Patents Examined by Sikarl A. Witherspoon
  • Synthetic cannabinoid compounds for treatment of epilepsy, substance addiction and Alzheimer's disease
    Patent number: 11629355
    Abstract: Synthetic cannabinoid compounds for treatment of epilepsy, substance addiction, and Alzheimer's disease by administering to an individual in need thereof a pharmaceutical composition including a compound having the structure: or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable vehicle therefor.
    Type: Grant
    Filed: July 22, 2021
    Date of Patent: April 18, 2023
    Assignee: MyMD Pharmaceuticals, Inc.
    Inventor: Jonnie R. Williams
  • Method to valorize 2G bioethanol waste streams
    Patent number: 11623937
    Abstract: An integrated approach for utilizing waste products of 2G bio-refineries to fractionate the lignin of high purity. The present invention also provides a method of recycling of two waste products (2-G ethanol residue as the substrate (LRBR) and fusel oil/synthetic fusel oil (SFO) as one of the solvent) of the biorefineries in a beneficial manner to fractionate the lignin of high purity. The present method of separating high purity lignin comprises fractioning extractive-free lignin rich residue with a solvent, wherein the solvent is a mixture of SFO/Fusel oil and Formic acid. An optimized ratio of waste fusel oil and formic acid gave more than >85% yields of high purity lignin.
    Type: Grant
    Filed: August 25, 2021
    Date of Patent: April 11, 2023
    Assignees: INDIAN OIL CORPORATION LIMITED, DEPARTMENT OF BIOTECHNOLOGY
    Inventors: Alok Satlewal, Ruchi Agrawal, Ravindra Kumar, Ravi Prakash Gupta, Suresh Kumar Puri, Deepak Saxena, Sankara Sri Venkata Ramakumar
  • Isolation and crystallization of cannabinoids without distillation or evaporation of solvents
    Patent number: 11623905
    Abstract: Cannabis plant material is extracted with a solvent matrix consisting of one or more organic solvents and optionally water. The cannabis plant material is agitated in the solvent matrix and then removed by filtration or centrifugation. Following extraction, the plant material is separated from the solvent matrix by centrifugation. The resulting extract is clarified by membrane filtration which also removes most of the water and water-soluble impurities. The resulting extract is dewaxed using membrane filtration and/or liquid-liquid extraction. Excess solvent and terpenoids are removed by means of molecular weight cutoff membrane filtration and the resulting cannabinoid solution is decarboxylated catalytically. Seed crystals are added to crystallize the cannabinoids.
    Type: Grant
    Filed: May 10, 2022
    Date of Patent: April 11, 2023
    Assignee: ENCANN SOLUTIONS INC.
    Inventor: Lawerance Lincoln Johnson
  • Oxygen stripping in etherification, ethers decomposition and isooctene production
    Patent number: 11623906
    Abstract: A process for supplying deaerated water to a chemical plant that includes a distillation column for separating a reaction effluent comprising water and a product. The process includes inventorying the distillation column with aerated water (water having an oxygen content of greater than 50 ppbw, such as greater than 1 ppmw). The aerated water in the distillation column may then be distilled to produce an oxygen-containing overheads and a bottoms fraction comprising deaerated water. The deaerated water in the bottoms fraction ma be transported to an upstream or a downstream unit operation, and utilizing the deaerated water in the upstream or downstream unit operation. The reaction effluent is fed to the distillation column, transitioning the distillation column from separating oxygen from water to operations for separating the product from the water.
    Type: Grant
    Filed: August 12, 2021
    Date of Patent: April 11, 2023
    Assignee: LUMMUS TECHNOLOGY LLC
    Inventors: Rosette Barias, Maurice Korpelshoek, Michael Jon Scott, Eric Arthur Schwarz, Shahid Jamal
  • Diphosphites with an open, 3-methylated outer unit
    Patent number: 11618760
    Abstract: Diphosphites having an open, 3-methylated outer unit and use thereof in hydroformylation.
    Type: Grant
    Filed: April 12, 2022
    Date of Patent: April 4, 2023
    Assignee: EVONIK OPERATIONS GMBH
    Inventors: Anna Chiara Sale, Robert Franke, Alexander Brächer, Dirk Fridag, Ana Markovic, Peter Kucmierczyk, Johannes Knossalla
  • Methylcyclohexane as allyl alcohol hydroformylation solvent
    Patent number: 11613510
    Abstract: A process for the production of 4-hydroxybutyraldehyde is described. The process comprises reacting allyl alcohol with a mixture of carbon monoxide and hydrogen in the presence of methylcyclohexane as a reaction solvent and a catalyst system comprising a rhodium complex and a substituted or unsubstituted diphosphine ligand. The use of the methylcyclohexane increases the reaction rate while also giving a high yield of 4-hydroxybutyraldehyde compared to 3-hydroxy-2-methylpropionaldehyde and improving the separation of the hydroxyaldehyde products from the catalyst system.
    Type: Grant
    Filed: April 7, 2022
    Date of Patent: March 28, 2023
    Assignee: Lyondell Chemical Technology, L.P.
    Inventors: Daniel F. White, Beaven S. Mandimutsira, Robert J. Rebman
  • Crystalline form of 6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-D3) pyridazine-3-carboxamide
    Patent number: 11613529
    Abstract: Disclosed is crystalline Form B of 6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methy-1H-1,2,4-triazol-3-yl)phenyl) amino)-N-methyl-d3)pyridazine-3-carboxamide. Form B is the HCl salt of a neat crystalline form. Characterization data for Form B are disclosed.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: March 28, 2023
    Assignee: Bristol-Myers Squibb Company
    Inventor: Daniel Richard Roberts
  • Two-step synthesis of pyrrole compounds from furan compounds
    Patent number: 11608317
    Abstract: Pyrrole compounds are produced by contacting a furan compound, a solid acid catalyst, and water to form a reaction mixture containing a ?-dicarbonyl compound, and then contacting the ?-dicarbonyl compound with ammonia or an ammonium salt to form a reaction product mixture containing the pyrrole compound. A representative pyrrole compound that can be synthesized using these processes is 2,5-dimethylpyrrole.
    Type: Grant
    Filed: March 16, 2021
    Date of Patent: March 21, 2023
    Assignee: Chevron Phillips Chemical Company, LP
    Inventor: Kenneth M. Lassen
  • Method of preparing composition containing factor VIII (FVIII) and von Willebrand factor (vWF) with controlled content of von Willebrand factor (vWF)
    Patent number: 11608358
    Abstract: Disclosed is a method for preparing a composition comprising factor VIII (FVIII) and von Willebrand factor (vWF), wherein the content of the von Willebrand factor (vWF) can be controlled by mixing the factor VIII (FVIII) with the von Willebrand factor (vWF) at an appropriate ratio after separately purifying the factor VIII (FVIII) and the von Willebrand factor (vWF) from plasma in a single process. The method can prepare and purify a composition comprising factor VIII (FVIII) and a varying content of von Willebrand factor (vWF) without increasing the amount of impurities other than the von Willebrand factor (vWF) compared to a method of purifying factor VIII (FVIII) separately, without significantly increasing the processing time (within 3 hours) compared to a method of purifying factor VIII (FVIII), and without changing the yield of factor VIII (FVIII).
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: March 21, 2023
    Assignee: GREEN CROSS HOLDINGS CORPORATION
    Inventors: Jee Won Ahn, Kwan Young Ko, Jeong Hye Yoon, Seung-Ho Baek, Min Jung Kim, Geun Hye Yeo, Jung-Ae Lim, Soo-kwang Kim
  • Inhibition of DYRK1A kinase
    Patent number: 11603343
    Abstract: Novel compounds which inhibit DYRK1A activity comprise thymoquinone derivatives including a pair of substituted or unsubstituted six-membered carbon rings selected from phenyl and cyclohexadiene linked by an alkyl or alkenyl linker. Each six-membered ring includes at least one oxygen-bearing substituent selected from carbonyl oxygens, hydroxyls, alkoxyls, and halogenated derivatives thereof. The compounds can be administered to mammalian subjects for inhibition of DYRK1A kinase proteins.
    Type: Grant
    Filed: August 31, 2021
    Date of Patent: March 14, 2023
    Assignee: Ankh Life Sciences Limited
    Inventors: Gene H. Zaid, Brian Scott Johnathan Blagg, Cameron E. West
  • Method of extracting one or more chemical extracts from a plant product
    Patent number: 11596875
    Abstract: A method of extracting one or more chemical extracts from a plant product includes mixing at least a first phytochemical-bearing part of a phytochemical plant product with an oil-bearing plant product, producing an oil mixture from the first phytochemical-bearing part and the oil-bearing plant product using a press device, and extracting at least a chemical extract from the oil mixture.
    Type: Grant
    Filed: June 24, 2021
    Date of Patent: March 7, 2023
    Assignee: Gildrien Farm, LLC
    Inventor: Jeremy Gildrien
  • Process for preparing tapinarof
    Patent number: 11597692
    Abstract: The present invention provides processes for the preparation of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and novel intermediates used therein. In some embodiments the 3, 5-Dihydroxy-4-isopropyl-trans-stilbene is prepared from (E)-2-chloro-2-isopropyl-5-styrylcyclohexane-1,3-dione. Also disclosed are crystal forms of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and pharmaceutical compositions comprising same.
    Type: Grant
    Filed: February 12, 2021
    Date of Patent: March 7, 2023
    Assignee: DERMAVANT SCIENCES GMBH
    Inventors: Ian Paul Andrews, Nicholas Calandra, Tyler Andrew Davis, Ravinder Reddy Sudini
  • Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents
    Patent number: 11597698
    Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Grant
    Filed: May 19, 2021
    Date of Patent: March 7, 2023
    Assignee: ModernaTX, Inc.
    Inventors: Kerry E. Benenato, Mark Cornebise, Edward Hennessy, Ellalahewage S. Kumarasinghe
  • Inhibitors of protein arginine methyltransferase 5 (PRMT5), pharmaceutical products thereof, and methods thereof
    Patent number: 11591326
    Abstract: The present invention provides PRMT5 inhibitors of Formula (I), wherein R1 is a non-hydrogen monovalent group; W is a direct bond or —NH—; T, U, and V are independently of each other selected from C and N; R2 is H or a halo; m is 1 or 2; X is a carbon, a nitrogen, or an oxygen; Y is C or N; Z is a direct bond or a carbon; R3 is H, a non-hydrogen monovalent group, an oxo group, a bivalent spiro ring-forming group, or a bivalent bridge-forming group; n is 1 or 2; and Formula (II) stands for a single bond or a double bond. Pharmaceutical products comprising the PRMT5 inhibitors and use thereof in treating proliferative disorders such as cancer, metabolic disorders, blood disorders, autoimmune diseases, and inflammatory diseases are also provided.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: February 28, 2023
    Assignee: Pharmablock Sciences (Nanjing), Inc.
    Inventors: Liu Liu, Jin Li, Minmin Yang
  • Method for preparing lenalidomide
    Patent number: 11591310
    Abstract: The present disclosure discloses a method for preparing lenalidomide. The present disclosure provides a method for preparing lenalidomide I, which comprises the following steps: in a solvent, the lenalidomide intermediate II is reduced with a metal in the presence of an organic acid to obtain the lenalidomide I, wherein the metal is one or more selected from zinc, iron, aluminum and manganese. The preparation method of the disclosure has simple and safe operation, simple post-processing steps, environmental friendliness, high total yield. Moreover, the product obtained in the method has a purity of more than 99.90%, maximum single impurity of less than 0.10%, total heavy metal residue of less than 10 ppm and meet the heavy metal residue standard and API standard. Furthermore, the method has a low production cost and is suitable for industrial production.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: February 28, 2023
    Assignee: SHANGHAI BOCIMED PHARMACEUTICAL CO., LTD.
    Inventors: Shuhuan Ying, Yuhui Guo, Jian Chen, Tingting Wang
  • Compositions and methods for removal of detergents from aqueous solutions
    Patent number: 11578099
    Abstract: Compositions and methods are described in which a primary detergent or surfactant in an aqueous solution is removed by the addition of a secondary detergent or surfactant in concentrations that exceed the critical micellar concentration (CMC) of the secondary detergent or surfactant. These compositions and methods are particularly applicable to protein-containing solutions. Typical primary detergents/surfactants include polysorbate 20, polysorbate 80, and Triton X-100. Suitable secondary detergents or surfactants can be ionic, nonionic, or zwitterionic. Typical secondary detergents/surfactants include, but are not limited to, galactoside detergents (e.g. octyl-?-galactoside), glucamide detergents (e.g. MEGA 8, MEGA 9, MEGA 10), cholamide detergents (e.g. CHAPS, CHAPSO, BIGCHAPS), and sulfobetaine detergents (such as sulfobetaine 3-10).
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: February 14, 2023
    Assignee: BioMadison, Inc.
    Inventors: Francis Mark Dunning, Ward C. Tucker
  • Aqueous antimicrobial composition
    Patent number: 11571376
    Abstract: [Problem to be Solved] An object of the present invention is to provide an aqueous antimicrobial composition which exhibits excellent antibacterial and antifungal activities even at a low concentration and has high safety, low skin irritation, and excellent long-term stability. [Solution] Aqueous antimicrobial compositions comprising two or more compounds selected from (a) benzoic acid or a salt thereof, (b) ?-gluconolactone, (c) ketonic acid or a salt thereof, and (d) sorbic acid or a salt thereof; and at least one or more dicarboxylic acid represented by General Formula (I) or a salt thereof.
    Type: Grant
    Filed: March 28, 2017
    Date of Patent: February 7, 2023
    Assignee: ARXADA AG
    Inventors: Kazuhiko Sakata, Mayumi Furukawa
  • Method for oxidation of cycloalkanes
    Patent number: 11572330
    Abstract: The present invention concerns a method of oxidizing a cycloalkane to form a product mixture containing a corresponding alcohol and ketone, said method comprising contacting the cycloalkane with a hydroperoxide compound in the presence of a heterogenous catalyst comprising gold.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: February 7, 2023
    Inventors: Sandra Chouzier, Sergio Mastroianni, Avelino Corma, Mercedes Boronat, Javier Tirso Lopez Ausens
  • Electrochemical sensor
    Patent number: 11567030
    Abstract: An electrochemical sensor with an ion-selective membrane that comprises a crosslinked alkyl methacrylate homopolymer or copolymer of two or more alkyl methacrylates 1. with a covalently attached electrically neutral or electrically charged ionophore that is selective for a target cation or anion, or 2. with a covalently attached cationic or anionic ionic site, or 3. with a covalently attached cationic or anionic ionic site and covalently attached electrically neutral or electrically charged ionophore.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: January 31, 2023
    Assignees: ROSEMOUNT INC., REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Xin Chen, Jinbo Hu, Philippe Buhlmann
  • Mixture of bisphosphites having an open and a closed outer unit and the use thereof as a catalyst mixture in hydroformylation
    Patent number: 11565991
    Abstract: Mixture of bisphosphites having an open and a closed outer unit and the use thereof as a catalyst mixture in hydroformylation.
    Type: Grant
    Filed: April 12, 2022
    Date of Patent: January 31, 2023
    Assignee: EVONIK OPERATIONS GMBH
    Inventors: Anna Chiara Sale, Robert Franke, Alexander Brächer, Dirk Fridag, Johannes Knossalla, Peter Kucmierczyk, Ana Markovic