Grant
    Filed: August 5, 2013
    Date of Patent: April 14, 2015
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventor: Hideyoshi Yanagisawa