Patents Examined by Rosanne Kosson
  • Spore-based probiotic composition for modulation of dermal and sub-dermal properties
    Patent number: 11129860
    Abstract: The present invention relates to methods of modulating dermal and sub-dermal properties of a subject. The present invention relates to methods comprising administering to a subject a spore-based probiotic composition.
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: September 28, 2021
    Assignee: Novozymes, A/S
    Inventors: Kiran Krishnan, Dale M. Kriz, Thomas F. Bayne
  • NEUPANEX®: neuroprotective, neuroregenerational, and neurogenesis supporting supplement combination
    Patent number: 11129865
    Abstract: The present invention provides a dietary supplement that contains necessary ingredients for neurological protection and neurogenesis in one formulation. This dietary supplement comprises combinations of vitamins and substances that are naturally endogenous to the brain, are known to decline with age, injury and disease and are essential for membrane structure, mitochondrial respiration and stem cell differentiation.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: September 28, 2021
    Inventor: Lewis Kilman Clarke
  • Engineered therapeutic probiotic system and method
    Patent number: 11123380
    Abstract: The claimed invention provides therapeutic as well as protective measures against colorectal cancer by utilizing genetically modified gut bacteria (101) in conjunction with an optimized diet high in cruciferous vegetable intake. According to the claimed system and method, engineered gut bacteria maximize the therapeutic value of the cruciferous vegetable diet to eradicate, offset or prophylactically prevent the onset of colorectal cancer. In the claimed invention gut bacteria Escherichia coli bind specifically to the heparan sulphate proteoglycan on colorectal cancer cells to secrete the enzyme myrosinase to transform host-ingested glucosinolates which are natural components of cruciferous vegetables to sulphoraphane, an organic small molecule with known anti-cancer activity.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: September 21, 2021
    Inventors: Matthew Wook Chang, Chun Loong Ho
  • Composition for recovering from fatigue and/or preventing fatigue accumulation
    Patent number: 11103543
    Abstract: An object of the present invention is to provide a novel food material effective for recovering from fatigue and/or preventing fatigue accumulation. The present invention provides a composition for use in recovering from fatigue and/or preventing fatigue accumulation, comprising a Lactococcus bacterium as an active ingredient.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: August 31, 2021
    Assignee: Kirin Holdings Kabushiki Kaisha
    Inventors: Kazunori Shimada, Kosuke Fukao, Yuta Komano, Toshio Fujii
  • Methods and compositions of biocontrol of plant pathogens
    Patent number: 11103540
    Abstract: The present invention comprises methods and composition for control of plant pathogens. Isolated bacteria, deposited with ATCC under the Budapest Treaty, are effective to control plant pathogens.
    Type: Grant
    Filed: March 25, 2020
    Date of Patent: August 31, 2021
    Assignee: Core Intellectual Properties Holdings, LLC
    Inventors: Luke C. Blotsky, Derex Q. Zellars, Michael L. Lindsey
  • Biological oils and production and uses thereof
    Patent number: 11104923
    Abstract: The present invention provides biological oils and methods and uses thereof. The biological oils are preferably produced by heterotrophic fermentation of one or more microorganisms using cellulose-containing feedstock as a main source of carbon. The present invention also provides methods of producing lipid-based biofuels and food, nutritional, and pharmaceutical products using the biological oils.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: August 31, 2021
    Assignee: DSM IP Assets B.V.
    Inventors: James Casey Lippmeier, Joseph W. Pfeifer, III, Jon Milton Hansen, Kirk E. Apt, William Robert Barclay, Paul Warren Behrens, David Christian Martin
  • Photobioreactor having movable maintenance device
    Patent number: 11098276
    Abstract: The present invention relates to a photobioreactor 1 for cultivating phototrophic microorganisms, comprising a reactor element 2, which has a tube 3, a maintenance device 4, and a drive system 5, which can move the maintenance device 4 in the tube 3. The photobioreactor is designed such that liquid culture medium 6 containing the microorganisms flows through at least some of the tube 3 when the photobioreactor 1 is in the operating state. The invention is characterised in that the photobioreactor 1 is designed such that the maintenance device 4 can be used in the tube 3 when the photobioreactor 1 is in operating state and can be moved in the tube 3 at least counter to the flow of the culture medium 6 by the drive system 5.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: August 24, 2021
    Assignee: Beco Invest B.V.
    Inventors: Franz Emminger, Silvia Fluch
  • Preparation and application of grain worm for treating diabetes
    Patent number: 11096970
    Abstract: This invention discloses the preparation and the application of Grain Worm for treating diabetes or regulating blood insulin level. The Grain Worm can be in the form of dry powder, tincture, or extracts by itself or in a compound. Grain Worm regulates the blood insulin levels and the human blood glucose level for treating diabetes. It has been discovered that Grain Worm can effectively treat diabetes in humans through reducing insulin resistance and improving the ?-cell function. The effect of this agent can last a long period of time (2-5 years). This is the first major discovery of using Grain Worm in treating diabetes.
    Type: Grant
    Filed: October 22, 2020
    Date of Patent: August 24, 2021
    Inventors: Xiangrong Hua, Amy Y. Huang
  • Collagenase Clostridium Histolyticum injection therapies
    Patent number: 11083781
    Abstract: Collagenase Clostridium histolyticum (EN3835) is a proteinase that can hydrolyze the triple-helical region of collagen under physiological conditions. EN3835 targets the collagenase structural matrix at the site of injection and does not require systemic exposure. Embodiments include methods of lysing subdermal collagen to treat various conditions such as benign prostatic hyperplasia, tracheal stenosis, subglottic stenosis and scleroderma.
    Type: Grant
    Filed: October 8, 2020
    Date of Patent: August 10, 2021
    Assignee: InnoMed Technologies, Inc.
    Inventor: John Joseph
  • Blood sample assay method
    Patent number: 11085066
    Abstract: The invention provides an enzymatic method for measuring the concentration of one or more analytes in the plasma portion of a blood derived sample, containing a first and a second component, where said second component interferes with the measurement of said first component.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: August 10, 2021
    Assignee: AXIS-SHIELD AS
    Inventors: Arne Ludvig Faaren, Frank Frantzen, Arne Kristian Nordhei, Erling Sundrehagen, Lars Ørning
  • Bioluminescent assays utilising secreted luciferases
    Patent number: 11078519
    Abstract: Disclosed herein are methods for determining the amount or activity of one or more luciferases and methods for measuring the luminescent signal generated by one or more luciferases in a sample, the methods comprising incubating the sample with a reactive substrate(s) of the luciferase(s) to be analysed and a reducing agent to inactivate a first luciferase, wherein the first luciferase, in its native form, is a secreted luciferase.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: August 3, 2021
    Assignee: GENE STREAM PTY LTD.
    Inventors: Marco Peter Leu, John Michael Daly
  • with methylamine degradability and application thereof
    Patent number: 11078457
    Abstract: The present invention discloses a strain of Lysinibacillus fusiformis with methylamine degradability and the application thereof. This strain, named Lysinibacillus fusiformis GDUTAN2, was deposited on May 24, 2017 in the China Center for Type Culture Collection in Wuhan University, Wuhan City, Hubei Province with a deposit number of CCTCC NO. M 2017284. This Lysinibacillus fusiformis GDUTAN2 was Grain-positive and rod-shaped, and the colony appeared to be round, white and transparent, having a diameter of 1-2 mm. The Lysinibacillus fusiformis GDUTAN2 of the present invention can be applied to environmental restoration, degrading methylamine in the environment at a high degradation efficiency. When it degraded methylamine for 96 h at a substrate concentration of 130 mg/L, the degradation efficiency could reach 32.8%.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: August 3, 2021
    Assignee: GUANGDONG UNIVERSITY OF TECHNOLOGY
    Inventors: Guiying Li, Shiai Li, Taicheng An, Yuetan Su, Xun'an Ning
  • Coral composite extract, composition including the same and method of producing the same
    Patent number: 11065282
    Abstract: The present invention relates to a coral composite extract, a composition including the same and a method of producing the same. The coral composite extract includes at least two briarane-type diterpenoid compounds from corals of Briareum violaceum, B. excavatum and B. stechei, thereby being applied as an effective ingredient of a skin external use composition, a cosmetic composition and a medicinal composition.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: July 20, 2021
    Assignee: National Sun Yat-Sen University
    Inventors: Zhi-Hong Wen, Ping-Jyun Sung, Han-Chun Hung, Chun-Hong Chen, Yu-Chia Chang
  • Maternal vitamin B12 administration for the prevention of increased adiposity, overweight or obesity in the offspring especially offspring overweight and/or obese mothers
    Patent number: 11065271
    Abstract: The present invention generally relates to the early prevention of overweight, obesity, excessive fat accumulation and/or associated metabolic disorders in infants or children. For example, the present invention relates to the prevention of over-weight, obesity, excessive fat accumulation and/or associated metabolic disorders in infants or children through appropriate nutrition for women desiring to get pregnant and/or during pregnancy and/or lactation. Embodiments of the present invention relate to vitamin B12 for use in the prevention of overweight, obesity, excessive fat accumulation and/or associated metabolic disorders in the off-spring, wherein the vitamin B12 is administered to an overweight and/or obese women desiring to get pregnant and/or to the over-weight and/or obese mother during pregnancy and/or lactation and to maternal food compositions that can be used for this purpose.
    Type: Grant
    Filed: November 12, 2019
    Date of Patent: July 20, 2021
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Cyrus Cooper, Peter David Gluckman, Irma Silva Zolezzi, Keith Malcolm Godfrey, Catherine Mace
  • Isolated complex endophyte compositions and methods for improved plant traits
    Patent number: 11064702
    Abstract: This invention relates to methods and materials for providing a benefit to a plant by associating the plant with a complex endophyte comprising a host fungus further comprising a component bacterium, including benefits to a plant derived from a seed or other plant element treated with a complex endophyte. For example, this invention provides purified complex endophytes, purified complex endophyte components such as bacteria or fungi, synthetic combinations comprising said complex endophytes and/or components, and methods of making and using the same.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: July 20, 2021
    Assignee: Indigo Ag, Inc.
    Inventors: Karen V. Ambrose, Brett A. Boghigian, Slavica Djonovic, Paul Andrew Gray, Gerardo V. Toldedo, Luis Miguel Marquez, Geoffrey von Maltzahn
  • Topical composition
    Patent number: 11065290
    Abstract: The invention discloses a therapeutic topical composition, includes an extract of Galenia Africana having anti-microbial and anti-oxidant action. The composition includes rooibos and/or an extract from rooibos tea plant. The composition is adapted for regenerating skin, stimulating cyto-keratin production, treating human external fungal infections and/or conditions, human skin bacterial conditions, psoriasis, psoriasis plaque, dandruff, acne, bacterial acnes, eczema, athletes' foot, nappy rash, baby rash and/or lesions and/or being used for anti-septic wound treatment, and/or treating Propionibacterium acnes and/or staphylococcus epidermidis.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: July 20, 2021
    Assignee: BIOPHARM NZ LIMITED
    Inventor: Michael-John Joseph Barry
  • Active substances of GKK2, composition comprising the same and method of promoting longevity using the same
    Patent number: 11058733
    Abstract: The present invention provides a Bifidobacterium lactis having active substances, a composition comprising the same, and a method of promoting longevity using the same by subjecting the composition to a subject, thereby increasing Cisd2 gene expression, reducing damage of mitochondria, delaying aging-related symptoms including nerve degeneration and sarcopenia, and so on.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: July 13, 2021
    Assignee: GRAPE KING BIO LTD
    Inventors: Chin-Chu Chen, Yen-Lien Chen, Shih-Wei Lin, Yen-Po Chen, Ci-Sian Wang, Yu-Hsin Hou, Yang-Tzu Shih, Ching-Wen Lin, Ya-Jyun Chen, Jia-Lin Jiang
  • In vitro model for pathological or physiologic conditions
    Patent number: 11061016
    Abstract: The present invention generally relates to in vitro methods for mimicking in vivo pathological or physiologic conditions. The methods comprise applying shear forces to a cell type or cell type plated on a surface within a cell culture container. Methods for testing drugs or compounds in such systems are also described.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: July 13, 2021
    Assignee: HemoShear, LLC
    Inventors: Brett R. Blackman, Brian R. Wamhoff, Ajit Dash, Michael B. Simmers, Ryan E. Feaver
  • Methods for treating polymicrobial infections
    Patent number: 11053532
    Abstract: Methods for detecting and treating polymicrobial infections, wherein a mixed population of microbes (e.g., bacteria) are present in a patient sample and the microbes are not first isolated from the sample. For example, the present invention describes specific polymicrobial infections and methods of treating said infections, wherein a particular antibiotic or a group of antibiotics are selected based on the composition of the polymicrobial infections.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: July 6, 2021
    Assignee: CAP DIAGNOSTICS, LLC
    Inventors: David A. Baunoch, Miguel F. R. Penaranda, Michael L. Opel, Maher Badir, Natalie Luke
  • Combination of aqueous extracts of watercress and nasturtium and ATP for use in the treatment of alopecia
    Patent number: 11045510
    Abstract: The present invention relates to a novel combination comprising an extract of watercress, an extract of Indian cress, and ATP, and to the use of said combination in the field of hair science, more particularly in the treatment or prevention of alopecia.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: June 29, 2021
    Assignee: PIERRE FABRE DERMO-COSMETIQUE
    Inventors: Sylvie Daunes-Marion, Marguerite Lévêque, Stéphane Poigny