Abstract: Methods for reaction electrospinning are provided to form collagen fibers. The method can include: acidifying a collagen in an acidic solvent to form an acidic collagen solution; electrospinning the acidic collagen solution within an alkaline atmosphere (e.g., including ammonia vapor) to form collagen fibers; and collecting the collagen fibers within a salt bath (e.g., including ammonium sulfate). The acidic solvent can include water and an alcohol, and can have a pH of about 2 to about 4 (e.g., including a strong acid, such as HCl). An albumin rubber is also provided, which can include albumin crosslinked with glutaraldehyde.
Type:
Grant
Filed:
September 28, 2015
Date of Patent:
August 4, 2020
Assignees:
University of South Carolina, MUSC Foundation for Research Development
Inventors:
Michael John Yost, Veronica Rodriguez-Rivera
Abstract: Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of glucose residues. The short-chain glucosyl stevia compositions were purified to >95% content of total steviol glycosides. The compositions can be used as sweetness enhancers, flavor enhancers and sweeteners in foods, beverages, cosmetics and pharmaceuticals.
Abstract: Disclosed herein is a method of preparing digestion-resistant maltodextrin from roasted dextrin. The method includes introducing activated carbon to be reacted with roasted dextrin after saccharification of the roasted dextrin and before filtration of the roasted dextrin.
Type:
Grant
Filed:
December 14, 2016
Date of Patent:
June 30, 2020
Assignee:
SAMYANG CORPORATION
Inventors:
Ji Won Park, Sung Won Park, Chong Jin Park
Abstract: The present disclosure relates to propiconazole resistant mutants of Chlorella species having Accession No. CCAP 211/134. The propiconazole resistant mutants of Chlorella species has increased tolerance to propiconazole and has increased tolerance to abiotic stress. The present disclosure further provides a method for preparing the propiconazole resistant mutants of Chlorella species. The propiconazole resistant mutants of Chlorella species can selectively grow in the presence of propiconazole, has increased tolerance to temperature stress, and hence can be used for large scale production of algal biomass.
Abstract: A treatment for pruritus is described that is based upon amylase. The amylases (?-, ?-, ?-amylase) are noted for the cleavage of the ?-glycosidic bonds of polysaccharides, yielding lower molecular weight carbohydrate/sugar fragments. It has now been found that ?-amylase is effective in the reduction of pruritus (itching) of affected tissue.
Type:
Grant
Filed:
March 23, 2016
Date of Patent:
June 23, 2020
Assignee:
ROCHAL INDUSTRIES, LLC
Inventors:
Joseph Charles Salamone, Ann Beal Salamone, Kelly Xiaoyu Chen Leung, Katelyn Elizabeth Reilly
Abstract: A method for algae disruption includes: a thermal treatment of microalgae belonging to Heterokontophyta at a pH of 3.5 or more and 9.5 or less and a temperature of 40° C. or more and 65° C. or less; and a physical treatment of the microalgae using a high pressure dispersion apparatus, the physical treatment following the thermal treatment.
Abstract: Described are systems and methods for monitoring administration of nitric oxide (NO) to ex vivo fluids. Examples of such fluids include blood in extracorporeal membrane oxygenation (ECMO) circuits or perfusion fluids used for preserving ex vivo organs prior to transplanting in a recipient. The systems and methods described herein provide for administering nitric oxide to the fluid, monitoring nitric oxide or a nitric oxide marker in the fluid, and adjusting the nitric oxide administration.
Type:
Grant
Filed:
March 10, 2016
Date of Patent:
June 2, 2020
Assignee:
MALLINCKRODT HOSPITAL PRODUCTS IP LIMITED
Inventors:
Jim Potenziano, Douglas R. Hansell, Jeff Griebel, Eddie Costa, Lisa Cooper, David William Newman
Abstract: A Pseudomonas sp. ECO-1 strain was preserved at the China General Microbiological Culture Collection Center (CGMCC) on Mar. 31, 2017, with the preservation number of CGMCC No. 13960. The Pseudomonas sp. ECO-1 strain was separated from POPs (Persistent Organic Pollutants) polluted soil for the first time. The bifunctional enzyme preparation capable of efficiently degrading polychlorinated biphenyl and atrazine was prepared by utilizing the strain for the first time; especially, the bifunctional enzyme preparation has remarkable degradation activity on the polychlorinated biphenyl which is difficult to degrade under an aerobic condition, which is completely different from functions of existing known Pseudomonas sp. and enzyme preparations thereof.
Type:
Grant
Filed:
June 12, 2018
Date of Patent:
May 26, 2020
Assignee:
Ecology Institute, Shandong Academy of Sciences
Inventors:
Lei Ji, Qiang Zhang, Guanhong Chen, Jianing Wang, Xiaowen Fu, Fanyong Song, Tianyuan Li
Abstract: Methods and devices are provided for pre-treatment of a sample containing microbial cells. In some embodiments, the pre-treatment of the sample is performed via the initial selective lysis, within a sample pre-treatment vessel, of non-microbial cells, such as blood cells, and the subsequent centrifugal separation of the sample to remove the resulting debris and concentrate the microbial cells. An immiscible and dense cushioning liquid may be included for collecting the microbial cells adjacent to the liquid interface formed by the cushioning liquid upon centrifugation of the pre-treatment vessel. After removal of a substantial quantity of the supernatant, resuspension of the collected microbial cells, and re-establishment of the cushioning liquid interface, at least a portion of the remaining suspension may be removed without substantially removing the cushioning liquid. One or more intermediate wash cycles may be performed prior to extraction of the remaining suspension, which provides a “pretreated” sample.
Type:
Grant
Filed:
June 2, 2017
Date of Patent:
May 26, 2020
Assignee:
QVELLA CORPORATION
Inventors:
Samad Talebpour, Aye Aye Khine, Robert Maaskant, Tino Alavie
Abstract: A flowable hemostatic gel composition is provided for use at a site of a defect within a biological tissue. The flowable hemostatic gel composition includes a flowable gel solution that includes a biopolymer dissolved in a first solvent. The biopolymer is configured to cross-link with red blood cells at the site to facilitate clot formation at the site. The flowable hemostatic gel composition also includes at least one additional active agent.
Abstract: The present invention provides nutritional compositions that are employed as oral supplementation to the human diet. The compositions of the present invention provide for supplementation to the diet of the cancer patient, as well as preventative dietary supplementation aimed at supporting the human immune system for those not currently suffering from cancer. The present invention is comprised of specific combinations of selected forms of unique sets of certain vitamins, minerals, protein, carbohydrates and phytochemicals.
Abstract: This invention provides for an improved method of stabilizing freeze dried bacterial extracts with a carbohydrate lyoprotectant such that the extracts can be for use in cell free protein synthesis. Also provided herein are formulations for stable, freeze dried bacterial extracts that when stored at room temperature retain at least about 70% protein synthesis activity compared to undried frozen bacterial extracts.
Type:
Grant
Filed:
January 8, 2016
Date of Patent:
May 12, 2020
Assignee:
SUTRO BIOPHARMA, INC.
Inventors:
Martin Chandler, Kirk Hayenga, Henry Heinsohn
Abstract: The group of inventions relates to the field of aesthetic, plastic and reconstructive cosmetology/medicine, and more particularly to meso threads used for remedying aesthetic and age-related changes to the skin, and to methods for producing such threads. Proposed is a multicomponent meso thread consisting of a core and a shell. The core is realized in the form of a fibroin thread, and the shell contains hyaluronic acid or a salt thereof or a polyelectrolyte complex of hyaluronic acid or a salt thereof and chitosan or a salt thereof. Also proposed are a variant of the thread having a plastifying agent in the shell, and methods for producing the proposed meso threads.
Type:
Grant
Filed:
October 10, 2018
Date of Patent:
May 5, 2020
Assignee:
MARTIN'EX International Research and Development Centre
Inventors:
Natal'ya Pavlovna Mihajlova, Mihail Anatol'evich Selyanin, Sergej Alekseevich Uspenskij
Abstract: Scalable, high throughput and power-efficient electromechanical lysis using low electric potential, which can be used for harvesting valuable intracellular biomolecules (DNA, RNA, and proteins) and metabolites (e.g., biodiesels, bioplastics, antibiotics, and antibodies), and for sterilizing large volume solutions (e.g. disinfection of bacterial contaminated drinking water). The method can be directly integrated with other microfluidic devices for all-in-one, fully integrated total-analysis systems for various bacterial (and cellular) studies and clinical applications.
Abstract: The present invention relates to the use of an hydrogel comprising silylated biomolecule for the three-dimensional culture of cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and to an aqueous composition comprising i) cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and ii) a hydrogel comprising silylated biomolecule, for use for treating heart failure, in particular heart failure following myocardial infarction.
Type:
Grant
Filed:
April 10, 2018
Date of Patent:
April 28, 2020
Assignees:
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITE DE NANTES
Inventors:
Pierre Weiss, Eva Mathieu, Jerome Guicheux, Patricia Lemarchand
Abstract: The present invention provides a pharmaceutical composition comprising mesenchymal stem cells, a hyaluronan and a pharmaceutically acceptable carrier. The pharmaceutical composition is used for the treatment of the joint disease. The mesenchymal stem cells in the composition are at least one selected from the group consisting of infra-patellar fat pad stromal cells, bone marrow stem cells, Wharton's jelly stem cells and adipose derived stem cells. The concentration of the hyaluronan is in a range from 25% (v/v) to 75% (v/v). The present invention further provides a method for treating a joint disease, comprising a step of administrating a composition containing mesenchymal stem cells, a hyaluronan and a pharmaceutically acceptable carrier to an injured joint tissue of a subject.
Type:
Grant
Filed:
May 11, 2015
Date of Patent:
April 21, 2020
Assignee:
Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Abstract: The present invention relates to a method for determining the isotropy of the skin surface of a subject, and hence the degree of maturation of the said skin surface, by examining various parameters reflecting the cell organization. Methods for identifying active agents, raw materials and formulation are also provided.
Type:
Grant
Filed:
September 6, 2019
Date of Patent:
April 14, 2020
Assignee:
LABORATOIRES EXPANSCIENCE
Inventors:
Philippe Msika, Nadege Lachmann, Joachim Fluhr
Abstract: The group of inventions relates to the field of aesthetic, plastic and reconstructive cosmetology/medicine, and more particularly to meso threads used for remedying aesthetic and age-related changes to the skin, and to methods for producing such threads. Proposed is a multicomponent meso thread consisting of a core and a shell. The core is realized in the form of a fibroin thread, and the shell contains hyaluronic acid or a salt thereof or a polyelectrolyte complex of hyaluronic acid or a salt thereof and chitosan or a salt thereof. Also proposed are a variant of the thread having a plastifying agent in the shell, and methods for producing the proposed meso threads.
Type:
Grant
Filed:
October 9, 2018
Date of Patent:
March 31, 2020
Assignee:
MARTIN'EX International Research and Development Centre
Inventors:
Natal'ya Pavlovna Mihajlova, Mihail Anatol'evich Selyanin, Sergej Alekseevich Uspenskij
Abstract: A novel method of growing fungi is disclosed which uses an engineered artificial media and produces high density filamentous fungi biomats that can be harvested with a minimum of processing and from which fungal products such as antibiotics, proteins, and lipids can be isolated, the method resulting in lowered fungus cultivation costs for energy usage, oxygenation, water usage and waste stream production.
Type:
Grant
Filed:
June 14, 2019
Date of Patent:
March 17, 2020
Assignee:
Sustainable Bioproducts, Inc.
Inventors:
Mark A. Kozubal, Richard E. Macur, Yuval C. Avniel