Patents Examined by Robert V. Hines
  • Dihydroxypropoxy derivatives of hydroxybenzamides
    Patent number: 4675443
    Abstract: New epoxy resins are prepared by reacting a hydroxybenzamide or derivative thereof with an epihalohydrin followed by dehydrohalogenation. These epoxy resins have crystalline melting points, self-cure at elevated temperatures and cure rapidly in the presence of the usual epoxy resin curing agents. Also disclosed are hydrolyzed products of these epoxy resins and subsequent reactions with polyisocyanates.
    Type: Grant
    Filed: May 13, 1982
    Date of Patent: June 23, 1987
    Assignee: The Dow Chemical Company
    Inventors: James L. Bertram, Edmund P. Woo
  • Method of making methacrylamides
    Patent number: 4675442
    Abstract: What is disclosed is a method for making an amide of acrylic acid or of methacrylic acid by the reaction of an alkyl ester of acrylic acid or of methacrylic acid with an amine at a temperature between 50.degree. C. and 180.degree. C., whereby the reaction with the amine is carried out in the presence of a catalytic amount of a compound of a metal of Group IVB of the periodic table of the elements or of a compound of lead, zinc, or tantalum.
    Type: Grant
    Filed: March 6, 1985
    Date of Patent: June 23, 1987
    Assignee: Rohm GmbH
    Inventors: Siegmund Besecke, Guenter Schroeder
  • Epoxy resins from hydroxy benzamides
    Patent number: 4673765
    Abstract: New epoxy resins are prepared by reacting a hydroxybenzamide or derivative thereof with an epihalohydrin followed by dehydrohalogenation. These epoxy resins have crystalline melting points, self-cure at elevated temperatures and cure rapidly in the presence of the usual epoxy resin curing agents. Also disclosed are hydrolyzed products of these epoxy resins and subsequent reactions with polyisocyanates.
    Type: Grant
    Filed: May 13, 1982
    Date of Patent: June 16, 1987
    Assignee: The Dow Chemical Company
    Inventors: James L. Bertram, Edmund P. Woo
  • Epoxy resins from hydroxy benzamides
    Patent number: 4673764
    Abstract: New epoxy resins are prepared by reacting a hydroxybenzamide or derivative thereof with an epihalohydrin followed by dehydrohalogenation. These epoxy resins have crystalline melting points, self-cure at elevated temperatures and cure rapidly in the presence of the usual epoxy resin curing agents. Also disclosed are hydrolyzed products of these epoxy resins and subsequent reactions with polyisocyanates.
    Type: Grant
    Filed: May 13, 1982
    Date of Patent: June 16, 1987
    Assignee: The Dow Chemical Company
    Inventors: James L. Bertram, Edmund P. Woo
  • Process for the production of urea
    Patent number: 4670588
    Abstract: A process for the synthesis of urea from ammonia and carbon dioxide in which high yield reaction and optimal reactor heat balance control are achieved at the same time by using two reaction zones, where two different NH.sub.3 /CO.sub.2 molar ratios are maintained, and by treating the effluent from the second reaction zone in a separation treatment in two steps in series; the reactant gas stream discharged from the second treatment step is recycled, after partial condensation, to the first reaction zone, while at least part of the gas stream discharged from the first treatment step is recycled directly to the second reaction zone, the gas stream from both the first and second treatment step being so controlled as to obtain optimal NH.sub.3 /CO.sub.2 ratios and optimal reaction temperatures in the two reaction zones.
    Type: Grant
    Filed: August 13, 1984
    Date of Patent: June 2, 1987
    Assignee: Ammonia Casle S.A.
    Inventor: Umberto Zardi
  • Preparation of N-acetyl-p-aminophenol
    Patent number: 4670589
    Abstract: Production of N-acetyl-p-aminophenol by hydrogenation of p-nitrophenol to p-aminophenol and concurrently acetylating the p-aminophenol with acetic anhydride with the acetylation controlled so that substantially no excess acetic anhydride is present in the system until the hydrogenation reaction has reached substantial completion.
    Type: Grant
    Filed: November 13, 1984
    Date of Patent: June 2, 1987
    Assignee: Monsanto Company
    Inventors: John H. Van Ness, J. Bruce Warner
  • Herbicidal 4-trifluoromethyl-4-nitrodiphenyl ethers
    Patent number: 4662935
    Abstract: Compounds of the formula ##STR1## wherein X is a hydrogen atom, a halogen atom, a trihalomethyl group, an alkyl group, or a cyano group,Y is a hydrogen atom, a halogen atom, or a trihalomethyl group, andZ is a substituted alkoxy group,and compositions containing these compounds exhibit herbicidal activity.
    Type: Grant
    Filed: September 16, 1981
    Date of Patent: May 5, 1987
    Assignee: Rohm and Haas Company
    Inventors: Horst O. Bayer, Colin Swithenbank, Roy Y. Yih
  • Basic ethers of 7-oxo-7H-benzo(c) fluorene and a process for their production
    Patent number: 4661297
    Abstract: Basic ethers of 7-oxo-7H-benzo(c) fluorene have been shown to evidence a pronounced antineoplastic and immunosuppressive effect in mammals suffering from leukemia. The technique for preparing the described ethers and the addition salts thereof with pharmaceutically acceptable organic and inorganic acids involves the aminoalkylation of 5-hydroxy-7-oxo-7H-benzo(c) fluorene and its corresponding nuclear substituted derivatives on the hydroxylic oxygen atom.
    Type: Grant
    Filed: September 14, 1982
    Date of Patent: April 28, 1987
    Assignee: SPOFA, spojene podniky pro zdravotnickou vyrobu
    Inventors: Jiri Krepelka, Iva Vancurova, Karel Rezabek, Milan Melka, Vojtech Pujman, Stanislava Pokorna, Ruzena Reichlova, Slavjanka Cernochova
  • Continuous preparation of furmamide
    Patent number: 4659866
    Abstract: Formamide is prepared continuously from methyl formate and ammonia, pure methanol being recovered, by a process wherein(a) the reaction of methyl formate and ammonia is carried out predominantly in the liquid phase in the upper region of a reaction column R having a total of from 15 to 30 theoretical plates,(b) the methanol formed in this reaction is removed, together with small amounts of formamide, from the column or the evaporator in vaporus form at the level of plates 1-5 (counted from the bottom),(c) the formamide is removed from this methanol/formamide mixture, together with small amounts of methanol, in a distillation column D1 and recycled to R, and(d) the small amounts of methanol contained in the bottom product from R, which substantially consists of formamide and in this column should be at from 110.degree. to 130.degree. C., are separated off in a distillation column D2.
    Type: Grant
    Filed: February 10, 1982
    Date of Patent: April 21, 1987
    Assignee: BASF Aktiengesellschaft
    Inventors: Kaspar Bott, Gerd Kaibel, Herwig Hoffmann, Rudolf Irnich, Otto Kratzer
  • Isoprenylamine derivatives
    Patent number: 4658063
    Abstract: A compound of the formula ##STR1## wherein R.sub.1 is a phenethyl group, R.sub.2 is a hydrogen atom, R.sub.3 is a lower alkyl group, and (alkylene) is a lower alkylene chain substituted with a hydroxyl group; or an acid addition salt thereof is described.
    Type: Grant
    Filed: April 15, 1985
    Date of Patent: April 14, 1987
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Yoshiyuki Tahara, Yasuhiro Komatsu, Hiroyasu Koyama, Reiko Kubota, Teruhito Yamaguchi, Toshihiro Takahashi
  • Preparation of (-)-5-(beta)-1-hydroxy-2-((beta)-1-methyl-3-phenylpropyl)aminoethyl) salicylamide
    Patent number: 4658060
    Abstract: There is disclosed a multistep process for producing (-)-5-[(R)-1-hydroxy-2-((R)-1-methyl-3-phenyl-propyl)aminoethyl]salicylami de in high yields which does not require chromatography.The process is stereoselective for the desired products starting with the reaction of D-(+)-alpha-methylbenzylamine with benzylacetone followed by reduction of the resulting Schiff's base to form an amine as an R,R: R,S diastereomeric mixture, resolution of the mixture to obtain the R,R stereoisomer as a salt, conversion to a free base, reaction of the R,R free base with an O-protected alpha-bromo-3-carbamoyl-acetophenone to produce the corresponding R,R-ketobenzamide, reduction to produce a mixture of S,R,R;R,R,R hydroxybenzamide, removal of the protecting groups, resolution of the deprotected product and then conversion to the free R,R-amine.
    Type: Grant
    Filed: April 26, 1982
    Date of Patent: April 14, 1987
    Assignee: Schering Corporation
    Inventors: Elijah J. Gold, Esther Babad, Lydia Peer, Wei K. Chang
  • Aminoalkoxy derivatives of propranolol for immunoassay applications
    Patent number: 4652681
    Abstract: Derivatives of propranolol which have the following structure: ##STR1## where R is X--(CH.sub.2).sub.n --O, X is NH.sub.2 or COOH, n is 1,2,3,4, or 5, provided that when n is 1, X must be COOH, and R is attached in the 4', 5', 6', 7' or 8' position. The compounds are useful in immunoassay applications to (1) conjugate to a protein carrier in order to prepare antibodies to propranolol and (2) to conjugate to a tracer moiety such as a radiolabeled ligand, an enzyme, an enzyme substrate or a fluorescent dye.
    Type: Grant
    Filed: April 15, 1982
    Date of Patent: March 24, 1987
    Assignee: Drug Science Foundation
    Inventors: Thomas D. Eller, Daniel R. Knapp
  • Process for the recovery of valuable components from the waste streams obtained in the preparation of urea
    Patent number: 4652678
    Abstract: An improved process for recovering usable components from waste streams containing urea, including a dilute aqueous urea solution, which result from the preparation of particulate urea products. The dilute aqueous urea solution is used to wash a urea containing waste gas stream whereby urea contained in the gas stream is dissolved in the aqueous urea solution. The aqueous urea solution thus obtained is then subjected to a hydrolysis treatment whereby the urea contained therein is hydrolyzed, and the ammonia and carbon dioxide thus formed are separated from the residual liquid stream.
    Type: Grant
    Filed: October 10, 1984
    Date of Patent: March 24, 1987
    Assignee: Stamicarbon B.V.
    Inventor: Adolphe M. Douwes
  • Process for producing mixed tertiary amine oxide
    Patent number: 4650904
    Abstract: A process for producing an aqueous solution of a straight-chain alkyl tertiary amine oxide and a branched-chain alkyl tertiary amine oxide by reacting aliphatic tertiary amines with an aqueous solution of hydrogen peroxide is disclosed. In this process, a tertiary amine which mainly consists of a branched-chain tertiary amine is first reacted with excess hydrogen peroxide, and then, a straight-chain alkyl tertiary amine which is substantially free of a branched-chain alkyl group is added to the reaction mixture for permitting further reaction with hydrogen peroxide. The process achieves a high overall conversion of the starting amines, and the final product has an extremely low level of residual hydrogen peroxide.
    Type: Grant
    Filed: November 30, 1984
    Date of Patent: March 17, 1987
    Assignee: Mitsubishi Petrochemical Company, Limited
    Inventor: Koichi Fujita
  • Dialkanolamine derivatives
    Patent number: 4649204
    Abstract: Dialkanolamines and nontoxic pharmaceutically-acceptable acid-addition salts of the compounds of the following formula ##STR1## wherein R.sub.1 is hydrogen lower alkyl, or fluoro; R.sub.2 is hydrogen or lower alkyl; R.sub.3 and R.sub.4 are the same or different and selected from the group consisting of hydrogen or lower alkyl or R.sub.3 and R.sub.4 together define a chemical bond directly linking the two alkanol chains so as to form a pyrrolidine ring; Ar, is phenyl or thienyl or phenyl substituted with one to three substituents selected from the group consisting of lower alkyl and halo; and Ar.sub.2 is phenyl and phenyl substituted with one to three substituents selected from the group consisting of lower alkyl and halo which have antidepressant activity.
    Type: Grant
    Filed: September 30, 1985
    Date of Patent: March 10, 1987
    Assignee: McNeilab, Inc.
    Inventor: Bruce E. Maryanoff
  • Substituted phenoxy-aminopropanols
    Patent number: 4649160
    Abstract: Substituted phenoxy-aminopropanols of the formula ##STR1## wherein R is a branched-chain alkyl of 3 or 4 carbon atoms, R.sup.1 is hydrogen, halogen or lower alkyl and R.sup.2 and R.sup.3, independently, are hydrogen, halogen, lower alkyl, lower alkoxy or lower alkylthio, and pharmaceutically acceptable acid addition salts thereof, are described. A process for their preparation, as well as pharmaceutical preparations containing them are also described. The compounds of formula I and their salts possess cardioselective .beta.-adrenergic blocking activity and antihypertensive activity.
    Type: Grant
    Filed: September 6, 1985
    Date of Patent: March 10, 1987
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Peter J. Machin
  • New diamines and a process for their production
    Patent number: 4647699
    Abstract: New aminoalkyl anilines having the formula: ##STR1## wherein k is 0 or 1; QNH.sub.2 is a residue of formula ##STR2## which is situated in one of the positions of the benzene ring ortho or para to the amino group and wherein n is an integer from 1 to 15, R.sub.1 is C.sub.1 -C.sub.8 alkyl, R.sub.2 is C.sub.1 -C.sub.4 alkyl or R.sub.1 and R.sub.2, together with the carbon atom to which they are attached, form a C.sub.5 -C.sub.8 cycloalkylene residue, R.sub.3 is H or C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.8 cycloalkyl, or C.sub.6 -C.sub.10 aryl; and R.sub.4 and R.sub.5 are H or C.sub.1 -C.sub.4 alkyl; as well as the corresponding salts of compounds of formula I with organic or inorganic acids and metal salt complexes; process for their production; and their use as intermediates for polyamides.
    Type: Grant
    Filed: April 3, 1985
    Date of Patent: March 3, 1987
    Assignee: Ciba-Geigy Corporation
    Inventor: Frederick H. Howell
  • Aminoethoxybenzylalcohol derivatives, process for their preparation and pharmaceutical compositions containing them
    Patent number: 4645774
    Abstract: The invention relates to new aminoethoxybenzylalcohol derivatives of the formula (I) ##STR1## wherein R.sub.1 is hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms;R.sub.2 is halogen, trihalomethyl, or alkoxy having from one to 4 carbon atoms;R.sub.3 and R.sub.4 stand for methyl or together with the adjacent nitrogen form an up to 8-membered ring optionally containing oxygen,and acid addition or quaternary ammonium salts thereof.The compounds of formula (I) are pharmacologically active, thus show enzyme-inducing effect. The pharmaceutical compositions containing them as active ingredient are also within the scope of the invention.
    Type: Grant
    Filed: December 2, 1985
    Date of Patent: February 24, 1987
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt
    Inventors: Edit Toth, Jozsef Torley, Eva Palosi, Szabolcs Szeberenyi, Laszlo Szporny, Sandor Gorog, Istvan Hajdu
  • Isoprenylamine derivatives
    Patent number: 4645862
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.3 each is benzyl or substituted with up to 3 methoxy groups, R.sub.2 is a hydrogen atom and (alkylene) is lower alkyl and the compounds are useful for controlling viral infections.
    Type: Grant
    Filed: April 15, 1985
    Date of Patent: February 24, 1987
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Yoshiyuki Tahara, Yasuhiro Komatsu, Hiroyasu Koyama, Reiko Kubota, Teruhito Yamaguchi, Toshihiro Takahashi
  • Dialkylaminoalkoxybenzylalcohol derivatives, process for their preparation and pharmaceutical compositions containing them
    Patent number: 4645779
    Abstract: The invention relates to new dialkylaminoalkoxybenzylalcohol derivatives of the formula (I) ##STR1## wherein R.sub.1 is hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms;R.sub.2 is halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms;R.sub.3 and R.sub.4 independently stand for an alkyl group having from 3 to 5 carbon atoms; andn is 2, 3, 4 or 5,and acid addition and quanernary ammonium salts thereof.According to another aspect of the invention there are provided processes for the preparation of these compounds.The new compounds provided by the invention are pharmaceutically active, in particular, they are suitable for the treatment of acute ethanolic intoxication. Pharmaceutical compositions containing them as active ingredient are another aspect of the invention.
    Type: Grant
    Filed: December 27, 1983
    Date of Patent: February 24, 1987
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt
    Inventors: Edit Toth, Jozsef Torley, Gyorgy Fekete, Laszlo Szporny, Laszlo Vereczkey, Eva Palosi, Imre Klebovich, Pal Vittay, Sandor Gorog, Istvan Hajdu