Abstract: According to the invention, these aims are achieved by means of a sensor, suitable for sensing one or more properties of one or more structures, the sensor comprising, a first optical propagation path which is configurable to cooperate with a structure whose properties are to be sensed; a second optical propagation path which is configurable to cooperate with a structure whose properties are to be sensed; a third optical propagation path; a means for amplifying a signal which propagates in the third optical propagation path, so that the signal is amplified before it begins propagation along the second optical propagation path, and a means to prevent the propagation of signals from the second optical propagation path to the third optical propagation path. There is further provided a corresponding method of sensing.

Abstract: The present invention relates to an inspection apparatus and method which include projecting a measurement radiation beam onto a target on a substrate in order to measure the radiation reflected from the target and obtain information related to properties of the substrate. In the present embodiments, the measurement spot, which is the focused beam on the substrate, is larger than the target. Information regarding the radiation reflected from the target is kept and information regarding the radiation reflected from the surface around the target is eliminated. This is done either by having no reflecting (or no specularly reflecting) surfaces around the target or by having known structures around the target, the information from which may be recognized and removed from the total reflected beam.

Abstract: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample.

Abstract: A method and system for reducing multi-path effects (stray light and multiple reflections) in 3D time of flight cameras by partly masking the camera's illumination elements.

Abstract: Method of detecting surface features of a microarray. The method includes providing a microarray to an optical scanner, wherein the microarray includes a surface having features. The method also includes carrying out a scanning process using the optical scanner, wherein the scanning process includes: (i) acquiring images of sequential regions on the surface, wherein a defocus spread is applied to the optical scanner during the acquiring, (ii) determining a focus score for the images, (iii) adjusting the optical scanner to a different defocus spread based on the focus score, and (iv) repeating (i) through (iii) at the different defocus spread, thereby acquiring images of further sequential regions on the surface. The method also includes analyzing the images to distinguish different target molecules at the features of the microarray. The images that are analyzed were acquired at the defocus spread and at the different defocus spread during the scanning process.

Abstract: Micro volume inline optical sensor comprising a flowcell having a sample chamber which has a volume less than 0.4 mL and increases in diameter from two ends toward the middle, a flow passageway intersecting the chamber where the diameter is the greatest, monitoring ports with optically transmissive windows at the ends of the chamber, mounting rings on opposite sides of the flowcell disposed coaxially of an optical axis that passes through the monitoring ports and the sample chamber, and a light source and an optical detector mounted on the mounting rings in alignment with each other along the optical axis. In one embodiment, the sample chamber has a side wall with oppositely inclined frusto-conical sections, and the ends of the chamber are closed and sealed by the monitoring port windows and O-ring gaskets that surround the open ends and are compressed between the body of the flowcell and the windows.

Abstract: A method is provided for the quantitative determination of surface properties, wherein a spatially resolved image of a surface to be analyzed, which contains a large number of measured values, is recorded. In a first method step, the measured values are analyzed in order to determine those surface areas which have a specific physical property. A result value of this physical property is then determined, wherein this result value is characteristic of the values of the physical property of all those surface areas of the image determined by analyzing the image. In addition to the result value, a further value (B) characteristic of the surface is determined and this characteristic value is displayed together with the result value (I).

Abstract: A positioning method and a positioning system based on light intensity are provided. The positioning system comprises a lighting system, a sense feedback device and a positioning module. The lighting system comprises at least three point light sources and sequentially adjusts luminance of these point light sources to light up a target. The sense feedback device is disposed on the target and used to collect light intensity information of the light projected on the target by the lighting system. The positioning module calculates a distance between the target and each of the point light sources based on the light intensity information and calculates a positioning location of the target based on the locations of the point light sources and the distances between the target and the point light sources.

Abstract: The present invention relates to a flow cell (10) comprising a fluid inlet (16) and a fluid outlet (18) separated by a sample flow-through chamber (12) comprising at least one UV-transparent window (22?), wherein the at least one UV-transparent window (22?) is made of a polymer material and has been subjected to Gamma radiation sterilization. In one aspect, the flow cell is combustible.

Abstract: An optical detection system for measuring a refractive index of a liquid analyte comprising a light transmitting assembly fiber, which includes a single-mode fiber, an optical fiber sensing module and a multi-mode fiber. The optical detection system is configured to emit a coherent light beam to one end of the assembly fiber; and a detector is configured to capture a specklegram from an exit end of the assembly fiber. When the optical detection system is in operation, the optical fiber sensing module is configured to be submerged into the liquid analyte. By analyzing the correlation between the specklegram corresponding to the liquid analyte and the reference specklegram, the refractive index of the liquid analyte can be obtained.

Abstract: A localization system includes: n+1 number of luminescent devices, where n is an integer greater than or equal to one; and a position measurement device moving in each direction of n number of axes, wherein the luminescent device includes a luminescent unit, the luminescent unit emitting a light for measurement having an intensity that varies at a predetermined time cycle, the luminescent unit also emitting a light for identification including an information representing a position of the luminescent device, the luminescent unit emitting the light for measurement and the light for identification in synchrony with a phase of those emitted by another luminescent device; and the position measurement device includes a light reception unit, a position obtaining unit, a phase computation unit, a standard luminescent device selection unit, a phase difference computation unit, and a position computation unit.

Abstract: Methods and apparatus for lock and key security, the lock including a light receptacle, a scatter pattern detecting module, and a locking mechanism, the key including a light source and a prism, the lock and key security including receiving, in the light receptacle of the lock, light transmitted by the light source in the key through the prism; identifying, by the scatter pattern detecting module, a scatter pattern of the received light; comparing, by the scatter pattern detecting module, the scatter pattern to a unique preauthorized pattern for operating the lock; if the scatter pattern matches the unique preauthorized pattern, switching, by the scatter pattern detecting module, the current locking state of the locking mechanism; and if the scatter pattern does not match the unique preauthorized pattern, maintaining the current locking state of the locking mechanism.

Abstract: In some embodiments, a system for evaluating coupled components includes a first diffraction grating provided on a first component, a second diffraction grating provided on a second component, a light source that emits light having a wavelength that is larger than the grating periods of the first and second diffraction gratings, and a photodetector that senses the intensity of the light after it passes through the diffraction gratings.

Abstract: A system and method for measuring a fluence of gas are disclosed. The system has a first light detector capable of outputting an electrical signal based on an amount of light received. A barrier is positionable adjacent the first light detector and is susceptible to a change in dimension from the fluence of the gas. The barrier permits a portion of light from being received by the first light detector. The change in the dimension of the barrier changes the electrical signal output from the first light detector. A second light detector is positionable to receive light representative of the first light detector without the barrier. The system and method have broad application to detect fluence of gas that may cause erosion chemical reaction causing erosive deterioration. One application is in low orbit Earth for detecting the fluence of atomic oxygen.

Abstract: An apparatus, a system and a method use a light-emitting diode (LED) to identify the presence of a material in a gas and/or a fluid and/or to determine properties of the material. The LED and a light detector may be used to determine a chemical compound in the material. The gas and/or the fluid may be located in a chamber. A first light detector may be positioned on the opposite side of the chamber relative to the LED, a second light detector may be positioned on the same side of the chamber as the LED, and/or a third light detector may be positioned inside the chamber. Additional light detectors with coatings may enable measurements to be corrected for the effects of temperature. The light detectors may determine light reflection, light refraction, light transmission, light diffraction, light interference, light diffusion, light collimation, light absorption and/or light focusing of the material.

Abstract: The present subject matter relates to methods of high-speed analysis of product samples. Light is directed to a portion of a product under analysis and reflected from or transmitted through the product toward an optical detector. Signals for the detector are compared with reference signals based on a portion of the illuminating light passing through a reference element to determine characteristics of the product under analysis. The products under analysis may be stationary, moved by an inspection point by conveyor or other means, or may be contained within a container, the container including a window portion through which the product illuminating light may pass.

Abstract: A method of identifying the elements of a blood sample including placing an aliquot of blood on a transparent substrate such as a coverslip. The blood is allowed to stand and the cells to settle to form a layer or matrix. Inverted microscopy is used to identify the elements in the sample. Various forms of illumination may be used alone or in multiple combinations. The method improves the accuracy due to homogenous distribution of formed elements in the wet drop or aliquot, simplifies the method, lowers the cost of the test and results in a shortened analytical cycle time.

Abstract: A micro-reactor is provided for observing small particles, cells, bacteria, viruses or protein molecules in a fluid. The micro-reactor includes a first channel for containing the fluid and a second channel adjacent to the first channel. A gap connects the first channel and the second channel and a window transparent to the method of inspection is provided at the gap. A static or dynamic gradient, such as a gradient in concentration of a chemical or biological material, in pressure, in temperature, in electric potential, or in magnetic field, is applied across the gap, thereby causing the particles to cross the gap. By detecting a property of the particles upstream in the first channel and then applying a pressure burst over the channels when the property meets certain pre-set criteria, only selected particles can be placed in the gap.

Abstract: A sample device and method for analyzing a sample are claimed. The sample device is a flat disc containing channels and wells for directing a sample to reagents located in the disc and for mixing the sample with the reagents. The disc is mounted on an analyzer and the sample is pumped into the disc, divided into a plurality of sub-sample, and at least some of the sub-samples are mixed with a number of reagents. The resultant analytes are analyzed spectrophotometrically for a determination of the concentration of various substances in the sample. The present invention permits multiple tests to be performed quickly and automatically with minimal operator involvement.

Abstract: A spectrometer having substantially increased spectral and spatial fields.