Patents Examined by Robert T. Crow
  • Patent number: 11602509
    Abstract: An inhalable microparticles having cysteamine hyaluronate salt is provided. Also a preparation method and a pharmaceutical composition thereof are provided.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: March 14, 2023
    Inventors: Paolo Colombo, Alessandra Rossi, Greta Adorni, Marco Barchielli
  • Patent number: 11590190
    Abstract: Various embodiments of the invention relate to compositions comprising vitamins, minerals and trace elements, antioxidants, amino acids, probiotics, and other components and methods for using such compositions to treat or prevent diseases associated with oxidative stress, including cardiovascular disease.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: February 28, 2023
    Assignee: Sweet Wellness AB
    Inventor: Per-Arne Öckerman
  • Patent number: 11592441
    Abstract: Provided is a nanoplasmonic sensor and a kit for biomolecule analysis, and a method of analyzing a biomolecule using the same. The method includes: providing the nanoplasmonic sensor including a dielectric grating extending in one direction, and a metal structure disposed to cover an upper surface and a side surface of the dielectric grating and have at least one bent portion; immobilizing a first probe molecule on a surface of the metal structure; hybridizing an analyte with the first probe molecule by introducing the analyte having a base sequence complementary to the first probe molecule; binding a second probe molecule that is hybridized with the first probe molecule to the analyte; binding an enzyme to the second probe molecule; introducing a substrate that reacts with the enzyme to produce a precipitate by an enzymatic reaction; and measuring localized surface plasmon resonance in the metal structure.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: February 28, 2023
    Inventors: Tae Geol Lee, Hee Kyung Na, Jung Sub Wi, Jong G. OK
  • Patent number: 11583550
    Abstract: Provided herein are pharmaceutically acceptable sodium nitrite and pharmaceutical compositions thereof. Also provided herein are methods for determining the total non-volatile organic carbon in a sodium nitrite-containing sample. Further provided herein are methods for producing pharmaceutically acceptable sodium nitrite. Still further provided herein are methods of treatment comprising the administration of pharmaceutically acceptable sodium nitrite.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: February 21, 2023
    Assignee: Hope Medical Enterprises, Inc.
    Inventors: Craig Sherman, Anthony James Lepine, Catherine Marie Smith, Kevin Robert Wirtz, Erich Schulze
  • Patent number: 11579110
    Abstract: The subject invention provides materials and methods for single-step fluorescence and electrochemical detection of small molecules, e.g., fentanyl and its analogs, in a sample. The subjection invention provides nucleic acids materials, e.g., aptamers (nucleic acid oligonucleotides) that can bind to fentanyl and its analogs with nanomolar affinity and high specificity against illicit drugs, adulterants, and cutting agents commonly existing in seized samples. The method for detecting fentanyl and/or its analogs in a sample comprises contacting the sample with an aptamer-based sensor selective for fentanyl and its analogs, and sensitively, specifically, and rapidly detecting fentanyl and/or its analogs in the sample.
    Type: Grant
    Filed: May 27, 2022
    Date of Patent: February 14, 2023
    Inventors: Yi Xiao, Juan Canoura
  • Patent number: 11564393
    Abstract: Provided herein are fatty-ammonium salt/starch inclusion complexes comprising one or more of a variety of fatty amines. Such complexes can be combined with film-forming agents, such as poly(vinyl) alcohol (PVOH) and plasticizing agents. The inclusion complexes of the present invention can be utilized as antimicrobial agents, preventing microbial growth on organic and inorganic surfaces. In specific embodiments, inclusion complexes of the present invention are applied to vegetable or fruit surfaces in order to impede microbial growth. Inclusion complexes of the present invention can be applied to wood in order to impede microbial growth and insect consumption and to wound dressings.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: January 31, 2023
    Assignee: The United States of America, as represented by The Secretary of Agriculture
    Inventors: William T. Hay, Gordon W. Selling, George F. Fanta, Fred J. Eller
  • Patent number: 11567029
    Abstract: The invention is directed to apparatus and methods for delivering multiple reagents to, and monitoring, a plurality of analytical reactions carried out on a large-scale array of electronic sensors under minimal noise conditions. In one aspect, the invention provides method of improving signal-to-noise ratios of output signals from the electronic sensors sensing analytes or reaction byproducts by subtracting an average of output signals measured from neighboring sensors where analyte or reaction byproducts are absent. In other aspects, the invention provides an array of electronic sensors integrated with a microwell array for confining analytes and/or particles for analytical reactions and a method for identifying microwells containing analytes and/or particles by passing a sensor-active reagent over the array and correlating sensor response times to the presence or absence of analytes or particles.
    Type: Grant
    Filed: January 23, 2014
    Date of Patent: January 31, 2023
    Inventors: John Nobile, George T. Roth, Todd Rearick, Jonathan M. Schultz, Jonathan Rothberg, David Marran
  • Patent number: 11565267
    Abstract: A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: January 31, 2023
    Assignee: Illumina, Inc.
    Inventors: Dale Buermann, John A. Moon, Bryan Crane, Mark Wang, Stanley S. Hong, Jason Harris, Matthew Hage, Mark J. Nibbe
  • Patent number: 11565258
    Abstract: An apparatus and method for performing analysis and identification of molecules have been presented. In one embodiment, a portable molecule analyzer includes a sample input/output connection to receive a sample, a nanopore-based sequencing chip to perform analysis on the sample substantially in real-time, and an output interface to output result of the analysis.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: January 31, 2023
    Inventors: Daniel Wai-Cheong So, Chi Yip Ho
  • Patent number: 11566273
    Abstract: Provided is a method for producing a cell contained base, the method being capable of providing a cell contained base highly accurately controlled in number of nucleic acid molecules contained in a low-concentration nucleic acid standard sample, the method including a liquid droplet discharging step of discharging a cell suspension in the form of a liquid droplet with a liquid droplet discharging unit onto a base including at least one cell contained region; a cell number counting step of counting a number of cells contained in the liquid droplet with a plurality of sensors from two or more directions while the liquid droplet is flying into the cell contained region; and a liquid droplet landing step of landing the liquid droplet in the at least one cell contained region in a manner that a predetermined number of cells are located in the at least one cell contained region.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: January 31, 2023
    Assignee: RICOH COMPANY, LTD.
    Inventors: Satoshi Izumi, Manabu Seo, Takahiko Matsumoto, Hiroki Somada, Ryuya Mashiko, Takeshi Orito, Hiroki Nakae
  • Patent number: 11559484
    Abstract: Disclosed herein is a self-supporting, dissolvable, film containing dexmedetomidine or a pharmaceutically acceptable salt thereof. The film is administered orally to treat various conditions, particularly agitation, by transmucosal delivery of the active agent.
    Type: Grant
    Filed: November 24, 2020
    Date of Patent: January 24, 2023
    Assignees: BioXcel Therapeutics, Inc., ARx, LLC
    Inventors: Vasukumar Kakumanu, David Christian Hanley, Frank Yocca, Chetan Dalpatbhai Lathia, Scott David Barnhart
  • Patent number: 11555219
    Abstract: The present application provides methods for detecting a nucleic acid molecule involving the use of a signal code sequence which corresponds to said nucleic acid molecule and a plurality of labelled detection probes which yield signals which make up the signal code sequence. In particular, the invention provides a sequential barcoding and decoding scheme which utilises a sequencing-by-hybridisation (SBH) strategy to sequence and decode a nucleotide barcode sequence, and to differentiate the nucleotide barcode sequence from other nucleotide barcode sequences. In an extension of the method, the application also provides a new coding scheme for providing a target nucleic acid with a detectable “colour” (or similar signal)-based code.
    Type: Grant
    Filed: June 1, 2021
    Date of Patent: January 17, 2023
    Assignee: 10x Genomics, Inc.
    Inventors: Malte Kühnemund, Toon Verheyen
  • Patent number: 11549939
    Abstract: A method for characterizing the interaction between a protein and a small molecule by detecting a change in fluorescence emitted by a fluorescent dye and a nucleic acid structure which can be used in said method.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: January 10, 2023
    Inventors: Hanna Beike, Herwin Daub, Ismajli Fjolla, Andreas Langer, Ulrich Rant, Ralf Strasser
  • Patent number: 11542552
    Abstract: A DNA sequencing device and related methods, wherein the device includes a substrate, a nanochannel formed in the substrate, a first electrode positioned on a first side of the nanochannel, and a second electrode. The second electrode is positioned on a second side of the nanochannel opposite the first electrode and is spaced apart from the first electrode to form an electrode gap that is exposed in the nanochannel. At least a portion of first electrode is movable relative to the second electrode to decrease a size of the electrode gap.
    Type: Grant
    Filed: June 23, 2020
    Date of Patent: January 3, 2023
    Inventors: Kim Yang Lee, Thomas Young Chang, David S. Kuo, ShuaiGang Xiao, Xiaomin Yang, Koichi Wago
  • Patent number: 11535892
    Abstract: The present disclosure provides compositions and methods that employ the compositions for conducting pairwise sequencing and for generating concatemer template molecules for pairwise sequencing. The concatemers can be generated using a rolling circle amplification reaction which is conducted either on-support, or conducted in-solution and then distributed onto a support. The rolling circle amplification reaction generates concatemers containing tandem copies of a sequence of interest and at least one universal adaptor sequence. An increase in the number of tandem copies in a given concatemer increases the number of sites along the concatemer for hybridizing to multiple sequencing primers which serve as multiple initiation sites for polymerase-catalyzed sequencing reactions. When the sequencing reaction employs detectably labeled nucleotides and/or detectably labeled multivalent molecules (e.g.
    Type: Grant
    Filed: July 15, 2021
    Date of Patent: December 27, 2022
    Assignee: Element Biosciences, Inc.
    Inventors: Sinan Arslan, Junhua Zhao, Molly He, Samantha Snow, William Light, Matthew Kellinger, Michael Previte, Michael Kim, Hua Yu, Yu-Hsien Hwang-Fu, Marco Tjioe, Andrew Boddicker
  • Patent number: 11536708
    Abstract: Embodiments of the present disclosure provide dual pore sensors and methods for producing these dual pore sensors. The method includes forming a film stack, where the film stack contains two silicon layers and two membrane layers, and then etching the film stack to produce a channel extending therethrough and having two reservoirs and two nanopores. The method also includes depositing a oxide layer on inner surfaces of the reservoirs and nanopores, depositing a dielectric layer on the oxide layer, and forming a metal contact extending through a portion of the stack. The method further includes etching the dielectric layers to form wells, etching the first silicon layer to reveal the protective oxide layer deposited on the inner surfaces of a reservoir, and etching the protective oxide layer deposited on the inner surfaces of the reservoirs and the nanopores.
    Type: Grant
    Filed: January 9, 2020
    Date of Patent: December 27, 2022
    Inventors: Mark J. Saly, Keenan Navarre Woods, Joseph R. Johnson, Bhaskar Jyoti Bhuyan, William J. Durand, Michael Chudzik, Raghav Sreenivasan, Roger Quon
  • Patent number: 11530437
    Abstract: A magnetic particle is disclosed. The magnetic particle comprises a magnetic material having a maximum field strength in a range of from about 20 emu/g to about 250 emu/g and a remanence in a range of from about 0 emu/g to about 30 emu/g. The magnetic particle further comprises an outer surface containing a ligand. The ligand interacts with an analyte of interest in the sample solution.
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: December 20, 2022
    Assignee: Beckman Coulter, Isse.
    Inventors: Jeffrey J. Corpstein, Evan Farthing, Thomas G. Keen, Jianli Zhao, Asmita Patel, Yuandan Liu, Cuong N. Hoang, Emmet Welch
  • Patent number: 11529308
    Abstract: The present disclosure relates to a vaginal system that prevents pregnancy comprised of segesterone acetate and ethinyl estradiol and is configured for thirteen 28-day product-use cycles.
    Type: Grant
    Filed: August 17, 2020
    Date of Patent: December 20, 2022
    Assignee: The Population Council, Inc.
    Inventor: Bruce Variano
  • Patent number: 11517524
    Abstract: Disclosed herein is a self-supporting, dissolvable, film containing dexmedetomidine or a pharmaceutically acceptable salt thereof. The film is administered orally to treat various conditions, particularly agitation, by transmucosal delivery of the active agent.
    Type: Grant
    Filed: December 23, 2021
    Date of Patent: December 6, 2022
    Assignees: BioXcel Therapeutics, Inc., ARx, LLC
    Inventors: Vasukumar Kakumanu, David Christian Hanley, Frank Yocca, Chetan Dalpatbhai Lathia, Scott David Barnhart
  • Patent number: 11517587
    Abstract: The invention provides a method of treatment comprising reducing therapy-induced adverse effects (TIAE), including chemotherapy-induced adverse effects (CIAE), such as chemotherapy-induced peripheral neuropathy (CIPN) and/or chemotherapy-induced cardiovascular adverse effects (CICAE) in a subject being treated with a CIAE-inducing anti-cancer active ingredient by co-administering to the subject a pharmaceutically effective amount of a NCS-1-protective composition. Related pharmaceutical compositions, diagnostics and screening techniques are also provided.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: December 6, 2022
    Inventors: Barbara Ehrlich, Sara Rockwell, Jennifer Benbow