Patents Examined by Sikarl A. Witherspoon
  • Diphosphites having an open and a closed 2,4-methylated outer unit
    Patent number: 11560396
    Abstract: Diphosphites having an open and a closed 2,4-methylated outer unit and use thereof in hydroformylation.
    Type: Grant
    Filed: April 12, 2022
    Date of Patent: January 24, 2023
    Assignee: EVONIK OPERATIONS GMBH
    Inventors: Robert Franke, Anna Chiara Sale, Alexander Brächer, Dirk Fridag, Ana Markovic, Peter Kucmierczyk, Johannes Knossalla
  • Process for the hydroformylation of olefins using a cobalt pre-catalyst
    Patent number: 11560348
    Abstract: Process for the hydroformylation of olefins using a cobalt pre-catalyst.
    Type: Grant
    Filed: May 25, 2022
    Date of Patent: January 24, 2023
    Assignee: EVONIK OPERATIONS GMBH
    Inventors: Baoxin Zhang, Christoph Kubis, Armin Börner, Robert Franke
  • Methods for isolating compounds
    Patent number: 11553724
    Abstract: The present invention in its broadest aspect relates to a method for reducing glycoalkaloid content and turbidity of an aqueous phase comprising compounds selected from two or more of PA, PI, PPO, LipO, pectin, lipid, glycoalkaloid and phenolic compounds of which at least one compound is selected from PA, PI, LipO and PPO; a) providing an aqueous phase comprising compounds selected from two or more of PA, PI, PPO, LipO, pectin, lipid, glycoalkaloid and phenolic compounds of which at least one compound is selected from PA, PI, LipO and PPO; and b) performing one or more steps to reduce the concentration of solanine in the dry matter of the aqueous phase with at least 15 percent, such as at least 20% such as at least 25% and to achieve an optical density at 620 nm of the remaining aqueous phase of less than 0.7; such as less than 0.5; such as less than 0.3; such as less than 0.2 such as less than 0.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: January 17, 2023
    Assignee: DUYNIE HOLDING B.V.
    Inventors: Allan Otto Fog Lihme, Marie Bendix Hansen, Bodil Ingrid Kjaer Lindved
  • Method of preparing 8-methyldecanal
    Patent number: 11548846
    Abstract: The present invention discloses a novel method of preparing 8-methyldecanal, a flavor and fragrance material. Specifically, starting from cheap and readily available material 6-chloro-1-hexanol, first, the hydroxyl group was protected with dihydropyran catalyzed by para-toluene sulfonic acid to produce 6-chloro-hexyl tetrahydropyran ether. Then 6-chloro-hexyl tetrahydropyran ether reacted with magnesium turnings to form a Grignard reagent and reacted with 1-bromo-2-methyl-butane under the catalysis of cuprous bromide to give the intermediate 8-methyl-sunny tetrahydropyran ether. Without purification, crude 8-methyl-sunny tetrahydropyran ether was treated under acidic conditions to remove the protecting group to generate 8-methyl-1-decyl alcohol. Finally, 8-methyl decanal was obtained after oxidation with 2, 2, 6, 6-tetramethylpiperidinyloxy.
    Type: Grant
    Filed: January 5, 2022
    Date of Patent: January 10, 2023
    Inventors: Yafei Tan, Xinhao Dong, Hua Zheng, Guotai Lei, Xiaoli Zhu
  • Methods of isolating phenols from phenol-containing media
    Patent number: 11548845
    Abstract: Methods of isolating phenols from phenol-containing media. The methods include combining a phospholipid-containing composition with the phenol-containing medium to generate a combined medium, incubating the combined medium to precipitate phenols in the combined medium and thereby form a phenol precipitate phase and a phenol-depleted phase, and separating the phenol precipitate phase and the phenol-depleted phase. The methods can further include extracting phenols from the separated phenol precipitate phase. The extracting can include mixing the separated phenol precipitate phase with an extraction solvent to solubilize in the extraction solvent at least a portion of the phenols originally present in the phenol precipitate phase.
    Type: Grant
    Filed: September 9, 2021
    Date of Patent: January 10, 2023
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Bradley Bolling, Yuwei Wu, Danielle Voss, Matthew Dorris
  • Process for preparing methacrolein from formaldehyde and propionaldehyde and preparation plant for the purpose
    Patent number: 11542218
    Abstract: A process and a preparation plant can prepare methacrolein from formaldehyde and propionaldehyde in the presence of a homogeneous catalyst mixture based at least on an acid and a base. For a good workup of the reaction mixture leaving the reactor, with a good energy balance and where the process has simplified apparatus implementation, the liquid reaction mixture under pressure is expanded in an expansion vessel and separated into a first expansion mixture in a gas phase and a second expansion mixture in a liquid phase. The first expansion mixture is condensed in a first condenser and the second expansion mixture is introduced into a first distillation column and separated therein, into a first distillation mixture in a gas phase at the top and a second distillation mixture in a liquid phase at the bottom. The first distillation mixture is condensed in the first condenser.
    Type: Grant
    Filed: August 20, 2020
    Date of Patent: January 3, 2023
    Assignee: Röhm GmbH
    Inventors: Rudolf Burghardt, Steffen Krill, Florian Zschunke, Eduard Rundal, Torsten Panak, Daniel Helmut König
  • Integrated process for the production of isononanol and stable / lubricating gasoline and diesel blending components
    Patent number: 11542447
    Abstract: In accordance with one or more embodiments of the present disclosure, a method for producing epoxide gasoline blending components includes cracking, in a steam cracker, a hydrocarbon feed to form a first ethylene stream, a first propylene stream, and a C4 stream comprising isobutene and butadiene; reacting, in a methyl tertiary butyl ether (MTBE) unit, the C4 stream with a methanol stream to form MTBE and a butadiene-rich C4 stream; selectively hydrogenating, in a butadiene unit, the butadiene-rich C4 stream to form a butene-rich C4 stream including butene-1, cis-butene-2, and trans-butene-2; producing, in an isononanol unit, isononanol and an olefin-rich stream from the butene-rich C4 stream; and oxidizing the olefin-rich stream in an oxidation unit by combining the olefin-rich stream with an oxidant stream and a catalyst composition to produce the epoxide gasoline blending components.
    Type: Grant
    Filed: March 9, 2021
    Date of Patent: January 3, 2023
    Assignee: Saudi Arabian Oil Company
    Inventors: Omer Refa Koseoglu, Sohel Shaikh, Zhonglin Zhang
  • Method for preparation of 2,5-dimethylphenol by selective catalytic conversion of lignin
    Patent number: 11524928
    Abstract: The present disclosure discloses a method for preparing 2,5-dimethylphenol by selective catalytic conversion of lignin, relates to the technical field of chemistry, and includes the following steps: mixing lignin, a catalyst, and ethanol, and then carrying out a catalytic conversion reaction of lignin under the gaseous supercritical conditions of ethanol; and cooling the reaction product by quenching after the completion of reaction, and then subjecting it to separation and extraction to obtain 2,5-dimethylphenol. The catalyst comprises a modified sepiolite carrier, an active metal Mo, and auxiliary agents Zr and Fe. The process of the present disclosure is simple, and the prepared catalyst is a solid catalyst, which avoids problems of difficult recovery, serious environmental pollution and equipment corrosion caused by the use of homogeneous organic acid-base catalysts.
    Type: Grant
    Filed: April 27, 2021
    Date of Patent: December 13, 2022
    Assignee: Anhui University of Science & Technology
    Inventors: Mingqiang Chen, Yishuang Wang, Zhonglian Yang, Jun Wang, Han Zhang, Jinhui Zhang
  • Phenylamine compounds
    Patent number: 11524934
    Abstract: The present invention relates to 4-substituted phenylamidine derivatives of the general formula (I), wherein R5-R6, ArA4, D, G, B, Q and an integer m have the meanings as defined in the description. The invention further relates to methods for their preparation and use of said compounds for controlling undesired phytopathogenic microorganisms, and agents for said purpose, comprising said phenylamine derivatives. This invention further relates to a method for controlling undesired phytopathogenic microorganisms by application of said 4-substituted phenylamidine derivatives of general formula (I) to such undesired microorganisms and/or to their habitat, according to the invention.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: December 13, 2022
    Assignee: PI INDUSTRIES LTD
    Inventors: Maruti Naik, Vishal A. Mahajan, Gulab E. Walunj, Dipak D. Nivdunge, Sulur G. Manjunatha, Ruchi Garg, Santosh Shridhar Autkar, Nitin Ramesh Tembhare, Hagalavadi M. Venkatesha, Konstantin Poscharny, Alexander G. M. Klausener
  • Method for producing alpha-allylated cycloalkanone
    Patent number: 11524929
    Abstract: Provided is a method with which an ?-allylated cycloalkanone is obtained from a cyclic compound cycloalkanone used as a starting material. The method is a method for producing an ?-allylated cycloalkanone represented by General Formula (III), and the method includes: a step 1: reacting a compound represented by General Formula (I) and alcohol having 1 or more and 4 or less of carbon atoms in the presence of a first acid catalyst and optionally a dehydrating agent; and a step 2: reacting a crude product obtained in the step 1 and a compound represented by General Formula (II) in the presence of a second acid catalyst to produce an ?-allylated cycloalkanone represented by General Formula (III). The step 1 and the step 2 are consecutively performed.
    Type: Grant
    Filed: March 17, 2020
    Date of Patent: December 13, 2022
    Assignee: Kao Corporation
    Inventors: Jun Deguchi, Makoto Sakakibara, Daichi Sakoda
  • Process for preparation of highly pure Fingolimod hydrochloride
    Patent number: 11518733
    Abstract: The present invention provides process for preparation of highly pure Fingolimod hydrochloride (I), without involving the use of column chromatographic purification in the entire process. Fingolimod hydrochloride (I) obtained by the process of present invention may be useful as active pharmaceutical ingredient in pharmaceutical compositions for the treatment of autoimmune related disorder including multiple sclerosis.
    Type: Grant
    Filed: September 8, 2021
    Date of Patent: December 6, 2022
    Assignee: SHIVALIK RASAYAN LIMITED
    Inventors: Akshay Kant Chaturvedi, Vimal Kumar Shrawat, Sahdev Singh
  • Commercially viable process for preparation of aryl ketones
    Patent number: 11518727
    Abstract: The present disclosure provides a process for preparing an aryl ketone of Formula I, comprising reacting a substituted benzene of Formula II with a carboxylic acid of formula IIIa and/or a carboxylic anhydride of formula IIIb in presence of an alkyl sulfonic acid acting as catalyst cum solvent/contacting medium. I, II, IIIa, IIIb, wherein, R1, R2, R3 and R4 are as defined in the description.
    Type: Grant
    Filed: April 13, 2019
    Date of Patent: December 6, 2022
    Assignee: ANTHEA AROMATICS PRIVATE LIMITED
    Inventors: Manoj Kumar Mohapatra, Ramamohanrao Bendapudi, Paul Vincent Menacherry, Vincent Paul
  • Process for perhydrolysis of aliphatic epoxides
    Patent number: 11512050
    Abstract: The present invention relates to a process for synthesizing hydroperoxy alcohols by perhydrolysis of epoxides, using an aqueous solution of hydrogen peroxide, in the presence of a catalyst consisting of phosphotungstic acid.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: November 29, 2022
    Assignees: DEMETA, UNIVERSITE DE RENNES 1
    Inventors: Corentin Bordier, Vincent Escande, Frédéric Caijo, Christophe Darcel
  • Transfer hydroformylation for the production of oxygenates
    Patent number: 11512035
    Abstract: The present disclosure provides a method for forming oxygenates from olefins which includes hydroformylation of aldehydes as a formyl source alternative to syngas. In at least one embodiment, a hydroformylation process is performed at low-temperature and at or near ambient pressure for the conversion of olefins into aldehydes, thus reducing the formation of by-products such as via double bond or skeletal isomerization of the feedstock; or via further conversion of the formed aldehydes and alcohols. In at least one embodiment, the use of gaseous olefinic products (e.g., ethylene) instead of strained olefins (e.g., norbornene) improves the control equilibria in transfer hydroformylation reactions.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: November 29, 2022
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Alex Carpenter, Andrew Wiersum, Luc Martens
  • Production method for crystal of reduced coenzyme Q10 having excellent stability
    Patent number: 11498893
    Abstract: Provided is a production method capable of efficiently producing a reduced coenzyme Q10 Form II crystal. A method for producing reduced coenzyme Q10 crystals comprises warming a mixture of a reduced coenzyme Q10 Form I crystal and a reduced coenzyme Q10 Form II crystal to 32° C. or higher, in the presence of 0.001 to 50 parts by weight of a solvent with respect to 100 parts by total weight of the crystals, so as to increase the content of the reduced coenzyme Q10 Form II crystal. The warming time may be 1 hour or more and less than 14 hours, and after the warming of the mixture in the presence of the solvent, drying may be performed at 45° C. or higher to remove the solvent.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: November 15, 2022
    Assignee: KANEKA CORPORATION
    Inventors: Yuka Fukuyama, Takao Yamaguchi
  • Compounds and uses thereof
    Patent number: 11497752
    Abstract: The present disclosure features compounds useful for the treatment of BAF complex-related disorders.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: November 15, 2022
    Assignee: Foghorn Therapeutics Inc.
    Inventors: Neville John Anthony, David Simon Millan, Rishi G. Vaswani, Shawn E. R. Schiller
  • Processes for the conversion of mixed oxygenates feedstocks to hydrocarbon fuels
    Patent number: 11492303
    Abstract: A method for forming a desired hydrocarbon fuel product from a mixed oxygenate feedstock by utilizing chemical processes to form ketones from the oxygenate feed, upgrade the ketones, recycle selected upgraded ketones through the upgrading process to obtain a desired intermediate and hydrogenating the desired intermediate to obtain the desired hydrocarbon fuel product. In various alternative configurations and embodiments this can be accomplished in a number of ways, and originate in a number of different positions and occasions.
    Type: Grant
    Filed: May 12, 2021
    Date of Patent: November 8, 2022
    Assignee: BATTELLE MEMORIAL INSTITUTE
    Inventors: Karthikeyan Kallupalayam Ramasamy, Mond F. Guo, Senthil Subramaniam, Udishnu Sanyal, Casper O. Brady
  • Alkoxylated secondary alcohol
    Patent number: 11485695
    Abstract: The invention relates to a compound of following formula (I): a preparation process, uses thereof and compositions containing the same, wherein R1 and R2, represent, independently of one another, a linear, branched or cyclic, saturated or unsaturated hydrocarbon-based group comprising from 1 to 6 carbon atoms, where the sum of the carbon atoms of the groups R1 and R2 ranges from 2 to 7, and where R1 and R2 may also form, together and with the carbon atom bearing them, a 6-, 7-, or 8-membered ring; n is an integer of between 1 and 100, limits included; A represents a sequence of one or more units chosen from ethylene oxide, propylene oxide, butylene oxide units and mixtures thereof; the group formed by R1, R2 and the carbon atom to which R1 and R2 are attached has a degree of branching equal to 0, 1 or 2.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: November 1, 2022
    Assignee: Arkema France
    Inventors: Jean-Philippe Gillet, Thierry Beillon
  • Vanillin and/or ethylvanillin, process for their preparations and use thereof
    Patent number: 11484052
    Abstract: The present invention relates to a new bio-sourced vanillin and/or ethylvanillin, containing specific impurities. The invention further relates to a process for their preparations and the use of such compounds.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: November 1, 2022
    Assignee: RHODIA OPERATIONS
    Inventors: Stephan Verdier, Frédéric Madelaine
  • Compositions and methods for treatment of pre-cancerous skin lesions
    Patent number: 11478549
    Abstract: The present disclosure encompasses compositions and methods for the treatment of precancerous skin lesions. Compositions of the invention comprise a cytotoxic agent and a thymic stromal lymphopoietin (TSLP) inducer.
    Type: Grant
    Filed: January 4, 2021
    Date of Patent: October 25, 2022
    Assignee: Washington University
    Inventors: Lynn Cornelius, Shadmehr Demehri, Raphael Kopan