Abstract: The present invention discloses a cancer treatment method which includes the step of treating a patient having cancer with an extract from Galenia Africana L. plant. The extract may include pinocembrin and/or 2?,4? dihydroxychalcone and/or 7-hydroxyflavanone. The cancer may be breast cancer or melanoma. The composition may be solubilized with MPG and/or Suganate.
Abstract: Cannabidiol (CBD) formulation comprising a mixture of full spectrum cannabidiol oil (FSO) and cannabidiol isolate (CBD isolate) is disclosed. The formulation contains a total amount of CBD derived from a combination of an amount of CBD in the FSO and an amount of CBD from the CBD isolate. The formulation of FSO and CBD isolate in used for medicinal and health benefits in a wide range of products, such as tinctures, capsules, creams or lotions, bath salts or bombs, soaps, pet or animal tinctures, and pet or animal edible chews.
Abstract: The present disclosure relates to a composition for preventing, treating or remedying female climacteric syndrome symptoms, which contains an extract of Pueraria thomsonii flower or bud. The composition according to the present disclosure shows quick effects for preventing, remedying and/or treating female climacteric syndrome symptoms, particularly facial flushing and/or osteoporosis, and thus can be utilized for the hormone replacement therapy (HRT) used for preventing or remedying climacteric syndrome symptoms.
Abstract: The present invention relates to a low-density lipoprotein (LDL)-cholesterol-lowering preparation, in particular to a bacterial cell extract for use as a medicament for lowering of the blood plasma LDL-cholesterol level, wherein the extract is obtained by extraction for between 10 minutes and 48 hours at between 8° C. and 37° C., while mixing the cells with the mixture, and wherein the ldl-cholesterol-lowering cell extract and food supplementldl-cholesterol-lowering cell extract and food supplement Rhodospirillum rubrum cells are extracted with the mixture in a volume ratio of between 10:1 and 1:10 of petroleum ether with a boiling point of between 60° C. and 80° C. and methanol comprising sodium chloride. More specifically, the present invention relates to a petroleum ether extract of Rhodospirillum rubrum obtainable by extraction of Rhodospirillum rubrum cells with a mixture of petroleum ether with a boiling point of between 60° C. and 80° C. and methanol comprising sodium chloride.
Type:
Grant
Filed:
June 14, 2018
Date of Patent:
June 8, 2021
Assignee:
ezCol B.V.
Inventors:
Ruddy Wattiez, Felice Mastroleo, Robertus Christiaan Josephus Suters
Abstract: A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein.
Type:
Grant
Filed:
March 20, 2019
Date of Patent:
June 8, 2021
Assignee:
Promega Corporation
Inventors:
Keith V. Wood, Georgyi V. Los, Robert F. Bulleit, Dieter Klaubert, Mark McDougall, Chad Zimprich
Abstract: The use of orally administrable compositions comprising Streptococcus salivarius is described, for the prevention or the treatment of psoriasis in all its forms. In particular, the present invention relates to the use of compositions comprising Streptococcus salivarius, for the treatment of psoriasis in all its forms.
Type:
Grant
Filed:
January 24, 2019
Date of Patent:
June 1, 2021
Inventors:
Stefano Di Girolamo, Laura Diluvio, Arianna Zangrilli
Abstract: The present invention relates to the use of eggshell membrane compositions to activate levels of nuclear factor kappa-light-chain-enhancer of activated B cells (“NF-?B”) in the gut of a host in need thereof and methods of treating conditions related to NF-?B dysregulation.
Abstract: The clarity method for biotissue using a biotissue clearing agent including CHAPS of the present invention enables fast tissue clarity without denaturation.
Type:
Grant
Filed:
February 23, 2018
Date of Patent:
June 1, 2021
Assignee:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Inventors:
Sun Hyun Park, Ki-Suk Kim, Dae-hwan Nam
Abstract: The present invention generally relates to an apparatus, method, system for the determination of the aggregation rate of red blood cells. More specifically, the invention concerns a method, system, and the relative apparatus used to determine the aggregation rate of red blood cells, and other parameters related to these, such as viscosity, deformability, elasticity, density, in the field of in vitro medical analyses, using optical systems after or during inducted forces for red blood cell disruption and redistribution generated by ultrasound waves.
Abstract: Disclosed are uses of ginseng saponin, which contains at least 90% of a compound K, Rd, F2, and Rg3 as a main ingredient and has effects in extending the lifespan of the cell, promoting the cell differentiation, increasing the number of red blood cells, and reducing the triglycerides by extracting, heat-treating, and enzyme-converting the ginseng saponin to prepare active saponins Rd, F2, and Rg3 including a compound K.
Type:
Grant
Filed:
April 22, 2020
Date of Patent:
May 18, 2021
Assignee:
KOREAN DRUG CO., LTD.
Inventors:
Jae Seon Kang, Bo Suel Kim, Heyong-Soo Kim, Gyu-Jin Rho, Sin-Ja Bae, Seo Hyun Lee, Jong Jin Park, Choel-Min Kim
Abstract: Methods for mimicking a tumor microenvironment in vitro are provided. The methods comprise indirectly applying a shear stress upon at least one tumor cell type plated on a surface within a cell culture container. Methods for mimicking tumor metastasis and methods for testing drugs or compounds in such systems are also provided.
Type:
Grant
Filed:
February 22, 2019
Date of Patent:
May 18, 2021
Assignee:
Hemoshear, LLC
Inventors:
Brian R. Wamhoff, Brett R. Blackman, Robert A. Figler, Daniel G. Gioeli, Michael B. Simmers
Abstract: A medicament for use in treating uremia and proteinuria, the medicament being a glycoprotein, a mixture of polysaccharide and protein, a polypeptide or a protein.
Abstract: A medicament for treating diabetes and complications thereof, the medicament being a glycoprotein, or a mixture of a polysaccharide and a protein, or a polypeptide, or a protein.
Abstract: Disclosed herein are botanical tinctures that can be variously formulated and packaged and used as dietary supplements and in the prevention and treatment of symptoms associated with disorders affecting digestion or the digestive tract (e.g., symptoms of functional gastrointestinal disorders, FGIDs).
Abstract: Disclosed are techniques and systems for producing microbials having anaplerotic oils that are rich in odd-chain fatty acids, and other beneficial components, at higher concentrations than those present in other natural dietary sources of OCFA, at lower cost, and higher production yield. Further, disclosed are examples of incorporation of these higher concentration OCFA products into food for human and non-human animal consumption.
Abstract: The present invention provides a new method for preventing and controlling viral diseases in salmonid fish using Quillaja extracts, wherein said method comprises administering to salmonid fish an effective amount of a medicinal composition comprising a Quillaja saponaria extract as active ingredient.
Type:
Grant
Filed:
July 31, 2019
Date of Patent:
April 27, 2021
Assignee:
SAPONIN RESEARCH CENTER S.A.
Inventors:
Trinidad Schlotterbeck Suárez, Hernán Alberto Cañon Jones, Mario Hernán Castillo Ruiz, Hernán Danilo Cortés González, Ricardo Manuel San Martín Gamboa
Abstract: The invention provides compositions comprising chitosan, manuka honey and one or more additional components that promotes digestive health (e.g., inulin, probiotics) for the treatment and prevention of gastric ulcers (esophageal, stomach, or duodenum) in a mammal (e.g., equine).
Type:
Grant
Filed:
March 2, 2018
Date of Patent:
April 27, 2021
Assignee:
Promend Animal Health, Inc.
Inventors:
Scott P. Noel, William Brian Austin, Alex Greene, John Kirk Shumpert
Abstract: The present invention discloses a new method for preventing and controlling bacterial diseases in salmonid fish using Quillaja extracts, wherein said method comprises administering to salmonid fish an effective amount of a medicinal composition comprising a Quillaja saponaria extract as active ingredient.
Type:
Grant
Filed:
July 31, 2019
Date of Patent:
April 27, 2021
Assignee:
SAPONIN RESEARCH CENTER S.A.
Inventors:
Trinidad Schlotterbeck Suárez, Hernán Alberto Cañon Jones, Mario Hernán Castillo Ruiz, Hernán Danilo Cortés González, Ricardo Manuel San Martín Gamboa
Abstract: The present application provides a safe, efficient, environmental friendly and convenient method for an enzyme assisted lipid-based extraction and stabilization of phyto-cannabinoids and terpenes/terpenoids from plant materials. The lipid-based extract presents high cannabinoid content and enhanced phyto-cannabinoids and terpenes/terpenoids stability, and it can be valorized toward multiple applications in the health, cosmetic, food and agricultural sectors.
Abstract: The present invention relates to compositions comprising one or more extracts and/or compounds having retinol-like activity and properties and methods of using the compositions to treat the eye.