Abstract: A computer program product comprising computer-readable code embodied in a non-transitory computer-readable storage medium which, when executed by one or more processors of a computing device, causes the computing device to perform a method comprising obtaining share portfolio information for one or more shareholders from a broker database, obtaining proxy voting requirements from at least one share issuer, receiving shareholder preference data from the one or more shareholders, generating proxy vote recommendations based on the share portfolio information, proxy voting requirements and the shareholder preference data, and providing the proxy vote recommendations to an interactive graphical interface of a shareholder access point using Application Programming Interface (API).

Abstract: Systems and methods for an emergency response system (ERS) to provide an augmented reality overlay on a real-world scene through the heads-up display (HUD) of an emergency responder. In addition to displaying information known to the ERS, an emergency responder terminal of the ERS can detect propagated signals from devices not registered with the ERS. The source and location of the propagated signal can be determined, and a generic display object can be generated representing the location of the propagated signal. The generic display object can be displayed on the HUD when the location of the source of the propagated signal falls within the field of view of a camera component of the emergency responder terminal.

Abstract: A sliding window assembly includes a frame with a track, and a sliding window portion disposed in the frame and displaceable in the track between a closed position and an open position. The sliding window portion includes a handle pivotable between a lock position and a slide position, and a driving pin coupled with the handle and engaging the track. The driving pin defines a pivot axis for the handle. A guide pin spaced from the driving pin is selectively engageable with the track when the handle is pivoted from the lock position to the slide position. With the handle in the slide position, the sliding window portion is displaceable from its closed position to an open position.

Abstract: The present description relates to a conjugated compound comprising cholic acid (ChAc) or a variant thereof, the ChAc conjugated to a non-cell penetrating peptide comprising a nuclear localization sequence (NLS) conjugated to a compound of interest.

Abstract: A console assembly for a vehicle includes a unitary main body. The unitary main body includes a first side wall, a second side wall, and a top finish portion that extends between the first and second side walls. The top finish portion defines at least one of a shifter receiving aperture and a cup holder opening. A cross bracket is coupled to the first and second side walls and extends between the first and second side walls of the unitary main body.

Abstract: Methods and systems are provided for a steering system for a vehicle. In one example, the steering system may include a steering assembly with a first linkage assembly extending along a first direction between a vehicle steering wheel and a first wheel plate of the steering assembly. The steering system may also include a second linkage assembly with a sliding middle link extending along a second direction between the first wheel plate and a second wheel plate of the steering assembly.

Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria.

Abstract: The disclosure provides Moloney murine leukemia virus (MMLV) reverse transcriptase (RTase) mutants. The disclosure as provides suitable amino acid positions in MMLV RTase for mutagenesis and methods and kits for using MMLV RTase mutants to synthesize cDNA from RNA templates.

Abstract: A synchronization circuit includes a first synchronizer, a second synchronizer, and selection circuitry. The first synchronizer is configured to synchronize a received signal to a clock signal. The second synchronizer is disposed in parallel with the first synchronizer and configured to synchronize the received signal to the clock signal. The selection circuitry is coupled to the first synchronizer and the second synchronizer. The selection circuitry is configured to provide an output value generated by the first synchronizer at an output terminal of the synchronization circuit based on the output value generated by the first synchronizer being the same as an output value generated by the second synchronizer.

Abstract: A system for generating and synchronously executing a multiplayer scenario, in one of a virtual, mixed and augmented reality environment and having a visual programming module allowing generation and management of at least one of an asset of a scenario and a visual acyclic relation action graph defined by a plurality of nodes and a network module configured to connect a plurality of clients over a network for synchronized execution of the nodes of the acyclic relation action graph. The network module operates using a network protocol including an identity component including a unique asset identifier and an asset container for each asset of the scenario and being replicable on the plurality of clients; and a node component defining a unique node identifier and a node container for each node of the visual acyclic relation action graph and being replicable on the plurality of clients.

Abstract: Covalently modified polypeptide antigens having improved immunogenicity and/or stability, as well as compositions, cells, and methods relating thereto, are described herein. Polypeptide antigens are covalently conjugated to a one or more of steroid acid moieties to improve their stability and/or to trigger improved cellular immunity, or improved cellular and humoral immunity, against the antigen upon administration to a subject. The steroid acids include bile acids and bile acid analogs that enhance endocytosis and/or endosomal escape of endosomally trapped cargoes by potentiating enzymatic cleavage of sphingomyelin to ceramide within endosomal membranes. The steroid acid moieties may be pre-conjugated to a peptide, and the steroid acid-peptide moiety subsequently conjugated to the polypeptide antigen. The peptide may comprise one or more domains that impart an additional functionality to the modified polypeptide antigen.

Abstract: The present disclosure, in its various aspects, is directed to expandable guide devices, implementation methods, and related systems. In one example, an expandable guide device is configured to receive an instrument through an instrument lumen of the device. Each of a plurality of expandable members are disposed circumferentially about a body of the device that defines the instrument lumen, and each expandable member is configured to be independently transitionable between an expanded configuration and an unexpanded configuration.

Abstract: Enclosed are embodiments for trajectory generation using a road network model. In an embodiment, a method includes: obtaining, using at least one processor of a vehicle, a location of the vehicle; obtaining, using the at least one processor, sensor data collected at the location; obtaining, using the at least one processor, map data for the location; generating, using the one or more processors, at least on possible trajectory for at least one object at the location, wherein the possible trajectory is constrained in accordance with the map data; and predicting, using a machine learning model, a score for the at least one trajectory.

Abstract: There is described a multi-clad optical fiber for propagating an optical signal having at least a single mode. The multi-clad optical fiber generally has a fiber core, an inner cladding surrounding the fiber core, and at least an outer cladding surrounding the inner cladding, the multi-clad optical fiber having at least a taper portion extending along a longitudinal dimension z, the taper portion having a radial dimension progressively decreasing at a normalized slope exceeding an adiabaticity criterion of a conventional single-clad optical fiber propagating at least the single-mode across its single-mode core.

Abstract: A method for designing an image filter, the method being executed by a machine learning algorithm (MLA), the method comprising: receiving unfiltered images, a desirable visual task and an undesirable visual task; for each unfiltered image, receiving a first label indicative of whether the desirable visual task is accomplishable and a second label indicative of whether the undesirable visual task is accomplishable; filtering the unfiltered image using a virtual filter model representative of the image filter; using the filtered images, training the MLA to perform the desirable visual task and prevent the undesirable visual task to be performed; using test images, determining a first efficiency for the MLA to perform the desirable task and a second efficiency for the MLA to prevent the undesirable task; adjusting a parameter of the virtual filter model based on the first and second efficiencies; and outputting the adjusted parameter.

Abstract: A synchronization circuit includes a first synchronizer, a second synchronizer, and selection circuitry. The first synchronizer is configured to synchronize a received signal to a clock signal. The second synchronizer is disposed in parallel with the first synchronizer and configured to synchronize the received signal to the clock signal. The selection circuitry is coupled to the first synchronizer and the second synchronizer. The selection circuitry is configured to provide an output value generated by the first synchronizer at an output terminal of the synchronization circuit based on the output value generated by the first synchronizer being the same as an output value generated by the second synchronizer.

Abstract: The invention relates to a flight time sensor (10) comprising:—a lighting device (11) comprising a light source (12) which emits a source beam (13) in the direction of a scene (3) comprising an object (4) which is capable of reflecting the source beam;—a detector (15) comprising a matrix (16) of photo-sensitive pixels (16A) which receive a portion (18) of the source beam reflected by the object; and—an electronic unit (19) which is configured:—to generate a modulation signal and to control the device by means of this signal so that the source beans has a source light power which is modulated temporally;—to process electric signals which are supplied as a function of time by the detector, each electric signal representing a fraction of the source light power reflected in the direction of a pixel; and—to deduce from the electric signals a characteristic distance (Dobj) between the object and the device.

Abstract: Methods and systems for a vehicle are provided. A transmission system includes, in one example, a first planetary gear set including a first ring gear and a first sun gear, a second planetary gear set that includes a second ring gear and a second sun gear, and a third planetary gear set that includes a third ring gear and a third sun gear. The transmission system further includes a first brake device configured to selectively ground the first ring gear, a second brake device configured to selectively ground the second ring gear, and a first lock-up clutch configured to selectively ground the first ring gear, wherein the first sun gear, the second sun gear, and the third sun gear are coupled in series.

Abstract: Methods and systems are provided for an electric heavy-duty vehicle. In one example, the vehicle includes a battery pack for supplying current to an electric motor of the vehicle, the battery pack arranged in a chassis of the vehicle and configured to form part of a floor of the vehicle. The vehicle also includes a motor coupled to front wheels of the vehicle, the front wheels having hub assemblies housing drive shaft adapters configured to permanently couple the hub assemblies to drive shafts of the front wheels, and a cradle configured to be mounted with electrical sub-systems of the vehicle.

Abstract: Methods and systems are provided for a steering system for a vehicle. In one example, the steering system may include a steering assembly with a first linkage assembly extending along a first direction between a vehicle steering wheel and a first wheel plate of the steering assembly. The steering system may also include a second linkage assembly with a sliding middle link extending along a second direction between the first wheel plate and a second wheel plate of the steering assembly.