Patents Examined by Robert T. Crow
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Patent number: 11622945Abstract: The present invention relates to topical pharmaceutical emulsion compositions comprising a therapeutically effective amount of 3,5-Dihydroxy-4-isopropyl-trans-stilbene or a pharmaceutically acceptable salt thereof, an oil phase, a water phase, a surfactant, and an antioxidant, and wherein the emulsion composition is homogeneous and/or the active is solubilized in the oil phase. The invention also relates to methods of treating a dermatological condition or disorder in a patient by administering the present compositions to the skin of the patient.Type: GrantFiled: December 21, 2018Date of Patent: April 11, 2023Assignee: DERMAVANT SCIENCES GMBHInventors: Sujatha D. Sonti, Joey Roger Thomas, Jon Lenn, Leandro Santos, Justin Whiteman, Michael Quinn Doherty, Mary Bedard, Piyush Jain
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Patent number: 11617717Abstract: The present invention relates to an anti-infection and anti-tumor mucosal immune preparation. The mucosal immune preparation includes mucosal immune substances that are mainly formed by organically bonding polyinosinic-polycytidylic acid, non-antibiotic amino compounds and metal cations through chemical bonds. The present invention provides a slow release effect on a local part or the whole body, prevents the degradation of serum ribonucleases of human beings and primates, prolong the half-life period of the mucosal immune preparation, increases the availability and effectiveness of drugs. The mucosal immune preparation can facilitate the mucosal immunity of the body by mucosal immunity and thus facilitate the activation and proliferation of various immune cells, rather than merely acting on diseased local parts, so that the purposes of anti-infection and anti-tumor prevention and treatment with almost no side effects are realized.Type: GrantFiled: June 18, 2018Date of Patent: April 4, 2023Inventors: Haixiang Lin, Fang Liu, Li Zha, Xiaolin Sun
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Patent number: 11617724Abstract: The present invention relates to topical pharmaceutical emulsion compositions comprising a therapeutically effective amount of 3,5-Dihydroxy-4-isopropyl-trans-stilbene or a pharmaceutically acceptable salt thereof, an oil phase, a water phase, a surfactant, and an antioxidant, and wherein the emulsion composition is homogeneous and/or the active is solubilized in the oil phase. The invention also relates to methods of treating a dermatological condition or disorder in a patient by administering the present compositions to the skin of the patient.Type: GrantFiled: November 9, 2017Date of Patent: April 4, 2023Assignee: DERMAVANT SCIENCES GMBHInventors: Sujatha D. Sonti, Joey Roger Thomas, Jon Lenn, Leandro Santos, Justin Whiteman, Michael Quinn Doherty, Mary Bedard, Piyush Jain
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Patent number: 11617715Abstract: A composition comprising Quinoline is described for the modification of undesirable or harmful behaviors or other behaviors or physiology in a variety of vertebrate species, as well as methods of using the compositions in vertebrates.Type: GrantFiled: August 1, 2017Date of Patent: April 4, 2023Assignee: TEXAS TECH UNIVERSITY SYSTEMInventor: John J. McGlone
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Patent number: 11612573Abstract: The present invention relates to topical pharmaceutical emulsion compositions comprising a therapeutically effective amount of 3,5-Dihydroxy-4-isopropyl-trans-stilbene or a pharmaceutically acceptable salt thereof, an oil phase, a water phase, a surfactant, and an antioxidant, and wherein the emulsion composition is homogeneous and/or the active is solubilized in the oil phase. The invention also relates to methods of treating a dermatological condition or disorder in a patient by administering the present compositions to the skin of the patient.Type: GrantFiled: September 30, 2019Date of Patent: March 28, 2023Assignee: DERMAVANT SCIENCES GMBHInventors: Sujatha D. Sonti, Joey Roger Thomas, Jon Lenn, Leandro Santos, Justin Whiteman, Michael Doherty, Mary Bedard, Piyush Jain
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Patent number: 11602509Abstract: An inhalable microparticles having cysteamine hyaluronate salt is provided. Also a preparation method and a pharmaceutical composition thereof are provided.Type: GrantFiled: May 17, 2019Date of Patent: March 14, 2023Assignee: RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA SPAInventors: Paolo Colombo, Alessandra Rossi, Greta Adorni, Marco Barchielli
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Patent number: 11590190Abstract: Various embodiments of the invention relate to compositions comprising vitamins, minerals and trace elements, antioxidants, amino acids, probiotics, and other components and methods for using such compositions to treat or prevent diseases associated with oxidative stress, including cardiovascular disease.Type: GrantFiled: April 19, 2019Date of Patent: February 28, 2023Assignee: Sweet Wellness ABInventor: Per-Arne Öckerman
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Patent number: 11592441Abstract: Provided is a nanoplasmonic sensor and a kit for biomolecule analysis, and a method of analyzing a biomolecule using the same. The method includes: providing the nanoplasmonic sensor including a dielectric grating extending in one direction, and a metal structure disposed to cover an upper surface and a side surface of the dielectric grating and have at least one bent portion; immobilizing a first probe molecule on a surface of the metal structure; hybridizing an analyte with the first probe molecule by introducing the analyte having a base sequence complementary to the first probe molecule; binding a second probe molecule that is hybridized with the first probe molecule to the analyte; binding an enzyme to the second probe molecule; introducing a substrate that reacts with the enzyme to produce a precipitate by an enzymatic reaction; and measuring localized surface plasmon resonance in the metal structure.Type: GrantFiled: December 11, 2018Date of Patent: February 28, 2023Assignees: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE, FOUNDATION FOR RESEARCH AND BUSINESS, SEOUL NATIONAL UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Tae Geol Lee, Hee Kyung Na, Jung Sub Wi, Jong G. OK
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Patent number: 11583550Abstract: Provided herein are pharmaceutically acceptable sodium nitrite and pharmaceutical compositions thereof. Also provided herein are methods for determining the total non-volatile organic carbon in a sodium nitrite-containing sample. Further provided herein are methods for producing pharmaceutically acceptable sodium nitrite. Still further provided herein are methods of treatment comprising the administration of pharmaceutically acceptable sodium nitrite.Type: GrantFiled: December 18, 2020Date of Patent: February 21, 2023Assignee: Hope Medical Enterprises, Inc.Inventors: Craig Sherman, Anthony James Lepine, Catherine Marie Smith, Kevin Robert Wirtz, Erich Schulze
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Patent number: 11579110Abstract: The subject invention provides materials and methods for single-step fluorescence and electrochemical detection of small molecules, e.g., fentanyl and its analogs, in a sample. The subjection invention provides nucleic acids materials, e.g., aptamers (nucleic acid oligonucleotides) that can bind to fentanyl and its analogs with nanomolar affinity and high specificity against illicit drugs, adulterants, and cutting agents commonly existing in seized samples. The method for detecting fentanyl and/or its analogs in a sample comprises contacting the sample with an aptamer-based sensor selective for fentanyl and its analogs, and sensitively, specifically, and rapidly detecting fentanyl and/or its analogs in the sample.Type: GrantFiled: May 27, 2022Date of Patent: February 14, 2023Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: Yi Xiao, Juan Canoura
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Patent number: 11565258Abstract: An apparatus and method for performing analysis and identification of molecules have been presented. In one embodiment, a portable molecule analyzer includes a sample input/output connection to receive a sample, a nanopore-based sequencing chip to perform analysis on the sample substantially in real-time, and an output interface to output result of the analysis.Type: GrantFiled: October 2, 2017Date of Patent: January 31, 2023Assignee: GENVIDA TECHNOLOGY COMPANY LIMITEDInventors: Daniel Wai-Cheong So, Chi Yip Ho
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Patent number: 11565267Abstract: A detection apparatus having a read head including a plurality of microfluorometers positioned to simultaneously acquire a plurality of the wide-field images in a common plane; and (b) a translation stage configured to move the read head along a substrate that is in the common plane. The substrate can be a flow cell that is included in a cartridge, the cartridge also including a housing for (i) a sample reservoir; (ii) a fluidic line between the sample reservoir and the flow cell; (iii) several reagent reservoirs in fluid communication with the flow cell, (iv) at least one valve configured to mediate fluid communication between the reservoirs and the flow cell; and (v) at least one pressure source configured to move liquids from the reservoirs to the flow cell. The detection apparatus and cartridge can be used together or independent of each other.Type: GrantFiled: January 6, 2020Date of Patent: January 31, 2023Assignee: Illumina, Inc.Inventors: Dale Buermann, John A. Moon, Bryan Crane, Mark Wang, Stanley S. Hong, Jason Harris, Matthew Hage, Mark J. Nibbe
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Patent number: 11567029Abstract: The invention is directed to apparatus and methods for delivering multiple reagents to, and monitoring, a plurality of analytical reactions carried out on a large-scale array of electronic sensors under minimal noise conditions. In one aspect, the invention provides method of improving signal-to-noise ratios of output signals from the electronic sensors sensing analytes or reaction byproducts by subtracting an average of output signals measured from neighboring sensors where analyte or reaction byproducts are absent. In other aspects, the invention provides an array of electronic sensors integrated with a microwell array for confining analytes and/or particles for analytical reactions and a method for identifying microwells containing analytes and/or particles by passing a sensor-active reagent over the array and correlating sensor response times to the presence or absence of analytes or particles.Type: GrantFiled: January 23, 2014Date of Patent: January 31, 2023Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: John Nobile, George T. Roth, Todd Rearick, Jonathan M. Schultz, Jonathan Rothberg, David Marran
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Patent number: 11566273Abstract: Provided is a method for producing a cell contained base, the method being capable of providing a cell contained base highly accurately controlled in number of nucleic acid molecules contained in a low-concentration nucleic acid standard sample, the method including a liquid droplet discharging step of discharging a cell suspension in the form of a liquid droplet with a liquid droplet discharging unit onto a base including at least one cell contained region; a cell number counting step of counting a number of cells contained in the liquid droplet with a plurality of sensors from two or more directions while the liquid droplet is flying into the cell contained region; and a liquid droplet landing step of landing the liquid droplet in the at least one cell contained region in a manner that a predetermined number of cells are located in the at least one cell contained region.Type: GrantFiled: June 13, 2018Date of Patent: January 31, 2023Assignee: RICOH COMPANY, LTD.Inventors: Satoshi Izumi, Manabu Seo, Takahiko Matsumoto, Hiroki Somada, Ryuya Mashiko, Takeshi Orito, Hiroki Nakae
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Patent number: 11564393Abstract: Provided herein are fatty-ammonium salt/starch inclusion complexes comprising one or more of a variety of fatty amines. Such complexes can be combined with film-forming agents, such as poly(vinyl) alcohol (PVOH) and plasticizing agents. The inclusion complexes of the present invention can be utilized as antimicrobial agents, preventing microbial growth on organic and inorganic surfaces. In specific embodiments, inclusion complexes of the present invention are applied to vegetable or fruit surfaces in order to impede microbial growth. Inclusion complexes of the present invention can be applied to wood in order to impede microbial growth and insect consumption and to wound dressings.Type: GrantFiled: July 6, 2018Date of Patent: January 31, 2023Assignee: The United States of America, as represented by The Secretary of AgricultureInventors: William T. Hay, Gordon W. Selling, George F. Fanta, Fred J. Eller
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Patent number: 11559484Abstract: Disclosed herein is a self-supporting, dissolvable, film containing dexmedetomidine or a pharmaceutically acceptable salt thereof. The film is administered orally to treat various conditions, particularly agitation, by transmucosal delivery of the active agent.Type: GrantFiled: November 24, 2020Date of Patent: January 24, 2023Assignees: BioXcel Therapeutics, Inc., ARx, LLCInventors: Vasukumar Kakumanu, David Christian Hanley, Frank Yocca, Chetan Dalpatbhai Lathia, Scott David Barnhart
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Patent number: 11555219Abstract: The present application provides methods for detecting a nucleic acid molecule involving the use of a signal code sequence which corresponds to said nucleic acid molecule and a plurality of labelled detection probes which yield signals which make up the signal code sequence. In particular, the invention provides a sequential barcoding and decoding scheme which utilises a sequencing-by-hybridisation (SBH) strategy to sequence and decode a nucleotide barcode sequence, and to differentiate the nucleotide barcode sequence from other nucleotide barcode sequences. In an extension of the method, the application also provides a new coding scheme for providing a target nucleic acid with a detectable “colour” (or similar signal)-based code.Type: GrantFiled: June 1, 2021Date of Patent: January 17, 2023Assignee: 10x Genomics, Inc.Inventors: Malte Kühnemund, Toon Verheyen
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Patent number: 11549939Abstract: A method for characterizing the interaction between a protein and a small molecule by detecting a change in fluorescence emitted by a fluorescent dye and a nucleic acid structure which can be used in said method.Type: GrantFiled: June 21, 2018Date of Patent: January 10, 2023Assignee: DYNAMIC BIOSENSORS GMBHInventors: Hanna Beike, Herwin Daub, Ismajli Fjolla, Andreas Langer, Ulrich Rant, Ralf Strasser
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Patent number: 11542552Abstract: A DNA sequencing device and related methods, wherein the device includes a substrate, a nanochannel formed in the substrate, a first electrode positioned on a first side of the nanochannel, and a second electrode. The second electrode is positioned on a second side of the nanochannel opposite the first electrode and is spaced apart from the first electrode to form an electrode gap that is exposed in the nanochannel. At least a portion of first electrode is movable relative to the second electrode to decrease a size of the electrode gap.Type: GrantFiled: June 23, 2020Date of Patent: January 3, 2023Assignee: SEAGATE TECHNOLOGY LLCInventors: Kim Yang Lee, Thomas Young Chang, David S. Kuo, ShuaiGang Xiao, Xiaomin Yang, Koichi Wago
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Patent number: 11535892Abstract: The present disclosure provides compositions and methods that employ the compositions for conducting pairwise sequencing and for generating concatemer template molecules for pairwise sequencing. The concatemers can be generated using a rolling circle amplification reaction which is conducted either on-support, or conducted in-solution and then distributed onto a support. The rolling circle amplification reaction generates concatemers containing tandem copies of a sequence of interest and at least one universal adaptor sequence. An increase in the number of tandem copies in a given concatemer increases the number of sites along the concatemer for hybridizing to multiple sequencing primers which serve as multiple initiation sites for polymerase-catalyzed sequencing reactions. When the sequencing reaction employs detectably labeled nucleotides and/or detectably labeled multivalent molecules (e.g.Type: GrantFiled: July 15, 2021Date of Patent: December 27, 2022Assignee: Element Biosciences, Inc.Inventors: Sinan Arslan, Junhua Zhao, Molly He, Samantha Snow, William Light, Matthew Kellinger, Michael Previte, Michael Kim, Hua Yu, Yu-Hsien Hwang-Fu, Marco Tjioe, Andrew Boddicker