Abstract: A synchronization circuit includes a first synchronizer having a first data input, a first clock input, and first output; a second synchronizer having a second data input, a second clock input, and a second output; selection circuitry having first, second, third and fourth inputs, and a synchronized data output, the first and second inputs coupled to the first and second outputs, respectively; and storage circuitry having a storage data input coupled to the synchronized data output, a third clock input, and a feedback output coupled to the fourth input.

Abstract: An example apparatus includes: bandwidth estimator circuitry configured to: obtain a first memory transaction; and determine a consumed bandwidth associated with the memory transaction; and gate circuitry configured to: permit transmission of the memory transaction to a memory controller circuitry; determine whether to gate a second memory transaction generated by a source of the first memory transaction based on the consumed bandwidth of the first memory transaction; and when it is determined to gate the second memory transaction, prevent transmission of the second memory transaction for an amount of time based on the consumed bandwidth.

Abstract: A memory system having an interconnect configured to receive commands from a system to read data from and/or write data to a memory device. The memory system also has a bridge configured to receive the commands from the interconnect, to manage ECC data and to perform address translation between system addresses and physical memory device addresses by calculating a first ECC memory address for a first ECC data block that is after and adjacent to a first data block having a first data address, calculating a second ECC memory address that is after and adjacent to the first ECC block, and calculating a second data address that is after and adjacent to the second ECC block. The bridge may also check and calculate ECC data for a complete burst of data, and/or cache ECC data for a complete burst of data that includes read and/or write data.

Abstract: A synchronization circuit includes a first synchronizer, a second synchronizer, and selection circuitry. The first synchronizer is configured to synchronize a received signal to a clock signal. The second synchronizer is disposed in parallel with the first synchronizer and configured to synchronize the received signal to the clock signal. The selection circuitry is coupled to the first synchronizer and the second synchronizer. The selection circuitry is configured to provide an output value generated by the first synchronizer at an output terminal of the synchronization circuit based on the output value generated by the first synchronizer being the same as an output value generated by the second synchronizer.

Abstract: The present description relates to a conjugated compound an antibody covalently linked to enhancer moiety composed by a nuclear localization sequence (NLS), covalently linked to a sterol variant, such as cholic acid (ChAc) or a variant thereof. The enhancer moiety as encompassed herein is able to induce endosome escape of the compound-conjugates by direct membrane destabilization or indirectly by ROS and ceramide production which destabilize endosome-lysosome membrane. The conjugated compound can further comprise payload.

Abstract: A vibratory conveyor includes a feed tray, an electromagnetic linear actuator and a movable drive train interconnecting the feed tray and the electromagnetic linear actuator such that the electromagnetic linear actuator will move the feed tray during energization of the electromagnetic linear actuator. A sensor assembly is positioned to detect movement of the electromagnetic linear actuator. A controller connected to receive an output of the sensor assembly and connected to control energization of electromagnetic linear actuator, wherein the controller is configured to adjust energization of the electromagnetic linear actuator based upon the output of the sensor assembly. A vibratory conveyor in which the movable drive train includes at least one parallel spring element therealong is also disclosed.

Abstract: The present invention relates to methods and kits of assessing status, risk or prognosis of type 1 diabetes. There is still a need for improved methods of prognosis of type 1 diabetes. The inventors have observed different alterations of iNKT and MAIT cells quantity, frequency and markers in T1D patients compared to controls and also in children with recent onset T1D compared to control children or children with established T1D. The present invention relates to a method of assessing status, risk or prognosis of type 1 diabetes in a subject comprising i) quantifying at least one population of innate-like T-cells in a blood sample obtained from the subject, ii) comparing the quantification value determined at step i) with a predetermined reference value and iii) detecting differential in the quantification value determined at step i) and the predetermined reference value is indicative of the status, risk of prognosis of type 1 diabetes.

Abstract: Systems and methods relating to machine learning. An edge device runs a new data point on a first neural network and determines activations on the layers within that neural network. The first neural network is a fully trained network based on a second neural network on a server. The activation data for the various layers in the first neural network are, starting with the output layer, sequentially transmitted to the server. The server continuously receives this activation data and continuously compares it with previously encountered activation data for the second neural network. If the received activation data is within an expected range, then the edge device is instructed to stop sending activation data. Otherwise, the server continues to receive the activation data for the other layers until the new data point is received by the server or the activation data is within the expected range of previously encountered activation data.

Abstract: A method for routing computer messages between parties is provided. The method is implemented using a message gateway computing system including a processor and a memory. The method includes receiving a message routing offer from a seller and a representing an offer to process payment card transactions. The method also includes receiving a message routing request from a buyer. The method further includes first message route between the buyer party and a first seller party of the plurality of seller parties on a message processing network. The method also includes receiving a payment card transaction from the buyer party. The method further includes identifying the first message route associated with the payment card transaction. The method also includes transmitting the payment card transaction to the first seller party based at least in part on the first message route.

Abstract: The disclosure provides Moloney murine leukemia virus (MMLV) reverse transcriptase (RTase) mutants with C-terminal peptide and/or N-terminal peptide extensions that improve the performance of the MMLV RTase mutants. The disclosure also provides suitable amino acid positions in MMLV RTases for mutagenesis and methods and kits for using MMLV RTase mutants to synthesize cDNA from RNA templates.

Abstract: A hinge assembly includes a first hinged body, a pivot pin assembly, and a second hinged body. The first hinged body includes a channel. The pivot pin assembly includes a pin body configured to slideably engage the channel. The pivot pin assembly may be translated within the channel and adjustably secured along the channel. The pin body includes a downwardly extending pin. The second hinged body comprises a pin aperture configured to cooperatively receive the pin. The first hinged body and the second hinged body are configured to hingedly pivot along a hinge axis defined by the pin when the pin is received in the pin aperture. The pin body may include a pin body aperture configured to receive an alignment fastener such that the pin body may be tilt adjusted relative to the first hinged body.

Abstract: A memory system having an interconnect configured to receive commands from a system to read data from and/or write data to a memory device. The memory system also has a bridge configured to receive the commands from the interconnect, to manage ECC data and to perform address translation between system addresses and physical memory device addresses by calculating a first ECC memory address for a first ECC data block that is after and adjacent to a first data block having a first data address, calculating a second ECC memory address that is after and adjacent to the first ECC block, and calculating a second data address that is after and adjacent to the second ECC block. The bridge may also check and calculate ECC data for a complete burst of data, and/or cache ECC data for a complete burst of data that includes read and/or write data.

Abstract: A packaged film for masking an aircraft component, wherein the packaged film is configured to form a tubular sleeve when unpackaged. The packaged film is formed by performing a longitudinal telescopic folding operation on a longitudinal portion of a film to provide a longitudinally parallelogram-shaped stacked film; and performing at least a first transverse folding operation on a first portion of the longitudinally parallelogram-shaped stacked film, the first transverse folding operation comprising an operation selected from accordion folding and roll folding to provide the packaged film. The packaged film is capable of being unfolded in a reverse order of the longitudinal telescopic folding operation and the first transverse folding operation to cover said aircraft component.

Abstract: Immunogen enhancers for admixture with an antigen of interest are described herein. The enhancers generally comprise a steroid acid and/or a steroid acid-peptide conjugate in an amount sufficient to improve or modify the adaptive immune response to antigens admixed therewith. In embodiments, the steroid acid may be a bile acid and the peptide may comprise one or more functional domains, such as a nuclear localization signal, which may facilitate antigen-presentation and/or antigen cross-presentation, thereby triggering improved cellular immunity, or improved cellular and humoral immunity, against the antigen.

Abstract: Agents having cytotoxic activity, as well as compositions, uses, and methods relating thereto, are described herein. Certain steroid acid-peptide conjugates or moieties have the ability to induce killing or inhibition of proliferation of mammalian cells, in vitro or in vivo upon administration to a subject. The steroid acid-peptide conjugates include bile acids and bile acid analogs and peptides that may include a nuclear localisation signal or a portion thereof. Also described herein is a method for treating cancer, an autoimmune disease, or any other disease or disorder ameliorated by treatment with an antiproliferative drug in a subject in a subject with the cytotoxic agents described herein.

Abstract: A hinge assembly includes a first hinged body, a pivot pin assembly, and a second hinged body. The first hinged body includes a channel. The pivot pin assembly includes a pin body configured to slideably engage the channel. The pivot pin assembly may be translated within the channel and adjustably secured along the channel. The pin body includes a downwardly extending pin. The second hinged body comprises a pin aperture configured to cooperatively receive the pin. The first hinged body and the second hinged body are configured to hingedly pivot along a hinge axis defined by the pin when the pin is received in the pin aperture. The pin body may include a pin body aperture configured to receive an alignment fastener such that the pin body may be tilt adjusted relative to the first hinged body.

Abstract: The invention solves the problem of protecting aircraft components during finishing. Such components are large and require masking films of vast dimensions which are difficult to handle and position rapidly. The invention relates to films packaged to facilitate transport, and to a method of positioning the packaged films on the corresponding components. The longitudinal and/or transverse portions of the films are packaged by means of at least one opération chosen from among: accordion folding, telescopic folding, gâte folding, roll folding, winding around a mandrel, and winding on itself. The packaged films can have positioning markers on at least one surface and/or tear lines suitable for detaching the portions of film to be separated. The invention also concerns a kit comprising a film and a guide element for guiding the positioning of the film on the component.

Abstract: Disclosed herein are several embodiments of a negative pressure appliance and methods of using the same in the treatment of wounds. Some embodiments are directed to improved fluidic connectors or suction adapters for connecting to a wound site, for example using softer, kink-free conformable suction adapters.

Abstract: A layer destacking system, for destacking a layer from a stacked layer pallet load, including a layer seating platform configured so as to seat the destacked layer on the layer seating platform, a slip sheet detection sensor arranged to sense a slip sheet in contact with the seated destacked layer, a slip sheet pickup removal mechanism, and a controller that receives a signal from the slip sheet detection sensor identifying presence of the slip sheet. The controller is operably connected to the slip sheet pickup removal mechanism so as to actuate the slip sheet pickup removal mechanism effecting discharge of the slip sheet off the layer seating platform.

Abstract: A technique for image processing, comprising: receiving input image data, wherein the image data is companded into a first bit depth, wherein the image data includes incomplete color values for pixels of the image data, and wherein the image data is associated with a first color space, interpolating the image data to generate color values for the incomplete color values for pixels of the image data, expanding the image data from the first bit depth to a second bit depth, wherein the color values of the expanded image data have a linear dynamic range, and wherein the second bit depth is higher than the first bit depth, converting the color values for pixels of the expanded image data from the first color space to a second color space, and compressing the color values for pixels of the image data to a third bit depth, the third bit depth lower than the second bit depth, and wherein the compressed color values have a nonlinear dynamic range.