Patents Examined by Vera Afremova
  • Patent number: 10314809
    Abstract: Application of Derivatives of Clostridium ghonii, especially in the application of Derivatives of Clostridium ghonii MW-DCG-HNCv-18 in preparation of medicines for treating non-small cell lung carcinoma. It also discloses a medicine combining the Derivatives of Clostridium ghonii MW-DCG-HNCv-18 strain with Docetaxel as the active ingredients. According to the invention, the MW-DCG-HNCv-18 strain is found to have specific inhibition effect on non-small cell lung carcinoma for the first time, the inhibition effect on the non-small cell lung carcinoma is significantly superior to that of other known similar strains, and through screening, the MW-DCG-HNCv-18 strain is found to have more prominent inhibition effect on non-small cell lung carcinoma when combined with Docetaxel injection.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: June 11, 2019
    Inventors: Laitian Xing, Yong Wang, Mingqian Wei, Yanqiu Xing, Lianlian Li, Lichao Xing, Guangxia Deng, Hong Meng, Tao Huang, Dongxia Yang
  • Patent number: 10300094
    Abstract: A method for inhibiting bacterial adhesion of oral pathogens, comprising administering a heat-inactivated Lactobacillus strain to a subject in need to inhibit bacterial adhesion of oral pathogens is disclosed. The Lactobacillus strain is selected from Lactobacillus paracasei GMNL-143, Lactobacillus helveticus GMNL-164 or Lactobacillus rhamnosus GMNL-464. A composition for inhibiting bacterial adhesion of oral pathogens is also disclosed.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: May 28, 2019
    Inventors: Yi-Hsing Chen, Ya-Hui Chen, Chien-Chen Wu
  • Patent number: 10260081
    Abstract: The present disclosure provides methods for generating sugars from a cellulosic biomass. The methods combine treatment of the biomass using a high-shear milling device and saccharification of the biomass to partially hydrolyze the biomass. The biomass can be saccharified either after or simultaneously with the high-shear milling treatment. The partially hydrolyzed biomass is then separated into a solids stream with saccharification enzymes, and a liquid stream with sugars. The solids stream and associated enzymes are further incubated under saccharification conditions to produce additional sugars, or are recycled and added to fresh biomass, which is saccharified under high-shear milling conditions. The methods result in improved conversion of cellulosic biomass to glucose.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: April 16, 2019
    Assignee: Edeniq, Inc.
    Inventors: Deepak Singh, Sandra Jacobson, Kris Ramos, Prachand Shrestha
  • Patent number: 10258567
    Abstract: A formulation for vaginal administration comprising an effective amount of a composition of dried Lactobacillus cells and boric acid, with a carrier. The composition can include one or more antioxidants. Optionally, the composition is in a unit dosage form. Also provided are methods for making and using the composition.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: April 16, 2019
    Inventor: Allison Krebs-Bensch
  • Patent number: 10251899
    Abstract: In accordance with the present invention, a novel method for improving the stool characteristics, reducing the incidence of diarrhea, and firming the stool of a formula-fed infant has been discovered. The method comprises administering to the infant at least one prebiotic and hydrolyzed pectin.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: April 9, 2019
    Inventors: Nagendra Rangavajla, Joaquin Franco
  • Patent number: 10245300
    Abstract: The present invention features compositions and methods for treating gluten-related disorders. We describe compositions comprising one or more metabolites produced by Lactobacillus paracasei CBA L74, International Depository Accession Number LMG P-24778 that reduce cellular entry of gliadin peptides. The compositions may include a physiologically acceptable carrier, for example, a food product or a pharmaceutical carrier. The compositions can be administered to a subject having a gluten-related disorder, for example, celiac disease or gluten sensitivity.
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: April 2, 2019
    Assignee: H.J. Heinz Company Brands LLC
    Inventors: Francesca Romana Fasano, Andrea Luigi Budelli
  • Patent number: 10238597
    Abstract: The present invention teaches compositions, methods and kits for treating skin conditions, including dandruff. In various embodiments, the compositions include an effective amount of one or more probiotic microorganism of vaginal origin and/or a fraction thereof and/or a component of the metabolome for preventing and/or treating skin disorders of the scalp.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: March 26, 2019
    Inventors: Marc M. Baum, Janelle M. Baum
  • Patent number: 10227558
    Abstract: The invention relates to a zinc-enriched biomass comprising living or subsequently killed micro-organisms, selected from the group consisting of Streptococcus thermophilus and Bifidobacterium animalis subsp. lactis and combinations thereof, a method for the manufacture of said zinc-enriched biomass, as well as food preparations, nutraceutic products, functional foods, cosmetic and cosmeceutic products, and food supplements, comprising the said biomass. Furthermore, new micro-organism strains are described which are able to concentrate zinc within the cell in very high amounts and therefore are particularly suitable for use in the method of the invention.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: March 12, 2019
    Assignee: BIOMAN S.R.L.
    Inventors: Alberto Benedetti, Francesco Girardo
  • Patent number: 10196663
    Abstract: Provided are methods and yeast cultures for producing glycolipids and glycolipid compositions.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: February 5, 2019
    Assignee: The Regents of the University of California
    Inventors: Kyria Boundy-Mills, Luis Antonio Garay Almada, Irnayuli Sitepu, J. Bruce German
  • Patent number: 10188685
    Abstract: The present invention is directed to a use of anti-fatigue probiotic bacteria for improving exercise performance, particularly the fatigue caused by exercise. The anti-fatigue probiotic bacteria increases muscle mass and endurance, decreases blood lactate, ammonia, and creatine kinase concentration, and changes body composition; the said bacteria can be used to improve exercise performance.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: January 29, 2019
    Inventors: Yi-Ming Chen, Tsung-Yu Tsai, Chi-Chang Huang
  • Patent number: 10172367
    Abstract: A novel Lactobacillus plantarum and use thereof are disclosed, which fall within the technical field of microorganisms. The Lactobacillus plantarum tlj-2014 is deposited in China General Microbiological Culture Collection Center (CGMCC) under CGMCC Accession No. 9405. With the strain, the lactic acid production rate can be up to 35 g/L/d, and the concentration of lactic acid after 71 hrs of fermentation is up to 95 g/L. The Lactobacillus plantarum is acid tolerant, survives well at pH 1.80, can degrade the nitrite quickly with a decomposition capability of up to 9.8 mg/h/kg, and is tolerant to 1% bile salt. When the strain is used in production of pickles, the nitrite concentration is less than 5 mg/kg throughout the entire fermentation process, which is far below the content specified in the national standard GB2714-2003.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: January 8, 2019
    Inventor: Zheng Li
  • Patent number: 10166261
    Abstract: The present invention discloses the use of probiotics for therapeutic management of major depressive disorder (MDD). Specifically, the invention discloses the method of therapeutically managing MDD in mammals with Irritable bowel syndrome using probiotic strain Bacillus coagulans MTCC 5856.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: January 1, 2019
    Inventors: Muhammed Majeed, Kalyanam Nagabhushanam, Sivakumar Arumugam, Furqan Ali
  • Patent number: 10160942
    Abstract: A biogas plant fermenter supply method increases total throughput of substrate through fermenter chambers while not changing the number of fermenter chambers. An inoculum fermenter chamber is supplied with raw fermentation substrate and fermenting for a dwell time, returning part of the substrate fermented in the inoculum fermenter chamber in the form of a self-inoculating substrate to the inoculum fermenter chamber by a return path, the part being mixed with the raw fermentation substrate, and supplying a fast fermenter chamber coupled to the inoculum fermenter chamber with an additional part of the substrate fermented in the inoculum fermenter chamber in the form of a fast fermenter inoculation substrate and mixing the additional part with fast fermenter raw substrate of an amount per unit of time, wherein fermented output substrate is removed from the fast fermenter chamber after a dwell time of the substrate mixture introduced into the fast fermenter chamber.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: December 25, 2018
    Inventors: Michael Oertig, Rene Leisner
  • Patent number: 10159269
    Abstract: A composition containing a Lactobacillus pentosus TUA4337L strain (accession number: NITE BP-1479), characterized in that the strain has proliferation ability in the small intestines and/or the large intestine, and preferably the small intestines, after having survived in the intestinal tract. Since the composition of the present invention contains lactic acid bacteria having proliferation ability in the intestinal tract, when ingested in the body, the lactic acid bacteria survive to the intestinal tract and proliferate, whereby the fat absorption can be blocked, and the weight gains can be blocked, so that the composition can be suitably used for the purposes of dieting effects.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: December 25, 2018
    Inventor: Eiji Fukushima
  • Patent number: 10155971
    Abstract: A testing method is disclosed. The testing method includes: providing a mixture solution of a gelling agent and a microbe to a gelling device; solidifying the mixture solution to form a solid thin film in which the microbe is immobilized; supplying a bioactive agent to the solid thin film and allowing the bioactive agent to diffuse into the solid thin film; and imaging the individual responses of the single microbial cells to the bioactive agent, and determining the minimum inhibitory concentration (MIC) of the bioactive agent based on the analysis of the images to obtain AST results.
    Type: Grant
    Filed: August 3, 2015
    Date of Patent: December 18, 2018
    Inventors: Sunghoon Kwon, Yong-Gyun Jung, Jung Il Choi, Hun Jong Na
  • Patent number: 10124027
    Abstract: The present invention provides methods of designing panels of bacteriophages as therapeutic compositions against bacterial infections. The present invention also provides panels of bacteriophages for use in the prevention or treatment of bacterial infections.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: November 13, 2018
    Inventors: David Harper, Katy Blake
  • Patent number: 10119158
    Abstract: The present invention provides an improved process for the preparation of fidaxomicin by culturing Actinoplanes deccanensis in the culture medium of the invention wherein the fidaxomicin is produced in a yield of greater than 500 mg/L broth. The present invention also provides a whole broth extraction process for the isolation of fidaxomicin from the fermentation broth. The present invention also provides fidaxomicin having purity of greater than 97% area by HPLC.
    Type: Grant
    Filed: April 21, 2014
    Date of Patent: November 6, 2018
    Inventors: Ankur Sudhir Vaid, Mitesh Jagdishkumar Patel, Dhimant Punjalal Mehta, Anand Mahadev Dhiman, Jayesh Chandubhai Patel, Traunkant Parshuram Sharma
  • Patent number: 10118851
    Abstract: A process for the anaerobic fermentation of biogenic waste materials including the steps that a fermentation material containing the waste materials is mixed with liquid and the fermentation material suspension obtained in this manner is anaerobically fermented in a fermenter and the digest produced in the fermentation of the fermentation material suspension is dewatered of a dewatering device, wherein, with separation of press water, a press cake is obtained that has a dry matter proportion increased with respect to the digest; the press water is subjected to a solids separation, wherein a residual liquid having a dry matter proportion reduced with respect to the press water of at most 15% by weight is obtained and the residual liquid is used at least in part for the mixing according to the fermentation material step.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: November 6, 2018
    Inventors: Adrian Schatz, René Leisner
  • Patent number: 10113192
    Abstract: A method for the enzymatic production of D-fructose from D-glucose in a one-pot synthesis, wherein D-glucose is oxidized enzymatically to D-glucosone and D-glucosone is reduced enzymatically to D-fructose and the use of the D-fructose produced in this way for the production of furan derivatives.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: October 30, 2018
    Assignee: ANNIKKI GMBH
    Inventors: Ortwin Ertl, Marta Sut, Martina Brandner
  • Patent number: 10087466
    Abstract: A method of synthesizing biogenic elemental selenium nanostructure using Enterobacter cloacae and its application. The method uses E. cloacae Z0206 to reduce selenite to zero valence selenium and forms nano-sized elemental selenium particles, including steps of inoculating activated E. cloacae Z0206 to fermentation broth, adding sodium selenite solution, shaking and incubating, collecting the fermentation broth and separating the elemental selenium nanoparticles.
    Type: Grant
    Filed: January 3, 2017
    Date of Patent: October 2, 2018
    Assignee: Zhejiang University
    Inventors: Yizhen Wang, Deguang Song, Zeqing Lu, Fengqin Wang, Yuanzhi Cheng, Xiaoxiao Li