Abstract: Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer may include pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.

Abstract: A cloud-based write-once object store is configured to store inode-based data exported to the store from an enterprise file system. For each version of data (e.g., a file) exported to the store, there is a version of the inode corresponding to that data. As versions of the data are exported to the cloud, the system creates multiple versions of the inode. The set of inode versions corresponding to the versions of the file have a pointer associated therewith that specifies the latest version of the data associated with the inode. The inode versions in the set share the same pointer. The inode versions represent a revision history for the inode. For each inode version corresponding to a version of the data, information is received and stored in a new portion of the object store. The inode version for a file version comprises a list of data chunks for the file.

Abstract: The invention relates to anti-inflammatory peptides, to pharmaceutical compositions comprising same and to uses thereof for treatment of inflammation including, but not limited to inflammation associated with immune activation.

Abstract: An agricultural implement for distributing fertilizer to a plurality of rows includes a fertilizer container, a plurality of fertilizer metering units, and a plurality of motors. The fertilizer containers are used for storing the fertilizer prior to the fertilizer being distributed to the soil. The plurality of fertilizer metering units each include a housing and a metering device positioned in the housing. The housing has an inlet configured to receive fertilizer from the fertilizer container and an outlet. The plurality of motors are each drivingly coupled to and configured to rotate at least one metering device to distribute fertilizer to a row of the plurality of rows.

Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, R4, R5, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGK?) and diacylglycerol kinase zeta (DGK?), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

Abstract: Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer may include pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.

Abstract: A compaction mitigation system for a work area and a method of mitigating compaction in a work area may include determining a compaction map of the work area having compaction data associated with a plurality of reference points, passing a work tool through the work area at the plurality of reference points, and adjusting the work tool at the plurality of reference points based on the compaction data.

Abstract: The present disclosure relates to antisense oligonucleotides, which target SNCA mRNA (e.g., at an intron exon junction) in a cell, leading to reduced expression of SNCA protein. Reduction of SNCA protein expression is beneficial for the treatment of certain medical disorders, e.g., a neurological disorder.

Abstract: A cloud-based write-once object store is configured to store inode-based data exported to the store from an enterprise file system. For each version of data (e.g., a file) exported to the store, there is a version of the inode corresponding to that data. As versions of the data are exported to the cloud, the system creates multiple versions of the inode. The set of inode versions corresponding to the versions of the file have a pointer associated therewith that specifies the latest version of the data associated with the inode. The inode versions in the set share the same pointer. The inode versions represent a revision history for the inode. For each inode version corresponding to a version of the data, information is received and stored in a new portion of the object store. The inode version for a file version comprises a list of data chunks for the file.

Abstract: In accordance with an example embodiment, a compaction mitigation system for a work area and a method of mitigating compaction in a work area are provided. The method includes determining a compaction map of the work area having compaction data associated with a plurality of reference points, passing a work tool through the work area at the plurality of reference points, and adjusting the work tool at the plurality of reference points based on the compaction data.

Abstract: Provided are spacers, ion-exchange devices comprising spacers, and methods of preparing spacers for improved fluid distribution and sealing throughout an ion-exchange device. These spacers can include an internal cavity surrounded by a perimeter of the spacer. The perimeter can have a first opening and a second opening within the perimeter, and the first opening and the second opening can be located on opposite sides of the internal cavity. The spacers can also have a first and second plurality of channels located within the perimeter, wherein each channel of the first and second plurality of channels extends from the internal cavity towards the first opening or the second opening.

Abstract: The present disclosure relates to antisense oligonucleotides, which target ANGPTL2 mRNA in a cell, leading to reduced expression of ANGPTL2 protein. Reduction of ANGPTL2 protein expression is beneficial for the treatment of certain medical disorders, such as those associated with abnormal ANGPTL2 expression and/or activity e.g., cardiovascular-related diseases or disorders.

Abstract: Provided are spacers, ion-exchange devices comprising spacers, and methods of preparing spacers for improved fluid distribution and sealing throughout an ion-exchange device. These spacers can include an internal cavity surrounded by a perimeter of the spacer. The perimeter can have a first opening and a second opening within the perimeter, and the first opening and the second opening can be located on opposite sides of the internal cavity. The spacers can also have a first and second plurality of channels located within the perimeter, wherein each channel of the first and second plurality of channels extends from the internal cavity towards the first opening or the second opening.

Abstract: The present disclosure relates to antisense oligonucleotides, which target SNCA mRNA (e.g., at an intron exon junction) in a cell, leading to reduced expression of SNCA protein. Reduction of SNCA protein expression is beneficial for the treatment of certain medical disorders, e.g., a neurological disorder.

Abstract: An example of an incorporation mix includes a liquid carrier, a complex, and a labeled nucleotide. The complex includes a polymerase and a plasmonic nanostructure linked to the polymerase. The labeled nucleotide includes a nucleotide, a 3? OH blocking group attached to a sugar of the nucleotide, and a dye label attached to a base of the nucleotide.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed for efficient material application. An example landscape treatment apparatus includes a main carrier tank to store a solvent, a concentrate tank to store a solute, and a first mix tank to receive the solvent and the solute as a first mixture. The example apparatus further includes a second mix tank to receive the solvent and the solute as a second mixture, where the first mix tank is to receive the solvent and the solute in alternation with the second mix tank receiving the solvent and the solute. The example apparatus also includes a boom to apply the first mixture and the second mixture to a landscape via a plurality of nozzles, where the boom is to apply the first mixture and the second mixture in alternation.

Abstract: Provided are spacers, ion-exchange devices comprising spacers, and methods of preparing spacers for improved fluid distribution and sealing throughout an ion-exchange device. These spacers can include an internal cavity surrounded by a perimeter of the spacer. The perimeter can have a first opening and a second opening within the perimeter, and the first opening and the second opening can be located on opposite sides of the internal cavity. The spacers can also have a first and second plurality of channels located within the perimeter, wherein each channel of the first and second plurality of channels extends from the internal cavity towards the first opening or the second opening.

Abstract: The present disclosure relates to antisense oligonucleotides, which target Alpha-synuclein (SNCA) transcript in a cell, leading to reduced expression of SNCA protein. Reduction of SNCA protein expression is beneficial for the treatment of certain medical disorders, e.g., a neurological disorder such as a synucleinopathy.

Abstract: A vehicle that includes a door, handle, shaft, and a latch assembly is provided. The latch assembly is coupled to the door to selectively secure the door. The latch assembly includes a security tether configured to prevent the shaft from moving the pawl when the lock lever is located in the locked condition.