Abstract: A bacterially induced crystal particle is formed by a composite shell that encloses a hollow space. The composite shell layer includes a biomaterial and a metallic material. The biomaterial includes cell wall or cell membrane of a bacterium. The metallic material includes oxides, sulfides, selenides, acid salt compounds of a transition metal, or any combination thereof. When the bacterially induced crystal particle is spheric, the composite shell is formed by two dome-shaped portions, and a thickness of each of the dome-shaped portions is not less than 1/73 of a diameter of the bacterially induced crystal particle. Alternatively, when the bacterially induced crystal particle is rod-shaped, the thickness of the dome-shaped portions is not less than 1/73 of a width of the bacterially induced crystal particle, and a thickness of the cylindrical portion is not less than 1/37 of the width of the bacterially induced crystal particle.
Abstract: The present invention is directed to pesticidal mixtures comprising sabadilla alkaloids and Bacillus thuringiensis and methods of controlling pests including insects and mites by application of pesticidal mixtures comprising sabadilla alkaloids and Bacillus thuringiensis.
Abstract: A probiotic-alcoholic beverage composition comprising Bacillus coagulans is disclosed herein wherein the said spore or vegetative cell of Bacillus coagulans exhibited high recovery, tolerability, compatibility and viability of spores and vegetative cells after brewing. Methods for brewing an alcoholic beverage composition comprising Bacillus coagulans wherein said spore or bacterium is added during pre-fermentation, during fermentation and post fermentation stages are also disclosed.
Abstract: Disclosed is a method for producing nanocelluloses from a cellulose substrate including cellulose fibers, the method including the following sequence of steps: —a step of enzymatic treatment of the cellulose substrate, by bringing same into contact with at least one cleaving enzyme, then—a step of mechanical treatment of the cellulose substrate subjected to the step of enzymatic treatment, in order to delaminate the cellulose fibres and obtain the nanocelluloses. The at least one cleaving enzyme is chosen from the enzymes belonging to the family of lytic polysaccharide monooxygenases (LPMOs) capable of achieving cleavage in the presence of an electron donor. Also disclosed are the nanocelluloses obtained according to the method.
Type:
Grant
Filed:
June 1, 2016
Date of Patent:
May 17, 2022
Assignee:
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
Inventors:
Bernard Cathala, Ana Villares, Jean-Guy Berrin, Celine Moreau
Abstract: Provided is a novel sleep-promoting composition. Provided is a sleep-promoting composition comprising bacteria belonging to Bifidobacterium breve as an active ingredient. The sleep-promoting composition related to the present technology may prolong a sleep time by prolonging non-REM sleep and REM sleep, reducing a spontaneous behavior amount during sleep, or reducing an awakening time during sleep. The sleep-promoting composition related to the present technology may also reduce difficulty in daytime awakening. The sleep-promoting composition related to the present technology may be used for a medical composition or a food and beverage composition.
Type:
Grant
Filed:
March 22, 2019
Date of Patent:
May 10, 2022
Assignee:
MORINAGA MILK INDUSTRY CO., LTD.
Inventors:
Mai Murata, Junichi Minami, Akio Yamada, Tetsuya Kuhara
Abstract: A Bifidobacterium lactis BL-99 strain capable of enhancing immunity and the use thereof, which belongs to the technical field of microorganisms, is described. The Bifidobacterium lactis BL-99 provided by the present invention is deposited in China General Microbiological Culture Collection Center CGMCC on Apr. 26, 2018 with the deposit number CGMCC No. 15650. The bacteria have gastric acid resistance and intestinal fluid resistance, can significantly promote the growth of Bifidobacterium and Lactobacillus, significantly increase antibody-producing cells and half hemolysis value HC50, activate NK cell activity, and can be used to prepare foods for immunity enhancement. It also has the effects in preventing osteoporosis, increasing blood calcium and/or phosphorus ions, which has a wide range of application prospects.
Type:
Grant
Filed:
March 30, 2021
Date of Patent:
April 12, 2022
Assignee:
Inner Mongolia Yili Industrial Group Co., Ltd.
Inventors:
Wei-Hsien Liu, Wen Zhao, Wei-Lian Hung, Ting Sun, Ignatius Man-Yau Szeto, Haotian Feng, Philip Andrew Wescombe, Haoqiu Li
Abstract: Human-derived probiotic strains Lactobacillus paracasei KBL382, Lactobacillus paracasei KBL384 and Lactobacillus paracasei KBL385 are described, as well as uses of the strains for improving intestinal health and treating or preventing intestinal diseases. The strains have excellent anti-inflammatory and immunomodulatory functions, superb strengthening effects on tight junctions of the intestinal tract wall, suppress enteritis-induced weight loss and colon length reduction, thereby exhibiting therapeutic effects for enteritis, and significantly alleviate the symptoms of atopic dermatitis. The strains can be used as probiotic material for enhancing anti-inflammatory effects, strengthening immunity, improving intestinal health functions, and alleviating allergic diseases.
Type:
Grant
Filed:
November 9, 2020
Date of Patent:
April 5, 2022
Assignee:
KoBioLabs, Inc.
Inventors:
Gwang Pyo Ko, Woonki Kim, You-Jin Jang, Boram Seo, June-Chul Lee, Tae-Wook Nam, Insu Kim, Jin-Woo Lee
Abstract: Endophytic microbial strains as biocatalysts isolated from fresh plant samples, compositions, and methods of use thereof to enhance the growth and/or yield of a plant in the presence of reduced synthetic nitrogen fertilizers are provided. Endophytic microbial strains serve as biocatalysts to solubilize organic (proteinaceous) nitrogen otherwise unavailable to plants for their nutritional needs. Thus defined, biocatalysts will serve to replace synthetic nitrogen fertilizers. Also provided are materials and methods for inoculating plants with these biocatalysts at carefully selected inoculum densities to reliably reduce the amount of nitrogen fertilizer by 50% thus accomplishing optimal yields in technically and cost-effective manner.
Abstract: Provided herein are Streptomyces isolates, designated MH71 and MH243, cultures thereof, and compositions comprising the same. Also provided are uses of the isolates, cultures and compositions, for example, for treating and preventing infections and diseases caused by or associated with plant pathogen infections, reducing the susceptibility of plants to diseases caused by or associated with plant pathogen infections, and for inhibiting or reducing the growth of pathogens on plants.
Type:
Grant
Filed:
September 11, 2018
Date of Patent:
March 29, 2022
Assignee:
Commonwealth Scientific and Industrial Research Organisation
Inventors:
Margaret Roper, Louise Thatcher, Cathryn O'Sullivan, Jonathan Anderson, Cindy Myers
Abstract: The invention relates to a process for the conversion of lignocellulose into an organic acid including an alkaline pretreatment step and a fermentation step, wherein liquid phase obtained in the fermentation step is recycled to the alkaline pretreatment step and/or the fermentation step. Organic acid is recovered as its magnesium of calcium salt from solid phase obtained in the fermentation step.
Type:
Grant
Filed:
October 23, 2012
Date of Patent:
March 22, 2022
Assignee:
PURAC BIOCHEM B.V.
Inventors:
Johan Pieter Marinus Sanders, Robert Reurd Christopher Bakker
Abstract: Lactobacillus plantarum TCI378 is provided. The Lactobacillus plantarum TCI378 was deposited at German Collection of Microorganisms and Cell Cultures (Deutsche Sammlung von Mikroorganismen and Zellkulturen, DSMZ) under the accession number DSM 32451. A method for losing fat and/or improving gastrointestinal functions is also provided. The method comprises administering to a subject in need an effective amount of a composition, wherein the composition comprises Lactobacillus plantarum TCI378 and/or its metabolites.
Type:
Grant
Filed:
April 21, 2020
Date of Patent:
March 15, 2022
Assignee:
TCI CO., LTD
Inventors:
Yung-Hsiang Lin, Chu-Han Huang, Cheng-Yu Ho
Abstract: The present invention relates to heat-killed Lactobacillus rhamnosus conjugated to a polysaccharide polymer binder, a preparation method therefor and a use thereof. The heat-killed Lactobacillus rhamnosus conjugated to a polysaccharide polymer binder of the present invention has an excellent therapeutic effect for atopic diseases, and particularly has high industrial applicability because membrane adhesion competitiveness, which is an advantage of existing lactic acid bacteria, is significantly improved, thereby exhibiting dermatitis preventing, alleviating and treating effects of the same level as steroid-based drugs.
Type:
Grant
Filed:
September 9, 2019
Date of Patent:
March 8, 2022
Assignee:
IL DONG PHARMACEUTICAL CO., LTD.
Inventors:
Seung-Hun Lee, Dae-Jung Kang, Jae-Hoon Kang
Abstract: Disclosed is a method of manufacturing a medium composition for cell culture, and a method of manufacturing a crushed stem cell extract using a method of manufacturing a medium composition for cell culture and a 3-low extracting method of active ingredients of a stem cell. The medium composition for cell culture includes a basal medium; a hyaluronic acid; and an additive composition. According to an embodiment, when active ingredients of a stem cell are extracted, a stem cell is crushed at a 3-low circumstance of low temperature, low pressure, a hypotonic circumstance.
Type:
Grant
Filed:
July 18, 2018
Date of Patent:
March 1, 2022
Assignee:
TIARA STEM CELL INSTITUTE
Inventors:
Young-Sil Kim, Jung-Eun Park, Hye-Jin Lee
Abstract: This document provides dietary supplement compositions. For example, multi-supplement compositions having combinations of dietary supplement formulations useful for human or animal consumption are provided.
Type:
Grant
Filed:
January 4, 2016
Date of Patent:
December 28, 2021
Assignee:
Melaleuca, Inc.
Inventors:
Alexander B. Rabovsky, Begonia Yeeman Ho, Stephanie Y. Nielson, Nasser A. Fredj, Subhendu Nayak, Erin A. Stone
Abstract: The invention relates to a method for protein enrichment of a microalga grown under heterotrophic conditions, said microalga being of the Chlorella genus, characterized in that the heterotrophic culture comprises a step aimed at limiting the growth of said microalga by means of a deficiency of the fermentation medium in terms of a non-nitrogenous nutritional source.
Type:
Grant
Filed:
January 22, 2019
Date of Patent:
December 7, 2021
Assignee:
Corbion Biotech, Inc.
Inventors:
Gabriel Macquart, Sylvain Delaroche, Marie Le Ruyet, Laurent Segueilha
Abstract: A method of controlling a bioreactor system includes providing a cell culture in a bioreactor, wherein conditions in the bioreactor enable the cell culture to produce a protein of interest (POI), measuring process parameters (PPs) of the culture within the bioreactor by RAMAN, wherein the process parameters are selected from the group consisting of nutrient concentration, viable cell concentration, and protein attributes, measuring a predetermined weight of the bioreactor with the cell culture, removing cell-free spent media from the cell culture using a first output conduit at a first specified rate, removing cells from the cell culture using a second output conduit at a second specified rate, and introducing one or both of fresh media or nutrients into the cell culture using an input conduit at a third specified rate.
Type:
Grant
Filed:
October 15, 2018
Date of Patent:
December 7, 2021
Assignee:
Regeneran Pharmaceuticals, Inc.
Inventors:
Matthew Angelini, Ashley Witmer, Anthony Debiase
Abstract: Compositions for methods of preventing or reducing pathogenic bacterial growth, proliferation, and/or colonization are described containing one or more types of non-pathogenic bacteria to be introduced into the gastrointestinal tract and effectively compete with pathogenic bacteria for monomeric or polymeric carbohydrate nutrients, and/or amino acid nutrients, and/or vitamin nutrients.
Type:
Grant
Filed:
February 4, 2014
Date of Patent:
November 30, 2021
Assignee:
Seres Therapeutics, Inc.
Inventors:
David N. Cook, Han Zhang, Anthony Mario D'Onofrio, David Arthur Berry, Mary-Jane Lombardo McKenzie, John Grant Aunins, Gregory McKenzie, Toshiro K. Ohsumi