Patents Examined by Robert J Yamasaki
  • Patent number: 10730928
    Abstract: Methods for reaction electrospinning are provided to form collagen fibers. The method can include: acidifying a collagen in an acidic solvent to form an acidic collagen solution; electrospinning the acidic collagen solution within an alkaline atmosphere (e.g., including ammonia vapor) to form collagen fibers; and collecting the collagen fibers within a salt bath (e.g., including ammonium sulfate). The acidic solvent can include water and an alcohol, and can have a pH of about 2 to about 4 (e.g., including a strong acid, such as HCl). An albumin rubber is also provided, which can include albumin crosslinked with glutaraldehyde.
    Type: Grant
    Filed: September 28, 2015
    Date of Patent: August 4, 2020
    Assignees: University of South Carolina, MUSC Foundation for Research Development
    Inventors: Michael John Yost, Veronica Rodriguez-Rivera
  • Patent number: 10729163
    Abstract: Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of glucose residues. The short-chain glucosyl stevia compositions were purified to >95% content of total steviol glycosides. The compositions can be used as sweetness enhancers, flavor enhancers and sweeteners in foods, beverages, cosmetics and pharmaceuticals.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: August 4, 2020
    Assignee: PureCirlce Sdn Bhd
    Inventor: Avetik Markosyan
  • Patent number: 10696752
    Abstract: Disclosed herein is a method of preparing digestion-resistant maltodextrin from roasted dextrin. The method includes introducing activated carbon to be reacted with roasted dextrin after saccharification of the roasted dextrin and before filtration of the roasted dextrin.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: June 30, 2020
    Assignee: SAMYANG CORPORATION
    Inventors: Ji Won Park, Sung Won Park, Chong Jin Park
  • Patent number: 10694752
    Abstract: The present disclosure relates to propiconazole resistant mutants of Chlorella species having Accession No. CCAP 211/134. The propiconazole resistant mutants of Chlorella species has increased tolerance to propiconazole and has increased tolerance to abiotic stress. The present disclosure further provides a method for preparing the propiconazole resistant mutants of Chlorella species. The propiconazole resistant mutants of Chlorella species can selectively grow in the presence of propiconazole, has increased tolerance to temperature stress, and hence can be used for large scale production of algal biomass.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: June 30, 2020
    Assignee: RELIANCE INDUSTRIES LIMITED
    Inventors: Chitranshu Kumar, Niraja Soni, Badrish Ranjitlal Soni, Gautam Das, Santanu Dasgupta
  • Patent number: 10688159
    Abstract: A treatment for pruritus is described that is based upon amylase. The amylases (?-, ?-, ?-amylase) are noted for the cleavage of the ?-glycosidic bonds of polysaccharides, yielding lower molecular weight carbohydrate/sugar fragments. It has now been found that ?-amylase is effective in the reduction of pruritus (itching) of affected tissue.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: June 23, 2020
    Assignee: ROCHAL INDUSTRIES, LLC
    Inventors: Joseph Charles Salamone, Ann Beal Salamone, Kelly Xiaoyu Chen Leung, Katelyn Elizabeth Reilly
  • Patent number: 10676690
    Abstract: A method for algae disruption includes: a thermal treatment of microalgae belonging to Heterokontophyta at a pH of 3.5 or more and 9.5 or less and a temperature of 40° C. or more and 65° C. or less; and a physical treatment of the microalgae using a high pressure dispersion apparatus, the physical treatment following the thermal treatment.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: June 9, 2020
    Assignee: KAO CORPORATION
    Inventors: Takafumi Uematsu, Kotaku Yuasa, Saki Hamada, Takaaki Watanabe
  • Patent number: 10667510
    Abstract: Described are systems and methods for monitoring administration of nitric oxide (NO) to ex vivo fluids. Examples of such fluids include blood in extracorporeal membrane oxygenation (ECMO) circuits or perfusion fluids used for preserving ex vivo organs prior to transplanting in a recipient. The systems and methods described herein provide for administering nitric oxide to the fluid, monitoring nitric oxide or a nitric oxide marker in the fluid, and adjusting the nitric oxide administration.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: June 2, 2020
    Assignee: MALLINCKRODT HOSPITAL PRODUCTS IP LIMITED
    Inventors: Jim Potenziano, Douglas R. Hansell, Jeff Griebel, Eddie Costa, Lisa Cooper, David William Newman
  • Patent number: 10662487
    Abstract: A Pseudomonas sp. ECO-1 strain was preserved at the China General Microbiological Culture Collection Center (CGMCC) on Mar. 31, 2017, with the preservation number of CGMCC No. 13960. The Pseudomonas sp. ECO-1 strain was separated from POPs (Persistent Organic Pollutants) polluted soil for the first time. The bifunctional enzyme preparation capable of efficiently degrading polychlorinated biphenyl and atrazine was prepared by utilizing the strain for the first time; especially, the bifunctional enzyme preparation has remarkable degradation activity on the polychlorinated biphenyl which is difficult to degrade under an aerobic condition, which is completely different from functions of existing known Pseudomonas sp. and enzyme preparations thereof.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: May 26, 2020
    Assignee: Ecology Institute, Shandong Academy of Sciences
    Inventors: Lei Ji, Qiang Zhang, Guanhong Chen, Jianing Wang, Xiaowen Fu, Fanyong Song, Tianyuan Li
  • Patent number: 10662420
    Abstract: Methods and devices are provided for pre-treatment of a sample containing microbial cells. In some embodiments, the pre-treatment of the sample is performed via the initial selective lysis, within a sample pre-treatment vessel, of non-microbial cells, such as blood cells, and the subsequent centrifugal separation of the sample to remove the resulting debris and concentrate the microbial cells. An immiscible and dense cushioning liquid may be included for collecting the microbial cells adjacent to the liquid interface formed by the cushioning liquid upon centrifugation of the pre-treatment vessel. After removal of a substantial quantity of the supernatant, resuspension of the collected microbial cells, and re-establishment of the cushioning liquid interface, at least a portion of the remaining suspension may be removed without substantially removing the cushioning liquid. One or more intermediate wash cycles may be performed prior to extraction of the remaining suspension, which provides a “pretreated” sample.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: May 26, 2020
    Assignee: QVELLA CORPORATION
    Inventors: Samad Talebpour, Aye Aye Khine, Robert Maaskant, Tino Alavie
  • Patent number: 10660945
    Abstract: A flowable hemostatic gel composition is provided for use at a site of a defect within a biological tissue. The flowable hemostatic gel composition includes a flowable gel solution that includes a biopolymer dissolved in a first solvent. The biopolymer is configured to cross-link with red blood cells at the site to facilitate clot formation at the site. The flowable hemostatic gel composition also includes at least one additional active agent.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: May 26, 2020
    Inventor: Victor Matthew Phillips
  • Patent number: 10653733
    Abstract: The present invention provides nutritional compositions that are employed as oral supplementation to the human diet. The compositions of the present invention provide for supplementation to the diet of the cancer patient, as well as preventative dietary supplementation aimed at supporting the human immune system for those not currently suffering from cancer. The present invention is comprised of specific combinations of selected forms of unique sets of certain vitamins, minerals, protein, carbohydrates and phytochemicals.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: May 19, 2020
    Inventor: Houn Simon Hsia
  • Patent number: 10648010
    Abstract: This invention provides for an improved method of stabilizing freeze dried bacterial extracts with a carbohydrate lyoprotectant such that the extracts can be for use in cell free protein synthesis. Also provided herein are formulations for stable, freeze dried bacterial extracts that when stored at room temperature retain at least about 70% protein synthesis activity compared to undried frozen bacterial extracts.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: May 12, 2020
    Assignee: SUTRO BIOPHARMA, INC.
    Inventors: Martin Chandler, Kirk Hayenga, Henry Heinsohn
  • Patent number: 10647959
    Abstract: The invention provides polymer scaffolds for cell-based tissue engineering.
    Type: Grant
    Filed: April 12, 2012
    Date of Patent: May 12, 2020
    Assignee: President and Fellows of Harvard College
    Inventors: David J. Mooney, Jaeyun Kim, Sidi A. Bencherif, Weiwei Aileen Li
  • Patent number: 10639245
    Abstract: The group of inventions relates to the field of aesthetic, plastic and reconstructive cosmetology/medicine, and more particularly to meso threads used for remedying aesthetic and age-related changes to the skin, and to methods for producing such threads. Proposed is a multicomponent meso thread consisting of a core and a shell. The core is realized in the form of a fibroin thread, and the shell contains hyaluronic acid or a salt thereof or a polyelectrolyte complex of hyaluronic acid or a salt thereof and chitosan or a salt thereof. Also proposed are a variant of the thread having a plastifying agent in the shell, and methods for producing the proposed meso threads.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: May 5, 2020
    Assignee: MARTIN'EX International Research and Development Centre
    Inventors: Natal'ya Pavlovna Mihajlova, Mihail Anatol'evich Selyanin, Sergej Alekseevich Uspenskij
  • Patent number: 10640744
    Abstract: Scalable, high throughput and power-efficient electromechanical lysis using low electric potential, which can be used for harvesting valuable intracellular biomolecules (DNA, RNA, and proteins) and metabolites (e.g., biodiesels, bioplastics, antibiotics, and antibodies), and for sterilizing large volume solutions (e.g. disinfection of bacterial contaminated drinking water). The method can be directly integrated with other microfluidic devices for all-in-one, fully integrated total-analysis systems for various bacterial (and cellular) studies and clinical applications.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: May 5, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Minseok Kim, Jongyoon Han
  • Patent number: 10632203
    Abstract: The present invention relates to the use of an hydrogel comprising silylated biomolecule for the three-dimensional culture of cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and to an aqueous composition comprising i) cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes, and ii) a hydrogel comprising silylated biomolecule, for use for treating heart failure, in particular heart failure following myocardial infarction.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: April 28, 2020
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITE DE NANTES
    Inventors: Pierre Weiss, Eva Mathieu, Jerome Guicheux, Patricia Lemarchand
  • Patent number: 10624928
    Abstract: The present invention provides a pharmaceutical composition comprising mesenchymal stem cells, a hyaluronan and a pharmaceutically acceptable carrier. The pharmaceutical composition is used for the treatment of the joint disease. The mesenchymal stem cells in the composition are at least one selected from the group consisting of infra-patellar fat pad stromal cells, bone marrow stem cells, Wharton's jelly stem cells and adipose derived stem cells. The concentration of the hyaluronan is in a range from 25% (v/v) to 75% (v/v). The present invention further provides a method for treating a joint disease, comprising a step of administrating a composition containing mesenchymal stem cells, a hyaluronan and a pharmaceutically acceptable carrier to an injured joint tissue of a subject.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: April 21, 2020
    Assignee: Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
    Inventors: Dah-Ching Ding, Kun-Chi Wu
  • Patent number: 10620189
    Abstract: The present invention relates to a method for determining the isotropy of the skin surface of a subject, and hence the degree of maturation of the said skin surface, by examining various parameters reflecting the cell organization. Methods for identifying active agents, raw materials and formulation are also provided.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: April 14, 2020
    Assignee: LABORATOIRES EXPANSCIENCE
    Inventors: Philippe Msika, Nadege Lachmann, Joachim Fluhr
  • Patent number: 10603255
    Abstract: The group of inventions relates to the field of aesthetic, plastic and reconstructive cosmetology/medicine, and more particularly to meso threads used for remedying aesthetic and age-related changes to the skin, and to methods for producing such threads. Proposed is a multicomponent meso thread consisting of a core and a shell. The core is realized in the form of a fibroin thread, and the shell contains hyaluronic acid or a salt thereof or a polyelectrolyte complex of hyaluronic acid or a salt thereof and chitosan or a salt thereof. Also proposed are a variant of the thread having a plastifying agent in the shell, and methods for producing the proposed meso threads.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: March 31, 2020
    Assignee: MARTIN'EX International Research and Development Centre
    Inventors: Natal'ya Pavlovna Mihajlova, Mihail Anatol'evich Selyanin, Sergej Alekseevich Uspenskij
  • Patent number: 10590379
    Abstract: A novel method of growing fungi is disclosed which uses an engineered artificial media and produces high density filamentous fungi biomats that can be harvested with a minimum of processing and from which fungal products such as antibiotics, proteins, and lipids can be isolated, the method resulting in lowered fungus cultivation costs for energy usage, oxygenation, water usage and waste stream production.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: March 17, 2020
    Assignee: Sustainable Bioproducts, Inc.
    Inventors: Mark A. Kozubal, Richard E. Macur, Yuval C. Avniel