Patents Examined by Raymond Covington
  • Patent number: 9000168
    Abstract: The present invention relates to a process for extracting, purifying and isolating cyclopamine from cyclopamine-containing biomass comprising the steps of contacting cyclopamine-containing organic matter with an extractant (e.g., aqueous extractant) capable of extracting cyclopamine, separating the extracted organic matter from the cyclopamine/extract solution, concentrating the cyclopamine/extract solution leaving a concentrated aqueous solution, contacting the concentrated aqueous solution with an organic extractant capable of selectively extracting cyclopamine from the aqueous phase, concentrating the cyclopamine-containing organic phase, providing an enriched extract containing cyclopamine, separating cyclopamine from the enriched extract using column chromatography, providing at least one fraction containing cyclopamine, and crystallizing select chromatography fractions to provide purified cyclopamine.
    Type: Grant
    Filed: July 3, 2009
    Date of Patent: April 7, 2015
    Assignee: Radient Technologies Inc.
    Inventors: Steven Splinter, Satyasagar Kadali
  • Patent number: 8993787
    Abstract: The present invention relates to a method for preparing 1,3,5-trioxane using a distillation tower including a reactor, a distillation section, and an extraction section. Particularly, the present invention relates to a method for preparing 1,3,5-trioxane, in which the water phase separated from the stream discharged through the extraction unit of the reaction distillation tower is used in the process of extracting 1,3,5-trioxane.
    Type: Grant
    Filed: August 18, 2011
    Date of Patent: March 31, 2015
    Assignee: KTP Industries, Inc.
    Inventors: In Gi Cho, Jin Sang Choi, Kyung Min Kang
  • Patent number: 8993790
    Abstract: Provide is an oxetane-ring containing (meth) acrylic ester compound which can give, through polymerization, a cured article being highly flexible or thermally stable. The oxetane-ring-containing (meth) acrylic ester compound is represented by formula (1) below, in which R1 represents a hydrogen atom or an alkyl group; R2 represent a hydrogen atom or a methyl group; and “A” represent either a linear alkylene group represented by following formula (a1) or a branched-chain alkylene group represented by following formula (a2).
    Type: Grant
    Filed: November 5, 2010
    Date of Patent: March 31, 2015
    Assignee: Daicel Corporation
    Inventors: Tamaki Son, Kiyoshi Ikura
  • Patent number: 8981127
    Abstract: The present invention relates to a process for the preparation of nebivolol and, more particularly, to an improved process of synthesizing an alpha-haloketone of formula a key intermediate in the preparation of nebivolol.
    Type: Grant
    Filed: September 22, 2009
    Date of Patent: March 17, 2015
    Assignee: Zach System
    Inventors: Yvon Derrien, Eric Chenard, Alain Burgos
  • Patent number: 8980943
    Abstract: Disclosed are substituted 2-oxaspiro[5.5]undec-8-ene derivatives of formula (I) and their use as odorants. This disclosure relates furthermore to a method of their production and flavor and fragrance compositions comprising them.
    Type: Grant
    Filed: April 28, 2010
    Date of Patent: March 17, 2015
    Assignee: Givaudan S.A.
    Inventors: Andreas Goeke, Yue Zou
  • Patent number: 8980942
    Abstract: Described herein are ?9-THC prodrugs, methods of making ?9-THC prodrugs, formulations comprising ?9-THC prodrugs and methods of using ?9-THC. One embodiment described herein relates to the transdermal administration of a ?9-THC prodrug for treating and preventing diseases and/or disorders.
    Type: Grant
    Filed: July 23, 2012
    Date of Patent: March 17, 2015
    Assignee: Zynerba Pharmaceuticals, Inc.
    Inventors: Audra Lynn Stinchcomb, Miroslaw Jerzy Golinski, Dana Carmel Hammell, Jeffrey Lynn Howard
  • Patent number: 8969595
    Abstract: This invention is directed to a process for preparation of acetal derivatives, 1,3:2,4-bis(3,4-dimethylbenzylidene)sorbitol (DMDBS) and 1,3:2,4-bis(4-methylbenzylidene)sorbitol (MDBS) by carrying out a dehydrocondensation reaction between an aldehyde and an alditol using an aqueous ionic fluid as the acid catalyst.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: March 3, 2015
    Assignee: Reliance Industries Limited
    Inventors: Parasu Veera Uppara, Pavankumar Aduri, Mangesh Sakhalkar, Uday Ratnaparkhi
  • Patent number: 8962870
    Abstract: Provided herein are compounds, compositions containing the compounds, and methods for the treatment of cancer in a cancer patient. In particular, the compounds are made by a process comprising treating a first compound represented by either Formula G? or Formula M?: with a second compound of generalized formula R8R9C(OCH3)2 and an acid selected from the group consisting of camphor sulfonic acid (CSA), p-toluene sulfonic acid (PTSA), hydrochloric acid (HCl) and acetic acid (AcOH), wherein R1 and R2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R7 is an alkyl group, an olefinic group, or an aromatic group; P1 is a hydroxyl protecting group; P5 is H or an acid labile protecting group at the 7-O position; R8 is H, alkyl group, olefinic or aromatic group; and R9 is: H, alkyl group, olefinic or aromatic or is as defined in the specification.
    Type: Grant
    Filed: November 24, 2010
    Date of Patent: February 24, 2015
    Assignee: Tapestry Pharmaceuticals, Inc.
    Inventors: Jan Zygmunt, James Ferrara, James D. McChesney
  • Patent number: 8962869
    Abstract: The invention relates to a method for synthesizing benzofuran derivatives, in particular the dronedarone of formula (D), including carrying out a Fries rearrangement reaction using a sulfonamido-benzofuran ester intermediate.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: February 24, 2015
    Assignee: Sanofi
    Inventors: Bernard Grimaud, Pierre-Jean Grossi
  • Patent number: 8962867
    Abstract: A method to produce levulinic acid (LA) and gamma-valerolactone (GVL) from biomass-derived cellulose or lignocellulose by selective extraction of LA using GVL and optionally converting the LA so isolated into GVL, with no purifications steps required to yield the GVL.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: February 24, 2015
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: James A. Dumesic, Stephanie G. Wettstein, David Martin Alonso, Elif Ispir Gurbuz
  • Patent number: 8957109
    Abstract: Chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and chemotherapeutic selective agents are described.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: February 17, 2015
    Assignee: MEI Pharma, Inc.
    Inventors: Andrew Heaton, Alan Husband
  • Patent number: 8952053
    Abstract: The present invention relates to prodrugs of compounds containing 1,3-dioxane moiety, pharmaceutical compositions thereof, and the use of the compounds and compositions for the modulation of thromboxane A2 or a peroxisome proliferator-activated receptor. The prodrugs of the compounds, analogs, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions can be used in the treatment and prevention of cancer.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: February 10, 2015
    Assignee: Evolva SA
    Inventors: Peteris Alberts, Alexandra Santana Sorensen
  • Patent number: 8952183
    Abstract: The present invention describes compounds of Formula I or a pharmaceutically acceptable salts or derivatives thereof. Compositions comprising compounds of Formula I are also described. The present invention further relates to a method of producing non-2-enonate compounds.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: February 10, 2015
    Assignee: National Research Council of Canada
    Inventors: Ian C. Schoenhofen, Dennis M. Whitfield, Susan M. Logan
  • Patent number: 8946457
    Abstract: Flavone derivatives, preparative method of the derivatives and use thereof as medicaments for treating diabetes. The structure of the derivatives is presented by formula 1: In the structure, R1 and R2, which are identical or not, represent hydrogen atom, halogen, cyano, hydroxyl, trifluoromethyl, thio-methyl, benzyloxy. C1-C8 linear chain or branch chain alkyl, C1-C8 linear chain or branch chain alkoxy. The pharmacological test indicates that the flavone derivatives can significantly increase the glucose consumption of Hep-G2 cell with insulin resistance activity, promote translocation of glucose transporter 4 of skeletal muscle cells (L6GLUT4myc) at different level, and significantly increase glucose intake and utilization by cells.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: February 3, 2015
    Assignee: Tianjin Medical University
    Inventors: Hongquan Duan, Nan Qin, Wenyan Niu, Meina Jin, Lihuan Shi, Ying Chen
  • Patent number: 8940913
    Abstract: Compounds of formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.
    Type: Grant
    Filed: August 7, 2008
    Date of Patent: January 27, 2015
    Assignee: Syngenta Crop Protection, LLC
    Inventors: Melloney Tyte, Stephane André Marie Jeanmart, Christopher John Mathews, Louisa Robinson
  • Patent number: 8937189
    Abstract: Novel 3,6-disubstituted pyrans, optionally with a further substituent at the 4-position, are monoamine reuptake inhibitors with activity profiles of antidepressants.
    Type: Grant
    Filed: August 26, 2013
    Date of Patent: January 20, 2015
    Assignee: Wayne State University
    Inventor: Aloke K. Dutta
  • Patent number: 8927594
    Abstract: The invention relates to compounds from the soft coral and the generation thereof. The invention also relates to the uses of the compounds from the soft coral in inhibiting inducible nitric oxide synthase and/or cyclooxygenase-2 and in treating the diseases associated with inducible nitric oxide synthase and/or cyclooxygenase-2.
    Type: Grant
    Filed: March 15, 2011
    Date of Patent: January 6, 2015
    Assignees: National Sun Yat-Sen University, National Museum of Marine Biology & Aquarium
    Inventors: Jyh-Horng Sheu, Wei-Hsien Wang, Zhi-Hong Wen, Bo-Wei Chen, Ping-Jyun Sung
  • Patent number: 8927977
    Abstract: An organic semiconductor thin film including an organic semiconductor material that is easily synthesized, and is chemically and physically stable, and shows a high carrier mobility, an organic semiconductor device and an organic field effect transistor including the organic semiconductor thin film are provided. An organic semiconductor thin film of the invention includes a compound represented by the following formula 1: wherein, in formula (1), X is oxygen, sulfur or selenium.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: January 6, 2015
    Assignees: JNC Corporation, Osaka University
    Inventors: Junichi Takeya, Toshihiro Okamoto, Tauto Nakanishi
  • Patent number: 8921578
    Abstract: A compound having a structure of: wherein X is S, SO, SO2, NR10, O, or Se; R1-R8 are each individually H, amino, alkynyl, substituted alkynyl, halogen, alkyl, aryl, substituted alkyl, substituted aryl, nitro, alkoxy, substituted alkoxy, cyano, thiol, substituted thiol, thioether, hydroxyl, heteroaryl, substituted heteroaryl, cycloalkyl, or substituted cycloalkyl, or R1 and R2 together form an aromatic ring and R5 and R6 together form an aromatic ring; and R10 is selected from H, amino, alkynyl, substituted alkynyl, halogen, alkyl, aryl, substituted alkyl, substituted aryl, nitro, alkoxy, substituted alkoxy, cyano, thiol, substituted thiol, thioether, hydroxyl, heteroaryl, substituted heteroaryl, cycloalkyl, or substituted cycloalkyl.
    Type: Grant
    Filed: December 12, 2012
    Date of Patent: December 30, 2014
    Assignee: State of Oregan Acting by and Through the State Board of Higher Education on Behalf of the University of Oregan
    Inventors: Michael M. Haley, Daniel T. Chase
  • Patent number: 8907111
    Abstract: Compounds having a structure of Formula I and compositions comprising these compounds are provided. Uses of such compounds and compositions are provided for treatment or prophylaxis of viral infection. In particular, compounds and compositions may be for use in the treatment or prophylaxis of viral influenza.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: December 9, 2014
    Assignee: The University of British Columbia
    Inventors: Stephen Withers, Andrew Graham Watts, Jin Hyo Kim, Tom Wennekes