Patents Examined by Robert V. Hines
  • Bis(aminoneopentyl) aromatics
    Patent number: 4564705
    Abstract: Aromatic-aliphatic diamines of the formula ##STR1## in which Ar is an arylene or substituted arylene are useful in preparing thermally stable, rigid, polyamides, polyureas and polyurethanes having a repeating unit of the formula ##STR2## in which Ar is arylene or substituted arylene, X is --NH-- or --O--, n is 0 or 1, and R is a divalent organic radical.
    Type: Grant
    Filed: May 21, 1981
    Date of Patent: January 14, 1986
    Assignee: E. I. Du Pont De Nemours and Company
    Inventors: August H. Frazer, John F. Harris, Jr.
  • Process for the preparation of propargyl amines
    Patent number: 4564706
    Abstract: The invention relates to a new process for the preparation of propargyl ammonium chlorides of the Formula I ##STR1## by alkaline decomposition of the d-tartarate of the 1-isomer of an amine of the Formula II ##STR2## and subsequent reaction of the amine of the Formula II with a halide of the Formula IIIX--CH.sub.2 --C.tbd.
    Type: Grant
    Filed: July 14, 1983
    Date of Patent: January 14, 1986
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.
    Inventors: Zoltan Ecsery, Eva Somfai, Judit Hermann nee Voros, Lajos Nagy, Gabor Szabo, Otto Orban, Laslzo Arvai
  • Linear N,N'-tetrasubstituted diamines and process for their preparation
    Patent number: 4564707
    Abstract: This invention relates to the following compounds: ##STR1## Process for their preparation and uses thereof, where R.sub.1 and R.sub.2 are substituted groups, and R.sub.6, R.sub.5, R.sub.4 and R.sub.3 are hydrogen or substituted groups.
    Type: Grant
    Filed: March 19, 1981
    Date of Patent: January 14, 1986
    Assignee: Petrolite Corporation
    Inventor: Bernardus A. Oude Alink
  • Biologically-active tricyclic amines
    Patent number: 4564698
    Abstract: The present invention relates to new tricyclic compounds of the formula: ##STR1## having valuable CNS and cardiovascular properties.
    Type: Grant
    Filed: January 24, 1983
    Date of Patent: January 14, 1986
    Assignee: Akzo N.V.
    Inventors: Johannes H. Wieringa, Frans A. van der Vlugt
  • Substituted 1-oxo-2-phenyl-2-(2-alkylaminoethyl)-1,2,3,4-tetrahydronaphthalenes, their preparation and their use
    Patent number: 4564641
    Abstract: 1-Oxo-2-phenyl-2-(2-alkylaminoethyl)-1,2,3,4-tetrahydronaphthalenes of the formula I ##STR1## where R.sup.1 and R.sup.2 are identical or different and are each hydrogen, halogen, trifluoromethyl, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkoxy, R.sup.3 is C.sub.1 -C.sub.6 -alkyl and R.sup.4 is hydrogen, C.sub.1 -C.sub.6 -alkyl or benzyl, or R.sup.3 and R.sup.4 together may furthermore be a C.sub.2 -C.sub.5 -alkylene chain, and their salts with physiologically tolerated acids, and their preparation, are described.The novel compounds are useful active compounds for treating disorders.
    Type: Grant
    Filed: November 22, 1983
    Date of Patent: January 14, 1986
    Assignee: BASF Aktiengesellschaft
    Inventors: Werner Seitz, Hans-Jurgen Teschendorf, Alfred Michel, Martin Traut, Hans P. Hofmann, Horst Kreiskott
  • Alkylene oxide adducts of vicinal toluenediamine
    Patent number: 4562290
    Abstract: The subject invention relates to adducts of vicinal toluenediamine prepared by:(a) reacting from one to three moles of ethylene oxide with vicinal toluenediamine at a temperature of 125.degree. C., and(b) reacting the product of (a) with four to eight moles of propylene oxide at a temperature of at least 140.degree. C. in the present of at least 1.0 part of an alkali metal hydroxide catalyst.The adducts generally have a hydroxyl number of 300 to 500 and are particularly useful for the preparation of rigid polyurethane foams.
    Type: Grant
    Filed: December 1, 1981
    Date of Patent: December 31, 1985
    Assignee: BASF Wyandotte Corporation
    Inventors: Alexander Korczak, William W. Levis, Jr.
  • Pharmaceutically active 2-substituted-1-(omega-aminoalkoxy)benzenes
    Patent number: 4562211
    Abstract: 2-Substituted-1-(omega-aminoalkoxy)benzenes are prepared and found useful as pharmaceutical agents, particularly as antidepressants.
    Type: Grant
    Filed: November 16, 1979
    Date of Patent: December 31, 1985
    Assignee: Mitsubishi Chemical Industries, Ltd.
    Inventors: Ryoji Kikumoto, Akihiro Tobe, Shinji Tonomura, Hidenobu Ikoma
  • Method for purifying cresidine sulfonic acid by resin extraction
    Patent number: 4559182
    Abstract: A method for removing residual cresidine from impure p-cresidine sulfonic acid which impure p-cresidine sulfonic acid contains from above two parts per billion to about 1500 parts per million of cresidine. The method comprises contacting an aqueous solution of the p-cresidine sulfonic acid with a sufficient quantity of particles of a crosslinked lipophilic porous resin for a sufficient time to reduce the concentration of p-cresidine in the cresidine sulfonic acid to less than 2 parts per billion.
    Type: Grant
    Filed: November 9, 1981
    Date of Patent: December 17, 1985
    Assignee: Buffalo Color Corporation
    Inventor: Henry M. Grotta
  • Process for preparation of 3,3'- or 3,4'-diamino benzophenone
    Patent number: 4556738
    Abstract: 3,3'- or 3,4'-diamino benzophenone is prepared by catalytically reducing and dehalogenating, in the presence of a reduction catalyst and a dehydrohalogenation agent, a benzophenone compound or benzophenone compounds of the general formula ##STR1## in which X is a halogen atom at position 2 or 4 of the benzene ring and Y is hydrogen or a halogen atom and in which the nitro group is at position 3' or 4' of the benzene ring if Y is hydrogen, while Y is at position 4' and the nitro group is at position 3' of the benzene ring if Y is a halogen atom.
    Type: Grant
    Filed: January 3, 1983
    Date of Patent: December 3, 1985
    Assignee: Mitsui Toatsu Chemicals, Inc.
    Inventors: Saburo Kawashima, Akihiro Yamaguchi
  • Antidepressant derivatives of trans-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
    Patent number: 4556676
    Abstract: Novel trans-isomeric derivatives of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine are useful as antidepressant agents. These novel compounds act to block the synaptosomal uptake of norepinephrine and serotonin (5-hydroxy-tryptamine), thereby alleviating abnormalities at central receptor sites. The preferred embodiment is the enantiomer trans-(1R)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalen amine and its pharmaceutically acceptable acid addition salts.
    Type: Grant
    Filed: September 5, 1980
    Date of Patent: December 3, 1985
    Assignee: Pfizer Inc.
    Inventors: Willard M. Welch, Jr., Charles A. Harbert, B. Kenneth Koe, Allen R. Kraska
  • Process for preparing polyamines with ion exchange resin catalysts
    Patent number: 4554378
    Abstract: Polyamines are prepared from aromatic amines and aliphatic aldehydes or ketones using cationic or acid ion exchange resins as a catalyst in an essentially oxygen-free atmosphere with the aromatic amines being distilled and protected from the atmosphere.
    Type: Grant
    Filed: February 22, 1983
    Date of Patent: November 19, 1985
    Assignee: The Dow Chemical Company
    Inventors: John L. Nafziger, Laura A. Rader, Irwin J. Seward, Jr.
  • Process for the production of 5-nitro-acet-2,4-xylidine
    Patent number: 4552981
    Abstract: The present invention is directed to a process for preparing 5-nitro-acet-2,4-xylidine comprising:(a) dissolving acet-2,4-xylidine in an aqueous sulfuric acid solution, said aqueous solution containing from 86 to 92% by weight of sulfuric acid, the weight ratio of sulfuric acid to acet-2,4-xylidine being from 3.5:1 to 6.5:1;(b) nitrating the resultant solution at a temperature of from 0.degree. to 15.degree. C. in a mixed acid containing nitric acid, sulfuric acid, and from 10 to 25% by weight water; and(c) recovering 5-nitro-acet-2,4-xylidine.
    Type: Grant
    Filed: November 27, 1981
    Date of Patent: November 12, 1985
    Assignee: Mobay Chemical Corporation
    Inventors: Karl W. Thiem, Daniel P. Vanderpool
  • Process for the preparation of benzene compounds
    Patent number: 4550207
    Abstract: The reduction of azoxybenzene, azobenzenes and mixtures of azoxybenzenes and azobenzene to the hydrazobenzenes is possible under mild conditions, with high yields and without any great excess of reducing agents in the presence of raney-nickel and compounds which have an alkaline action with hydrogen or hydrazine hydrate.
    Type: Grant
    Filed: March 4, 1977
    Date of Patent: October 29, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gunter Stephan, Karl Heinz Schundehutte
  • Conversion of Fischer-Tropsch oxygenates to middle distillate
    Patent number: 4547601
    Abstract: Water soluble oxygenates of Fischer-Tropsch synthesis separated from water and acids are sequentially converted by a dehydration catalyst and a special zeolite catalyst to provide a product containing a major proportion of middle distillate.
    Type: Grant
    Filed: December 23, 1980
    Date of Patent: October 15, 1985
    Assignee: Mobil Oil Corporation
    Inventors: Robert E. Holland, Samuel A. Tabak
  • Method of treating coccidiosis with acyl guanidines
    Patent number: 4544670
    Abstract: Methods for the treatment of physiological disorders, including protozoal infections in mammalian and avian species and gastrointestinal and cardiovascular disorders in mammalian species by administering a class of aralkyl- and aralkenyl-acyl, and thioacyl, guanidine compounds, pharmaceutical compositions containing such compounds for systemic administration, and a class of novel aralkenyl-, aryl-substituted cycloalkyl-, and arylsubstituted heterocycle-acyl and thioacyl guanidines.
    Type: Grant
    Filed: August 24, 1982
    Date of Patent: October 1, 1985
    Assignee: William H. Rorer, Inc.
    Inventors: William L. Studt, Stuart A. Dodson, Harry K. Zimmerman, James L. Barnes
  • Process for producing liquid hydrocarbon fuels
    Patent number: 4543434
    Abstract: A process for the synthesis of liquid hydrocarbon fuels and hydrogen based on the use of sulfur as an oxidant.
    Type: Grant
    Filed: January 28, 1981
    Date of Patent: September 24, 1985
    Assignee: Mobil Oil Corporation
    Inventor: Clarence D. Chang
  • Hydration of nitriles
    Patent number: 4543423
    Abstract: A nitrile, such as acrylonitrile, is hydrated to the corresponding amide in the presence of a Raney copper catalyst that, before use in the reaction, is partially oxidized by contact with a controlled oxidizing system comprising oxygen, peroxide, iodate, chlorate, bromate or nitrate.
    Type: Grant
    Filed: October 28, 1982
    Date of Patent: September 24, 1985
    Assignee: Allied Colloids Limited
    Inventors: David Farrar, Peter Flesher
  • Process for the preparation of 5-amino-2,4-dimethylacetanilide
    Patent number: 4540817
    Abstract: A process for the preparation of 5-amino-2,4-dimethylacetanilide by reduction of 5-nitro-2,4-dimethylacetanilide with hydrogen is disclosed characterized in that a crude mixture containing 5-nitro-2,4-dimethylacetanilide in admixture with at least one of its position isomers is hydrogenated in a water-miscible organic solvent which optionally contains water. The 5-amino-2,4-dimethylacetanilide is separated off from the reaction mixture by means of crystallization employing a mixture of water-miscible organic solvent and water.
    Type: Grant
    Filed: July 25, 1983
    Date of Patent: September 10, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Behre, Heinz U. Blank, Alfred Seyberlich, Ferdinand Hagedorn
  • Process for preparation of 3,3'- or 3,4'-diaminodiphenylmethane
    Patent number: 4540818
    Abstract: Preparation of 3,3'- or 3,4'-diaminodiphenylmethane by catalytically reducing and dechlorinating, in the presence of a reduction catalyst, a dinitrobenzophenone compound having the formula ##STR1## wherein X is chlorine and attached to a position 4 or 6 on the benzene ring, and Y is hydrogen or chlorine with the proviso that when Y is hydrogen, the nitro group is attached to a position 3' or 4', and when Y is chlorine, Y is attached to a position 4' and the nitro group is attached to a position 3'.
    Type: Grant
    Filed: May 2, 1983
    Date of Patent: September 10, 1985
    Assignee: Mitsui Toatsu Chemicals, Inc.
    Inventors: Keizaburo Yamaguchi, Kenichi Sugimoto, Yoshimitsu Tanabe, Saburo Kawashima, Akihiro Yamaguchi
  • Process for preparing secondary amines
    Patent number: 4540819
    Abstract: New intermediates and processes for preparing 6-halo-7,8-dihydroxy-1-(p-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepi nes involve the reaction of a p-methoxyphenylglyoxal, lower alkyl hemimercaptal with a 2-chloro-3,4-dimethoxyphenethylamine, followed by a borohydride reduction.
    Type: Grant
    Filed: April 28, 1983
    Date of Patent: September 10, 1985
    Assignee: SmithKline Beckman Corporation
    Inventors: Kathleen L. Wert, Alan W. Tremper