Patents Examined by Vera Afremova
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Patent number: 11965153Abstract: A method of controlling a bioreactor system includes providing a cell culture in a bioreactor, wherein conditions in the bioreactor enable the cell culture to produce a protein of interest (POI), measuring process parameters (PPs) of the culture within the bioreactor by RAMAN, wherein the process parameters are selected from the group consisting of nutrient concentration, viable cell concentration, and protein attributes, measuring a predetermined weight of the bioreactor with the cell culture, removing cell-free spent media from the cell culture using a first output conduit at a first specified rate, removing cells from the cell culture using a second output conduit at a second specified rate, and introducing one or both of fresh media or nutrients into the cell culture using an input conduit at a third specified rate.Type: GrantFiled: November 2, 2021Date of Patent: April 23, 2024Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Matthew Angelini, Ashley Witmer, Anthony Debiase
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Patent number: 11963986Abstract: The application discloses Lactobacillus strains having a beneficial effect on the metabolic health on a mammalian subject. Further disclosed is compositions comprising such strains and the use thereof for improving the metabolic health or for lowering the blood glucose level in a mammalian subject.Type: GrantFiled: October 24, 2019Date of Patent: April 23, 2024Assignee: Novozymes A/SInventors: Nanna Ny Kristensen, Alexandra Mattern, Delphine Marie Anne Saulnier, Jeffrey Schultchen, Teis Jensen, Benjamin Anderschou Holbech Jensen
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Patent number: 11959907Abstract: A device and method for analyte detection and analytes in a particulate bearing fluid such as whole blood having an instrument for partitioning the particles from the fluid that is integrated with a detector for analyzes of one or more particulate bearing fluid analytes while the particles in the particulate bearing fluid are partitioned.Type: GrantFiled: January 11, 2016Date of Patent: April 16, 2024Assignee: INSTRUMENTATION LABORATORY COMPANYInventors: Hansong Zeng, Gert Blankenstein
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Patent number: 11911423Abstract: A Bifidobacterium lactis BL-99 strain capable of enhancing immunity and the use thereof, which belongs to the technical field of microorganisms, is described. The Bifidobacterium lactis BL-99 provided by the present invention is deposited in China General Microbiological Culture Collection Center CGMCC on Apr. 26, 2018 with the deposit number CGMCC No. 15650. The bacteria have gastric acid resistance and intestinal fluid resistance, can significantly promote the growth of Bifidobacterium and Lactobacillus, significantly increase antibody-producing cells and half hemolysis value HC50, activate NK cell activity, and can be used to prepare foods for immunity enhancement. It also has the effects in preventing osteoporosis, increasing blood calcium and/or phosphorus ions, which has a wide range of application prospects.Type: GrantFiled: March 3, 2022Date of Patent: February 27, 2024Assignee: Inner Mongolia Yili Industrial Group Co., Ltd.Inventors: Wei-Hsien Liu, Wei-Lian Hung, Ting Sun, Wen Zhao, Ignatius Man-Yau Szeto
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Patent number: 11911422Abstract: A Bifidobacterium lactis BL-99 strain capable of enhancing immunity and the use thereof, which belongs to the technical field of microorganisms, is described. The Bifidobacterium lactis BL-99 provided by the present invention is deposited in China General Microbiological Culture Collection Center CGMCC on Apr. 26, 2018 with the deposit number CGMCC No. 15650. The bacteria have gastric acid resistance and intestinal fluid resistance, can significantly promote the growth of Bifidobacterium and Lactobacillus, significantly increase antibody-producing cells and half hemolysis value HC50, activate NK cell activity, and can be used to prepare foods for immunity enhancement. It also has the effects in preventing osteoporosis, increasing blood calcium and/or phosphorus ions, which has a wide range of application prospects.Type: GrantFiled: March 3, 2022Date of Patent: February 27, 2024Assignee: Inner Mongolia Yili Industrial Group Co., Ltd.Inventors: Wei-Hsien Liu, Wei-Lian Hung, Ting Sun, Wen Zhao, Ignatius Man-Yau Szeto
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Patent number: 11883442Abstract: A composition for treating irritable bowel syndrome can include a mixture of Bacillus amyloliquefaciens, Enterococcus faecium, and Vitamin D (Calciferol). The composition can be administered to a patient to treat irritable bowel syndrome or symptoms associated with irritable bowel syndrome. For example, the composition can be used to treat colitis. The composition can include about 1×106 to 1×1012 colony forming units (CFU) of Bacillus amyloliquefaciens and Enterococcus faecium per unit dose. In an embodiment, the composition can include at least 1 to 25 mg/L Vitamin-D.Type: GrantFiled: June 30, 2023Date of Patent: January 30, 2024Assignee: KING FAISAL UNIVERSITYInventors: Hairul Islam Mohamed Ibrahim, Ashraf Yassin Zaky Khalifa
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Patent number: 11882853Abstract: The present invention relates to a feed supplement for addition to drinking water, for improved animal health. The feed supplement includes short chain fatty acids, a nitrogenous compound, a source of inositol and a source of xylanase. The feed supplement reduces the need for pharmaceutical inputs and increases both animal health and yield.Type: GrantFiled: December 18, 2018Date of Patent: January 30, 2024Assignee: INTEGENE (PTY) LIMITEDInventor: Leigh-Ann Hasselbach
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Patent number: 11878039Abstract: A composition for treating irritable bowel syndrome can include a mixture of Bacillus amyloliquefaciens, Enterococcus faecium, and Vitamin D (Calciferol). The composition can be administered to a patient to treat irritable bowel syndrome or symptoms associated with irritable bowel syndrome. For example, the composition can be used to treat colitis. The composition can include about 1×106 to 1×1012 colony forming units (CFU) of Bacillus amyloliquefaciens and Enterococcus faecium per unit dose. In an embodiment, the composition can include at least 1 to 25 mg/L Vitamin-D.Type: GrantFiled: March 1, 2023Date of Patent: January 23, 2024Assignee: KING FAISAL UNIVERSITYInventors: Hairul Islam Mohamed Ibrahim, Ashraf Yassin Zaky Khalifa
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Patent number: 11871775Abstract: A method of inhibiting oral pathogens comprising administering to a subject in need thereof an effective amount of Lactobacillus strain-containing food composite, medical composite and oral cleaning composite. The food composite, medical composite and oral cleaning composite comprises at least one Lactobacillus strain, which is at least one isolated Lactobacillus strain selected from a group including Lactobacillus acidophilus F-1 strain, CCTCC NO: M2011124; Lactobacillus salivarius subsp. salicinius AP-32 strain, CCTCC NO: M2011127; Lactobacillus reuteri GL-104 strain, CCTCC NO: M209138; Lactobacillus paracasei GL-156 strain, CCTCC NO: M2014590; Lactobacillus helveticus RE-78 strain, CGMCC No. 13513; Lactobacillus rhamnosus CT-53 strain, CCTCC NO: M2011129; and Lactobacillus paracasei ET-66 strain, CGMCC No. 13514, which are respectively preserved in China Center for Type Culture Collection (CCTCC) and China General Microbiological Culture Collection Center (CGMCC).Type: GrantFiled: November 15, 2019Date of Patent: January 16, 2024Assignee: GLAC BIOTECH CO., LTD.Inventors: Pei-Shan Hsieh, Chung-Wei Kuo, Yi-Chun Tsai, Hsieh-Hsun Ho, Yi-Wei Kuo
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Patent number: 11864559Abstract: The present disclosure relates to amoebae (slime molds) and uses thereof. In particular, the present disclosure relates to the use of amoebae or their environmentally stable spores to control agricultural infections and other uses.Type: GrantFiled: June 17, 2020Date of Patent: January 9, 2024Assignee: AmebaGone, LLCInventors: Marcin Filutowicz, Ryan Kessens, Amy Jancewicz
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Patent number: 11865203Abstract: Disclosed are the skin care applications of a composition containing the partially purified extracellular metabolite isolated from Bacillus coagulans MTCC 5856. More specifically, the invention discloses the ability of the partially purified extracellular metabolite isolated from Bacillus coagulans MTCC 5856 to confer protection to the skin fibroblasts against UV induced cell damage and apoptosis, oxidative stress and inflammation.Type: GrantFiled: May 19, 2021Date of Patent: January 9, 2024Assignee: SAMI LABS LIMITEDInventors: Muhammed Majeed, Kalyanam Nagabhushanam, Sivakumar Arumugam, Furqan Ali, Shaheen Majeed, Lakshmi Mundkur
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Patent number: 11865144Abstract: Provided herein are composition and methods for the treatment of cancer by the administration of uropathogenic bacteria. In particular, CP1 E. coli is administered for the treatment of prostate cancer.Type: GrantFiled: August 1, 2018Date of Patent: January 9, 2024Inventors: Jonathan F. Anker, Praveen Thumbikat, Sarki A. Abdulkadir, Anthony J. Schaeffer
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Patent number: 11857579Abstract: An object of the present invention is to provide a novel composition for promoting the secretion of FGF21. The object is achieved by a composition for promoting the secretion of FGF21, including a Bifidobacterium bacterium as an active ingredient.Type: GrantFiled: March 23, 2018Date of Patent: January 2, 2024Assignee: Morinaga Milk Industry Co., Ltd.Inventors: Tatsuya Ehara, Hirohisa Izumi, Takashi Shimizu
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Patent number: 11851644Abstract: The invention provides a method and related compositions for preparing an effective probiotic bacteria formulation that can be stored, transported and used for protecting a variety of marine organisms against infection by potential pathogens.Type: GrantFiled: May 4, 2020Date of Patent: December 26, 2023Assignee: University of Rhode Island Board of TrusteesInventors: David R. Nelson, Jason LaPorte, David C Rowley, Marta Gomez-Chiarri
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Patent number: 11839640Abstract: Prebiotic composition including grape ferment, a first component, and a second component is provided. The first component is lactitol or xylooligosaccharide, and the second component is fructooligosaccharide, xylooligosaccharide, or inulin. The first component is different from the second component, and a weight ratio of the grape ferment, the first component and the second component falls within the range of 1-2:1-2:1-2. Based on this, the prebiotic composition prepared by grape ferment can be used to promote intestinal health of a subject in need thereof and enhance antioxidation in the subject.Type: GrantFiled: February 17, 2022Date of Patent: December 12, 2023Assignee: TCI CO., LTD.Inventors: Yung-Hsiang Lin, Chu-Han Huang
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Patent number: 11814668Abstract: To determine the presence of Mycobacterium in an environment, a sample from the environment can be plated onto a growth medium that is selective for Mycobacterium. The agar based growth medium can include a high concentration of crystal violet, in excess of 0.5 ?g/ml. The process may be made further selective for Mycobacterium by treating the sample with sodium dodecyl sulfate containing glycine hydrochloride for at least 4 minutes at room temperature, prior to plating. Mycobacterium colonies will generally appear white while other colonies will generally appear stained purple or another color.Type: GrantFiled: February 10, 2021Date of Patent: November 14, 2023Assignee: Phigenics, LLCInventors: Leah Wickenberg, Avneet K. Chhabra, Katherine E. Fisher, William F. McCoy
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Patent number: 11801274Abstract: Disclosed herein is a method for alleviating atopic dermatitis using a composition containing at least one lactic acid bacterial strain. The at least one lactic acid bacterial strain is selected from the group consisting of Lactobacillus salivarius subsp. salicinius AP-32 which is deposited at the China Center for Type Culture Collection (CCTCC) under an accession number CCTCC M 2011127, and Bifidobacterium animalis subsp. lactis CP-9 which is deposited at the CCTCC under an accession number CCTCC M 2014588.Type: GrantFiled: August 10, 2022Date of Patent: October 31, 2023Assignee: GLAC BIOTECH CO., LTD.Inventors: Hsieh-Hsun Ho, Yi-Wei Kuo, Yen-Yu Huang, Jia-Hung Lin, Ko-Chiang Hsia, Ching-Wei Chen, Shin-Yu Tsai
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Patent number: 11786565Abstract: Disclosed herein are compositions and methods for treating periodontal disease.Type: GrantFiled: March 18, 2020Date of Patent: October 17, 2023Assignee: Trustees of Tufts CollegeInventors: Linden Hu, Louis Cornacchione
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Patent number: 11788051Abstract: A cell separation device configured for separating cells from microcarriers or spheroids in a liquid is provided. The cell separation device includes a vessel comprising a first port, a second port, and a cavity; and a porous mesh disposed within the cavity to divide the cavity into a first compartment and a second compartment, wherein the first port is in communication with the first compartment of the cavity, the first port located to a first side of the porous mesh, wherein the second port is in communication with the second compartment of the cavity, the second port located to a second side of the porous mesh, and wherein the porous mesh is positioned within the cavity to have a substantially vertical orientation or an inclined orientation with respect to a flow of liquid through the porous mesh.Type: GrantFiled: December 13, 2016Date of Patent: October 17, 2023Assignee: CORNING INCORPORATEDInventors: Gregory Roger Martin, Allison Jean Tanner
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Patent number: 11779616Abstract: A probiotic composition of improving memory and learning ability is disclosed. The probiotic composition comprises Lactobacillus acidophilus GMNL-185 and Lactobacillus rhamnosus GMNL-680, wherein the Lactobacillus acidophilus GMNL-185 was deposited in the China Center for Type Culture Collection in Wuhan, China on Nov. 3, 2017 under an accession number CCTCC NO. M 2017764, and the Lactobacillus rhamnosus GMNL-680 was deposited in the China Center for Type Culture Collection in Wuhan, China on Nov. 3, 2017 under an accession number CCTCC NO. M 2017766, wherein a ratio of a number of bacteria of the Lactobacillus acidophilus GMNL-185 to a number of bacteria of the Lactobacillus rhamnosus GMNL-680 is 1:1.Type: GrantFiled: August 11, 2022Date of Patent: October 10, 2023Assignee: GENMONT BIOTECH INC.Inventors: Wan-hua Tsai, I-ling Hsu, Chih-ho Lai, Chia-lin Wu