Patents Examined by Robert V. Hines
  • Patent number: 4605765
    Abstract: A novel polyamine compound, N,N'-bis(3-aminomethylbenzyl)-2-hydroxytrimethylenediamine, having the formula ##STR1## which is useful as a hardening agent for epoxy resins and as a modifier for polyamide resins.
    Type: Grant
    Filed: October 29, 1984
    Date of Patent: August 12, 1986
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Akira Miyamoto, Katsuo Sato, Masahiro Kurokawa
  • Patent number: 4605673
    Abstract: The invention is concerned with 7H-dibenzo(a,c)-cyclohepten-5-one-(7) derivatives of general formula I ##STR1## wherein R.sup.1 and R.sup.2 can be the same or different, a hydrogen atom, an alkyl radical containing 1 to 3 carbon atoms, or, together with the nitrogen atom to which they are attached form a heterocyclic ring containing 3 to 6 carbon atoms,n is 2 or 3R.sup.3 is a hydrogen atom or a halogen atom andX is either a methylene radical or an oxygen atomand the pharmacologically acceptable salts thereof with inorganic and organic acids.The invention is furthermore concerned with analogous processes for the preparation thereof and their application for controlling psychic diseases and gastric and/or intestinal ulcers.
    Type: Grant
    Filed: December 19, 1983
    Date of Patent: August 12, 1986
    Assignee: Warner-Lambert Company
    Inventors: Gerhard Satzinger, Edgar Fritschi, Manfred Herrmann
  • Patent number: 4605767
    Abstract: Process for the preparation of 2,6-dichloro-4-nitroaniline by chlorination of 4-nitroaniline with chlorine bleaching liquor in water using acids, which comprises chlorinating 1 mole of 4-nitroaniline in 3-6 moles of hydrochloric acid (HCl) or nitric acid (HNO.sub.3) in the form of a dilute, aqueous acid in the presence of a dispersing agent which is stable under the reaction conditions, the chlorination initially being carried out at 5.degree. to 10.degree. C. and then at 15.degree.-20.degree. C. and, finally, after 90-95% of the 2-chloro-4-nitroaniline intermediately formed has been converted into 2,6-dichloro-4-nitroaniline, the temperature of the aqueous suspension being increased from 15.degree.-20.degree. C. to 70.degree. C., without further addition of chlorine bleaching liquor, and then by post-chlorinating, by renewed addition of chlorine bleaching liquor, at temperatures between 20.degree. and 70.degree. C., bringing the pH of the aqueous suspension to 9.
    Type: Grant
    Filed: May 16, 1985
    Date of Patent: August 12, 1986
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Otto Arndt, Theodor Papenfuhs
  • Patent number: 4605672
    Abstract: The invention relates to the preparation of new diethylaminoalkoxybenzhydrol derivatives of the formula (I) ##STR1## wherein R.sub.1 is hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms,R.sub.2 is halogen, trihalomethyl, or alkoxy having from one to 4 carbon atoms, andn is 1, 2, 3 or 4,and acid addition and quaternary ammonium salts thereof.According to another aspect of the invention, there are provided new compounds of the formula (I), and acid addition and quaternary salts thereof. The compounds can be used for the treatment of acute ethanolic intoxication and depression syndromes. Pharmaceutical compositions containing them as active ingredient are also within the scope of the invention.
    Type: Grant
    Filed: December 27, 1983
    Date of Patent: August 12, 1986
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Edit Toth, Jozsef Torley, Gyorgy Fekete, Laszlo Szporny, Laszlo Vereczkey, Eva Palosi, Imre Klebovich, Pal Vittay, Sandor Gorog, Istvan Hajdu
  • Patent number: 4603019
    Abstract: This invention relates to new N-(methoxyphenacyl)-amine derivatives selected from the group consisting of(i) the N-(methoxyphenacyl)-alkylamines of the general formula ##STR1## wherein A is OCH.sub.3, and R is C.sub.3 -C.sub.8 -alkyl or C.sub.3 -C.sub.8 -hydroxyalkyl; and,(ii) addition salts thereof.These new derivatives are useful as pharmaceuticals, in particular as peripheral vasodilating agents.
    Type: Grant
    Filed: November 23, 1984
    Date of Patent: July 29, 1986
    Assignee: Laboratoire L. Lafon
    Inventor: Louis Lafon
  • Patent number: 4602044
    Abstract: .beta.-Phenethanolamines are useful as antiobesity agents.
    Type: Grant
    Filed: December 19, 1983
    Date of Patent: July 22, 1986
    Assignee: Eli Lilly and Company
    Inventors: Klaus K. Schmiegel, Walter N. Shaw
  • Patent number: 4596891
    Abstract: There is disclosed diamines of the formula ##STR1## wherein R.sub.6 is H, Cl, or CH.sub.3 ; andR.sub.8 " is H, Cl, or CH.sub.3, with the provisos that(a) if R.sub.8 " is H or CH.sub.3, R.sub.7 " is CH.sub.3 ; and(b) if R.sub.8 " is Cl, R.sub.7 " is F; and(c) if R.sub.6 and R.sub.8 " are both H, R.sub.7 " is any of CH.sub.3, F, CF.sub.3, trifluoromethoxy, trifluoromethylsulfonyl, cyclohexyl, C.sub.2 -C.sub.10 alkyl, p-chlorophenoxy or p-chlorophenyl alkyl having 7 or 8 carbon atoms. The diamines have algicidal activity.
    Type: Grant
    Filed: November 20, 1980
    Date of Patent: June 24, 1986
    Assignee: Duphar International Research B.V.
    Inventors: Jaap van Gilse, Gerard B. Paerels
  • Patent number: 4596892
    Abstract: 2,2'-Bridged[1,1'-biphenyl]-3-ylmethyl carboxamides and insecticidal compositions containing these carboxamides are useful for the control of a broad range of insects and acarids.
    Type: Grant
    Filed: April 19, 1985
    Date of Patent: June 24, 1986
    Assignee: FMC Corporation
    Inventor: Ernest L. Plummer
  • Patent number: 4588746
    Abstract: Disclosed are e.g. certain novel 2-benzyl-3-(substituted)-phenoxypropylamines, their methods of synthesis and pharmaceutical compositions. Said compounds are useful as potent and centrally active serotonin uptake inhibitors for the treatment of psychotropic disorders, particularly depression.
    Type: Grant
    Filed: January 4, 1984
    Date of Patent: May 13, 1986
    Assignee: Ciba-Geigy Corporation
    Inventor: Jeffrey W. H. Watthey
  • Patent number: 4584404
    Abstract: Selective biogenic amine uptake inhibitors, 3-substituted phenyloxy-3-phenylpropyldimethylamines.
    Type: Grant
    Filed: October 24, 1983
    Date of Patent: April 22, 1986
    Assignee: Eli Lilly and Company
    Inventors: Bryan B. Molloy, Klaus K. Schmiegel
  • Patent number: 4579972
    Abstract: New intermediates and processes for preparing 6-halo-7,8-dihydroxy-1-(p-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepi nes involve the reaction of a p-methoxyphenylglyoxal, lower alkyl hemimercaptal with a 2-chloro-3,4-dimethoxyphenethylamine, followed by a borohydride reduction.
    Type: Grant
    Filed: June 28, 1985
    Date of Patent: April 1, 1986
    Assignee: SmithKline Beckman Corporation
    Inventors: Kathleen L. Wert, Alan W. Tremper
  • Patent number: 4579971
    Abstract: A cyclohexane derivative having the formula ##STR1## wherein X is 2-(ethylthio)propyl or 2-(4-chlorophenylthio)ethyl.
    Type: Grant
    Filed: March 25, 1985
    Date of Patent: April 1, 1986
    Assignee: Nippon Soda Co. Ltd.
    Inventors: Isao Iwataki, Kagari Fujita, Hisao Ishikawa, Hideo Hosaka, Kenichi Kohara
  • Patent number: 4578515
    Abstract: Ethylidene bisformamide is prepared by reacting, at elevated temperatures, dry acetaldehyde and formamide in the presence of an acidic catalyst and an ammonia scavenger such as acetic anhydride. The bisformamide is recovered as a bottoms product of high speed low residence time distillation techniques, e.g., wiped film evaporation. The resulting ethylidene bisformamide may be cracked to N-vinylformamide, which monomer is useful in the preparation of active polymers and copolymers, including poly(vinylformamide) which can be hydrolyzed to poly(vinylamine) salts by contact with acid. These amine salts can then be converted to the free amines, which are precursors of polymeric dyes and pharmaceuticals.
    Type: Grant
    Filed: June 7, 1984
    Date of Patent: March 25, 1986
    Assignee: Air Products and Chemicals, Inc.
    Inventors: Daniel J. Dawson, Kenneth M. Otteson
  • Patent number: 4570023
    Abstract: A process for the preparation of a trichlorobenzene by chlorination of o-dichlorobenzene in the presence of a catalyst is disclosed. The catalyst comprises aluminum chloride. Preferably an iron or iron chloride containing aluminum chloride catalyst is employed.
    Type: Grant
    Filed: March 25, 1981
    Date of Patent: February 11, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gerd-Michael Petruck, Raimund Wambach, Adolf Wissner, Sigurd Hartung
  • Patent number: 4568383
    Abstract: Cyclohexane-1,3-dione deriatives of the general formula ##STR1## where R.sub.1 is cyclohexenyl or cyclohexadienyl, X is hydrogen or alkoxycarbonyl, R.sub.2 is alkyl and R.sub.3 is alkyl, alkenyl, propargyl or haloalkenyl, and salts thereof, and herbicides containing these compounds.
    Type: Grant
    Filed: May 25, 1983
    Date of Patent: February 4, 1986
    Assignee: BASF Aktiengesellschaft
    Inventors: Dieter Jahn, Wolfgang Rohr, Rainer Becker, Norbert Gotz, Bruno Wurzer
  • Patent number: 4568695
    Abstract: Novel 2-amino-3-benzoylphenethylalcohols are provided having the formula: ##STR1## wherein; X is hydrogen, loweralkyl, loweralkoxy, halogen or trifluoromethyl, andY is hydrogen, loweralkyl, loweralkoxy, halogen, trifluoromethyl, --S--loweralkyl, ##STR2## The compounds exhibit anti-inflammatory activity.
    Type: Grant
    Filed: December 7, 1983
    Date of Patent: February 4, 1986
    Assignee: A. H. Robins Company, Incorporated
    Inventors: Henry W. Moran, William J. Welstead, Jr.
  • Patent number: 4568765
    Abstract: This invention relates to new isoprenylamine derivatives and acid addition salts thereof, which are useful as medicines for controlling virus infection of vertebrate animals, or the intermediates therefor.
    Type: Grant
    Filed: May 12, 1982
    Date of Patent: February 4, 1986
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Yoshiyuki Tahara, Yasuhiro Komatsu, Hiroyasu Koyama, Reiko Kubota, Teruhito Yamaguchi, Toshihiro Takahashi
  • Patent number: 4568788
    Abstract: An improved olefin disproportionation catalyst produced by contacting an inorganic refractory oxide containing a catalytic amount of molybdenum oxide with a promoting amount of at least one elemental metal selected from the group consisting of barium and magnesium.
    Type: Grant
    Filed: November 17, 1980
    Date of Patent: February 4, 1986
    Assignee: Phillips Petroleum Company
    Inventors: Semyon Kukes, Robert L. Banks
  • Patent number: 4565890
    Abstract: An improved process for the preparation of N-acetyl-p-aminophenol. p-Aminophenol is acetylated in an aqueous medium to produce a crude aqueous reaction mixture and N-acetyl-p-aminophenol product is recovered by crystallization from an aqueous system comprising the reaction mixture. Crystals are separated from the crude mother liquor which contains residual N-acetyl-p-aminophenol and unreacted acetic acid. According to the improvement, residual N-acetyl-p-aminophenol and acetic acid are recovered from the crude mother liquor by liquid-liquid extraction with a water-immiscible organic solvent to produce an extract containing N-acetyl-p-aminophenol and acetic acid. The extract is distilled to strip off the solvent and acetic acid.
    Type: Grant
    Filed: October 27, 1983
    Date of Patent: January 21, 1986
    Assignee: Mallinckrodt, Inc.
    Inventor: Sharad S. Sathe
  • Patent number: 4565891
    Abstract: A process for the catalytic oxidation of nonaromatic tertiary amines to the respective amine oxides is disclosed. An aqueous solvent system containing the tertiary amine is formed with an initial pH about equal to or greater than the pKa of the tertiary amine. This aqueous system is contacted with gaseous molecular oxygen at an oxygen partial pressure of at least about 50 psi and a temperature of at least about 80.degree. C. in the presence of certain octacyanomolybdate or iron (III) salts. The resulting oxidation converts the tertiary amine to the respective amine oxide in good yield.
    Type: Grant
    Filed: July 19, 1984
    Date of Patent: January 21, 1986
    Assignee: The Procter & Gamble Company
    Inventors: Paul E. Correa, Dennis P. Riley