Patents Examined by Robert V. Hines
  • Propenylamines, pharmaceutical compositions containing them and their use as pharmaceuticals
    Patent number: 4755534
    Abstract: A compound of the formula: ##STR1## wherein the double bond is in the trans configuration and R.sub.1 is a radical of formula IIa, ##STR2## R.sub.2, R.sub.3, R.sub.5, R.sub.7 and R.sub.8 are each hydrogen, R.sub.4 is methyl, andR.sub.6 is a radical of formula IIIa--C.tbd.C--R.sub.11 IIIawhere R.sub.11 is n-butyl, tertiary butyl or phenyl or a chemotherapeutically acceptable acid addition salt thereof;processes for their production, their use as pharmaceuticals and pharmaceutical compositions containing them.
    Type: Grant
    Filed: September 4, 1984
    Date of Patent: July 5, 1988
    Assignee: Sandoz Ltd.
    Inventor: Anton Stuetz
  • Antifungal derivatives of N-(6,6-dimethyl-2-hepten-4-ynyl)-1-naphthalenemethanamine and method of using same
    Patent number: 4751245
    Abstract: N-(6,6-dimethyl-2-hepten-4-ynyl)-1-naphthalenemethanamine derivatives are provided having the general formula ##STR1## wherein R.sub.1 is methoxy, iminomethyl or 1-iminoethyl and R.sub.2 and R.sub.3 are each hydrogen; or R.sub.1 is methyl and one of R.sub.2 and R.sub.3 is hydrogen and the other is halogen.The above compounds as well as acid-addition salts thereof are useful as antifungal agents.
    Type: Grant
    Filed: June 25, 1986
    Date of Patent: June 14, 1988
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Gregory S. Bisacchi, Robert Zahler
  • Compositions and method
    Patent number: 4751246
    Abstract: Alpha-(aminoalkyl)-4-hydroxy-3-(alkylsulfinyl)benzenemethanols and 2-[4-hydroxy-3-(alkylsulfinyl)phenyl]ethylamines useful as antihypertensive agents are prepared by oxidation of the corresponding alpha-(aminoalkyl)-4-hydroxy-3-(alkylthio)benzenemethanols and 2-[4-hydroxy-3-(alkylthio)phenyl]ethylamines respectively.
    Type: Grant
    Filed: July 28, 1982
    Date of Patent: June 14, 1988
    Assignee: Sterling Drug Inc.
    Inventor: Richard E. Philion
  • Process for preparing N,N-bis(2-hydroxyethyl)benzylamine and N,N-bis(2-chloroethyl)benzylamine
    Patent number: 4748276
    Abstract: Improvements are shown in the successive preparations of N,N-bis(2-hydroxyethyl)benzylamine starting with benzyl chloride, its conversion to the corresponding N,N-bis(2-chloroethyl)benzylamine in substantially quantitative yield in toluene solution and using the latter by reaction with phenylacetonitrile in the presence of aqueous sodium hydroxide solution and a tetra-n-butylammonium salt, preferably the hydrogen sulfate, to produce improved over-all yields of up to over 75% (based on benzyl chloride) of 1-benzyl-4-cyano-4-phenylpiperidine hydrochloride, an intermediate for preparing meperidine.
    Type: Grant
    Filed: March 6, 1985
    Date of Patent: May 31, 1988
    Assignee: Sterling Drug Inc.
    Inventors: John R. Handley, Allen F. Dow
  • Non-hygroscopic trialkylamine oxides
    Patent number: 4748275
    Abstract: A solid non-hygroscopic flakeable di-C.sub.14-30 alkyl C.sub.1-2 alkylamine oxide is made by reacting di-C.sub.14-30 alkyl C.sub.1-2 alkylamine with aqueous hydrogen peroxide containing at least 40 weight percent H.sub.2 O.sub.2 in the absence of a solvent.
    Type: Grant
    Filed: September 8, 1986
    Date of Patent: May 31, 1988
    Assignee: Ethyl Corporation
    Inventors: Kim R. Smith, James E. Borland
  • Process for the preparation of monocyclohexylurea
    Patent number: 4740618
    Abstract: Monocyclohexylurea can be prepared particularly selectively if 100 parts by weight of cyclohexylamine are reacted with 70 to 300 parts by weight of urea in the presence of water in the boiling range of water.
    Type: Grant
    Filed: September 19, 1983
    Date of Patent: April 26, 1988
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rudolf Fauss, Kurt Findelsen, Uwe Dobereiner
  • Process for preparing 2-acyl-3,4-dialkoxyanilines
    Patent number: 4731480
    Abstract: A process for preparing 2-acyl-3,4-dialkoxyanilines is described. The 2-acyl-3,4-dialkoxyanilines are useful intermediates in the preparation of 5,6-dialkoxy-4-alkyl-2(1H)-quinazolinones. The substituted quinazolinones are active as cardiotonic agents.
    Type: Grant
    Filed: July 29, 1985
    Date of Patent: March 15, 1988
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Richard A. Conley, Donald L. Barton
  • Moderated reduction reactions for producing arylhydroxylamines
    Patent number: 4723030
    Abstract: A method is provided for enhancing the production rate of arylhydroxylamines by moderated catalytic hydrogenation reactions. Small quantities of acid introduced to the reaction medium doubles the hydrogenation rate of nitroaromatic compounds without a significant loss in selectivity to arylhydroxylamines.
    Type: Grant
    Filed: August 5, 1985
    Date of Patent: February 2, 1988
    Assignee: General Electric Company
    Inventor: Gary C. Davis
  • Isoprenylamine derivatives
    Patent number: 4723008
    Abstract: A compound of the formula ##STR1## wherein R.sub.1 is a phenethyl group, R.sub.2 and R.sub.3, taken together with the nitrogen atom to which they are bonded, form an N' hydroxylalkyl substituted piperazine, and (aklylene) is a lower alkylene chain substituted with a hydroxyl group; or an acid addition salt thereof is described.
    Type: Grant
    Filed: August 21, 1986
    Date of Patent: February 2, 1988
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Yoshiyuki Tahara, Yasuhiro Komatsu, Hiroyasu Koyama, Reiko Kubota, Teruhito Yamaguchi, Toshihiro Takahashi
  • Nitro substituted diphenyl ethers and derivatives thereof
    Patent number: 4720584
    Abstract: Nitro-isopropenyldiphenyl ethers are provided which can serve as a useful source of known monomer intermediates or as intermediates for the preparation of nitro-haloisopropyl substituted diphenyl ethers. The latter have been discovered to act as facile alkylating agents with phenols providing nitro-p-hydroxyphenylisopropyl substituted diphenyl ethers. When the latter compounds are reduced there are obtained the corresponding amino-p-hydroxyphenylisopropyl substituted diphenyl ethers.The polymerization of this last class of compounds with acid halides provides polyamide-esters. The polymers can be used in the manufacture of such articles as tubing, hose, bellows hose, and the like.
    Type: Grant
    Filed: June 30, 1986
    Date of Patent: January 19, 1988
    Assignee: The Dow Chemical Company
    Inventor: Shenghong A. Dai
  • Aromatic aryl amine polymers
    Patent number: 4714779
    Abstract: A polymer of the formula ##STR1## wherein .PHI.=phenyl or phenyleneb=0, 1, 2 or 3n=3 or greater.
    Type: Grant
    Filed: November 20, 1980
    Date of Patent: December 22, 1987
    Assignee: Xerox Corporation
    Inventors: S. Richard Turner, John F. Yanus
  • Method for the preparation of 4-phenyl-1,3-benzodiazepines and precursors thereof
    Patent number: 4709093
    Abstract: A compound of the formula ##STR1## is prepared by reacting an N-acylated-o-toluidine of the formula ##STR2## with n-alkyllithium to form a dilithio intermediate of the formula ##STR3## which can then be quenched with N-benzylidenemethylamine to form compound II. Hydrolysis of compound(II)yields the free base ##STR4## or its salt, which can be cyclized to form 4,5-dihydro-2,3-dimethyl-4-phenyl-3H-1,3-benzodiazepine or its physiologically acceptable salts, which are useful as pharmacological agents.
    Type: Grant
    Filed: July 23, 1985
    Date of Patent: November 24, 1987
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Thomas B. K. Lee, George E. Lee
  • Amine derivatives
    Patent number: 4705807
    Abstract: Novel amines of formula:R--(CH.sub.2).sub.n --NR.sup.1 R.sup.2where R is cis-2-phenylbicyclo[2,2,2]octane or 2-phenylbicyclo[2,2,2]oct-2-ene nucleus, n is 1 to 3, R.sup.1 is C.sub.1-3 alkyl and R.sup.2 is hydrogen or C.sub.1-3 alkyl, and acid-addition salts thereof, which are useful for the treatment of disorders of the central nervous system.
    Type: Grant
    Filed: December 10, 1982
    Date of Patent: November 10, 1987
    Assignee: Lilly Industries Limited
    Inventors: David C. Horwell, Graham H. Timms
  • N-substituted pseudo-aminosugars, their production and use
    Patent number: 4701559
    Abstract: A compound of the formula: ##STR1## wherein A is a chain hydrocarbon group having 1 to 10 carbon atoms optionally substituted by hydroxyl, phenoxy, thienyl, furyl, pyridyl, cyclohexyl or an optionally substituted phenyl group, or a cyclic hydrocarbon group having 3 to 7 carbon atoms optionally substituted by hydroxyl, B is hydrogen or hydroxyl, and their production and use.These compounds exhibit excellent inhibitory activity against .alpha.-glucoside hydrolase, thus are useful for hyperglycemic symptoms and various disorders caused by hyperglycemia.
    Type: Grant
    Filed: December 28, 1981
    Date of Patent: October 20, 1987
    Assignee: Takeda Chemical Industries, Inc.
    Inventors: Satoshi Horii, Yukihiko Kameda, Hiroshi Fukase
  • Fluoroallylamine derivatives
    Patent number: 4699928
    Abstract: Fluoroallylamine derivatives of the following Formula I are novel MAO-inhibitors and at low dose levels selectively inhibit MAO-B: ##STR1## wherein: R.sub.1 and R.sub.2 independently represent hydrogen, chlorine or fluroine;R.sub.3 represents hydrogen or (C.sub.1 -C.sub.4)alkyl; andX represents oxygen or sulfur.They are useful for the treatment of depression and, co-administered with L-dopa, in the treatment of Parkinsonism.
    Type: Grant
    Filed: November 6, 1986
    Date of Patent: October 13, 1987
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventor: Ian A. McDonald
  • Isoprenylamine derivatives
    Patent number: 4700002
    Abstract: This invention relates to isoprenylamine derivatives and acid addition salts thereof, which compounds are useful for controlling virus infection of vertebrate animals.
    Type: Grant
    Filed: April 15, 1985
    Date of Patent: October 13, 1987
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Yoshiyuki Tahara, Yasuhiro Komatsu, Hiroyasu Koyama, Reiko Kubota, Teruhito Yamaguchi, Toshihiro Takahashi
  • Alpha-(aminoalkyl-4-hydroxy-3-(alkylthio)benzenemethanols
    Patent number: 4695589
    Abstract: Alpha-(aminoalkyl)-4-hydroxy-3-(alkylthio)benzenemethanols useful as intermediates and as antihypertensive agents are prepared by reduction of the corresponding aminoalkyl 4-hydroxy-3-(alkylthio)phenyl ketones.
    Type: Grant
    Filed: May 27, 1983
    Date of Patent: September 22, 1987
    Assignee: Sterling Drug Inc.
    Inventor: Richard E. Philion
  • Process for the recovery of ethylene amines from an aqueous solution
    Patent number: 4683337
    Abstract: In the recovery of ethylene amines from aqueous solutions by alcohol extraction the alcoholic extract is treated with carbon dioxide so as to convert the extracted amines into carbamates, which are then back extracted with water and recovered by conventional decarbonation and dehydration. The double extraction technique results in an aqueous concentrate of at least twice the original amine concentration.
    Type: Grant
    Filed: November 21, 1983
    Date of Patent: July 28, 1987
    Assignee: Akzo nv
    Inventor: Frederik J. Budde
  • N-N-disubstituted alkenamides and phenylalkenamides
    Patent number: 4681898
    Abstract: Compounds of the formula ##STR1## where n is 0 or 1,R is alkyl, phenyl or R.sub.4 -substituted phenyl,R.sub.2 and R.sub.3 are, independently, alkyl orR.sub.2 and R.sub.3 together with N is ##STR2## m is 1, 2 or 3, R.sub.1 and R.sub.4 are, independently hydrogen, halo, alkyl or alkoxy, andR.sub.5 is hydrogen or alkyl of 1 to 6 carbon atomsor their pharmaceutically acceptable salts are useful as anti-diabetic agents, in particular, as hypoglycemic agents or inhibitors of post-prandial hypoglycemia.
    Type: Grant
    Filed: May 8, 1984
    Date of Patent: July 21, 1987
    Assignee: Sandoz Pharmaceuticals Corp.
    Inventor: Jeffrey Nadelson
  • Propenylamines, processes for their production and pharmaceutical compositions containing them
    Patent number: 4680291
    Abstract: The present invention provides propenylamines useful as anti-mycotic agents.
    Type: Grant
    Filed: August 18, 1978
    Date of Patent: July 14, 1987
    Assignee: Sandoz Ltd.
    Inventors: Helmut Hamberger, Adrian Stephen, Anton Stutz, Peter Stutz