Abstract: The present disclosure is directed to ion-exchange systems and devices that can monitor key parameters related to the performance of the ion-exchange device. Specifically, the ion-exchange systems and devices disclosed herein can provide real time voltage drop across groups of membrane pairs using diagnostic spacer borders between the pairs. In addition, the ion-exchange systems and devices disclosed herein can monitor the compression force applied by the compression plates holding the ion-exchange systems and devices together.

Abstract: A map is obtained by an agricultural system. The map includes values of one or more characteristics at different geographic locations in a worksite. In-situ sensor data indicative of values of one or more crop constituents at cut heights is obtained as the mobile machine operates at the worksite. A predictive model generator generates a predictive model that models a relationship between values of the one or more crop constituents at cut heights and the values of the one or more characteristics in the map. A predictive map generator generates a predictive map that predicts values of the one or more crop constituents at two or more cut heights at different geographic locations in the worksite based on the predictive model. The predictive map can be output and used in automated machine control.

Abstract: A mobile agricultural machine includes a header configured to engage crop at a worksite and a controllable header actuator configured to drive movement of the header relative to a surface of the worksite. The mobile agricultural machine further includes a crop constituent sensor system configured to sense the crop and generate a crop constituent sensor signal indicative of a value of a constituent of the crop. The mobile agricultural machine further includes a control system configured to generate a control signal to control the mobile agricultural machine based on the detected value of the constituent of the crop.

Abstract: The present disclosure relates to antisense oligonucleotides, which target SNCA mRNA (e.g., at an intron exon junction) in a cell, leading to reduced expression of SNCA protein. Reduction of SNCA protein expression is beneficial for the treatment of certain medical disorders, e.g., a neurological disorder.

Abstract: Provided are spacers, ion-exchange devices comprising spacers, and methods of preparing spacers for improved fluid distribution and sealing throughout an ion-exchange device. These spacers can include an internal cavity surrounded by a perimeter of the spacer. The perimeter can have a first opening and a second opening within the perimeter, and the first opening and the second opening can be located on opposite sides of the internal cavity. The spacers can also have a first and second plurality of channels located within the perimeter, wherein each channel of the first and second plurality of channels extends from the internal cavity towards the first opening or the second opening.

Abstract: A versioned file system comprising network accessible storage is provided. Aspects of the system include globally locking files or groups of files so as to better control the stored files in the file system and to avoid problems associated with simultaneous remote access or conflicting multiple access requests for the same files. A method for operating, creating and using the global locks is also disclosed. A multiprotocol global lock can be provided for filing nodes that have multiple network protocols for generating local lock requests.

Abstract: A vehicle that includes a door, handle, shaft, and a latch assembly is provided. The latch assembly is coupled to the door to selectively secure the door. The latch assembly includes a security tether configured to prevent the shaft from moving the pawl when the lock lever is located in the locked condition.

Abstract: The present disclosure is directed ion-exchange systems and devices that include composite ion-exchange membranes having 3D printed spacers on them. These 3D printed spacers can drastically reduce the total intermembrane spacing within the system/device while maintaining a reliable sealing surface around the exterior border of the membrane. By adding the spacers directly to the membrane using additive manufacturing, the amount of material used can be reduced without adversely impacting the manufacturability of the composite membrane as well as allow for complex spacer geometries that can reduce the restrictions to flow resulting in less pressure drop associated with the flow in the active area of the membranes.

Abstract: An operations server synchronizes updates to a cloud-based shared versioned file system. The shared versioned file system includes directories and sub-directories that are divided into shards. The operations server coordinates requests from local filer servers, each running a respective local version of the shared versioned file system, to update a shard in the cloud-based shared versioned file system. The operations server can provide a global lock on the shard to a local filer server before it updates the shard in the cloud-based shared versioned file system.

Abstract: Provided are spacers, ion-exchange devices comprising spacers, and methods of preparing spacers for improved fluid distribution and sealing throughout an ion-exchange device. These spacers can include an internal cavity surrounded by a perimeter of the spacer. The perimeter can have a first opening and a second opening within the perimeter, and the first opening and the second opening can be located on opposite sides of the internal cavity. The spacers can also have a first and second plurality of channels located within the perimeter, wherein each channel of the first and second plurality of channels extends from the internal cavity towards the first opening or the second opening.

Abstract: A pickup truck having a tonneau cover is provided. The tonneau cover includes a first panel section pivotable with respect to the opposing first and second upward-extending side walls. A first latching assembly is attached to the first panel section and is configured to selectively secure and release the first panel section with respect to the first and second side walls of the pickup truck. The first latching assembly includes first and second pinch latch assemblies. The first pinch latch assembly is located adjacent the first upward-extending side wall of the pickup truck and the second pinch latch assembly is located adjacent the second upward-extending side wall of the pickup truck.

Abstract: The present invention relates to novel phosphorous (V) (P(V)) reagents, methods for preparing thereof, and methods for preparing organophosphorous (V) compounds by using the novel reagents.

Abstract: Provided are inhibitors of diacylglycerol kinases (DGK) and methods for treating diseases that would benefit from the stimulation of the immune system, such as cancer and infections diseases, comprising administering a DGK inhibitor in combination with an antagonist of the PD 1/PD-L 1 axis and/or an antagonist of CTLA4.

Abstract: The present disclosure is directed ion-exchange systems and devices that include composite ion-exchange membranes having 3D printed spacers on them. These 3D printed spacers can drastically reduce the total intermembrane spacing within the system/device while maintaining a reliable sealing surface around the exterior border of the membrane. By adding the spacers directly to the membrane using additive manufacturing, the amount of material used can be reduced without adversely impacting the manufacturability of the composite membrane as well as allow for complex spacer geometries that can reduce the restrictions to flow resulting in less pressure drop associated with the flow in the active area of the membranes.

Abstract: A geographic position of an agricultural machine is captured. Agricultural data is received that corresponds to a geographic position. Georeferenced visual indicia are displayed that are indicative of the received agricultural data.

Abstract: A geographic position of an agricultural machine is captured. Agricultural data is received that corresponds to a geographic position. Georeferenced visual indicia are displayed that are indicative of the received agricultural data.

Abstract: A geographic position of an agricultural machine is captured. Agricultural data is received that corresponds to a geographic position. Georeferenced visual indicia are displayed that are indicative of the received agricultural data.

Abstract: A commercial vehicle used for parcel delivery is installed with a control module. The control module communicates wirelessly with a transmitter to give control to the vehicle operator. The vehicle operator can access the vehicle's cargo compartment through the bulkhead door and/or the rear door solely by using the transmitter as opposed to manually actuating the door latch. A door actuator is added to the bulkhead door such that when the bulkhead door is wirelessly actuated the door opens without operator assistance, and the process of the door opening does not damage the vehicle. Additionally, the vehicle operator can initiate the control module to allow a push-button start and stop of the vehicle's ignition system. Such elements contribute to time savings and cost savings for parcel delivery operators.

Abstract: Provided are spacers, ion-exchange devices comprising spacers, and methods of preparing spacers for improved fluid distribution and sealing throughout an ion-exchange device. These spacers can include an internal cavity surrounded by a perimeter of the spacer. The perimeter can have a first opening and a second opening within the perimeter, and the first opening and the second opening can be located on opposite sides of the internal cavity. The spacers can also have a first and second plurality of channels located within the perimeter, wherein each channel of the first and second plurality of channels extends from the internal cavity towards the first opening or the second opening.

Abstract: A versioned file system comprising network accessible storage is provided. Aspects of the system include globally locking files or groups of files so as to better control the stored files in the file system and to avoid problems associated with simultaneous remote access or conflicting multiple access requests for the same files. A method for operating, creating and using the global locks is also disclosed. A multiprotocol global lock can be provided for filing nodes that have multiple network protocols for generating local lock requests.